Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors

Oncotarget

Volumn 3, Issue 11, 2012, Pages 1320-1334

  Callahan, Robert ^a   Mudunuri, Uma ^b   Bargo, Sharon ^a   Raafat, Ahmed ^a   McCurdy, David ^a   Boulanger, Corinne ^a   Lowther, William ^a   Stephens, Robert ^b   Luke, Brian T ^b   Stewart, Claudia ^b   Wu, Xiaolin ^b   Munroe, David ^b   Smith, Gilbert H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Genes; Human breast carcinomas; Mammary tumors; Metastases; Mouse mammary tumor virus; Premalignant lesions

Indexed keywords

FIBROBLAST GROWTH FACTOR; WNT PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GROWTH; CANCER INVASION; COLONY FORMATION; COMMON INTEGRATION SITE; CONTROLLED STUDY; DDN GENE; FEMALE; FGF GENE; FOXL1 GENE; GENE; GENE ACTIVATION; GENE CLUSTER; GENE CONTROL; GENE INSERTION; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; GENETIC IDENTIFICATION; HUMAN; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; NPM3 GENE; PHF19 GENE; POLYMERASE CHAIN REACTION; PRECANCER; RSPO GENE; SDC2 GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; VIRUS CARCINOGENESIS; VIRUS DNA CELL DNA INTERACTION; WNT GENE;

EID: 84872763507     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.682     Document Type: Article

References (44)

