Recent advances in thermoregulation

Advances in Physiology Education

Volumn 39, Issue 1, 2015, Pages 139-148

  Tansey, Etain A ^a   Johnson, Christopher D ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Brown adipose tissue; Cold; Heat; Preoptic area of the hypothalamus; Set point; Thermoregulation; Transient receptor potential channel

Indexed keywords

ADAPTATION; ADULT; BODY TEMPERATURE; FEMALE; FEVER; HUMAN; HYPOTHERMIA; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SHIVERING; SKIN TEMPERATURE; SWEATING; TEMPERATURE SENSE; THERMORECEPTOR; THERMOREGULATION;

ADAPTATION, PHYSIOLOGICAL; ADULT; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; FEMALE; FEVER; HUMANS; HYPOTHERMIA; MALE; SENSITIVITY AND SPECIFICITY; SHIVERING; SKIN TEMPERATURE; SWEATING; THERMORECEPTORS; THERMOSENSING;

EID: 84957894191     PISSN: 10434046     EISSN: 15221229     Source Type: Journal    
DOI: 10.1152/advan.00126.2014     Document Type: Article

References (83)

1. Alsene KM, Carasso BS, Connors EE, Bakshi VP. Disruption of prepulse inhibition after stimulation of central but not peripheral a-1 adrenergic receptors. Neuropsychopharmacology 31: 2150-2161, 2006.
2. Armstrong LE, Hubbard RW, Jones BH, Daniels JT. Preparing Alberto Salazar for the heat of the 1984 Olympic Marathon. Phys Sportsmed 14: 73-81, 1986.
3. Bates GP, Miller VS. Sweat rate and sodium loss during work in the heat. J Occup Med Toxicol 3: 4, 2008.
4. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448: 204-208, 2007.
5. Best S, Thompson M, Caillaud C, Holvik L. Exercise-heat acclimation in young and older trained cyclists. J Sci Med Sport 17: 677-682, 2014.
6. Blair DA, Glover WE, Roddie IC. Vasomotor responses in the human arm during leg exercise. Circ Res 9: 264-274, 1960.
7. Boegli Y, Gremion G, Golay S, Kubli S, Liaudet L, Leyvraz PF, Waeber B, Feihl F. Endurance training enhances vasodilation induced by nitric oxide in human skin. J Invest Dermatol 121: 1197-1204, 2003.
8. Brade C, Dawson B, Wallman K. Effect of precooling and acclimation on repeat-sprint performance in heat. J Sports Sci 31: 779-86, 2013.
9. Bradley E, Law A, Bell D, Johnson CD. Contributions of cotransmitters to sympathetically-evoked responses in isolated rat tail artery. Am J Physiol Heart Circ Physiol 284: H2007-H2014, 2003.
10. Burnstock G. Cotransmission in the autonomic nervous system. Handb Clin Neurol 117: 23-35, 2013.
11. Carter J, Jeukendrup AE, Mundel T, Jones DA. Carbohydrate supplementation improves moderate and high-intensity exercise in the heat. Pflügers Arch 446: 211-219, 2003.
12. Caterina MJ. Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol Regul Integr Comp Physiol 292: R64-R76, 2007.
13. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398: 436-441, 1999.
14. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824, 1997.
15. Charkoudian N. Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. Mayo Clin Proc 78: 603-612, 2003.
16. Clarke S, Parris R, Reynard K. Core-peripheral temperature gradient as a diagnostic test in dyspnoea. Emerg Med J 22: 633-635, 2005.
17. Cotter JD, Patterson MJ, Taylor NA. Sweat distribution before and after repeated heat exposure. Eur J Appl Physiol 76: 181-186, 1997.
18. Craig AD, Krout K, Andrew D. Quatitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat. J Neurophysiol 86: 1459-1480, 2001.
19. DeGroot D, Kenney WL. Impaired defense of core temperature in aged humans during mild cold stress. Am J Physiol Regul Integr Comp Physiol 292: R103-R108, 2007.
20. Eyolfson DA, Tikuisis P, Xu XJ, Weseen G, Giesbrecht GG. Measurement and prediction of peak shivering intensity in humans. Eur J Appl Physiol 84: 100-106, 2001.
21. Febbraio MA, Snow RJ, Hargreaves M, Slathis CG, Martin IK, Carey MF. Muscle metabolism during exercise and heat stress in trained men: effect of acclimation. J Appl Physiol 76: 589-597, 1994.
22. Flouris AD. Functional architecture of behavioural thermoregulation. Eur J Appl Physiol 111: 1-8, 2011.
23. Galloway SD, Maughan RJ. Effects of ambient temperature on the capacity to perform prolonged cycle exercise in man. Med Sci Sports Exerc 9: 1240-1249, 1997.
24. González-Alonso J, Teller C, Andersen SL, Jensen FB, Hyldig T, Nielsen B. Influence of body temperature on the development of fatigue during prolonged exercise in the heat. J Appl Physiol 86: 1032-1039, 1999.
