White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain

Stroke

Volumn 45, Issue 6, 2014, Pages 1721-1726

  Maillard, Pauline ^a   Fletcher, Evan ^a   Lockhart, Samuel N ^a   Roach, Alexandra E ^a   Reed, Bruce ^a   Mungas, Dan ^a   Decarli, Charles ^a   Carmichael, Owen T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aging; diffusion tensor imaging; magnetic resonance imaging; neuroimaging

Indexed keywords

AGED; AGING; ARTICLE; BRAIN INJURY; BRAIN MAPPING; DIFFUSION TENSOR IMAGING; FEMALE; FOLLOW UP; FRACTIONAL ANISOTROPY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; PRIORITY JOURNAL; WHITE MATTER;

AGING; DIFFUSION TENSOR IMAGING; MAGNETIC RESONANCE IMAGING; NEUROIMAGING;

AGED; AGED, 80 AND OVER; AGING; CEREBRAL CORTEX; DIFFUSION TENSOR IMAGING; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; TIME FACTORS;

EID: 84901824116     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.004084     Document Type: Article

References (27)

1. Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, et al. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol. 2012;11:1039-1047.
2. Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, et al. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke. 2010;41:600-606.
3. Wen W, Sachdev PS. Extent and distribution of white matter hyper-intensities in stroke patients: the Sydney Stroke Study. Stroke. 2004;35:2813-2819.
4. Maillard P, Carmichael O, Fletcher E, Reed B, Mungas D, DeCarli C. Coevolution of white matter hyperintensities and cognition in the elderly. Neurology. 2012;79:442-448.
5. Lo RY, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative. Vascular burden and Alzheimer disease pathologic progression. Neurology. 2012;79:1349-1355.
6. Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, et al. Stroke risk profle predicts white matter hyperintensity volume: the Framingham Study. Stroke. 2004;35:1857-1861.
7. DeCarli C, Massaro J, Harvey D, Hald J, Tullberg M, Au R, et al. Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal. Neurobiol Aging. 2005;26:491-510.
8. Maillard P, Fletcher E, Harvey D, Carmichael O, Reed B, Mungas D, et al. White matter hyperintensity penumbra. Stroke. 2011;42:1917-1922.
9. de Groot M, Verhaaren BF, de Boer R, Klein S, Hofman A, van der Lugt A, et al. Changes in normal-appearing white matter precede development of white matter lesions. Stroke. 2013;44:1037-1042.
10. Maillard P, Carmichael O, Harvey D, Fletcher E, Reed B, Mungas D, et al. FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities. AJNR Am J Neuroradiol. 2013;34:54-61.
11. Lee DY, Fletcher E, Martinez O, Ortega M, Zozulya N, Kim J, et al. Regional pattern of white matter microstructural changes in normal aging, MCI, and AD. Neurology. 2009;73:1722-1728.
12. Carmichael O, Mungas D, Beckett L, Harvey D, Tomaszewski Farias S, Reed B, et al. MRI predictors of cognitive change in a diverse and carefully characterized elderly population. Neurobiol Aging. 2012;33:83-95.
13. DeCarli C, Fletcher E, Ramey V, Harvey D, Jagust WJ. Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden. Stroke. 2005;36:50-55.
14. Kochunov P, Lancaster JL, Thompson P, Woods R, Mazziotta J, Hardies J, et al. Regional spatial normalization: toward an optimal target. J Comput Assist Tomogr. 2001;25:805-816.
15. Godin O, Tzourio C, Maillard P, Mazoyer B, Dufouil C. Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes: the Three-City (3C)-Dijon Magnetic Resonance Imaging Study. Circulation. 2011;123:266-273.
16. Dufouil C, Chalmers J, Coskun O, Besançon V, Bousser MG, Guillon P, et al; PROGRESS MRI Substudy Investigators. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation. 2005;112:1644-1650.
17. Hajjar I, Brown L, Mack WJ, Chui H. Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series. Arch Neurol. 2012;69:1632-1638.
18. Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM, et al. Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology. 2006;67:2192-2198.
19. Raz N, Yang Y, Dahle CL, Land S. Volume of white matter hyperin-tensities in healthy adults: contribution of age, vascular risk factors, and infammation-related genetic variants. Biochim Biophys Acta. 2012;1822:361-369.
20. Salat DH. The declining infrastructure of the aging brain. Brain Connect. 2011;1:279-293.
21. O'Sullivan M, Rich PM, Barrick TR, Clark CA, Markus HS. Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoen-cephalopathy. AJNR Am J Neuroradiol. 2003;24:1348-1354.
22. Spilt A, Goekoop R, Westendorp RG, Blauw GJ, de Craen AJ, van Buchem MA. Not all age-related white matter hyperintensities are the same: a magnetization transfer imaging study. AJNR Am J Neuroradiol. 2006;27:1964-1968.
23. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. Pathologic correlates of incidental MRI white matter signal hyper-intensities. Neurology. 1993;43:1683-1689.
24. Constans JM, Meyerhoff DJ, Norman D, Fein G, Weiner MW. 1H and 31P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects. Neuroradiology. 1995;37:615-623.
25. Chabriat H, Pappata S, Poupon C, Clark CA, Vahedi K, Poupon F, et al. Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI. Stroke. 1999;30:2637-2643.
26. Gunning-Dixon FM, Brickman AM, Cheng JC, Alexopoulos GS. Aging of cerebral white matter: a review of MRI fndings. Int J Geriatr Psychiatry. 2009;24:109-117.
27. Clarner T, Diederichs F, Berger K, Denecke B, Gan L, van der Valk P, et al. Myelin debris regulates infammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia. 2012;60:1468-1480.