Association of Aortic Stiffness with Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study

Hypertension

Volumn 67, Issue 3, 2016, Pages 513-519

  Pase, Matthew P ^a,b,c   Himali, Jayandra J ^a,b   Mitchell, Gary F ^b,d   Beiser, Alexa ^a,b,e   Maillard, Pauline ^f   Tsao, Connie ^g   Larson, Martin G ^b   Decarli, Charles ^f   Vasan, Ramachandran S ^b   Seshadri, Sudha ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

^d CARDIOVASCULAR ENGINEERING INC   (United States)

^e BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

brain; cerebrovascular disorders; cognition; pulse wave analysis; vascular stiffness

Indexed keywords

ADULT; AGING; ARTERIAL STIFFNESS; ARTICLE; BRAIN INJURY; BRAIN SIZE; CAROTID FEMORAL PULSE WAVE VELOCITY; COGNITION; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; EXECUTIVE FUNCTION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PULSE WAVE; WHITE MATTER INJURY; YOUNG ADULT; AORTA; BRAIN; BRAIN CIRCULATION; FOLLOW UP; PHYSIOLOGY; PROSPECTIVE STUDY; TIME FACTOR; VASCULARIZATION;

ADULT; AGING; AORTA; BRAIN; CEREBROVASCULAR CIRCULATION; COGNITION; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PROSPECTIVE STUDIES; PULSE WAVE ANALYSIS; TIME FACTORS; VASCULAR STIFFNESS; YOUNG ADULT;

EID: 84958045110     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06610     Document Type: Article

References (43)

