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Volumn 16, Issue 3, 2016, Pages 163-170

Reversing the effect of oral anticoagulant drugs: Established and newer options

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; ANDEXANET ALFA; ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 2A INHIBITOR; BLOOD CLOTTING INHIBITOR; CIRAPARANTAG; DABIGATRAN; DABIGATRAN ETEXILATE; EDOXABAN; ENOXAPARIN; HEPARIN; IDARUCIZUMAB; LOW MOLECULAR WEIGHT HEPARIN; RIVAROXABAN; UNCLASSIFIED DRUG; ANTIFIBRINOLYTIC AGENT; ANTITHROMBIN; ARGININE; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10A; COAGULATING AGENT; FIBRINOLYTIC AGENT; MONOCLONAL ANTIBODY; NEW DRUG; PIPERAZINE DERIVATIVE; PROTHROMBIN COMPLEX CONCENTRATES; RECOMBINANT PROTEIN; VITAMIN K GROUP;

EID: 84957973629     PISSN: 11753277     EISSN: 1179187X     Source Type: Journal    
DOI: 10.1007/s40256-016-0162-7     Document Type: Review
Times cited : (21)

References (58)
  • 1
    • 84862607903 scopus 로고    scopus 로고
    • For the American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ, for the American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(No. 2 Suppl):e1S–e801S.
    • (2012) Chest , vol.141 , Issue.2 , pp. e1S-e801S
    • Guyatt, G.H.1    Akl, E.A.2    Crowther, M.3    Gutterman, D.D.4
  • 2
    • 81855169543 scopus 로고    scopus 로고
    • Emergency hospitalizations for adverse drug events in older Americans
    • Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalizations for adverse drug events in older Americans. N Eng J Med. 2011;365:2002–12.
    • (2011) N Eng J Med , vol.365 , pp. 2002-2012
    • Budnitz, D.S.1    Lovegrove, M.C.2    Shehab, N.3    Richards, C.L.4
  • 3
    • 38449106799 scopus 로고    scopus 로고
    • Medication use leading to emergency department visits for adverse drug events in older adults
    • Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147:755–65.
    • (2007) Ann Intern Med , vol.147 , pp. 755-765
    • Budnitz, D.S.1    Shehab, N.2    Kegler, S.R.3    Richards, C.L.4
  • 4
    • 84857000847 scopus 로고    scopus 로고
    • Adverse drug reaction deaths reported in United States Vital Statistics, 1999–2006
    • Shepherd G, Mohorn P, Yacoub K, May DW. Adverse drug reaction deaths reported in United States Vital Statistics, 1999–2006. Ann Pharmacother. 2012;46:169–75.
    • (2012) Ann Pharmacother , vol.46 , pp. 169-175
    • Shepherd, G.1    Mohorn, P.2    Yacoub, K.3    May, D.W.4
  • 5
    • 45949103309 scopus 로고    scopus 로고
    • The pharmacology and management of the vitamin K antagonists: ACCP evidence-based clinical practice guidelines
    • Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. The pharmacology and management of the vitamin K antagonists: ACCP evidence-based clinical practice guidelines. Chest. 2008;133:160S–98S.
    • (2008) Chest , vol.133 , pp. 160S-198S
    • Ansell, J.1    Hirsh, J.2    Hylek, E.3    Jacobson, A.4    Crowther, M.5    Palareti, G.6
  • 6
    • 84856776395 scopus 로고    scopus 로고
    • New antithrombotic drugs: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Weitz JI, Eikelboom JW, Samama MM. New antithrombotic drugs: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2_suppl):e120S–151S.
    • (2012) Chest , vol.141 , Issue.2 , pp. e120S-151S
    • Weitz, J.I.1    Eikelboom, J.W.2    Samama, M.M.3
  • 7
    • 84907662267 scopus 로고    scopus 로고
    • The impact of bleeding complications in patients receiving target-specific oral anticoagulants: A systematic review and meta-analysis
    • Chai-Adisaksopha C, Crowther M, Isayama T, Lim W. The impact of bleeding complications in patients receiving target-specific oral anticoagulants: a systematic review and meta-analysis. Blood. 2014;124:2450–8.
    • (2014) Blood , vol.124 , pp. 2450-2458
    • Chai-Adisaksopha, C.1    Crowther, M.2    Isayama, T.3    Lim, W.4
  • 8
    • 84946569791 scopus 로고    scopus 로고
    • Risk of fatal bleeding in episodes of major bleeding with new oral anticoagulants and vitamin K antagonists: A systematic review and meta-analysis
    • Skaistis J, Tagami T. Risk of fatal bleeding in episodes of major bleeding with new oral anticoagulants and vitamin K antagonists: a systematic review and meta-analysis. PLoS One. 2015;. doi:10.1371/journal.pone.0137444.
