Physiological role of gut microbiota for maintaining human health

Digestion

Volumn 93, Issue 3, 2016, Pages 176-181

  Andoh, Akira ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Bacteroides; Butyrate; Firmicutes; Short chain fatty acids

Indexed keywords

BUTYRIC ACID; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SHORT CHAIN FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; VOLATILE FATTY ACID;

CARBOHYDRATE METABOLISM; CELL ACTIVATION; DIETARY FIBER; FAECALIBACTERIUM PRAUSNITZII; FERMENTATION; GASTROINTESTINAL TRACT; GENE EXPRESSION; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INTESTINE FLORA; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; TH17 CELL; TIGHT JUNCTION; DIET; HEALTH; IMMUNITY; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHYSIOLOGY;

CARBOHYDRATE METABOLISM; CYTOKINES; DIET; FATTY ACIDS, VOLATILE; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HEALTH; HUMANS; IMMUNITY; INFLAMMATION;

EID: 84957927568     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000444066     Document Type: Review

References (41)

1. Goldsmith JR, Sartor RB. The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol 2014; 49: 785-798.
2. Sheehan D, Moran C, Shanahan F. The microbiota in inflammatory bowel disease. J Gastroenterol 2015; 50: 495-507.
3. Norman JM, Handley SA, Virgin HW. Kingdom-Agnostic metagenomics and the importance of complete characterization of enteric microbial communities. Gastroenterology 2014; 146: 1459-1469.
4. Ursell LK, Haiser HJ, Van Treuren W, et al. The intestinal metabolome: an intersection between microbiota and host. Gastroenterology 2014; 146: 1470-1476.
5. Guarner F. The intestinal flora in inflammatory bowel disease: normal or abnormal?. Curr Opin Gastroenterol 2005; 21: 414-418.
6. Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361: 512-519.
7. Mahida YR, Rolfe VE. Host-bacterial interactions in inflammatory bowel disease. Clin Sci (Lond) 2004; 107: 331-341.
8. Hollister EB, Gao C, Versalovic J. Compositional and functional features of the gastrointestinal microbiome and their effects on human health. Gastroenterology 2014; 146: 1449-1458.
9. Claesson MJ, Jeffery IB, Conde S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 2012; 488: 178-184.
10. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A 2010; 107: 14691-14696.
11. Cantarel BL, Lombard V, Henrissat B. Complex carbohydrate utilization by the healthy human microbiome. PLoS One 2012; 7: e28742.
12. Wu GD, Chen J, Hoffmann C, et al. Linking long-Term dietary patterns with gut microbial enterotypes. Science 2011; 334: 105-108.
13. Flint HJ, Scott KP, Louis P, et al. The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol 2012; 9: 577-589.
14. Schwiertz A, Taras D, Schafer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010; 18: 190-195.
15. Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut 2016; 65: 330-339.
16. McNeil NI. The contribution of the large intestine to energy supplies in man. Am J Clin Nutr 1984; 39: 338-342.
17. Macfarlane GT, Macfarlane S. Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics. J Clin Gastroenterol 2011; 45(suppl): S120-S127.
18. Simpson HL, Campbell BJ. Review article: dietary fibre-microbiota interactions. Aliment Pharmacol Ther 2015; 42: 158-179.
19. Duncan SH, Louis P, Thomson JM, et al. The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol 2009; 11: 2112-2122.
20. Kamada N, Nunez G. Regulation of the immune system by the resident intestinal bacteria. Gastroenterology 2014; 146: 1477-1488.
21. Hooper LV, Macpherson AJ. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol 2010; 10: 159-169.
22. Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011; 331: 337-341.
23. Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013; 504: 446-450.
24. Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569-573.
25. Fujimoto T, Imaeda H, Takahashi K, et al. Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn s disease. J Gastroenterol Hepatol 2013; 28: 613-619.
26. Waite JC, Skokos D. Th17 response and inflammatory autoimmune diseases. Int J Inflam 2012; 2012: 819467.
27. Weaver CT, Hatton RD, Mangan PR, et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007; 25: 821-852.
28. Ivanov II, Frutos Rde L, Manel N, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008; 4: 337-349.
29. Atarashi K, Tanoue T, Ando M, et al. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 2015; 163: 367-380.
30. Vinolo MA, Rodrigues HG, Nachbar RT, et al. Regulation of inflammation by short chain fatty acids. Nutrients 2011; 3: 858-876.
31. Andoh A, Fujiyama Y, Hata K, et al. Counterregulatory effect of sodium butyrate on tumour necrosis factor-Alpha (TNF-Alpha)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells. Clin Exp Immunol 1999; 118: 23-29.
32. Inatomi O, Andoh A, Kitamura K, et al. Butyrate blocks interferon-gamma-inducible protein-10 release in human intestinal subepithelial myofibroblasts. J Gastroenterol 2005; 40: 483-489.
33. Glozak MA, Sengupta N, Zhang X, et al. Acetylation and deacetylation of non-histone proteins. Gene 2005; 363: 15-23.
34. Halsall J, Gupta V, O'Neill LP, et al. Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. PLoS One 2012; 7: e33453.
35. Forsythe P, Kunze WA. Voices from within: gut microbes and the CNS. Cell Mol Life Sci 2013; 70: 55-69.
36. Cryan JF, Dinan TG. Mind-Altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012; 13: 701-712.
37. Ganapathy V, Thangaraju M, Prasad PD, et al. Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Curr Opin Pharmacol 2013; 13: 869-874.
38. Karaki S, Mitsui R, Hayashi H, et al. Shortchain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 2006; 324: 353-360.
39. Nohr MK, Pedersen MH, Gille A, et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology 2013; 154: 3552-3564.
40. Cherbut C, Ferrier L, Roze C, et al. Shortchain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. Am J Physiol 1998; 275: G1415-G1422.
41. Your microbes at work: fiber fermenters keep us healthy Nature 2015 518 S9.