메뉴 건너뛰기




Volumn 373, Issue 1, 2016, Pages 1-11

VEGF/NRP-1axis promotes progression of breast cancer via enhancement of epithelial-mesenchymal transition and activation of NF-κB and β-catenin

Author keywords

Breast cancer; Epithelial mesenchymal transition; NRP 1; Tumor progression; VEGF

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPILIN 1; TRANSCRIPTION FACTOR RELA; VASCULOTROPIN; CTNNB1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84958056552     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.01.010     Document Type: Article
Times cited : (125)

References (39)
  • 1
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246(4935):1306-1309.
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1
  • 2
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: molecular pathways and therapeutic targets
    • Weis S.M., Cheresh D.A. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med 2011, 17(11):1359-1370.
    • (2011) Nat. Med , vol.17 , Issue.11 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 3
    • 79960227968 scopus 로고    scopus 로고
    • VEGF and angiopoietin signaling in tumor angiogenesis and metastasis
    • Saharinen P., et al. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol. Med 2014, 17(7):347-362.
    • (2014) Trends Mol. Med , vol.17 , Issue.7 , pp. 347-362
    • Saharinen, P.1
  • 4
    • 77958465052 scopus 로고    scopus 로고
    • Bevacizumab: current updates in treatment
    • Van Meter M.E., Kim E.S. Bevacizumab: current updates in treatment. Curr. Opin. Oncol 2010, 22(6):586-591.
    • (2010) Curr. Opin. Oncol , vol.22 , Issue.6 , pp. 586-591
    • Van Meter, M.E.1    Kim, E.S.2
  • 5
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med 2007, 357(26):2666-2676.
    • (2007) N. Engl. J. Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1
  • 6
    • 84860356630 scopus 로고    scopus 로고
    • Autocrine VEGF-VEGFR2-Neuropilin-signaling promotes glioma stem-like cell viability and tumor growth
    • Hamerlik P., et al. Autocrine VEGF-VEGFR2-Neuropilin-signaling promotes glioma stem-like cell viability and tumor growth. J. Exp. Med 2012, 209(3):507-520.
    • (2012) J. Exp. Med , vol.209 , Issue.3 , pp. 507-520
    • Hamerlik, P.1
  • 7
    • 2442639176 scopus 로고    scopus 로고
    • Neuropilin-in human colon cancer: expression, regulation, and role in induction of angiogenesis
    • Parikh A.A., et al. Neuropilin-in human colon cancer: expression, regulation, and role in induction of angiogenesis. Am. J. Pathol 2004, 164(6):2139-2151.
    • (2004) Am. J. Pathol , vol.164 , Issue.6 , pp. 2139-2151
    • Parikh, A.A.1
  • 8
    • 33344474679 scopus 로고    scopus 로고
    • Neuropilins in neoplasms: expression, regulation, and function
    • Bielenberg D.R., et al. Neuropilins in neoplasms: expression, regulation, and function. Exp. Cell Res 2006, 312(5):584-593.
    • (2006) Exp. Cell Res , vol.312 , Issue.5 , pp. 584-593
    • Bielenberg, D.R.1
  • 9
    • 80055003796 scopus 로고    scopus 로고
    • A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
    • Beck B., et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature 2011, 478(7369):399-403.
    • (2011) Nature , vol.478 , Issue.7369 , pp. 399-403
    • Beck, B.1
  • 10
    • 74549133965 scopus 로고    scopus 로고
    • Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development
    • Lichtenberger B.M., et al. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 2010, 140(2):268-279.
    • (2010) Cell , vol.140 , Issue.2 , pp. 268-279
    • Lichtenberger, B.M.1
  • 11
    • 84865141645 scopus 로고    scopus 로고
    • VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression
    • Cao Y., et al. VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res 2012, 72(16):3912-3918.
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 3912-3918
    • Cao, Y.1
  • 12
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes M., et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009, 15(3):220-231.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Pàez-Ribes, M.1
  • 13
    • 77449108417 scopus 로고    scopus 로고
    • VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
    • Gonzalez-Moreno O., et al. VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop. Exp. Cell Res 2010, 316(4):554-567.
    • (2010) Exp. Cell Res , vol.316 , Issue.4 , pp. 554-567
    • Gonzalez-Moreno, O.1
  • 14
    • 0035422178 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    • Bachelder R.E., et al. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res 2001, 61(15):5736-5740.
    • (2001) Cancer Res , vol.61 , Issue.15 , pp. 5736-5740
    • Bachelder, R.E.1
  • 15
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S., et al. Neuropilin-is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998, 92(6):735-745.
    • (1998) Cell , vol.92 , Issue.6 , pp. 735-745
    • Soker, S.1
  • 17
    • 33751073938 scopus 로고    scopus 로고
    • Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades
    • Katoh M., Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol. Ther 2006, 5(9):1059-1064.
    • (2006) Cancer Biol. Ther , vol.5 , Issue.9 , pp. 1059-1064
    • Katoh, M.1    Katoh, M.2
  • 18
    • 4344612243 scopus 로고    scopus 로고
    • NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber M.A., et al. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest 2004, 114(4):569-581.
    • (2004) J. Clin. Invest , vol.114 , Issue.4 , pp. 569-581
    • Huber, M.A.1
  • 19
    • 0036985699 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications
    • Napoleone F. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol 2002, 29(6, Suppl. 16):10-14.
    • (2002) Semin. Oncol , vol.29 , Issue.6 , pp. 10-14
    • Napoleone, F.1
  • 20
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 2008, 8(8):579-591.
