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Volumn 8, Issue 2, 2016, Pages 126-137

Targeting dormant micrometastases: Rationale, evidence to date and clinical implications

Author keywords

dormant cancer cells; micrometastatic cells; prevention

Indexed keywords

NEW DRUG;

EID: 84958058830     PISSN: 17588340     EISSN: 17588359     Source Type: Journal    
DOI: 10.1177/1758834015624277     Document Type: Review
Times cited : (24)

References (72)
  • 1
    • 77953362501 scopus 로고    scopus 로고
    • Molecular mechanisms underlying tumor dormancy
    • Almog N., (2010) Molecular mechanisms underlying tumor dormancy. Cancer Lett 294: 139-146
    • (2010) Cancer Lett , vol.294 , pp. 139-146
    • Almog, N.1
  • 2
    • 84902326794 scopus 로고    scopus 로고
    • Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression
    • Bailey-Downs L., Thorpe J., Disch B., Bastian A., Hauser P., Farasyn T., et al. (2014) Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression. PLoS One 9: e98624
    • (2014) PLoS One , vol.9 , pp. e98624
    • Bailey-Downs, L.1    Thorpe, J.2    Disch, B.3    Bastian, A.4    Hauser, P.5    Farasyn, T.6
  • 3
    • 84955372451 scopus 로고    scopus 로고
    • Neoadjuvant therapy in muscle-invasive bladder cancer: A model for rational accelerated drug development
    • Balar A., Milowsky M., (2015) Neoadjuvant therapy in muscle-invasive bladder cancer: a model for rational accelerated drug development. Urol Clin North Am 42: 217-224
    • (2015) Urol Clin North Am , vol.42 , pp. 217-224
    • Balar, A.1    Milowsky, M.2
  • 4
    • 80355145642 scopus 로고    scopus 로고
    • An in vitro system to study tumor dormancy and the switch to metastatic growth
    • Barkan D., Green J., (2011) An in vitro system to study tumor dormancy and the switch to metastatic growth. J Vis Exp 54: e2914
    • (2011) J Vis Exp , vol.54 , pp. e2914
    • Barkan, D.1    Green, J.2
  • 5
    • 77950594400 scopus 로고    scopus 로고
    • Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth
    • Barkan D., Green J., Chambers A., (2010) Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur J Cancer 46: 1181-1188
    • (2010) Eur J Cancer , vol.46 , pp. 1181-1188
    • Barkan, D.1    Green, J.2    Chambers, A.3
  • 6
    • 51049119424 scopus 로고    scopus 로고
    • Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
    • Barkan D., Kleinman H., Simmons J., Asmussen H., Kamaraju A., Hoenorhoff M., et al. (2008) Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 68: 6241-6250
    • (2008) Cancer Res , vol.68 , pp. 6241-6250
    • Barkan, D.1    Kleinman, H.2    Simmons, J.3    Asmussen, H.4    Kamaraju, A.5    Hoenorhoff, M.6
  • 7
    • 84941416946 scopus 로고    scopus 로고
    • A phase II evaluation of cediranib in the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study
    • Bender D., Sill M., Lankes H., Reyes H., Darus C., Delmore J., et al. (2015) A phase II evaluation of cediranib in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol 138: 507-512
    • (2015) Gynecol Oncol , vol.138 , pp. 507-512
    • Bender, D.1    Sill, M.2    Lankes, H.3    Reyes, H.4    Darus, C.5    Delmore, J.6
  • 8
    • 84937758074 scopus 로고    scopus 로고
    • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
    • Caruana I., Savoldo B., Hoyos V., Weber G., Liu H., Kim E., et al. (2015) Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes. Nat Med 21: 524-529
    • (2015) Nat Med , vol.21 , pp. 524-529
    • Caruana, I.1    Savoldo, B.2    Hoyos, V.3    Weber, G.4    Liu, H.5    Kim, E.6
  • 9
    • 84904011693 scopus 로고    scopus 로고
