Rational modification of a dendrimeric peptide with antimicrobial activity: Consequences on membrane-binding and biological properties

Amino Acids

Volumn 48, Issue 3, 2016, Pages 887-900

  Batoni, Giovanna ^a   Casu, Mariano ^b   Giuliani, Andrea ^c   Luca, Vincenzo ^d   Maisetta, Giuseppantonio ^a   Mangoni, Maria Luisa ^d   Manzo, Giorgia ^b   Pintus, Manuela ^b   Pirri, Giovanna ^c   Rinaldi, Andrea C ^b   Scorciapino, Mariano A ^b   Serra, Ilaria ^b   Ulrich, Anne S ^e   Wadhwani, Parvesh ^e  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c Research and Development Unit   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Antimicrobial peptides; Biofilms; Dendrimers; Gram negative; Gram positive; Model membranes

Indexed keywords

DEN SB 056; DEN SB 056 1; DENDRIMER; LIN SB 056; LIN SB 056 1; PEPTIDE DERIVATIVE; PHOSPHATIDYLCHOLINE; SB 056; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IONIC STRENGTH; LIPID VESICLE; MEMBRANE BINDING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; BACTERIUM; CELL MEMBRANE; CHEMISTRY; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL MEMBRANE; HUMANS; MICROBIAL SENSITIVITY TESTS;

EID: 84958125731     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-2136-5     Document Type: Article

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