-
1
-
-
78649474147
-
Ras history: The saga continues
-
Cox AD, Der CJ. Ras history: the saga continues. Small GTPases 2010;1: 2-27.
-
(2010)
Small GTPases
, vol.1
, pp. 2-27
-
-
Cox, A.D.1
Der, C.J.2
-
2
-
-
84923853645
-
Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
-
Fetics SK, Guterres H, Kearney BM, Buhrman G, Ma B, Nussinov R, et al. Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD. Structure 2015;23:505-16.
-
(2015)
Structure
, vol.23
, pp. 505-516
-
-
Fetics, S.K.1
Guterres, H.2
Kearney, B.M.3
Buhrman, G.4
Ma, B.5
Nussinov, R.6
-
3
-
-
84922287331
-
K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membranetargeting motif
-
Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, et al. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membranetargeting motif. Proc Natl Acad Sci U S A 2015;112:779-84.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 779-784
-
-
Tsai, F.D.1
Lopes, M.S.2
Zhou, M.3
Court, H.4
Ponce, O.5
Fiordalisi, J.J.6
-
4
-
-
22544440260
-
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling
-
Roy S, Plowman S, Rotblat B, Prior IA, Muncke C, Grainger S, et al. Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol 2005;25:6722-33.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6722-6733
-
-
Roy, S.1
Plowman, S.2
Rotblat, B.3
Prior, I.A.4
Muncke, C.5
Grainger, S.6
-
5
-
-
84908491115
-
Drugging the undruggable RAS: Mission possible?
-
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov 2014;13:828-51.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 828-851
-
-
Cox, A.D.1
Fesik, S.W.2
Kimmelman, A.C.3
Luo, J.4
Der, C.J.5
-
6
-
-
84927620483
-
Targeting RAS membrane association: Back to the future for anti-RAS drug discovery?
-
Cox AD, Der CJ, Philips MR. Targeting RAS membrane association: back to the future for anti-RAS drug discovery? Clin Cancer Res 2015;21: 1819-27.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1819-1827
-
-
Cox, A.D.1
Der, C.J.2
Philips, M.R.3
-
7
-
-
40949127740
-
Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain
-
Laude AJ, Prior IA. Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain. J Cell Sci 2008;121:421-7.
-
(2008)
J Cell Sci
, vol.121
, pp. 421-427
-
-
Laude, A.J.1
Prior, I.A.2
-
8
-
-
84927144988
-
Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region
-
Jang H, Abraham SJ, Chavan TS, Hitchinson B, Khavrutskii L, Tarasova NI, et al. Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region. J Biol Chem 2015;290:9465-77.
-
(2015)
J Biol Chem
, vol.290
, pp. 9465-9477
-
-
Jang, H.1
Abraham, S.J.2
Chavan, T.S.3
Hitchinson, B.4
Khavrutskii, L.5
Tarasova, N.I.6
-
9
-
-
75749150934
-
Ras membrane orientation and nanodomain localization generate isoformdiversity
-
Abankwa D, Gorfe AA, Inder K, Hancock JF. Ras membrane orientation and nanodomain localization generate isoformdiversity. Proc Natl Acad SciUS A 2010;107:1130-5.
-
(2010)
Proc Natl Acad SciUS A
, vol.107
, pp. 1130-1135
-
-
Abankwa, D.1
Gorfe, A.A.2
Inder, K.3
Hancock, J.F.4
-
10
-
-
0036787584
-
Intramembrane electrostatic interactions destabilize lipid vesicles
-
Shoemaker SD, Vanderlick TK. Intramembrane electrostatic interactions destabilize lipid vesicles. Biophys J 2002;83:2007-14.
-
(2002)
Biophys J
, vol.83
, pp. 2007-2014
-
-
Shoemaker, S.D.1
Vanderlick, T.K.2
-
11
-
-
84936847680
-
GTP-dependent K-Ras dimerization
-
Muratcioglu S, Chavan TS, Freed BC, Jang H, Khavrutskii L, Freed RN, et al. GTP-dependent K-Ras dimerization. Structure 2015;23:1325-35.
-
(2015)
Structure
, vol.23
, pp. 1325-1335
-
-
Muratcioglu, S.1
Chavan, T.S.2
Freed, B.C.3
Jang, H.4
Khavrutskii, L.5
Freed, R.N.6
-
12
-
-
33750266831
-
Trafficking and signaling by fatty-acylated and prenylated proteins
-
Resh MD. Trafficking and signaling by fatty-acylated and prenylated proteins. Nat Chem Biol 2006;2:584-90.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 584-590
-
-
Resh, M.D.1
-
13
-
-
24744449132
-
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
-
Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ, et al. RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years. Blood 2005;106:2113-9.
