Suppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell "Dormancy"

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Hurst, Robert E ^a,d   Hauser, Paul J ^a,d   Kyker, Kimberly D ^a,d   Heinlen, Jonathan E ^a   Hodde, Jason P ^c   Hiles, Michael C ^c   Kosanke, Stanley D ^a   Dozmorov, Mikhail ^e   Ihnat, Michael A ^a,b,d  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c DormaTarg Inc ^*  (United States)

^d DormaTarg Inc   (United States)

^e OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; GREEN FLUORESCENT PROTEIN; MATRIGEL; INTEGRIN-LINKED KINASE; KI 67 ANTIGEN; PROTEIN SERINE THREONINE KINASE; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER CELL; CANCER GRADING; CANCER GROWTH; CANCER SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DORMANCY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; MICROMETASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BLADDER TUMOR; CLUSTER ANALYSIS; CULTURE TECHNIQUE; DISEASE MODEL; GENE EXPRESSION; HUMAN; METABOLISM; MORTALITY; PATHOLOGY; PROTEIN MICROARRAY; REPORTER GENE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENES, REPORTER; HETEROGRAFTS; HUMANS; KI-67 ANTIGEN; MICE; PHENOTYPE; PROTEIN ARRAY ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR BURDEN; URINARY BLADDER NEOPLASMS; VIMENTIN;

EID: 84878125523     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064181     Document Type: Article

References (35)

1. Iozzo RV, (1995) Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue. Lab Invest 73: 157-160.
2. Ronnov-Jessen L, Petersen OW, Bissell MJ, (1996) Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 76: 69-125.
3. Vessella RL, Pantel K, Mohla S (2007) Tumor Cell Dormancy: An NCI Workshop Report. Cancer Biol Ther 6.
4. Willis L, Alarcon T, Elia G, Jones JL, Wright NA, et al. (2010) Breast cancer dormancy can be maintained by small numbers of micrometastases. Cancer Res 70: 4310-4317.
5. Hoffman RM, (2008) In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells. Apmis 116: 716-729.
6. Talmadge JE, Fidler IJ, (2010) AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res 70: 5649-5669.
7. Leung CT, Brugge JS (2012) Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature.
8. Rao JY, Hemstreet GP, Hurst RE, Bonner RB, Jones PL, et al. (1993) Alterations in phenotypic biochemical markers in bladder epithelium during tumorigenesis. Proc Natl Acad Sci U S A 90: 8287-8291.
9. Brennan JA, Mao L, Hruban RH, Boyle JO, Eby YJ, et al. (1995) Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. N Engl J Med 332: 429-435.
10. Milojkovic D, Apperley J, (2009) Mechanisms of Resistance to Imatinib and Second-Generation Tyrosine Inhibitors in Chronic Myeloid Leukemia. Clin Cancer Res 15: 7519-7527.
11. Pohlmann PR, Mayer IA, Mernaugh R, (2009) Resistance to Trastuzumab in Breast Cancer. Clin Cancer Res 15: 7479-7491.
12. Quesnel B, (2008) Dormant tumor cells as a therapeutic target? Cancer Lett 267: 10-17.
13. Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA, (2005) A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Lett 217: 171-180.
14. Hurst RE, Kyker KD, Bonner RB, Bowditch RG, Hemstreet GP, (2003) Matrix-Dependent Plasticity of the Malignant Phenotype of Bladder Cancer Cells. Anticancer Res 23: 3119-3128.
15. Orkin RW, Gehron P, McGoodwin EB, Martin GR, Valentine T, et al. (1977) A murine tumor producing a matrix of basement membrane. J Exp Med 145: 204-220.
16. Dinney CP, Fishbeck R, Singh RK, Eve B, Pathak S, et al. (1995) Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice. J Urol 154: 1532-1538.
17. Badylak SF, Record R, Lindberg K, Hodde J, Park K, (1998) Small intestinal submucosa: a substrate for in vitro cell growth. J Biomater Sci Polym Ed 9: 863-878.
18. Barkan D, Kleinman H, Simmons JL, Asmussen H, Kamaraju AK, et al. (2008) Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 68: 6241-6250.
19. Saudemont A, Jouy N, Hetuin D, Quesnel B, (2005) NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells. Blood 105: 2428-2435.
20. O'Reilly MS, Holmgren L, Chen C, Folkman J, (1996) Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2: 689-692.
21. Holmgren L, O'Reilly MS, Folkman J, (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1: 149-153.
22. Barkan D, Green JE, Chambers AF, (2010) Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur J Cancer 46: 1181-1188.
23. Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov IM, et al. (2006) Analysis of the Interaction of Extracellular Matrix and Phenotype of Bladder Cancer Cells. BMC Cancer 6: 12.
24. Muschler J, Lochter A, Roskelley CD, Yurchenco P, Bissell MJ, (1999) Division of labor among the α6β4 integrin, β1 integrins, and an E3 laminin receptor to signal morphogenesis and β-casein expression in mammary epithelial cells. Mol Biol Cell 10: 2817-2828.
25. Hurst RE, Kyker KD, Dozmorov MG, Takemori N, Singh A, et al. (2006) Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells. Proteome Sci 4: 13.
26. Knowlton N, Dozmorov I, Kyker K, Saban R, Cadwell C, et al. (2006) A Template-Driven Gene Selection Procedure. IEE Proceedings-Systems Biology 153: 4-12.
27. Amling CL, (2001) Diagnosis and management of superficial bladder cancer. Curr Probl Cancer 25: 219-278.
28. Hockel M, Dornhofer N, (2005) The hydra phenomenon of cancer: why tumors recur locally after microscopically complete resection. Cancer Res 65: 2997-3002.
29. Voytik-Harbin SL, (2001) Three-dimensional extracellular matrix substrates for cell culture. Methods Cell Biol 63: 561-581.
30. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
31. Wettenhall JM, Simpson KM, Satterley K, Smyth GK, (2006) affylmGUI: a graphical user interface for linear modeling of single channel microarray data. Bioinformatics 22: 897-899.
32. Reiner A, Yekutieli D, Benjamini Y, (2003) Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19: 368-375.
33. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550.
34. Kanehisa M, Goto S, (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28: 27-30.
35. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.