Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 9, 2012, Pages 1841-1848

  Pragst, I ^a   Zeitler, S H ^a   Doerr, B ^a   Kaspereit, F J ^a   Herzog, E ^a   Dickneite, G ^a   van Ryn, J ^b  

^a CSL BEHRING GMBH   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Animal; Anticoagulation reversal; Direct thrombin inhibitors; Hemorrhage; Interventional procedures; Models; Prothrombin complex concentrate

Indexed keywords

DABIGATRAN; PLACEBO; PROTHROMBIN COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLEEDING; BLEEDING TENDENCY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; EXPERIMENTAL RABBIT; FEMALE; HEMOSTASIS; KIDNEY INJURY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBIN TIME; THROMBOELASTOGRAPHY; THROMBOGENESIS;

ANIMALS; ANTICOAGULANTS; BENZIMIDAZOLES; BETA-ALANINE; DRUG COMBINATIONS; FACTOR IX; FACTOR VII; FACTOR X; FEMALE; MODELS, ANIMAL; PLACEBOS; PROTHROMBIN; RABBITS;

EID: 84865773023     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2012.04859.x     Document Type: Article

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