25. Greenfield AD. The circulation through the skin. In: Handbook of Physiology. Circulation. Washington, DC: Am. Physiol. Soc., 1963, sect. 2, vol. II, chapt. 39, p. 1325-1351.
26. Guyton AC, Hall JE. Textbook of Medical Physiology (13th ed.). Philadelphia, PA: Elsevier Saunders, 2011.
27. Hargreaves M. Physiological limits to exercise performance in the heat. J Sci Med Sport 11: 66-71, 2008.
28. Höfler W. Changes in regional distribution of sweating during acclimatization to heat. J Appl Physiol 25: 503-505, 1968.
29. Holowatz LA, Thompson-Torgerson C, Kenney WL. Aging and the control of human skin blood flow. Front Biosci 1: 718-739, 2010.
30. Johnson JM, Kellogg DL Jr. Thermoregulatory and thermal control in the human cutaneous circulation. Front Biosci 2: 825-853, 2010.
31. Johnson JM, Minson CT, Kellogg DL. Cutaneous vasodilator and vasoconstrictor mechanisms in temperature regulation. Compr Physiol 4: 33-89, 2014.
32. Johnson JM, Pérgola PE, Liao FK, Kellogg DL Jr., Crandall CG. Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system. J Appl Physiol 78: 948-954, 1995.
33. Kenney WL, Johnson JM. Control of skin blood flow during exercise. Med Sci Sport Exerc 24: 303-312, 1992.
34. Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88: 141-148, 2003.
35. Kondo N, Taylor NA, Shibasaki M, Aoki K, Che Muhamed AM. Thermoregulatory adaptation in humans and its modifying factors. Global Environ Res 13: 35-41, 2009.
36. Latorre R, Brauchi S, Madrid R, Orio P. A cool channel in cold transduction. Physiology 26: 273-285, 2011.
37. Lee JB, Kim TW, Min YK, Yang HM. Long distance runners present upregulated sweating responses than sedentary counterparts. PLos One 9: e93976, 2014.
38. Lepock JR. Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage. Int J Hyperthermia 19: 252-266, 2003.
39. Lorenzo S, Halliwill JR, Sawka MN, Minson CT. Heat acclimation improves exercise performance. J Appl Physiol 109: 1140-1147, 2010.
40. Mallet ML. Pathophysiology of accidental hypothermia. Q J Med 95: 775-785, 2002.
41. McAllen RM, Tanaka M, Ootsuka Y, McKinley MJ. Multiple thermoregulatory effectors with independent central controls. Eur J Appl Physiol 109: 17-33, 2010.
42. Morrison SF, Madden CJ. Central nervous system regulation of brown adipose tissue. Comp Physiol 4: 1677-1713, 2014.
43. Morrisson SF, Nakamura K. Preoptic mechanism for cold-defensive responses to skin cooling. J Physiol 586: 2611-2620, 2008.
44. Morrisson SF, Nakamura K. A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci USA 107: 8848-8853, 2010.
45. Morrisson SF, Nakamura K. Central neural pathways for thermoregulation. Front Biosci 16: 74-104, 2011.
46. Munce TA, Kenney WL. Age-specific modification of local cutaneous vasodilation by capsaicin-sensitive primary afferents. J Appl Physiol 95: 1016-1024, 2003.
47. Nakamura K. Central circuities for body temperature regulation and fever. Am J Physiol Regul Integr Comp Physiol 301: R1207-R1228, 2011.
48. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293: E444-E452, 2007.
49. Nielsen B, Strange S, Christensen NJ, Warberg J, Saltin B. Acute and adaptive responses in humans to exercise in a warm, humid environment. Pflügers Arch 434: 49-56, 1997.
50. Nielsen TA, da Silver LB, Arendt-Nielsen L, Gazerani P. The effect of topical capsaicin-induced sensitization of heat-evoked cutaneous vasomotor responses. Int J Physiol Pathophysiol Pharmacol 5: 148-160, 2013.
51. Nybo L. CNS fatigue provoked by prolonged exercise in the heat. Front Biosci 2: 779-792, 2010.
52. Nybo L, Rasmussen P, Sawka MN. Performance in the heat-physiological factors of importance for hyperthermia-induced fatigue. Compr Physiol 4: 657-689, 2014.
53. Ootsuka Y, McAllen RM. Comparison between two rat sympathetic pathways activated by cold defense. Am J Physiol Regul Integr Comp Physiol 291: R589-R595, 2006.
54. Parsons K. Human Thermal Environments: the Effects of Hot, Moderate, and Cold Environments on Human Health, Comfort, and Performance (3rd ed.). Abingdon, UK: Taylor & Francis, 2014.
55. Patterson MJ, Stocks JM, Taylor NA. Humid heat acclimation does not elicit a preferential sweat redistribution toward the limbs. Am J Physiol Regul Integr Comp Physiol 286: R512-R518, 2004.
