Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5′ stem-loop of COL1a1 and COL1a2 mRNA

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7264-7274

  Blackstock, Christopher D ^a   Higashi, Yusuke ^a   Sukhanov, Sergiy ^a   Shai, Shaw Yung ^a   Stefanovic, Branko ^b   Tabony, A Michael ^a   Yoshida, Tadashi ^a   Delafontaine, Patrice ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MAMMALS; POLYMERASE CHAIN REACTION;

ATHEROSCLEROTIC PLAQUE; EXTRACELLULAR ACCUMULATIONS; HUMAN AORTIC SMOOTH MUSCLE CELLS; IMMUNOPRECIPITATIONS; INSULIN-LIKE GROWTH FACTOR-1; MRNA-BINDING PROTEIN; POST-TRANSCRIPTIONAL; VASCULAR SMOOTH MUSCLES;

COLLAGEN;

COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA SUBUNIT 1; COLLAGEN TYPE 1 ALPHA SUBUNIT 2; LA RIBONUCLEOPROTEIN DOMAIN FAMILY MEMBER 6; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RNA BINDING PROTEIN; S6 KINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC SMOOTH MUSCLE FIBER; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; UPREGULATION;

5′ STEM-LOOP; ACHERON; AKT; ATHEROSCLEROSIS; FIBRILLOGENESIS; INSULIN-LIKE GROWTH FACTOR (IGF); POST-TRANSCRIPTIONAL; PROTEIN SYNTHESIS; TRANSLATION; VASCULAR SMOOTH MUSCLE CELLS;

ANIMALS; AORTA; ATHEROSCLEROSIS; AUTOANTIGENS; CELLS, CULTURED; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SMOOTH; MUTATION; MYOCYTES, SMOOTH MUSCLE; OXIDATIVE STRESS; PLAQUE, ATHEROSCLEROTIC; RIBONUCLEOPROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84896302141     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.518951     Document Type: Article

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