    • Cocultures of mesenchymal stem cells and endothelial cells as organotypic models of prostate cancer metastasis
    • Chong M., Lim J., Goh J., Sia M., Chan J., Teoh S., (2014) Cocultures of mesenchymal stem cells and endothelial cells as organotypic models of prostate cancer metastasis. Mol Pharm 11: 2126-2133
    • (2014) Mol Pharm , vol.11 , pp. 2126-2133
    • Chong, M.1    Lim, J.2    Goh, J.3    Sia, M.4    Chan, J.5    Teoh, S.6
  • 10
    • 0028072345 scopus 로고
    • Abnormal expression of perlecan proteoglycan in metastatic melanomas
    • Cohen I., Murdoch A., Naso M., Marchetti D., Berd D., Iozzo R., (1994) Abnormal expression of perlecan proteoglycan in metastatic melanomas. Cancer Res 54: 5771-5774
    • (1994) Cancer Res , vol.54 , pp. 5771-5774
    • Cohen, I.1    Murdoch, A.2    Naso, M.3    Marchetti, D.4    Berd, D.5    Iozzo, R.6
  • 11
    • 84930047827 scopus 로고    scopus 로고
    • A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An NRG Oncology/Gynecologic Oncology Group study
    • Coleman R., Sill M., Bell-Mcguinn K., Aghajanian C., Gray H., Tewari K., et al. (2015a) A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation-an NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol 137: 386-391
    • (2015) Gynecol Oncol , vol.137 , pp. 386-391
    • Coleman, R.1    Sill, M.2    Bell-Mcguinn, K.3    Aghajanian, C.4    Gray, H.5    Tewari, K.6
  • 12
    • 84931577723 scopus 로고    scopus 로고
    • A phase II evaluation of selumetinib (AZD6244, ARRY-142886), a selective MEK-1/2 inhibitor in the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study
    • Coleman R., Sill M., Thaker P., Bender D., Street D., McGuire W., et al. (2015b) A phase II evaluation of selumetinib (AZD6244, ARRY-142886), a selective MEK-1/2 inhibitor in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol 138: 30-35
    • (2015) Gynecol Oncol , vol.138 , pp. 30-35
    • Coleman, R.1    Sill, M.2    Thaker, P.3    Bender, D.4    Street, D.5    McGuire, W.6
  • 13
    • 84874745627 scopus 로고    scopus 로고
    • Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of estrogen receptor-positive breast cancer: ATLAS, a randomized trial
    • Davies C., Pan H., Godwin J., Gray R., Arriagada R., Raina V., et al. (2013) Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of estrogen receptor-positive breast cancer: ATLAS, a randomized trial. Lancet 381: 805-816
    • (2013) Lancet , vol.381 , pp. 805-816
    • Davies, C.1    Pan, H.2    Godwin, J.3    Gray, R.4    Arriagada, R.5    Raina, V.6
  • 14
    • 84930216484 scopus 로고    scopus 로고
    • The impact of bevacizumab on health-related quality of life in patients treated for recurrent glioblastoma: Results of the randomized controlled phase II BELOB trial
    • Dirven L., Van Den Bent M., Bottomley A., Van Der Meer N., Van Der Holt B., Vos M., et al. (2015) The impact of bevacizumab on health-related quality of life in patients treated for recurrent glioblastoma: results of the randomized controlled phase II BELOB trial. Eur J Cancer 51: 1321-1330
    • (2015) Eur J Cancer , vol.51 , pp. 1321-1330
    • Dirven, L.1    Van Den Bent, M.2    Bottomley, A.3    Van Der Meer, N.4    Van Der Holt, B.5    Vos, M.6
  • 15
    • 84933678156 scopus 로고    scopus 로고
    • Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomized, double-blind, phase III trial
    • Eggermont A., Chiarion-Sileni V., Grob J., Dummer R., Wolchok J., Schmidt H., et al. (2015) Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomized, double-blind, phase III trial. Lancet Oncol 16: 522-530
    • (2015) Lancet Oncol , vol.16 , pp. 522-530
