Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients

Developmental Biology

Volumn 408, Issue 2, 2015, Pages 328-344

  Nakayama, Takuya ^a   Fisher, Marilyn ^a   Nakajima, Keisuke ^b   Odeleye, Akinleye O ^a   Zimmerman, Keith B ^a   Fish, Margaret B ^a,e   Yaoita, Yoshio ^b   Chojnowski, Jena L ^c   Lauderdale, James D ^c   Netland, Peter A ^d   Grainger, Robert M ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF GEORGIA   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Lens; Neural patterning; Retina; Transcription Activator Like Effector Nuclease (TALEN); Xenopus tropicalis

Indexed keywords

GLUTATHIONE TRANSFERASE A2; MESSENGER RNA; TRANSCRIPTION FACTOR PAX6; DNA; EYE PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; PAX6 PROTEIN, HUMAN; REPRESSOR PROTEIN; STOP CODON;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANIRIDIA; ARTICLE; BRAIN DEVELOPMENT; CARBOXY TERMINAL SEQUENCE; CATARACT; CELL STRUCTURE; CONTROLLED STUDY; CORNEA DISEASE; DOWN REGULATION; EMBRYO; EXON; EYE DEVELOPMENT; EYE MALFORMATION; FEMALE; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GERMLINE MUTATION; HISTOPATHOLOGY; HUMAN; IN SITU HYBRIDIZATION; MALE; MOUSE; MUTAGENESIS; NONHUMAN; NULL ALLELE; ONCOGENE C MYC; PHENOTYPE; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; STEM CELL; STOP CODON; XENOPUS TROPICALIS; ANIMAL; DEFICIENCY; DISEASE MODEL; EMBRYOLOGY; EYE; GENE TARGETING; GENETICS; GROWTH, DEVELOPMENT AND AGING; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; SPECIES DIFFERENCE; XENOPUS;

ANIMALS; ANIRIDIA; BASE SEQUENCE; CODON, NONSENSE; DISEASE MODELS, ANIMAL; DNA; EXONS; EYE; EYE PROTEINS; GENE TARGETING; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PAIRED BOX TRANSCRIPTION FACTORS; PAX6 TRANSCRIPTION FACTOR; PHENOTYPE; REPRESSOR PROTEINS; SPECIES SPECIFICITY; XENOPUS;

EID: 84947283866     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2015.02.012     Document Type: Article

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