Mechanical Stimulation and IGF-1 Enhance mRNA Translation Rate in Osteoblasts Via Activation of the AKT-mTOR Pathway

Journal of Cellular Physiology

Volumn 231, Issue 6, 2016, Pages 1283-1290

  Bakker, Astrid D ^a   Gakes, Tom ^a   Hogervorst, Jolanda M A ^a   de Wit, Gerard M J ^a   Klein Nulend, Jenneke ^a   Jaspers, Richard T ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; DNA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P70S6K; RAPAMYCIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C; UNCLASSIFIED DRUG; IGF1 PROTEIN, HUMAN; MTOR PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA CONTENT; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; MECHANICAL STIMULATION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PULSATILE FLOW; PULSATING FLUID FLOW; QUANTITATIVE ANALYSIS; RNA TRANSLATION; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE TECHNIQUE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MECHANOTRANSDUCTION; METABOLISM; PHOSPHORYLATION; STIMULATION; TIME FACTOR;

3T3 CELLS; ANIMALS; CELL CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; INSULIN-LIKE GROWTH FACTOR I; MECHANOTRANSDUCTION, CELLULAR; MICE; OSTEOBLASTS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PHYSICAL STIMULATION; PROTEIN BIOSYNTHESIS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PULSATILE FLOW; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; TIME FACTORS; TOR SERINE-THREONINE KINASES;

EID: 84958122112     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25228     Document Type: Article

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