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Volumn 130, Issue 4, 2016, Pages 247-258

Intra-tumoral IFN-γ-producing Th22 cells correlate with TNM staging and the worst outcomes in pancreatic cancer

Author keywords

IFN ; IL 22; Pancreatic cancer; Th22; Tumour infiltrating lymphocytes

Indexed keywords

GAMMA INTERFERON; GRANZYME A; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 22 RECEPTOR; INTERLEUKIN RECEPTOR; LIPOCORTIN 5; PERFORIN; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; GRANZYME; GZMA PROTEIN, HUMAN; IFNG PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22;

EID: 84958073288     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150437     Document Type: Article
Times cited : (30)

References (50)
  • 3
    • 84893436855 scopus 로고    scopus 로고
    • Risk factors for pancreatic cancer: underlying mechanisms and potential targets
    • Kolodecik, T., Shugrue, C., Ashat, M. and Thrower, E.C. (2014) Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Front. Physiol. 4, 415
    • (2014) Front. Physiol , vol.4 , pp. 415
    • Kolodecik, T.1    Shugrue, C.2    Ashat, M.3    Thrower, E.C.4
  • 4
    • 84872598312 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Candido, J. and Hagemann, T. (2013) Cancer-related inflammation. J. Clin. Immunol. 33 Suppl., S79-S8
    • (2013) J. Clin. Immunol , vol.33 , pp. S79-S88
    • Candido, J.1    Hagemann, T.2
  • 5
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • Lin, W.W. and Karin, M. (2007) A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 117, 1175-1183
    • (2007) J. Clin. Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 6
    • 78649757427 scopus 로고    scopus 로고
    • Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
    • Witte, E., Witte, K., Warszawska, K., Sabat, R. and Wolk, K. (2010) Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Cytokine Growth Factor Rev. 21, 365-379
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 365-379
    • Witte, E.1    Witte, K.2    Warszawska, K.3    Sabat, R.4    Wolk, K.5
  • 8
    • 1842841846 scopus 로고    scopus 로고
    • IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells
    • Lécart, S., Morel, F., Noraz, N., Pène, J., Garcia, M., Boniface, K., Lecron, J.C. and Yssel, H. (2002) IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells. Int. Immunol. 14, 1351-1356
    • (2002) Int. Immunol , vol.14 , pp. 1351-1356
    • Lécart, S.1    Morel, F.2    Noraz, N.3    Pène, J.4    Garcia, M.5    Boniface, K.6    Lecron, J.C.7    Yssel, H.8
  • 9
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva, S., Sun, R., Pan, H.N., Hong, F. and Gao, B. (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39, 1332-1342
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 10
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    • Wolk, K., Witte, E., Wallace, E., Döcke, W.D., Kunz, S., Asadullah, K., Volk, H.D., Sterry, W. and Sabat, R. (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36, 1309-1323.
    • (2006) Eur. J. Immunol , vol.36 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3    Döcke, W.D.4    Kunz, S.5    Asadullah, K.6    Volk, H.D.7    Sterry, W.8    Sabat, R.9
  • 13
    • 45549092326 scopus 로고    scopus 로고
    • Interleukin 22 receptor 1 expression in pancreas islets
    • Shioya, M., Andoh, A., Kakinoki, S., Nishida, A. and Fujiyama, Y. (2008) Interleukin 22 receptor 1 expression in pancreas islets. Pancreas 36, 197-199
    • (2008) Pancreas , vol.36 , pp. 197-199
    • Shioya, M.1    Andoh, A.2    Kakinoki, S.3    Nishida, A.4    Fujiyama, Y.5
  • 14
    • 57849117363 scopus 로고    scopus 로고
    • RORγ t and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46
    • Sanos, S.L., Bui, V.L., Mortha, A., Oberle, K., Heners, C., Johner, C. and Diefenbach, A. (2009) RORγ t and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46 cells. Nat. Immunol. 10, 83-91
    • (2009) cells. Nat. Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1    Bui, V.L.2    Mortha, A.3    Oberle, K.4    Heners, C.5    Johner, C.6    Diefenbach, A.7
  • 19
    • 33751120140 scopus 로고    scopus 로고
    • Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
    • Chung, Y., Yang, X., Chang, S.H., Ma, L., Tian, Q. and Dong, C. (2006) Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 16, 902-907
    • (2006) Cell Res , vol.16 , pp. 902-907