    • (2015) PLoS One
    • Skaistis, J.1    Tagami, T.2
  • 13
  • 14
    • 84856772158 scopus 로고    scopus 로고
    • Evidence-based management of anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e152S–84S.
    • (2012) Chest , vol.141 , Issue.2 , pp. e152S-e184S
    • Holbrook, A.1    Schulman, S.2    Witt, D.M.3
  • 15
    • 84922468304 scopus 로고    scopus 로고
    • A systematic review of prothrombin complex concentrate dosing strategies to reverse vitamin K antagonist therapy
    • Khorsand N, Kooistra HAM, van Hest RM, Veeger NJGM, Meijer K. A systematic review of prothrombin complex concentrate dosing strategies to reverse vitamin K antagonist therapy. Thromb Res. 2014;135:9–19.
    • (2014) Thromb Res , vol.135 , pp. 9-19
    • Khorsand, N.1    Kooistra, H.A.M.2    van Hest, R.M.3    Veeger, N.J.G.M.4    Meijer, K.5
  • 16
    • 84884354180 scopus 로고    scopus 로고
    • Efficacy and Safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: A randomized, plasma-controlled, phase IIIb study
    • Sarode R, Milling TJ, Refaai MA, Mangione A, Schneider A, Durn BL, Goldstein JN. Efficacy and Safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circ. 2013;128:1234–43.
    • (2013) Circ , vol.128 , pp. 1234-1243
    • Sarode, R.1    Milling, T.J.2    Refaai, M.A.3    Mangione, A.4    Schneider, A.5    Durn, B.L.6    Goldstein, J.N.7
  • 18
    • 3142622908 scopus 로고    scopus 로고
    • Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates
    • Dusel CH, Grundmann C, Eich S, Seitz R, König H. Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagul Fibrinolysis. 2004;15:405–11.
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 405-411
    • Dusel, C.H.1    Grundmann, C.2    Eich, S.3    Seitz, R.4    König, H.5
  • 20
    • 84884351753 scopus 로고    scopus 로고
    • Four-factor prothrombin complex concentrate for urgent reversal of vitamin K antagonists in patients with major bleeding
    • Quinlan DJ, Eikelboom JW, Weitz JI. Four-factor prothrombin complex concentrate for urgent reversal of vitamin K antagonists in patients with major bleeding. Circ. 2013;128:1179–81.
    • (2013) Circ , vol.128 , pp. 1179-1181
    • Quinlan, D.J.1    Eikelboom, J.W.2    Weitz, J.I.3
  • 21
    • 84867260031 scopus 로고    scopus 로고
    • Pro: Antidote for new anticoagulants—specific target of inhibition requires a specific target for neutralisation
    • Roldan V, Marin F. Pro: antidote for new anticoagulants—specific target of inhibition requires a specific target for neutralisation. Thromb Haemost. 2012;108:621–2.
    • (2012) Thromb Haemost , vol.108 , pp. 621-622
    • Roldan, V.1    Marin, F.2
  • 22
    • 84867252375 scopus 로고    scopus 로고
    • Contra: Antidotes for novel anticoagulants—do we really need them
    • Eerenberg ES, Levi M, Buller HR. Contra: antidotes for novel anticoagulants—do we really need them. Thromb Haemost. 2012;108:623–4.
    • (2012) Thromb Haemost , vol.108 , pp. 623-624
    • Eerenberg, E.S.1    Levi, M.2    Buller, H.R.3
  • 23
    • 84898598715 scopus 로고    scopus 로고
    • Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants
    • Miller MP, Trujillo TC, Nordenholz KE. Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants. Am J Emerg Med. 2014;32:375–82.
    • (2014) Am J Emerg Med , vol.32 , pp. 375-382
    • Miller, M.P.1    Trujillo, T.C.2    Nordenholz, K.E.3
  • 24
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate. A randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate. A randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124:1573–9.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 25
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban
    • Marlu R, Hodaj E, Paris A, Albaladejo P, Crackowski JL, Pernod G. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. Thromb Haemost. 2012;108:217–24.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Crackowski, J.L.5    Pernod, G.6
  • 26
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents
    • Fukuda T, Honda Y, Kamisato C, Morishima Y, Shibano T. Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents. Thromb Haemost. 2012;107:253–9.