    • Eggermont, A.1    Chiarion-Sileni, V.2    Grob, J.3    Dummer, R.4    Wolchok, J.5    Schmidt, H.6
  • 16
    • 84892903022 scopus 로고    scopus 로고
    • Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells
    • El Touny L., Vieira A., Mendoza A., Khanna C., Hoenerhoff M., Green J., (2013) Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells. J Clin Invest 124: 156-168
    • (2013) J Clin Invest , vol.124 , pp. 156-168
    • El Touny, L.1    Vieira, A.2    Mendoza, A.3    Khanna, C.4    Hoenerhoff, M.5    Green, J.6
  • 17
    • 38149006909 scopus 로고    scopus 로고
    • Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    • Gao D., Nolan D., Mellick A., Bambino K., McDonnell K., Mittal V., (2008) Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319: 195-198
    • (2008) Science , vol.319 , pp. 195-198
    • Gao, D.1    Nolan, D.2    Mellick, A.3    Bambino, K.4    McDonnell, K.5    Mittal, V.6
  • 18
    • 84925669716 scopus 로고    scopus 로고
    • Metastasis prevention by targeting the dormant niche
    • Ghajar C., (2015) Metastasis prevention by targeting the dormant niche. Nat Rev Cancer 15: 238-247
    • (2015) Nat Rev Cancer , vol.15 , pp. 238-247
    • Ghajar, C.1
  • 20
    • 33751270222 scopus 로고    scopus 로고
    • Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective
    • Gotte M., Yip G., (2006) Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. Cancer Res 66: 10233-10237
    • (2006) Cancer Res , vol.66 , pp. 10233-10237
    • Gotte, M.1    Yip, G.2
  • 21
    • 0041302570 scopus 로고    scopus 로고
    • Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors
    • Gray J., (2003) Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors. Cancer Cell 4: 4-6
    • (2003) Cancer Cell , vol.4 , pp. 4-6
    • Gray, J.1
  • 22
    • 84926631267 scopus 로고    scopus 로고
    • Investigating breast cancer cell behavior using tissue engineering scaffolds
    • Guiro K., Patel S., Greco S., Rameshwar P., Arinzeh T., (2015) Investigating breast cancer cell behavior using tissue engineering scaffolds. PLoS One 10: e0118724
    • (2015) PLoS One , vol.10 , pp. e0118724
    • Guiro, K.1    Patel, S.2    Greco, S.3    Rameshwar, P.4    Arinzeh, T.5
  • 23
    • 84931569778 scopus 로고    scopus 로고
    • A phase II study of cediranib in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: A trial of the Princess Margaret, Chicago and California Phase II Consortia
    • Hirte H., Lheureux S., Fleming G., Sugimoto A., Morgan R., Biagi J., et al. (2015) A phase II study of cediranib in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: a trial of the Princess Margaret, Chicago and California Phase II Consortia. Gynecol Oncol 138: 55-61
    • (2015) Gynecol Oncol , vol.138 , pp. 55-61
    • Hirte, H.1    Lheureux, S.2    Fleming, G.3    Sugimoto, A.4    Morgan, R.5    Biagi, J.6
  • 24
    • 84878125523 scopus 로고    scopus 로고
    • Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: A model for tumor cell 'dormancy'
    • Hurst R., Hauser P., Kyker K., Heinlen J., Hodde J., Hiles M., et al. (2013) Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell 'dormancy'. PLoS One 8: e64181
    • (2013) PLoS One , vol.8 , pp. e64181
    • Hurst, R.1    Hauser, P.2    Kyker, K.3    Heinlen, J.4    Hodde, J.5    Hiles, M.6
  • 26
    • 11144309560 scopus 로고    scopus 로고
    • A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SISgel
    • Hurst R., Kamat C., Kyker K., Green D., Ihnat M., (2005) A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SISgel. Cancer Lett 217: 171-180
    • (2005) Cancer Lett , vol.217 , pp. 171-180
    • Hurst, R.1    Kamat, C.2    Kyker, K.3    Green, D.4    Ihnat, M.5
