Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge

ACS Chemical Biology

Volumn 9, Issue 10, 2014, Pages 2263-2273

  Chen, Gang ^a   Koellhoffer, Jayne F ^b   Zak, Samantha E ^c   Frei, Julia C ^b   Liu, Nina ^b   Long, Hua ^a   Ye, Wei ^a   Nagar, Kaajal ^a   Pan, Guohua ^a   Chandran, Kartik ^b   Dye, John M ^c   Sidhu, Sachdev S ^a   Lai, Jonathan R ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; MONOCLONAL ANTIBODY; SUDAN EBOLAVIRUS SPECIFIC MONOCLONAL ANTIBODY'; UNCLASSIFIED DRUG; ANTIBODY; EPITOPE; INTERFERON RECEPTOR; NEUTRALIZING ANTIBODY; PEPTIDE LIBRARY; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EBOLA VIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNITY; INFECTION PREVENTION; MALE; MOUSE; NONHUMAN; SUDAN EBOLAVIRUS INFECTION; VIRUS INFECTION; VIRUS NEUTRALIZATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; MOLECULAR GENETICS; PATHOGENICITY; PEPTIDE LIBRARY; PHYSIOLOGY; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SUDAN; VIROLOGY;

MUS; SUDAN EBOLAVIRUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODIES, NEUTRALIZING; ANTIGENS, VIRAL; EBOLAVIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HEMORRHAGIC FEVER, EBOLA; HUMANS; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN CONFORMATION; RECEPTORS, INTERFERON; SEQUENCE HOMOLOGY, AMINO ACID; SUDAN; VIRAL ENVELOPE PROTEINS;

EID: 84908204878     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5006454     Document Type: Article

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