56. Roberts MF, Wenger CB, Stolwijk JA, Nadel ER. Skin blood flow and sweating changes following exercise training and heat acclimation. J Appl Physiol 43: 133-137, 1977.
57. Romanovsky AA. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol Regul Integr Comp Physiol 292: R37-R46, 2007.
58. Sato F, Owen M, Matthes R, Sato K, GisolfiCV. Functional and morphological changes in the eccrine sweat gland with heat acclimation. J Appl Physiol 69: 232-236, 1990.
59. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58: 1526-1531, 2009.
60. Schepers RJ, Ringkamp M. Thermoreceptors and thermosensitive afferents. Neurosci Biobehav Rev 34: 177-184, 2010.
61. Shibasaki M, Crandall CG. Mechanisms and controllers of eccrine sweating in humans. Front Biosci 2: 685-696, 2010.
62. Shibasaki M, Wilson TE, Crandall CG. Neural control and mechanisms of eccrine sweating during heat stress and exercise. J Appl Physiol 100: 1692-1701, 2006.
63. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Oo L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418: 86-190, 2002.
64. Stephens DP, Aoki K, Kosiba WA, Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol 280: H1496-H1504, 2001.
65. Stephens DP, Charkoudian N, Benevento JM, Johnson JM, Saumet JL. The influence of topical capsaicin on the local thermal control of skin blood flow in humans. Am J Physiol Regul Integr Comp Physiol 281: R894-R901, 2001.
66. Stephens DP, Saad AR, Bennett LA, Kosiba WA, Johnson JM. Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol 287: H1404-H1409, 2004.
67. Stern L. Thermoregulation in the newborn infant: historical, physiological and clinical considerations. In: Historical Review and Recent Advances in Neonatal and Perinatal Medicine. Evansville, IN: Mead Johnson Nutritional Division, 1980.
68. Sund-Levander M, Forsberg C, Wahren LK. Normal oral, rectal, tympanic and axillary body temperature in adult men and women: a systematic literature review. Scand J Caring Sci 16: 122-128, 2002.
69. Tansey EA, Roe SM, Johnson CJ. The sympathetic release test: a test used to assess thermoregulation and autonomic control of blood flow. Adv Physiol Educ 38: 87-92, 2014.
70. Tatterson AJ, Hahn AG, Martini DT, Febbraio MA. Effects of heat stress on physiological responses and exercise performance in elite cyclists. J Sci Med Sport 3: 186-193, 2000.
71. Taylor NAS, Machado-Moreira CA. Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans. Extrem Physiol Med 2: 4, 2013.
72. Taylor NA, Machado-Moreira CA, van den Heuvel AM, Caldwell JN. Hands, and feet: physiological insulators, radiators and evaporators. Eur J Appl Physiol 114: 2037-2060, 2014.
73. Tseng TH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 9: 465-526, 2010.
74. van Beaumont W, Bullard RW. Sweating: its rapid response to muscular work. Science 141: 643-646, 1963.
75. van der Lans AA, Wierts R, Vosselman MJ, Schrauwen P, Brans B, van Marken Lichtenbelt WD. Cold-activated brown adipose tissue in human adults-methodological issues. Am J Physiol Regul Integr Comp Physiol 307: R103-R113, 2014.
76. van der Lans AA, Hoeks J, Brans B, Vijgen GH, Visser MG, Vosselman MJ, Hansen J, Jörgensen JA, Wu J, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 123: 3395-3403, 2013.
77. Vitali Murano IA, Zingaretti MC, Frontini A, Ricquier D, Cinti S. The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J Lipid Res 53: 619-629, 2012.
78. Watanabe H, Vriens J, Suh SH, Benham CD, Droogmans G, Nilius B. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem 277: 47044-47051, 2002.
79. Wechselberger M, Wright CL, Bishop GL, Boulant JA. Ionic currents and conductance-based models for hypothalamic neuronal sensitivity. Am J Physiol Regul Integr Comp Physiol 291: R518-R529, 2006.
80. Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev 27: 234-250, 2013.
81. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 62: 381-404, 2010.
82. Zhang L, Jones S, Brody K, Costa M, Brookes SJ. Thermo-sensitive transient receptor potential channels in vagal afferent neurons of the mouse. Am J Physiol Gastrointest Liver Physiol 286: G983-G991, 2004.
83. Zhao Y, Boulant JA. Temperature effects on neuronal membrane potentials and inward currents in rat hypothalamic tissue slices. J Physiol 564: 245-257, 2005.