  • 27
    • 0029353166 scopus 로고
    • Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue
    • Iozzo R., (1995) Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue. Lab Invest 73: 157-160
    • (1995) Lab Invest , vol.73 , pp. 157-160
    • Iozzo, R.1
  • 28
    • 84863221252 scopus 로고    scopus 로고
    • The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis
    • Izraely S., Sagi-Assif O., Klein A., Meshel T., Tsarfaty G., Pasmanik-Chor M., et al. (2011) The metastatic microenvironment: brain-residing melanoma metastasis and dormant micrometastasis. Int J Cancer 131: 1071-1082
    • (2011) Int J Cancer , vol.131 , pp. 1071-1082
    • Izraely, S.1    Sagi-Assif, O.2    Klein, A.3    Meshel, T.4    Tsarfaty, G.5    Pasmanik-Chor, M.6
  • 29
    • 84923197615 scopus 로고    scopus 로고
    • Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy
    • Kenny H., Lal-Nag M., White E., Shen M., Chiang C., Mitra A., et al. (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat Commun 6: 6220
    • (2015) Nat Commun , vol.6 , pp. 6220
    • Kenny, H.1    Lal-Nag, M.2    White, E.3    Shen, M.4    Chiang, C.5    Mitra, A.6
  • 30
    • 84859994398 scopus 로고    scopus 로고
    • Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer
    • Kim R., Avivar-Valderas A., Estrada Y., Bragado P., Sosa M., Aguirre-Ghiso J., et al. (2012) Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS One 7: e35569
    • (2012) PLoS One , vol.7 , pp. e35569
    • Kim, R.1    Avivar-Valderas, A.2    Estrada, Y.3    Bragado, P.4    Sosa, M.5    Aguirre-Ghiso, J.6
  • 31
    • 84862917865 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
    • Kobayashi A., Okuda H., Xing F., Pandey P., Watabe M., Hirota S., et al. (2011) Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med 208: 2641-2655
    • (2011) J Exp Med , vol.208 , pp. 2641-2655
    • Kobayashi, A.1    Okuda, H.2    Xing, F.3    Pandey, P.4    Watabe, M.5    Hirota, S.6
  • 32
    • 84856023489 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
    • Landreville S., Agapova O., Matatall K., Kneass Z., Onken M., Lee R., et al. (2012) Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Clin Cancer Res 18: 408-416
    • (2012) Clin Cancer Res , vol.18 , pp. 408-416
    • Landreville, S.1    Agapova, O.2    Matatall, K.3    Kneass, Z.4    Onken, M.5    Lee, R.6
  • 33
    • 84936743121 scopus 로고    scopus 로고
    • Phase II trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)
    • Lassman A., Pugh S., Gilbert M., Aldape K., Geinoz S., Beumer J., et al. (2015) Phase II trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627). Neuro Oncol 17: 992-998
    • (2015) Neuro Oncol , vol.17 , pp. 992-998
    • Lassman, A.1    Pugh, S.2    Gilbert, M.3    Aldape, K.4    Geinoz, S.5    Beumer, J.6
  • 34
    • 2342644800 scopus 로고    scopus 로고
    • Why we're losing the war on cancer (and how to win it)
    • Leaf C., (2004) Why we're losing the war on cancer (and how to win it). Fortune 149: 76-88
    • (2004) Fortune , vol.149 , pp. 76-88
    • Leaf, C.1
  • 35
    • 84899507722 scopus 로고    scopus 로고
    • Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: A lingering challenge in the development of targeted therapies
    • Lin W., Rajbhandari N., Wagner K., (2014) Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. Cancer Res 74: 2138-2143
    • (2014) Cancer Res , vol.74 , pp. 2138-2143
    • Lin, W.1    Rajbhandari, N.2    Wagner, K.3
  • 36
    • 83455208311 scopus 로고    scopus 로고
    • VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