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 21
    • 34548064808 scopus 로고    scopus 로고
    • Targeting neuropilin 1 as an antitumor strategy in lung cancer
    • Hong T., et al. Targeting neuropilin 1 as an antitumor strategy in lung cancer. Clin. Cancer Res 2007, 13(16):4759-4768.
    • (2007) Clin. Cancer Res , vol.13 , Issue.16 , pp. 4759-4768
    • Hong, T.1
  • 23
    • 84868616455 scopus 로고    scopus 로고
    • Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity
    • Prud'Homme G.J., Glinka Y. Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget 2012, 3(9):921.
    • (2012) Oncotarget , vol.3 , Issue.9 , pp. 921
    • Prud'Homme, G.J.1    Glinka, Y.2
  • 24
    • 84888328750 scopus 로고    scopus 로고
    • VEGF targets the tumour cell
    • Goel H.L., Mercurio A.M. VEGF targets the tumour cell. Nat. Rev. Cancer 2013, 13(12):871-882.
    • (2013) Nat. Rev. Cancer , vol.13 , Issue.12 , pp. 871-882
    • Goel, H.L.1    Mercurio, A.M.2
  • 25
    • 84876908762 scopus 로고    scopus 로고
    • Targeting VEGF signalling via the neuropilin co-receptor
    • Djordjevic S., Driscoll P.C. Targeting VEGF signalling via the neuropilin co-receptor. Drug Discov. Today 2013, 18(9-10):447-455.
    • (2013) Drug Discov. Today , vol.18 , Issue.9-10 , pp. 447-455
    • Djordjevic, S.1    Driscoll, P.C.2
  • 26
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat. Rev. Cancer 2004, 4(7):540-550.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.7 , pp. 540-550
    • Balkwill, F.1
  • 27
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., et al. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139(5):871-890.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1
  • 28
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A., Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010, 29(34):4741-4751.
    • (2010) Oncogene , vol.29 , Issue.34 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 29
    • 77950476293 scopus 로고    scopus 로고
    • ERb impedes prostate cancer EMT by destabilizing HIF-1a and inhibiting VEGF-mediated snail nuclear localization: implications for gleason grading
    • Paul Mak I.L.B.P. ERb impedes prostate cancer EMT by destabilizing HIF-1a and inhibiting VEGF-mediated snail nuclear localization: implications for gleason grading. Cancer Cell 2010, 10.1016/j.ccr.2010.02.030.
    • (2010) Cancer Cell
    • Paul Mak, I.L.B.P.1
  • 30
    • 84863754907 scopus 로고    scopus 로고
    • VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    • Lu K.V., et al. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell 2012, 22(1):21-35.
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 21-35
    • Lu, K.V.1
  • 31
    • 31544463515 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
    • Yang A.D., et al. Vascular endothelial growth factor receptor-activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res 2006, 66(1):46-51.
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 46-51
    • Yang, A.D.1
  • 32
    • 72549116879 scopus 로고    scopus 로고
    • Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma
    • Yanagawa J., et al. Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma. Clin. Cancer Res 2009, 15(22):6820-6829.
    • (2009) Clin. Cancer Res , vol.15 , Issue.22 , pp. 6820-6829
    • Yanagawa, J.1
  • 33
    • 41349099759 scopus 로고    scopus 로고
    • IL-stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-expression in pancreatic cancer cells
    • Feurino L.W., et al. IL-stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-expression in pancreatic cancer cells. Cancer Biol. Ther 2007, 6(7):1096-1100.
    • (2007) Cancer Biol. Ther , vol.6 , Issue.7 , pp. 1096-1100
    • Feurino, L.W.1
  • 34
    • 35948964766 scopus 로고    scopus 로고
    • Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1
    • Matsushita A., Gotze T., Korc M. Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Cancer Res 2007, 67(21):10309-10316.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10309-10316
    • Matsushita, A.1    Gotze, T.2    Korc, M.3
  • 35
    • 84880869807 scopus 로고    scopus 로고
    • The complexity of NF-κB signaling in inflammation and cancer
    • Hoesel B., Schmid J.A. The complexity of NF-κB signaling in inflammation and cancer. Mol. Cancer 2013, 12(86):1-15.
    • (2013) Mol. Cancer , vol.12 , Issue.86 , pp. 1-15
    • Hoesel, B.1    Schmid, J.A.2
  • 36
    • 0034692686 scopus 로고    scopus 로고
    • The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways
    • D'Amico M., et al. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways. J. Biol. Chem 2000, 275(42):32649-32657.
    • (2000) J. Biol. Chem , vol.275 , Issue.42 , pp. 32649-32657
    • D'Amico, M.1
  • 37
    • 39049107744 scopus 로고    scopus 로고
    • GSK-3β regulates cyclin D1 expression: a new target for chemotherapy
    • Takahashi-Yanaga F., Sasaguri T. GSK-3β regulates cyclin D1 expression: a new target for chemotherapy. Cell. Signal 2008, 20(4):581-589.
    • (2008) Cell. Signal , vol.20 , Issue.4 , pp. 581-589
    • Takahashi-Yanaga, F.1    Sasaguri, T.2
  • 38
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O., Brabletz S., Brabletz T. E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009, 28(1-2):151-166.
    • (2009) Cancer Metastasis Rev , vol.28 , Issue.1-2 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 39
    • 7244229604 scopus 로고    scopus 로고
    • Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes
    • Gottardi C.J., Gumbiner B.M. Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes. J. Cell Biol 2004, 167(2):339-349.
    • (2004) J. Cell Biol , vol.167 , Issue.2 , pp. 339-349
    • Gottardi, C.J.1    Gumbiner, B.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.