    • (2012) Thromb Haemost , vol.107 , pp. 253-259
    • Fukuda, T.1    Honda, Y.2    Kamisato, C.3    Morishima, Y.4    Shibano, T.5
  • 27
    • 84947488106 scopus 로고    scopus 로고
    • Prothrombin complex concentrate is effective in treating the anticoagulant effects of dabigatran in a porcine polytrauma model
    • Honickel M, Braunschweig T, van Ryn J, ten Cate H, Spronk HMH, Rossaint R, Grottke O. Prothrombin complex concentrate is effective in treating the anticoagulant effects of dabigatran in a porcine polytrauma model. Anesthesiology. 2015;123:1350–61.
    • (2015) Anesthesiology , vol.123 , pp. 1350-1361
    • Honickel, M.1    Braunschweig, T.2    van Ryn, J.3    ten Cate, H.4    Spronk, H.M.H.5    Rossaint, R.6    Grottke, O.7
  • 28
    • 84957577892 scopus 로고    scopus 로고
    • Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model
    • (publish online Sep 3)
    • Honickel M, Maron B, van Ryn L, Braunschweig T, ten Cate H, Spronk HMH, Rossaint R, Grottke O. Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model. Thromb Haemost. 2015. doi:10.1160/TH15-03-0266(publish online Sep 3).
    • (2015) Thromb Haemost.
    • Honickel, M.1    Maron, B.2    van Ryn, L.3    Braunschweig, T.4    ten Cate, H.5    Spronk, H.M.H.6    Rossaint, R.7    Grottke, O.8
  • 29
    • 84901602200 scopus 로고    scopus 로고
    • Reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat-tail bleeding model and lack of effect on assays of coagulation
    • van Ryn J, Schure J, Kink-Eiband M, Clemens A. Reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat-tail bleeding model and lack of effect on assays of coagulation. Anesthesiology. 2014;120:1429–40.
    • (2014) Anesthesiology , vol.120 , pp. 1429-1440
    • van Ryn, J.1    Schure, J.2    Kink-Eiband, M.3    Clemens, A.4
  • 30
    • 84893171895 scopus 로고    scopus 로고
    • Reversing the new oral anticoagulants with prothrombin complex concentrates (PCCs): What is the evidence?
    • Dickneite G, Hoffman M. Reversing the new oral anticoagulants with prothrombin complex concentrates (PCCs): what is the evidence? Thromb Haemost. 2014;111:189–98.
    • (2014) Thromb Haemost , vol.111 , pp. 189-198
    • Dickneite, G.1    Hoffman, M.2
  • 32
    • 84865793090 scopus 로고    scopus 로고
    • Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
    • Lambourne MD, Eltringham-Smith LJ, Gataiance S, Arnold DM, Crowther MA, Sheffield WP. Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate. J Thromb Haemost. 2012;10:1830–40.
    • (2012) J Thromb Haemost , vol.10 , pp. 1830-1840
    • Lambourne, M.D.1    Eltringham-Smith, L.J.2    Gataiance, S.3    Arnold, D.M.4    Crowther, M.A.5    Sheffield, W.P.6
  • 34
    • 84883812030 scopus 로고    scopus 로고
    • In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for rivaroxaban
    • Dinkelaar J, Molenaar PJ, Ninivaggi M, de Laat B, Brinkman JM, Leyte A. In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for rivaroxaban. J Thromb Haemost. 2013;11:1111–8.
    • (2013) J Thromb Haemost , vol.11 , pp. 1111-1118
    • Dinkelaar, J.1    Molenaar, P.J.2    Ninivaggi, M.3    de Laat, B.4    Brinkman, J.M.5    Leyte, A.6
  • 36
    • 84898538852 scopus 로고    scopus 로고
    • Novel oral anticoagulants: Pharmacology, coagulation measures, and considerations for reversal
    • Jackson LR, Becker RC. Novel oral anticoagulants: pharmacology, coagulation measures, and considerations for reversal. J Thromb Thrombolysis. 2014;37:380–91.
    • (2014) J Thromb Thrombolysis , vol.37 , pp. 380-391
    • Jackson, L.R.1    Becker, R.C.2
  • 37
    • 84925497457 scopus 로고    scopus 로고
    • Managing target-specific oral anticoagulant associated bleeding including an update on pharmacological reversal agents
    • Siegal DM. Managing target-specific oral anticoagulant associated bleeding including an update on pharmacological reversal agents. J Thromb Thrombolysis. 2015;39:395–402.
