Prothrombin complex concentrate is effective in treating the anticoagulant effects of dabigatran in a porcine polytrauma model

Anesthesiology

Volumn 123, Issue 6, 2015, Pages 1350-1361

  Honickel, Markus ^a   Braunschweig, Till ^a   Van Ryn, Joanne ^b   Ten Cate, Hugo ^c   Spronk, Henri M H ^c   Rossaint, Rolf ^a   Grottke, Oliver ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DABIGATRAN ETEXILATE; FIBRINOGEN; PROTHROMBIN COMPLEX; THROMBIN; ANTITHROMBIN; BLOOD CLOTTING FACTOR; DABIGATRAN; PROTHROMBIN COMPLEX CONCENTRATES; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULANT THERAPY; ANTICOAGULATION; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; BLOOD SAMPLING; BLUNT TRAUMA; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMUR FRACTURE; FIBRINOGEN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEMORRHAGIC SHOCK; HEMOSTASIS; HISTOPATHOLOGY; LIVER INJURY; MALE; MULTIPLE TRAUMA; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PORCINE MODEL; PRIORITY JOURNAL; SURVIVAL; THROMBOCYTE COUNT; TISSUE INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD CLOTTING TEST; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; FEMUR; HEMORRHAGE; INJURIES; LIVER; PIG;

ANIMALS; ANTITHROMBINS; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; BLOOD COAGULATION TESTS; DABIGATRAN; DISEASE MODELS, ANIMAL; FEMUR; HEMORRHAGE; LIVER; MALE; MULTIPLE TRAUMA; SODIUM CHLORIDE; SWINE;

EID: 84947488106     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000863     Document Type: Article

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