-
(2005)
Blood
, vol.106
, pp. 2113-2119
-
-
Bowen, D.T.1
Frew, M.E.2
Hills, R.3
Gale, R.E.4
Wheatley, K.5
Groves, M.J.6
-
14
-
-
34547621066
-
Oncogenic NRAS KRAS, and HRAS exhibit different leukemogenic potentials in mice
-
Parikh C, Subrahmanyam R, Ren R. Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res 2007;67: 7139-46.
-
(2007)
Cancer Res
, vol.67
, pp. 7139-7146
-
-
Parikh, C.1
Subrahmanyam, R.2
Ren, R.3
-
15
-
-
52949118488
-
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
-
To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet 2008;40:1240-4.
-
(2008)
Nat Genet
, vol.40
, pp. 1240-1244
-
-
To, M.D.1
Wong, C.E.2
Karnezis, A.N.3
Del Rosario, R.4
Di Lauro, R.5
Balmain, A.6
-
16
-
-
0034790751
-
Calmodulin binds to K-Ras, but not to H- or N-Ras, andmodulates its downstream signaling
-
Villalonga P, Lopez-Alcala C, Bosch M, Chiloeches A, Rocamora N, Gil J, et al. Calmodulin binds to K-Ras, but not to H- or N-Ras, andmodulates its downstream signaling. Mol Cell Biol 2001;21:7345-54.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7345-7354
-
-
Villalonga, P.1
Lopez-Alcala, C.2
Bosch, M.3
Chiloeches, A.4
Rocamora, N.5
Gil, J.6
-
17
-
-
44849117286
-
Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization
-
Lopez-Alcala C, Alvarez-Moya B, Villalonga P, Calvo M, Bachs O, Agell N. Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization. J Biol Chem 2008;283:10621-31.
-
(2008)
J Biol Chem
, vol.283
, pp. 10621-10631
-
-
Lopez-Alcala, C.1
Alvarez-Moya, B.2
Villalonga, P.3
Calvo, M.4
Bachs, O.5
Agell, N.6
-
18
-
-
0032555491
-
Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1)
-
Bosch M, Gil J, Bachs O, Agell N. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1). J Biol Chem 1998;273:22145-50.
-
(1998)
J Biol Chem
, vol.273
, pp. 22145-22150
-
-
Bosch, M.1
Gil, J.2
Bachs, O.3
Agell, N.4
-
19
-
-
84941808747
-
The key role of calmodulin in KRAS-driven adenocarcinomas
-
Nussinov R, Muratcioglu S, Tsai CJ, Jang H, Gursoy A, Keskin O. The key role of calmodulin in KRAS-driven adenocarcinomas. Mol Cancer Res 2015;13:1265-73.
-
(2015)
Mol Cancer Res
, vol.13
, pp. 1265-1273
-
-
Nussinov, R.1
Muratcioglu, S.2
Tsai, C.J.3
Jang, H.4
Gursoy, A.5
Keskin, O.6
-
20
-
-
0030722224
-
Calmodulin activates phosphatidylinositol 3-kinase
-
Joyal JL, Burks DJ, Pons S, Matter WF, Vlahos CJ, White MF, et al. Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem 1997;272: 28183-6.
-
(1997)
J Biol Chem
, vol.272
, pp. 28183-28186
-
-
Joyal, J.L.1
Burks, D.J.2
Pons, S.3
Matter, W.F.4
Vlahos, C.J.5
White, M.F.6
-
21
-
-
33749570066
-
Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms
-
Liao J, Planchon SM, Wolfman JC, Wolfman A. Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms. J Biol Chem 2006;281:29730-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 29730-29738
-
-
Liao, J.1
Planchon, S.M.2
Wolfman, J.C.3
Wolfman, A.4
-
22
-
-
68849095670
-
The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin
-
Abraham SJ, Nolet RP, Calvert RJ, Anderson LM, Gaponenko V. The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin. Biochemistry 2009;48:7575-83.
