Isomerization of an Antimicrobial Peptide Broadens Antimicrobial Spectrum to Gram-Positive Bacterial Pathogens

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Falciani, Chiara ^a   Lozzi, Luisa ^a   Pollini, Simona ^a   Luca, Vincenzo ^b   Carnicelli, Veronica ^c   Brunetti, Jlenia ^d   Lelli, Barbara ^a   Bindi, Stefano ^a,e   Scali, Silvia ^a   Di Giulio, Antonio ^c   Rossolini, Gian Maria ^a,e   Mangoni, Maria Luisa ^b   Bracci, Luisa ^a,e   Pini, Alessandro ^a,e  

^a UNIVERSITY OF SIENA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d SetLance srl   (Italy)

^e UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRO AMINO ACID; M33 D PEPTIDE; M33 L PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEINASE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BAGG ALBINO MOUSE; BIOFILM; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VIVO STUDY; ISOMER; ISOMERIZATION; MULTIDRUG RESISTANCE; NONHUMAN; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION; SURVIVAL RATE;

ANTI-BACTERIAL AGENTS; BIOFILMS; ISOMERISM; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PEPTIDES; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

BACTERIA (MICROORGANISMS); MUS; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 84867024731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046259     Document Type: Article

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