    • Lu X., Mu E., Wei Y., Riethdorf S., Yang Q., Yuan M., et al. (2011) VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell 20: 701-714
    • (2011) Cancer Cell , vol.20 , pp. 701-714
    • Lu, X.1    Mu, E.2    Wei, Y.3    Riethdorf, S.4    Yang, Q.5    Yuan, M.6
  • 37
    • 84933678811 scopus 로고    scopus 로고
    • Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): An open-label, randomized phase III trial
    • Machiels J., Haddad R., Fayette J., Licitra L., Tahara M., Vermorken J., et al. (2015) Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomized phase III trial. Lancet Oncol 16: 583-594
    • (2015) Lancet Oncol , vol.16 , pp. 583-594
    • Machiels, J.1    Haddad, R.2    Fayette, J.3    Licitra, L.4    Tahara, M.5    Vermorken, J.6
  • 38
    • 84931562283 scopus 로고    scopus 로고
    • Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study 0229N
    • Makker V., Filiaci V., Chen L., Darus C., Kendrick J., Sutton G., et al. (2015) Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N. Gynecol Oncol 138: 24-29
    • (2015) Gynecol Oncol , vol.138 , pp. 24-29
    • Makker, V.1    Filiaci, V.2    Chen, L.3    Darus, C.4    Kendrick, J.5    Sutton, G.6
  • 39
    • 84916918791 scopus 로고    scopus 로고
    • The inherent premise of immunotherapy for cancer dormancy
    • Manjili M., (2014) The inherent premise of immunotherapy for cancer dormancy. Cancer Res 74: 6745-6749
    • (2014) Cancer Res , vol.74 , pp. 6745-6749
    • Manjili, M.1
  • 40
  • 41
    • 84855490610 scopus 로고    scopus 로고
    • A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies
    • Marsden C., Wright M., Carrier L., Moroz K., Pochampally R., Rowan B., (2012) A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies. BMC Cancer 12: 10
    • (2012) BMC Cancer , vol.12 , pp. 10
    • Marsden, C.1    Wright, M.2    Carrier, L.3    Moroz, K.4    Pochampally, R.5    Rowan, B.6
  • 42
    • 84866061054 scopus 로고    scopus 로고
    • Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer
    • Marshall J., Collins J., Nakayama J., Horak C., Liewehr D., Steinberg S., et al. (2012) Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer. J Natl Cancer Inst 104: 1306-1319
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1306-1319
    • Marshall, J.1    Collins, J.2    Nakayama, J.3    Horak, C.4    Liewehr, D.5    Steinberg, S.6
  • 43
    • 0031037160 scopus 로고    scopus 로고
    • Early tumor cell dissemination in patients with clinically localized carcinoma of the prostate
    • Melchior S., Corey E., Ellis W., Ross A., Layton T., Oswin M., et al. (1997) Early tumor cell dissemination in patients with clinically localized carcinoma of the prostate. Clin Cancer Res 3: 249-256
    • (1997) Clin Cancer Res , vol.3 , pp. 249-256
    • Melchior, S.1    Corey, E.2    Ellis, W.3    Ross, A.4    Layton, T.5    Oswin, M.6
  • 44
    • 77955285905 scopus 로고    scopus 로고
    • Modeling metastasis biology and therapy in real time in the mouse lung
    • Mendoza A., Hong S., Osborne T., Khan M., Campbell K., Briggs J., et al. (2010) Modeling metastasis biology and therapy in real time in the mouse lung. J Clin Invest 120: 2979-2988
    • (2010) J Clin Invest , vol.120 , pp. 2979-2988
    • Mendoza, A.1    Hong, S.2    Osborne, T.3    Khan, M.4    Campbell, K.5    Briggs, J.6
  • 45
    • 73349097214 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib and second-generation tyrosine inhibitors in chronic myeloid leukemia
    • Milojkovic D., Apperley J., (2009) Mechanisms of resistance to imatinib and second-generation tyrosine inhibitors in chronic myeloid leukemia. Clin Cancer Res 15: 7519-7527
    • (2009) Clin Cancer Res , vol.15 , pp. 7519-7527
