The expression of TALEN before fertilization provides a rapid knock-out phenotype in Xenopus laevis founder embryos

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Miyamoto, Kei ^a,c   Suzuki, Ken Ichi T ^b   Suzuki, Miyuki ^b   Sakane, Yuto ^b   Sakuma, Tetsushi ^b   Herberg, Sarah ^a   Simeone, Angela ^a   Simpson, David ^a   Jullien, Jerome ^a   Yamamoto, Takashi ^b   Gurdon, J B ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b HIROSHIMA UNIVERSITY   (Japan)

^c KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; DEOXYRIBONUCLEASE; EYE PROTEIN; HOMEODOMAIN PROTEIN; MONOPHENOL MONOOXYGENASE; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PAX6;

ARTICLE; DEVELOPMENTAL STAGE; DNA SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; EXON; FERTILIZATION; GENE; GENE DELETION; GENE FREQUENCY; GENE TARGETING; GERMINAL VESICLE; IN VITRO STUDY; MUTAGENESIS; NONHUMAN; OOCYTE; OOCYTE MATURATION; PAX6 GENE; PHENOTYPE; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TADPOLE; TYRA GENE; XENOPUS LAEVIS; ANIMAL; CYTOLOGY; DEFICIENCY; EMBRYOLOGY; FEMALE; FOUNDER EFFECT; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INTRACYTOPLASMIC SPERM INJECTION; LETHAL GENE; MALE; METABOLISM; MICROINJECTION; MOLECULAR GENETICS; NONMAMMALIAN EMBRYO; NUCLEOTIDE SEQUENCE; PROCEDURES; SEQUENCE ALIGNMENT; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; DEOXYRIBONUCLEASES; EMBRYO, NONMAMMALIAN; EYE PROTEINS; FEMALE; FERTILIZATION; FOUNDER EFFECT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; GENES, LETHAL; HOMEODOMAIN PROTEINS; MALE; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; OOCYTES; PAIRED BOX TRANSCRIPTION FACTORS; PAX6 TRANSCRIPTION FACTOR; PHENOTYPE; REPRESSOR PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SPERM INJECTIONS, INTRACYTOPLASMIC; TRANSCRIPTIONAL ACTIVATION; XENOPUS LAEVIS;

EID: 84957922305     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0142946     Document Type: Article

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