Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of ebola hemorrhagic fever

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Marzi, Andrea ^a   Yoshida, Reiko ^b   Miyamoto, Hiroko ^b   Ishijima, Mari ^b   Suzuki, Yasuhiko ^b   Higuchi, Megumi ^b   Matsuyama, Yukie ^b   Igarashi, Manabu ^b   Nakayama, Eri ^b   Kuroda, Makoto ^b   Saijo, Masayuki ^c   Feldmann, Friederike ^a   Brining, Douglas ^a   Feldmann, Heinz ^a   Takada, Ayato ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b HOKKAIDO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CH133; MONOCLONAL ANTIBODY CH226; UNCLASSIFIED DRUG; VIRUS RNA; EPITOPE; HYBRID PROTEIN; NEUTRALIZING ANTIBODY;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG EFFICACY; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PASSIVE IMMUNIZATION; PROTECTION; RHESUS MONKEY; SURVIVAL RATE; VERO CELL; VIRUS LOAD; VIRUS NEUTRALIZATION; VIRUS REPLICATION; ANIMAL; ANTIBODY SPECIFICITY; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DISEASE MODEL; HAMSTER; HUMAN; IMMUNOLOGY; MACACA MULATTA; MOUSE; PATHOGENICITY; PHYSIOLOGY; PROTEIN CONFORMATION;

ANIMALIA; EBOLA VIRUS; MACACA MULATTA; PRIMATES; RODENTIA; ZAIRE EBOLAVIRUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; CERCOPITHECUS AETHIOPS; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; EBOLAVIRUS; EPITOPES; HEMORRHAGIC FEVER, EBOLA; HUMANS; IMMUNIZATION, PASSIVE; MACACA MULATTA; MALE; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; VERO CELLS; VIRAL LOAD;

EID: 84860456246     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036192     Document Type: Article

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