    • Milojkovic, D.1    Apperley, J.2
  • 46
    • 84929645752 scopus 로고    scopus 로고
    • EMT, CTCs and CSCs in tumor relapse and drug resistance
    • Mitra A., Mishra L., Li S., (2015) EMT, CTCs and CSCs in tumor relapse and drug resistance. Oncotarget 6: 10697-10711
    • (2015) Oncotarget , vol.6 , pp. 10697-10711
    • Mitra, A.1    Mishra, L.2    Li, S.3
  • 47
    • 84941413704 scopus 로고    scopus 로고
    • A phase II trial of trebananib (AMG 386; IND#111071), a selective angiopoietin 1/2 neutralizing peptibody, in patients with persistent/recurrent carcinoma of the endometrium: An NRG/Gynecologic Oncology Group trial
    • Moore K., Sill M., Tenney M., Darus C., Griffin D., Werner T., et al. (2015) A phase II trial of trebananib (AMG 386; IND#111071), a selective angiopoietin 1/2 neutralizing peptibody, in patients with persistent/recurrent carcinoma of the endometrium: an NRG/Gynecologic Oncology Group trial. Gynecol Oncol 138: 513-518
    • (2015) Gynecol Oncol , vol.138 , pp. 513-518
    • Moore, K.1    Sill, M.2    Tenney, M.3    Darus, C.4    Griffin, D.5    Werner, T.6
  • 48
    • 33847784034 scopus 로고    scopus 로고
    • Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy
    • Nash K., Phadke P., Navenot J., Hurst D., Accavitti-Loper M., Sztul E., et al. (2007) Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy. J Natl Cancer Inst 99: 309-321
    • (2007) J Natl Cancer Inst , vol.99 , pp. 309-321
    • Nash, K.1    Phadke, P.2    Navenot, J.3    Hurst, D.4    Accavitti-Loper, M.5    Sztul, E.6
  • 49
    • 84908879731 scopus 로고    scopus 로고
    • Mechanisms of metastatic tumor dormancy
    • Osisami M., Keller E., (2013) Mechanisms of metastatic tumor dormancy. J Clin Med 2: 136-150
    • (2013) J Clin Med , vol.2 , pp. 136-150
    • Osisami, M.1    Keller, E.2
  • 51
    • 34047111239 scopus 로고    scopus 로고
    • Cancer dormancy: Lessons from a B-cell lymphoma and adenocarcinoma of the prostate
    • Rabinovsky R., Uhr J., Vitetta E., Yefenof E., (2007) Cancer dormancy: lessons from a B-cell lymphoma and adenocarcinoma of the prostate. Adv Cancer Res 97: 189-202
    • (2007) Adv Cancer Res , vol.97 , pp. 189-202
    • Rabinovsky, R.1    Uhr, J.2    Vitetta, E.3    Yefenof, E.4
  • 52
    • 33751198957 scopus 로고    scopus 로고
    • Tumor cell dormancy induced by p38SAPK and ER-stress signaling: An adaptive advantage for metastatic cells?
    • Ranganathan A., Adam A., Zhang L., Guirre-Ghiso J., (2006) Tumor cell dormancy induced by p38SAPK and ER-stress signaling: an adaptive advantage for metastatic cells? Cancer Biol Ther 5: 729-735
    • (2006) Cancer Biol Ther , vol.5 , pp. 729-735
    • Ranganathan, A.1    Adam, A.2    Zhang, L.3    Guirre-Ghiso, J.4
  • 53
    • 84928938542 scopus 로고    scopus 로고
    • Identification of molecular determinants of primary and metastatic tumor reinitiation in breast cancer
    • Ross J., Huh D., Noble L., Tavazoie S., (2015) Identification of molecular determinants of primary and metastatic tumor reinitiation in breast cancer. Nat Cell Biol 17: 651-664
    • (2015) Nat Cell Biol , vol.17 , pp. 651-664
    • Ross, J.1    Huh, D.2    Noble, L.3    Tavazoie, S.4
  • 54
    • 84928092645 scopus 로고    scopus 로고
    • New metastatic model of human small cell lung cancer by orthotopic transplantation in mice
    • Sakamoto S., Inoue H., Ohba S., Kohda Y., Usami I., Masuda T., et al. (2015) New metastatic model of human small cell lung cancer by orthotopic transplantation in mice. Cancer Sci 106: 367-374
    • (2015) Cancer Sci , vol.106 , pp. 367-374
    • Sakamoto, S.1    Inoue, H.2    Ohba, S.3    Kohda, Y.4    Usami, I.5    Masuda, T.6
