A specific antidote for dabigatran: Functional and structural characterization

Blood

Volumn 121, Issue 18, 2013, Pages 3554-3562

  Schiele, Felix ^a   Van Ryn, Joanne ^a   Canada, Keith ^b   Newsome, Corey ^b   Sepulveda, Eliud ^b   Park, John ^a   Nar, Herbert ^a   Litzenburger, Tobias ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADABI FAB; ANTIDOTE; DABIGATRAN; DABIGATRAN ETEXILATE; THROMBIN; UNCLASSIFIED DRUG; ANTITHROMBIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; DRUG DERIVATIVE;

AMINO ACID SEQUENCE; ANTIBODY BLOOD LEVEL; ANTIBODY ENGINEERING; ANTIBODY SCREENING; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING TEST; BLOOD CLOTTING TIME; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SEQUENCE; HEART ATRIUM FIBRILLATION; HYDROGEN BOND; IC 50; IMMUNOGENICITY; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DRUG ANTAGONISM; ENZYME SPECIFICITY; HAMSTER; ISOLATION AND PURIFICATION; MALE; RAT; WISTAR RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIDOTES; ANTITHROMBINS; BENZIMIDAZOLES; BETA-ALANINE; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MODELS, MOLECULAR; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY;

MLCS; MLOWN;

EID: 84879548455     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-11-468207     Document Type: Article

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