    • (2015) J Thromb Thrombolysis , vol.39 , pp. 395-402
    • Siegal, D.M.1
  • 39
    • 84867240886 scopus 로고    scopus 로고
    • New direct oral anticoagulants-current therapeutic options and treatment recommendations for bleeding complications
    • Miesbach W, Seifried E. New direct oral anticoagulants-current therapeutic options and treatment recommendations for bleeding complications. Thromb Haemost. 2012;108:625–32.
    • (2012) Thromb Haemost , vol.108 , pp. 625-632
    • Miesbach, W.1    Seifried, E.2
  • 41
    • 84896397052 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Immediate, complete and sustained reversal of dabigatran induced anticoagulation in healthy male volunteers
    • Glund S, Stangier J, Schmohl M, De Smet M, Gansser D, Lang B, Moschetti V, Ramael S, Reilly PA. A specific antidote for dabigatran: immediate, complete and sustained reversal of dabigatran induced anticoagulation in healthy male volunteers. Circulation. 2013;128:A17765.
    • (2013) Circulation , vol.128 , pp. A17765
    • Glund, S.1    Stangier, J.2    Schmohl, M.3    De Smet, M.4    Gansser, D.5    Lang, B.6    Moschetti, V.7    Ramael, S.8    Reilly, P.A.9
  • 43
    • 84942154840 scopus 로고    scopus 로고
    • Idarucizumab, a specific dabigatran reversal agent, reduces blood loss in a porcine model of trauma with dabigatran anticoagulation
    • Grottke O, Honickel M, van Ryn J, ten Cate H, Rossaint R, Sprink HM. Idarucizumab, a specific dabigatran reversal agent, reduces blood loss in a porcine model of trauma with dabigatran anticoagulation. J Am Coll Cardiol. 2015;66:1518–9.
    • (2015) J Am Coll Cardiol , vol.66 , pp. 1518-1519
    • Grottke, O.1    Honickel, M.2    van Ryn, J.3    ten Cate, H.4    Rossaint, R.5    Sprink, H.M.6
  • 44
    • 85012840254 scopus 로고    scopus 로고
    • Praxbind package insert. http://us.boehringer-ingelheim.com/content/dam/internet/opu/us_EN/documents/Media_Press_Releases/2015/Praxbind.pdf. Accessed 20 Nov 2015
    • Praxbind package insert. http://us.boehringer-ingelheim.com/content/dam/internet/opu/us_EN/documents/Media_Press_Releases/2015/Praxbind.pdf. Accessed 20 Nov 2015.
  • 46
    • 84963579736 scopus 로고    scopus 로고
    • Reversal agents for anticoagulants: Focus on andexanet alfa
    • Shah N, Rattu MA. Reversal agents for anticoagulants: focus on andexanet alfa. Am Student Res J. 2014;1:16–28.
    • (2014) Am Student Res J , vol.1 , pp. 16-28
    • Shah, N.1    Rattu, M.A.2
  • 49
    • 84948746294 scopus 로고    scopus 로고
    • ANNEXA™-R: A phase 3 randomized, double-blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in older subjects by andexanet alfa, a universal antidote for factor Xa inhibitors
    • (abstract)
    • Gold AM, Crowther M, Levy G, Lu G, Leeds J, Barron L, Conley P, Castillo J, Curnutte J, Connolly S. ANNEXA™-R: a phase 3 randomized, double-blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in older subjects by andexanet alfa, a universal antidote for factor Xa inhibitors. JACC. 2015;65:A23 (abstract).
    • (2015) JACC , vol.65 , pp. A23
    • Gold, A.M.1    Crowther, M.2    Levy, G.3    Lu, G.4    Leeds, J.5    Barron, L.6    Conley, P.7    Castillo, J.8    Curnutte, J.9    Connolly, S.10
  • 50
    • 84979578521 scopus 로고    scopus 로고
    • ANNEXA-A Part 2: A phase 3 randomized, double-blind, placebo-controlled trial demonstrating sustained reversal of apixaban-induced anticoagulation in older subjects by andexanet alfa, a universal antidote for factor Xa inhibitors
    • (LB004 abstract)
    • Crowther M, Gold A, Lu G, Leeds JM, Wiens BL, Mathur V, Castillo J, Conley PB, Connolly S, Curnutte JT. ANNEXA-A Part 2: a phase 3 randomized, double-blind, placebo-controlled trial demonstrating sustained reversal of apixaban-induced anticoagulation in older subjects by andexanet alfa, a universal antidote for factor Xa inhibitors. J Thromb Haemost. 2015;13(Suppl 2):84 (LB004 abstract).