  • 55
    • 84944060083 scopus 로고    scopus 로고
    • Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer: An open-label phase II multicenter trial (COVeRT study)
    • Singhal N., Mislang A., Karapetis C., Stephens S., Borg M., Woodman R., et al. (2015) Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer: an open-label phase II multicenter trial (COVeRT study). Anticancer Drugs 26: 1083-1088
    • (2015) Anticancer Drugs , vol.26 , pp. 1083-1088
    • Singhal, N.1    Mislang, A.2    Karapetis, C.3    Stephens, S.4    Borg, M.5    Woodman, R.6
  • 56
    • 84906937205 scopus 로고    scopus 로고
    • Mechanisms of disseminated cancer cell dormancy: An awakening field
    • Sosa M., Bragado P., Aguirre-Ghiso J., (2014) Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer 14: 611-622
    • (2014) Nat Rev Cancer , vol.14 , pp. 611-622
    • Sosa, M.1    Bragado, P.2    Aguirre-Ghiso, J.3
  • 57
    • 41549150295 scopus 로고    scopus 로고
    • Ten-year survival and cost following breast cancer recurrence: Estimates from SEER-Medicare data
    • Stokes M., Thompson D., Montoya E., Weinstein M., Winer E., Earle C., (2008) Ten-year survival and cost following breast cancer recurrence: estimates from SEER-Medicare data. Value Health 11: 213-220
    • (2008) Value Health , vol.11 , pp. 213-220
    • Stokes, M.1    Thompson, D.2    Montoya, E.3    Weinstein, M.4    Winer, E.5    Earle, C.6
  • 58
    • 84934890113 scopus 로고    scopus 로고
    • The emerging molecular machinery and therapeutic targets of metastasis
    • Sun Y., Ma L., (2015) The emerging molecular machinery and therapeutic targets of metastasis. Trends Pharmacol Sci 36: 349-359
    • (2015) Trends Pharmacol Sci , vol.36 , pp. 349-359
    • Sun, Y.1    Ma, L.2
  • 60
    • 84923052492 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
    • Swain S., Baselga J., Kim S., Ro J., Semiglazov V., Campone M., et al. (2015) Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 372: 724-734
    • (2015) N Engl J Med , vol.372 , pp. 724-734
    • Swain, S.1    Baselga, J.2    Kim, S.3    Ro, J.4    Semiglazov, V.5    Campone, M.6
  • 61
    • 77955015464 scopus 로고    scopus 로고
    • AACR centennial series: The biology of cancer metastasis: Historical perspective
    • Talmadge J., Fidler I., (2010) AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res 70: 5649-5669
    • (2010) Cancer Res , vol.70 , pp. 5649-5669
    • Talmadge, J.1    Fidler, I.2
  • 62
    • 0025228518 scopus 로고
    • Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo
    • Teicher B., Herman T., Holden S., Wang Y., Pfeffer M., Crawford J., et al. (1990) Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247: 1457-1461
    • (1990) Science , vol.247 , pp. 1457-1461
    • Teicher, B.1    Herman, T.2    Holden, S.3    Wang, Y.4    Pfeffer, M.5    Crawford, J.6
  • 63
    • 84941253843 scopus 로고    scopus 로고
    • An in vitro dormancy model of estrogen-sensitive breast cancer in the bone marrow: A tool for molecular mechanism studies and hypothesis generation
    • Tivari S., Korah R., Lindy M., Wieder R., (2015) An in vitro dormancy model of estrogen-sensitive breast cancer in the bone marrow: a tool for molecular mechanism studies and hypothesis generation. J Vis Exp 100: e52672
    • (2015) J Vis Exp , vol.100 , pp. e52672
    • Tivari, S.1    Korah, R.2    Lindy, M.3    Wieder, R.4
  • 64
    • 0023221815 scopus 로고
    • In vivo -like drug responses of human tumors growing in three-dimensional gel-supported primary culture