1. Kenemans P, Verstraeten RA, Verheijen RH: Oncogenic pathways in hereditary and sporadic breast cancer. Maturitas 2004, 49(1):34-43.
2. Callahan R, Smith GH: Common integration sites for MMTV in viral induced mouse mammary tumors. J Mammary Gland Biol Neoplasia 2008, 13(3):309-321.
3. Squartini F: Responsiveness and progression of mammary tumors in high-cancer-strain mice. J Natl Cancer Inst 1962, 28:911-926.
4. Foulds L: The histologic analysis of mammary tumors of mice. J Natl Cancer Inst 1956, 17(6):701-801.
5. Gattelli A, Zimberlin MN, Meiss RP, Castilla LH, Kordon EC: Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. J Virol 2006, 80(22):11409-11415.
6. Lee AE: Genetic and viral influences of mammary tumours in BR6 mice. Br J Cancer 1968, 22(1):77-82.
7. van Nie R, Verstraeten AA: Studies of genetic transmission of mammary tumour virus by C3Hf mice. Int J Cancer 1975, 16(6):922-931.
8. Callahan R, Smith GH: MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways. Oncogene 2000, 19(8):992-1001.
9. Callahan R, Drohan W, Gallahan D, D'Hoostelaere L, Potter M: Novel class of mouse mammary tumor virusrelated DNA sequences found in all species of Mus, including mice lacking the virus proviral genome. Proc Natl Acad Sci U S A 1982, 79(13):4113-4117.
10. Kim HH, van den Heuvel AP, Schmidt JW, Ross SR: Novel common integration sites targeted by mouse mammary tumor virus insertion in mammary tumors have oncogenic activity. PLoS One 2011, 6(11):e27425.
11. Ross SR, Schmidt JW, Katz E, Cappelli L, Hultine S, Gimotty P, Monroe JG: An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumors. J Virol 2006, 80(18):9000-9008.
12. Theodorou V, Kimm MA, Boer M, Wessels L, Theelen W, Jonkers J, Hilkens J: MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nat Genet 2007, 39(6):759-769.
13. Lowther W, Wiley K, Smith GH, Callahan R: A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences. J Virol 2005, 79(15):10093-10096.
14. Silver J, Keerikatte V: Novel use of polymerase chain reaction to amplify cellular DNA adjacent to an integrated provirus. J Virol 1989, 63(5):1924-1928.
15. Mikkers H, Allen J, Knipscheer P, Romeijn L, Hart A, Vink E, Berns A: High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 2002, 32(1):153-159.
16. URL-2: http://mmtv.abcc.ncifcrf.gov/visual.php.
17. URL-6: http://www.ncbi.nlm.nih.gov/unigene.
18. Wheeler DL, Church DM, Federhen S, Lash AE, Madden TL, Pontius JU, Schuler GD, Schriml LM, Sequeira E, Tatusova TA et al: Database resources of the National Center for Biotechnology. Nucleic Acids Res 2003, 31(1):28-33.
19. Gallahan D, Callahan R: The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 1997, 14(16):1883-1890.
20. Peters G, Brookes S, Smith R, Placzek M, Dickson C: The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors. Proc Natl Acad Sci U S A 1989, 86(15):5678-5682.
21. Sarkar NH, Haga S, Lehner AF, Zhao W, Imai S, Moriwaki K: Insertional mutation of int protooncogenes in the mammary tumors of a new strain of mice derived from the wild in China: normal- and tumor-tissue-specific expression of int-3 transcripts. Virology 1994, 203(1):52-62.
22. Lee FS, Lane TF, Kuo A, Shackleford GM, Leder P: Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. Proc Natl Acad Sci U S A 1995, 92(6):2268-2272.
23. Lazo PA, Lee JS, Tsichlis PN: Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas. Proc Natl Acad Sci U S A 1990, 87(1):170-173.
24. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM: ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004, 6(1):1-6.
25. URL-3: http://www.oncomine.org.
26. Radvanyi L, Singh-Sandhu D, Gallichan S, Lovitt C, Pedyczak A, Mallo G, Gish K, Kwok K, Hanna W, Zubovits J et al: The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci U S A 2005, 102(31):11005-11010.
27. Wang S, Robertson GP, Zhu J: A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers. Gene 2004, 343(1):69-78.
28. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455(7216):1061-1068.
29. URL-4: http://cbio.mskcc.org/tcga-generanker/sources.jsp.
30. URL-7: http://www.sanger.ac.uk/genetics/CGP/cosmic.
31. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR: A census of human cancer genes. Nat Rev Cancer 2004, 4(3):177-183.
32. Vogelstein B, Kinzler KW: Cancer genes and the pathways they control. Nat Med 2004, 10(8):789-799.
33. Jackson BC, Carpenter C, Nebert DW, Vasiliou V: Update of human and mouse forkhead box (FOX) gene families. Hum Genomics 2010, 4(5):345-352.
34. Katoh M, Katoh M: Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. Int J Mol Med 2009, 23(6):763-769.
35. Han I, Park H, Oh ES: New insights into syndecan-2 expression and tumourigenic activity in colon carcinoma cells. J Mol Histol 2004, 35(3):319-326.
36. Rapraeger AC: Syndecan-regulated receptor signaling. J Cell Biol 2000, 149(5):995-998.
37. Schwartz MS, Smith GH, Medina D: The effect of parity, tumor latency and transplantation on the activation of int loci in MMTV-induced, transplanted C3H mammary preneoplasias and their tumors. Int J Cancer 1992, 51(5):805-811.
38. Dzuris JL, Zhu W, Kapkov D, Golovkina TV, Ross SR: Expression of mouse mammary tumor virus envelope protein does not prevent superinfection in vivo or in vitro. Virology 1999, 263(2):418-426.
39. Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N et al: R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell 2008, 19(6):2588-2596.
40. Kwan H, Pecenka V, Tsukamoto A, Parslow TG, Guzman R, Lin TP, Muller WJ, Lee FS, Leder P, Varmus HE: Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol 1992, 12(1):147-154.
41. Smith GH, Boulanger CA: Mammary epithelial stem cells: transplantation and self-renewal analysis. Cell Prolif 2003, 36 Suppl 1:3-15.
42. Li J, Shen H, Himmel KL, Dupuy AJ, Largaespada DA, Nakamura T, Shaughnessy JD, Jr., Jenkins NA, Copeland NG: Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet 1999, 23(3):348-353.
43. URL-5: http://genome.ucsc.edu.
44. URL-1: http://mmtv.abcc.ncifcrf.gov/cis.php.