Design and in vitro evaluation of branched peptide conjugates: Turning nonspecific cytotoxic drugs into tumor-selective agents

ChemMedChem

Volumn 5, Issue 4, 2010, Pages 567-574

  Falciani, Chiara ^a   Brunetti, Jlenia ^a   Pagliuca, Chiara ^b   Menichetti, Stefano ^b   Vitellozzi, Lucia ^b   Lelli, Barbara ^a   Pini, Alessandro ^a   Bracci, Luisa ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antitumor agents; Cancer; Cytotoxicity; Peptides; Selectivity

Indexed keywords

CELL RECEPTOR; COMBRETASTAIN; CYTOTOXIC AGENT; DISODIUM COMBRETASTATIN A4 3 O PHOSPHATE; ISPINESIB; MERCAPTOPURINE; MONASTROL; MONOMER; NEUROTENSIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW TOXICITY; CANCER CELL CULTURE; CANCER INCIDENCE; CARDIOTOXICITY; CELL KILLING; CLINICAL TRIAL; CONJUGATE; CYTOTOXICITY; DRUG BINDING; DRUG CONJUGATION; DRUG DESIGN; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; LIVER TOXICITY; MORTALITY; PANCREAS CANCER; PANCREAS TUMOR; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; TUMOR CELL;

6-MERCAPTOPURINE; ANTINEOPLASTIC AGENTS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; NEUROTENSIN; PEPTIDES; PYRIMIDINES; RECEPTORS, NEUROTENSIN; STILBENES; THIONES;

EID: 77950646635     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900527     Document Type: Article

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