    • Vescio R., Redfern C., Nelson T., Ugoretz S., Stern P., Hoffman R., (1987) In vivo -like drug responses of human tumors growing in three-dimensional gel-supported primary culture. Proc Natl Acad Sci USA 84: 5029-5033
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5029-5033
    • Vescio, R.1    Redfern, C.2    Nelson, T.3    Ugoretz, S.4    Stern, P.5    Hoffman, R.6
  • 65
    • 84911861458 scopus 로고    scopus 로고
    • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
    • Viale A., Pettazzoni P., Lyssiotis C., Ying H., Sánchez N., Marchesini M., et al. (2014) Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514: 628-632
    • (2014) Nature , vol.514 , pp. 628-632
    • Viale, A.1    Pettazzoni, P.2    Lyssiotis, C.3    Ying, H.4    Sánchez, N.5    Marchesini, M.6
  • 66
    • 0035228621 scopus 로고    scopus 로고
    • Chapter 26 three-dimensional extracellular matrix substrates for cell culture
    • Voytik-Harbin S., (2001) Chapter 26 three-dimensional extracellular matrix substrates for cell culture. Cytometry 63: 561-581
    • (2001) Cytometry , vol.63 , pp. 561-581
    • Voytik-Harbin, S.1
  • 67
    • 84937858832 scopus 로고    scopus 로고
    • A six-gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia
    • Wang J., Mi J., Debernardi A., Vitte A., Emadali A., Meyer J., et al. (2015) A six-gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia. Oncotarget 6: 16527-16542
    • (2015) Oncotarget , vol.6 , pp. 16527-16542
    • Wang, J.1    Mi, J.2    Debernardi, A.3    Vitte, A.4    Emadali, A.5    Meyer, J.6
  • 68
    • 84870365240 scopus 로고    scopus 로고
    • Why does cancer therapy lack effective antimetastasis drugs?
    • Weber G., (2013) Why does cancer therapy lack effective antimetastasis drugs? Cancer Lett 328: 207-211
    • (2013) Cancer Lett , vol.328 , pp. 207-211
    • Weber, G.1
  • 69
    • 84927573797 scopus 로고    scopus 로고
    • Spontaneous dormancy of metastatic breast cancer cells in an all-human liver microphysiologic system
    • Wheeler S., Clark A., Taylor D., Young C., Pillai V., Stolz D., et al. (2014) Spontaneous dormancy of metastatic breast cancer cells in an all-human liver microphysiologic system. Br J Cancer 111: 2342-2350
    • (2014) Br J Cancer , vol.111 , pp. 2342-2350
    • Wheeler, S.1    Clark, A.2    Taylor, D.3    Young, C.4    Pillai, V.5    Stolz, D.6
  • 70
    • 84909639538 scopus 로고    scopus 로고
    • Overdetection of recurrence after radical prostatectomy: Estimates based on patient and tumor characteristics
    • Xia J., Trock B., Gulati R., Mallinger L., Cooperberg M., Carroll P., et al. (2014) Overdetection of recurrence after radical prostatectomy: estimates based on patient and tumor characteristics. Clin Cancer Res 20: 5302-5310
    • (2014) Clin Cancer Res , vol.20 , pp. 5302-5310
    • Xia, J.1    Trock, B.2    Gulati, R.3    Mallinger, L.4    Cooperberg, M.5    Carroll, P.6
  • 71
    • 84876019175 scopus 로고    scopus 로고
    • Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients
    • Yang Y., Mauldin P., Ebeling M., Hulsey T., Liu B., Thomas M., et al. (2013) Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients. Cancer 119: 1512-1520
    • (2013) Cancer , vol.119 , pp. 1512-1520
    • Yang, Y.1    Mauldin, P.2    Ebeling, M.3    Hulsey, T.4    Liu, B.5    Thomas, M.6
  • 72
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H., Kimmelman A., Lyssiotis C., Hua S., Chu G., Fletcher-Sananikone E., et al. (2012) Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149: 656-670.
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1    Kimmelman, A.2    Lyssiotis, C.3    Hua, S.4    Chu, G.5    Fletcher-Sananikone, E.6


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