    • Chung, Y.1    Yang, X.2    Chang, S.H.3    Ma, L.4    Tian, Q.5    Dong, C.6
  • 20
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng, Y., Danilenko, D.M., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J. and Ouyang, W. (2007) Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6    Ouyang, W.7
  • 21
  • 22
  • 24
    • 84871018340 scopus 로고    scopus 로고
    • Increased intratumoral IL-22-producing CD4+ T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival
    • Zhuang, Y., Peng, L.S., Zhao, Y.L., Shi, Y., Mao, X.H., Guo, G., Chen, W., Liu, X.F., Zhang, J.Y., Liu, T. et al. (2012) Increased intratumoral IL-22-producing CD4+ T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival. Cancer Immunol. Immunother. 61, 1965-1975
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1965-1975
    • Zhuang, Y.1    Peng, L.S.2    Zhao, Y.L.3    Shi, Y.4    Mao, X.H.5    Guo, G.6    Chen, W.7    Liu, X.F.8    Zhang, J.Y.9    Liu, T.10
  • 25
    • 84878249123 scopus 로고    scopus 로고
    • Increased circulating Th22 and Th17 cells are associated with tumor progression and patient survival in human gastric cancer
    • Liu, T., Peng, L., Yu, P., Zhao, Y., Shi, Y., Mao, X., Chen, W., Cheng, P., Wang, T., Chen, N. et al. (2012) Increased circulating Th22 and Th17 cells are associated with tumor progression and patient survival in human gastric cancer. J. Clin. Immunol. 32, 1332-1339
    • (2012) J. Clin. Immunol , vol.32 , pp. 1332-1339
    • Liu, T.1    Peng, L.2    Yu, P.3    Zhao, Y.4    Shi, Y.5    Mao, X.6    Chen, W.7    Cheng, P.8    Wang, T.9    Chen, N.10
  • 26
    • 84883615553 scopus 로고    scopus 로고
    • Differential expression of IL-17, 22 and 23 in the progression of colorectal cancer in patients with K-ras mutation: Ras signal inhibition and crosstalk with GM-CSF and IFN-γ
    • Petanidis, S., Anestakis, D., Argyraki, M., Hadzopoulou-Cladaras, M. and Salifoglou, A. (2013) Differential expression of IL-17, 22 and 23 in the progression of colorectal cancer in patients with K-ras mutation: Ras signal inhibition and crosstalk with GM-CSF and IFN-γ . PLoS One 8, e73616
    • (2013) PLoS One , vol.8
    • Petanidis, S.1    Anestakis, D.2    Argyraki, M.3    Hadzopoulou-Cladaras, M.4    Salifoglou, A.5
  • 27
    • 84875250659 scopus 로고    scopus 로고
    • Elevated serum IL-22 levels correlate with chemoresistant condition of colorectal cancer
    • Wu, T., Cui, L., Liang, Z., Liu, C., Liu, Y. and Li, J. (2013) Elevated serum IL-22 levels correlate with chemoresistant condition of colorectal cancer. Clin. Immunol. 147, 38-39
    • (2013) Clin. Immunol , vol.147 , pp. 38-39
    • Wu, T.1    Cui, L.2    Liang, Z.3    Liu, C.4    Liu, Y.5    Li, J.6
  • 28
    • 84896688553 scopus 로고    scopus 로고
    • Increased intratumoral interleukin 22 levels and frequencies of interleukin 22-producing CD4+ T cells correlate with pancreatic cancer progression
    • Xu, X., Tang, Y., Guo, S., Zhang, Y., Tian, Y., Ni, B. and Wang, H. (2014) Increased intratumoral interleukin 22 levels and frequencies of interleukin 22-producing CD4+ T cells correlate with pancreatic cancer progression. Pancreas 43, 470-477
    • (2014) Pancreas , vol.43 , pp. 470-477
    • Xu, X.1    Tang, Y.2    Guo, S.3    Zhang, Y.4    Tian, Y.5    Ni, B.6    Wang, H.7
  • 29
    • 84891674362 scopus 로고    scopus 로고
    • High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma
    • Wen, Z., Liao, Q., Zhao, J., Hu, Y., You, L., Lu, Z., Jia, C., Wei, Y. and Zhao, Y. (2014) High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma. Ann. Surg. Oncol. 21, 125-132
    • (2014) Ann. Surg. Oncol , vol.21 , pp. 125-132
    • Wen, Z.1    Liao, Q.2    Zhao, J.3    Hu, Y.4    You, L.5    Lu, Z.6    Jia, C.7    Wei, Y.8    Zhao, Y.9
  • 32
    • 0033107768 scopus 로고    scopus 로고
    • In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice
    • Bruns, C.J., Harbison, M.T., Kuniyasu, H., Eue, I. and Fidler, I.J. (1999) In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1, 50-62
    • (1999) Neoplasia , vol.1 , pp. 50-62
    • Bruns, C.J.1    Harbison, M.T.2    Kuniyasu, H.3    Eue, I.4    Fidler, I.J.5
  • 33
    • 77956494792 scopus 로고    scopus 로고
    • IL-22-producing CD4+ T cells: middle-men between the immune system and its environment