1. Singh-Manoux A, Kivimaki M, Glymour MM, Elbaz A, Berr C, Ebmeier KP, Ferrie JE, Dugravot A. Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. BMJ. 2012; 344: d7622. doi: 10.1136/bmj.d7622.
2. Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol Rev. 1996; 103: 403-428.
3. Deary IJ, Corley J, Gow AJ, Harris SE, Houlihan LM, Marioni RE, Penke L, Rafnsson SB, Starr JM. Age-associated cognitive decline. Br Med Bull. 2009; 92: 135-152. doi: 10.1093/bmb/ldp033.
4. Hartshorne JK, Germine LT. When does cognitive functioning peak? The asynchronous rise and fall of different cognitive abilities across the life span. Psychol Sci. 2015; 26: 433-443. doi: 10.1177/0956797614567339.
5. Nichols WW, O'Rourke MF, Vlachopoulos C. Mcdonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. London: Hodder Arnold; 2011.
6. Mitchell GF. Arterial stiffness and hypertension: chicken or egg? Hypertension. 2014; 64: 210-214. doi: 10.1161/HYPERTENSIONAHA.114.03449.
7. O'Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension. 2005; 46: 200-204. doi: 10.1161/01. HYP.0000168052.00426.65.
8. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004; 43: 1239-1245. doi: 10.1161/01. HYP.0000128420.01881.aa.
9. Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson ?, Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ. Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility-Reykjavik study. Brain. 2011; 134(pt 11): 3398-3407. doi: 10.1093/brain/awr253.
10. Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol (1985). 2008; 105: 1652-1660. doi: 10.1152/japplphysiol.90549.2008.
11. Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, Au R, Himali JJ, Hamburg NM, Vita JA, Levy D, Larson MG, Benjamin EJ, Wolf PA, Vasan RS, Mitchell GF. Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology. 2013; 81: 984-991. doi: 10.1212/WNL.0b013e3182a43e1c.
12. Waldstein SR, Rice SC, Thayer JF, Najjar SS, Scuteri A, Zonderman AB. Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging. Hypertension. 2008; 51: 99-104. doi: 10.1161/HYPERTENSIONAHA.107.093674.
13. Elias MF, Robbins MA, Budge MM, Abhayaratna WP, Dore GA, Elias PK. Arterial pulse wave velocity and cognition with advancing age. Hypertension. 2009; 53: 668-673. doi: 10.1161/HYPERTENSIONAHA.108.126342.
14. Benetos A, Watfa G, Hanon O, Salvi P, Fantin F, Toulza O, Manckoundia P, Agnoletti D, Labat C, Gautier S; PARTAGE Study Investigators. Pulse wave velocity is associated with 1-year cognitive decline in the elderly older than 80 years: the PARTAGE study. J Am Med Dir Assoc. 2012; 13: 239-243. doi: 10.1016/j.jamda.2010.08.014.
15. Scuteri A, Tesauro M, Appolloni S, Preziosi F, Brancati AM, Volpe M. Arterial stiffness as an independent predictor of longitudinal changes in cognitive function in the older individual. J Hypertens. 2007; 25: 1035-1040. doi: 10.1097/HJH.0b013e3280895b55.
16. Poels MM, van Oijen M, Mattace-Raso FU, Hofman A, Koudstaal PJ, Witteman JC, Breteler MM. Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study. Stroke. 2007; 38: 888-892. doi: 10.1161/01.STR.0000257998.33768.87.
17. Watson NL, Sutton-Tyrrell K, Rosano C, Boudreau RM, Hardy SE, Simonsick EM, Najjar SS, Launer LJ, Yaffe K, Atkinson HH, Satterfield S, Newman AB. Arterial stiffness and cognitive decline in well-functioning older adults. J Gerontol A Biol Sci Med Sci. 2011; 66: 1336-1342. doi: 10.1093/gerona/glr119.
18. Pase MP, Pipingas A, Kras M, Nolidin K, Gibbs AL, Wesnes KA, Scholey AB, Stough C. Healthy middle-aged individuals are vulnerable to cognitive deficits as a result of increased arterial stiffness. J Hypertens. 2010; 28: 1724-1729. doi: 10.1097/HJH.0b013e32833b1ee7.
19. McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR; ACCT Investigators. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol. 2005; 46: 1753-1760. doi: 10.1016/j.jacc.2005.07.037.
20. Dawber TR, Meadors GF, Moore FE Jr. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health Nations Health. 1951; 41: 279-281.
21. Feinleib M, Kannel WB, Garrison RJ, McNamara PM, Castelli WP. The Framingham Offspring Study. Design and preliminary data. Prev Med. 1975; 4: 518-525.
22. Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, D'Agostino RB Sr, Fox CS, Larson MG, Murabito JM, O'Donnell CJ, Vasan RS, Wolf PA, Levy D. The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol. 2007; 165: 1328-1335. doi: 10.1093/aje/kwm021.
23. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H; European Network for Non-Invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27: 2588-2605. doi: 10.1093/eurheartj/ehl254.
24. McGrew KS. The cattell-horn carroll theory of cognitive abilities: past, present and future. In: Flanagan DP, Harrison PL, eds. Contemporary Intellectual Assessment: Theories, Tests and Issues. New York: The Guilford Press; 2005.
25. DeCarli C, Fletcher E, Ramey V, Harvey D, Jagust WJ. Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden. Stroke. 2005; 36: 50-55. doi: 10.1161/01.STR.0000150668.58689.f2.
26. Fletcher E, Carmichael O, Decarli C. MRI non-uniformity correction through interleaved bias estimation and B-spline deformation with a template. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012: 106-109. doi: 10.1109/EMBC.2012.6345882.
27. Fletcher E, Singh B, Harvey D, Carmichael O, DeCarli C. Adaptive image segmentation for robust measurement of longitudinal brain tissue change. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012: 5319-5322. doi: 10.1109/EMBC.2012.6347195.
28. Wardlaw JM, Smith EE, Biessels GJ, et al; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013; 12: 822-838. doi: 10.1016/S1474-4422(13)70124-8.
29. Mancia G, Fagard R, Narkiewicz K, et al; 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013; 31: 1281-1357.
30. Mancia G, De Backer G, Dominiczak A, et al; Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007; 25: 1105-1187. doi: 10.1097/HJH.0b013e3281fc975a.
31. van Sloten TT, Protogerou AD, Henry RM, Schram MT, Launer LJ, Stehouwer CD. Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: a systematic review and metaanalysis. Neurosci Biobehav Rev. 2015; 53: 121-130. doi: 10.1016/j. neubiorev.2015.03.011.
32. Pase MP, Herbert A, Grima NA, Pipingas A, O'Rourke MF. Arterial stiffness as a cause of cognitive decline and dementia: a systematic review and meta-analysis. Intern Med J. 2012; 42: 808-815. doi: 10.1111/j.1445-5994.2011.02645.x.
33. van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain. 1991; 114(pt 2): 761-774.
34. Hopkins RO, Beck CJ, Burnett DL, Weaver LK, Victoroff J, Bigler ED. Prevalence of white matter hyperintensities in a young healthy population. J Neuroimaging. 2006; 16: 243-251. doi: 10.1111/j.1552-6569.2006.00047.x.
35. Maillard P, Fletcher E, Lockhart SN, Roach AE, Reed B, Mungas D, DeCarli C, Carmichael OT. White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain. Stroke. 2014; 45: 1721-1726. doi: 10.1161/STROKEAHA.113.004084.
36. DeCarli C, Massaro J, Harvey D, Hald J, Tullberg M, Au R, Beiser A, D'Agostino R, Wolf PA. Measures of brain morphology and infarction in the Framingham heart study: establishing what is normal. Neurobiol Aging. 2005; 26: 491-510. doi: 10.1016/j.neurobiolaging.2004.05.004.
37. Stoodley MA, Brown SA, Brown CJ, Jones NR. Arterial pulsationdependent perivascular cerebrospinal fluid flow into the central canal in the sheep spinal cord. J Neurosurg. 1997; 86: 686-693. doi: 10.3171/jns.1997.86.4.0686.
38. Brodbelt A, Stoodley M. CSF pathways: a review. Br J Neurosurg. 2007; 21: 510-520. doi: 10.1080/02688690701447420.
39. Bilston LE, Fletcher DF, Brodbelt AR, Stoodley MA. Arterial pulsationdriven cerebrospinal fluid flow in the perivascular space: a computational model. Comput Methods Biomech Biomed Engin. 2003; 6: 235-241. doi: 10.1080/10255840310001606116.
40. Breteler MM, van Amerongen NM, van Swieten JC, Claus JJ, Grobbee DE, van Gijn J, Hofman A, van Harskamp F. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study. Stroke. 1994; 25: 1109-1115.
41. Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005; 4: 487-499. doi: 10.1016/S1474-4422(05)70141-1.
42. Gorelick PB, Scuteri A, Black SE, et al; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011; 42: 2672-2713. doi: 10.1161/STR.0b013e3182299496.
43. Pase MP. Modifiable vascular markers for cognitive decline and dementia: the importance of arterial aging and hemodynamic factors. J Alzheimers Dis. 2012; 32: 653-663. doi: 10.3233/JAD-2012-120565.