-
(2009)
Biochemistry
, vol.48
, pp. 7575-7583
-
-
Abraham, S.J.1
Nolet, R.P.2
Calvert, R.J.3
Anderson, L.M.4
Gaponenko, V.5
-
23
-
-
84899422030
-
Genetic analysis of Ras genes in epidermal development and tumorigenesis
-
Drosten M, Lechuga CG, Barbacid M. Genetic analysis of Ras genes in epidermal development and tumorigenesis. Small GTPases 2013;4: 236-41.
-
(2013)
Small GTPases
, vol.4
, pp. 236-241
-
-
Drosten, M.1
Lechuga, C.G.2
Barbacid, M.3
-
24
-
-
84886948259
-
'Pathway drug cocktail': Targeting Ras signaling based on structural pathways
-
Nussinov R, Tsai CJ, Mattos C. 'Pathway drug cocktail': targeting Ras signaling based on structural pathways. Trends Mol Med 2013;19: 695-704.
-
(2013)
Trends Mol Med
, vol.19
, pp. 695-704
-
-
Nussinov, R.1
Tsai, C.J.2
Mattos, C.3
-
25
-
-
0038143229
-
Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras
-
Baker TL, Zheng H, Walker J, Coloff JL, Buss JE. Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras. J Biol Chem 2003;278:19292-300.
-
(2003)
J Biol Chem
, vol.278
, pp. 19292-19300
-
-
Baker, T.L.1
Zheng, H.2
Walker, J.3
Coloff, J.L.4
Buss, J.E.5
-
26
-
-
0023445442
-
Dynamic fatty acylation of p21N-ras
-
Magee AI, Gutierrez L, McKay IA, Marshall CJ, Hall A. Dynamic fatty acylation of p21N-ras. EMBO J 1987;6:3353-7.
-
(1987)
EMBO J
, vol.6
, pp. 3353-3357
-
-
Magee, A.I.1
Gutierrez, L.2
McKay, I.A.3
Marshall, C.J.4
Hall, A.5
-
27
-
-
78651468721
-
FKBP12 binds to acylated H-ras and promotes depalmitoylation
-
Ahearn IM, Tsai FD, Court H, Zhou M, Jennings BC, Ahmed M, et al. FKBP12 binds to acylated H-ras and promotes depalmitoylation.Mol Cell 2011;41:173-85.
-
(2011)
Mol Cell
, vol.41
, pp. 173-185
-
-
Ahearn, I.M.1
Tsai, F.D.2
Court, H.3
Zhou, M.4
Jennings, B.C.5
Ahmed, M.6
-
28
-
-
42649125571
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
-
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 2008;40:600-8.
-
(2008)
Nat Genet
, vol.40
, pp. 600-608
-
-
Haigis, K.M.1
Kendall, K.R.2
Wang, Y.3
Cheung, A.4
Haigis, M.C.5
Glickman, J.N.6
-
29
-
-
79960038169
-
Functional specificity of ras isoforms: So similar but so different
-
Castellano E, Santos E. Functional specificity of ras isoforms: so similar but so different. Genes Cancer 2011;2:216-31.
-
(2011)
Genes Cancer
, vol.2
, pp. 216-231
-
-
Castellano, E.1
Santos, E.2
-
30
-
-
45749098853
-
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
-
Schuhmacher AJ, Guerra C, Sauzeau V, Canamero M, Bustelo XR, Barbacid M. A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest 2008;118:2169-79.
-
(2008)
J Clin Invest
, vol.118
, pp. 2169-2179
-
-
Schuhmacher, A.J.1
Guerra, C.2
Sauzeau, V.3
Canamero, M.4
Bustelo, X.R.5
Barbacid, M.6
-
31
-
-
84875246715
-
Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding
-
Nishimura A, Linder ME. Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding. Mol Cell Biol 2013;33:1417-29.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 1417-1429
-
-
Nishimura, A.1
Linder, M.E.2
-
32
-
-
84941578528
-
Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases
-
Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, et al. Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases. J Biol Chem 2015;290:22851-61.
-
(2015)
J Biol Chem
, vol.290
, pp. 22851-22861
-
-
Gentry, L.R.1
Nishimura, A.2
Cox, A.D.3
Martin, T.D.4
Tsygankov, D.5
Nishida, M.6
-
33
-
-
84907546523
-
The structural basis for cancer treatment decisions
-
Nussinov R, Jang H, Tsai CJ. The structural basis for cancer treatment decisions. Oncotarget 2014;5:7285-302.
-
(2014)
Oncotarget
, vol.5
, pp. 7285-7302
-
-
Nussinov, R.1
Jang, H.2
Tsai, C.J.3
|