Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Lou, Hubing ^a   Chen, Min ^b,e   Black, Susan S ^c   Bushell, Simon R ^a   Ceccarelli, Matteo ^d   Mach, Tivadar ^b   Beis, Konstantinos ^a,f   Low, Alison S ^c   Bamford, Victoria A ^a,g   Booth, Ian R ^c   Bayley, Hagan ^b   Naismith, James H ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d UNIVERSITY OF CAGLIARI   (Italy)

^e UNIVERSITY OF MASSACHUSETTS   (United States)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFOTAXIME; K12 PORIN; OUTER MEMBRANE PROTEIN C; OUTER MEMBRANE PROTEIN C 20; OUTER MEMBRANE PROTEIN C 26; OUTER MEMBRANE PROTEIN C 28; OUTER MEMBRANE PROTEIN C 33; PORIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BACTERIAL OUTER MEMBRANE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG TRANSPORT; ELECTRIC FIELD; ESCHERICHIA COLI; ION CONDUCTANCE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; CHANNEL GATING; CHEMISTRY; DRUG EFFECT; GENETICS; HYDROGEN BOND; ION TRANSPORT; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGICAL EXAMINATION; MUTATION; X RAY CRYSTALLOGRAPHY;

NEGIBACTERIA;

ANTI-BACTERIAL AGENTS; CEFOTAXIME; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; HYDROGEN BONDING; ION CHANNEL GATING; ION TRANSPORT; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; MOLECULAR DYNAMICS SIMULATION; MUTATION; PORINS;

EID: 80055047308     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025825     Document Type: Article

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