    • Trifari, S. and Spits, H. (2010) IL-22-producing CD4+ T cells: middle-men between the immune system and its environment. Eur. J. Immunol. 40, 2369-2371
    • (2010) Eur. J. Immunol , vol.40 , pp. 2369-2371
    • Trifari, S.1    Spits, H.2
  • 35
    • 77953128344 scopus 로고    scopus 로고
    • Serum IL-22 correlates with psoriatic severity and serum IL-6 correlates with susceptibility to phototherapy
    • Lo, Y.H., Torii, K., Saito, C., Furuhashi, T., Maeda, A. and Morita, A. (2010) Serum IL-22 correlates with psoriatic severity and serum IL-6 correlates with susceptibility to phototherapy. J. Dermatol. Sci. 58, 225-227
    • (2010) J. Dermatol. Sci , vol.58 , pp. 225-227
    • Lo, Y.H.1    Torii, K.2    Saito, C.3    Furuhashi, T.4    Maeda, A.5    Morita, A.6
  • 36
    • 80052023399 scopus 로고    scopus 로고
    • Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
    • Jiang, R., Tan, Z., Deng, L., Chen, Y., Xia, Y., Gao, Y., Wang, X. and Sun, B. (2011) Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology 54, 900-909
    • (2011) Hepatology. , vol.54 , pp. 900-909
    • Jiang, R.1    Tan, Z.2    Deng, L.3    Chen, Y.4    Xia, Y.5    Gao, Y.6    Wang, X.7    Sun, B.8
  • 37
    • 2142659288 scopus 로고    scopus 로고
    • IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues
    • Gurney, A.L. (2004) IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues. Int. Immunopharmacol. 4, 669-677
    • (2004) Int. Immunopharmacol , vol.4 , pp. 669-677
    • Gurney, A.L.1
  • 38
    • 32344453016 scopus 로고    scopus 로고
    • IFNγ R2 trafficking tunes IFNγ-STAT1 signaling in T lymphocytes
    • Regis, G., Conti, L., Boselli, D. and Novelli, F. (2006) IFNγ R2 trafficking tunes IFNγ-STAT1 signaling in T lymphocytes. Trends Immunol. 27, 96-101
    • (2006) Trends Immunol. , vol.27 , pp. 96-101
    • Regis, G.1    Conti, L.2    Boselli, D.3    Novelli, F.4
  • 40
    • 84879552667 scopus 로고    scopus 로고
    • Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions
    • Amedei, A., Niccolai, E., Benagiano, M., Della Bella, C., Cianchi, F., Bechi, P., Taddei, A., Bencini, L., Farsi, M., Cappello, P. et al. (2013) Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions. Cancer Immunol. Immunother. 62, 1249-1260
    • (2013) Cancer Immunol. Immunother , vol.62 , pp. 1249-1260
    • Amedei, A.1    Niccolai, E.2    Benagiano, M.3    Della Bella, C.4    Cianchi, F.5    Bechi, P.6    Taddei, A.7    Bencini, L.8    Farsi, M.9    Cappello, P.10
  • 41
    • 84899835126 scopus 로고    scopus 로고
    • Endogenous IL 22 plays a dual role in arthritis: regulation of established arthritis via IFN-γ responses
    • Justa, S., Zhou, X. and Sarkar, S. (2014) Endogenous IL 22 plays a dual role in arthritis: regulation of established arthritis via IFN-γ responses. PLoS One 9, e93279
    • (2014) PLoS One , vol.9
    • Justa, S.1    Zhou, X.2    Sarkar, S.3
  • 42
    • 58149183235 scopus 로고    scopus 로고
    • Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts
    • Zhang, W., Chen, Y., Wei, H., Zheng, C., Sun, R., Zhang, J. and Tian, Z. (2008) Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts. Clin. Cancer Res. 14, 6432-6439
    • (2008) Clin. Cancer Res , vol.14 , pp. 6432-6439
    • Zhang, W.1    Chen, Y.2    Wei, H.3    Zheng, C.4    Sun, R.5    Zhang, J.6    Tian, Z.7
  • 44
    • 84859244400 scopus 로고    scopus 로고
    • Pro-tumour activity of interleukin-22 in HPAFII human pancreatic cancer cells
    • Curd, L.M., Favors, S.E. and Gregg, R.K. (2012) Pro-tumour activity of interleukin-22 in HPAFII human pancreatic cancer cells. Clin. Exp. Immunol. 168, 192-199
    • (2012) Clin. Exp. Immunol , vol.168 , pp. 192-199
    • Curd, L.M.1    Favors, S.E.2    Gregg, R.K.3
  • 46
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo, M. (2010) Pancreatic cancer. N. Engl. J. Med. 362, 1605-1617
    • (2010) N. Engl. J. Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 50
    • 54949126709 scopus 로고    scopus 로고
    • Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization
    • Roman, E., Meza-Zepeda, L.A., Kresse, S.H., Myklebost, O., Vasstrand, E.N. and Ibrahim, S.O. (2008) Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization. Oncol. Rep. 20, 825-843
    • (2008) Oncol. Rep. , vol.20 , pp. 825-843
    • Roman, E.1    Meza-Zepeda, L.A.2    Kresse, S.H.3    Myklebost, O.4    Vasstrand, E.N.5    Ibrahim, S.O.6


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