Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract

Archives of Toxicology

Volumn 90, Issue 2, 2016, Pages 449-461

  Wang, Bairu ^a,b   Liu, Yi ^a,b   Luo, Fei ^a,b   Xu, Yuan ^a,b   Qin, Yu ^c   Lu, Xiaolin ^a,b   Xu, Wenchao ^a,b   Shi, Le ^a,b   Liu, Qizhan ^a,b   Xiang, Quanyong ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Medical University   (China)

^c JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Cancer stem cell like properties; Carcinogenesis; Cigarette smoke extract (CSE); Epigenetic silencing; miR 218

Indexed keywords

3 DEAZANEPLANOCIN A; BMI1 PROTEIN; CD133 ANTIGEN; CIGARETTE SMOKE; HERMES ANTIGEN; HISTONE H3; LYSINE; MESSENGER RNA; MICRORNA; MICRORNA 218; NANOCARRIER; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; EZH2 PROTEIN, HUMAN; HISTONE; MAPK7 PROTEIN, HUMAN; MIRN218 MICRORNA, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 7;

ARTICLE; BRONCHUS MUCOSA; CANCER INHIBITION; CANCER STEM CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; EPIGENETIC REPRESSION; EPITHELIUM CELL; GENE OVEREXPRESSION; GENE SILENCING; HISTONE METHYLATION; HUMAN; HUMAN BRONCHIAL EPITHELIAL CELL; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; NANOPHARMACEUTICS; PRIORITY JOURNAL; PROMOTER REGION; RNAI THERAPEUTICS; SIGNAL TRANSDUCTION; STEM CELL SELF-RENEWAL; TRANSFORMED CELL; UPREGULATION; ADVERSE EFFECTS; BRONCHUS; CELL LINE; CELL TRANSFORMATION; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; LUNG TUMOR; METABOLISM; METHYLATION; PATHOLOGY; SMOKING;

BRONCHI; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; EPIGENESIS, GENETIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; LUNG NEOPLASMS; LYSINE; METHYLATION; MICRORNAS; MITOGEN-ACTIVATED PROTEIN KINASE 7; SMOKING;

EID: 84958117918     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1435-z     Document Type: Article

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