    • (2015) J Thromb Haemost , vol.13 , pp. 84
    • Crowther, M.1    Gold, A.2    Lu, G.3    Leeds, J.M.4    Wiens, B.L.5    Mathur, V.6    Castillo, J.7    Conley, P.B.8    Connolly, S.9    Curnutte, J.T.10
  • 51
    • 84950138350 scopus 로고    scopus 로고
    • Reversal of factor Xa inhibitors-induced anticoagulation in healthy subjects by andexanet alfa
    • Crowther M, Lu G, Conley P, Leeds J, Castillo J, Levy G, Connolly S, Curnutte J. Reversal of factor Xa inhibitors-induced anticoagulation in healthy subjects by andexanet alfa. Crit Care Med 2014;42:pA1469.
    • (2014) Crit Care Med , vol.42 , pp. A1469
    • Crowther, M.1    Lu, G.2    Conley, P.3    Leeds, J.4    Castillo, P.5    Levy, G.6    Connolly, S.7
  • 52
    • 85012827765 scopus 로고    scopus 로고
    • Presented at the 24th Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, June 29–July 4. 2013. Abstract (http://www.eventure-online.com/eventure/publicAbstractView.do?id=226718&congressId=6839). Accessed 27 Jan 2016
    • Laulicht B, Bakhru S, Jiang X, et al. Antidote for new oral anticoagulants: mechanism of action and binding specificity of PER977. Presented at the 24th Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, June 29–July 4. 2013. Abstract (http://www.eventure-online.com/eventure/publicAbstractView.do?id=226718&congressId=6839). Accessed 27 Jan 2016.
    • (2016) Antidote for new oral anticoagulants: Mechanism of action and binding specificity of PER977.
    • Laulicht, B.1    Bakhru, S.2    Jiang, X.3
  • 54
    • 84922313318 scopus 로고    scopus 로고
    • Reversal of anticoagulant-induced bleeding in external and internal bleeding models by PER977, a small molecule anticoagulant antidote
    • (abstract)
    • Bakhru S, Laulicht B, Jiang X, Chen L, Grosso M, Morishima Y, Brown K, Mercuri M, Masumoto H, Costin J, Steiner S. Reversal of anticoagulant-induced bleeding in external and internal bleeding models by PER977, a small molecule anticoagulant antidote. Circ. 2014;130:A19361 (abstract).
    • (2014) Circ , vol.130 , pp. A19361
    • Bakhru, S.1    Laulicht, B.2    Jiang, X.3    Chen, L.4    Grosso, M.5    Morishima, Y.6    Brown, K.7    Mercuri, M.8    Masumoto, H.9    Costin, J.10    Steiner, S.11
  • 56
    • 84968808413 scopus 로고    scopus 로고
    • PER977 (ciraparantag) reverses edoxaban anticoagulation at steady state and has no effect on re-anticoagulation at the next scheduled dose [Abstract No. 4971]
    • Laulicht B, Bakhru S, Steiner S, Brown K, Grosso M, Lanz H, Mercuri M, Costin J. PER977 (ciraparantag) reverses edoxaban anticoagulation at steady state and has no effect on re-anticoagulation at the next scheduled dose [Abstract No. 4971]. Eur Heart J 2015;36(Abstract Supplement):859–60.
    • (2015) Eur Heart J , vol.36 , pp. 859-860
    • Laulicht, B.1    Bakhru, S.2    Steiner, S.3    Brown, K.4    Grosso, M.5    Lanz, H.6    Mercuri, M.7    Costin, J.8
  • 57
    • 84968808438 scopus 로고    scopus 로고
    • PER977 reverses low molecular weight heparin in addition to IIa and Xa new oral anticoagulants
    • (abstract)
    • Costin J, Laulicht B, Bakhru S, Laulicht B, Steiner S. PER977 reverses low molecular weight heparin in addition to IIa and Xa new oral anticoagulants. J Am Coll Cardiol. 2015:65(10_S)(abstract). doi:10.1016/S0735-1097/(15)62056-3.
    • (2015) J Am Coll Cardiol. , vol.65 , Issue.10
    • Costin, J.1    Laulicht, B.2    Bakhru, S.3    Laulicht, B.4    Steiner, S.5
  • 58
    • 84979533130 scopus 로고    scopus 로고
    • The new oral anticoagulants: Clinical use and reversal agent development
    • Costin J, Ansell J, Bakhru S, Laulicht B, Solomon S. The new oral anticoagulants: clinical use and reversal agent development. ISBT Science Series. 2015;10(Suppl 1):324–31.
    • (2015) ISBT Science Series , vol.10 , pp. 324-331
    • Costin, J.1    Ansell, J.2    Bakhru, S.3    Laulicht, B.4    Solomon, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.