메뉴 건너뛰기




Volumn 76, Issue 1, 2016, Pages 18-23

A new view of ras isoforms in cancers

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; H RAS PROTEIN; K RAS4A PROTEIN; K RAS4B PROTEIN; N RAS PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; ISOPROTEIN;

EID: 84957890940     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1536     Document Type: Review
Times cited : (88)

References (33)
  • 1
    • 78649474147 scopus 로고    scopus 로고
    • Ras history: The saga continues
    • Cox AD, Der CJ. Ras history: the saga continues. Small GTPases 2010;1: 2-27.
    • (2010) Small GTPases , vol.1 , pp. 2-27
    • Cox, A.D.1    Der, C.J.2
  • 3
    • 84922287331 scopus 로고    scopus 로고
    • K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membranetargeting motif
    • Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, et al. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membranetargeting motif. Proc Natl Acad Sci U S A 2015;112:779-84.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 779-784
    • Tsai, F.D.1    Lopes, M.S.2    Zhou, M.3    Court, H.4    Ponce, O.5    Fiordalisi, J.J.6
  • 4
    • 22544440260 scopus 로고    scopus 로고
    • Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling
    • Roy S, Plowman S, Rotblat B, Prior IA, Muncke C, Grainger S, et al. Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol 2005;25:6722-33.
    • (2005) Mol Cell Biol , vol.25 , pp. 6722-6733
    • Roy, S.1    Plowman, S.2    Rotblat, B.3    Prior, I.A.4    Muncke, C.5    Grainger, S.6
  • 6
    • 84927620483 scopus 로고    scopus 로고
    • Targeting RAS membrane association: Back to the future for anti-RAS drug discovery?
    • Cox AD, Der CJ, Philips MR. Targeting RAS membrane association: back to the future for anti-RAS drug discovery? Clin Cancer Res 2015;21: 1819-27.
    • (2015) Clin Cancer Res , vol.21 , pp. 1819-1827
    • Cox, A.D.1    Der, C.J.2    Philips, M.R.3
  • 7
    • 40949127740 scopus 로고    scopus 로고
    • Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain
    • Laude AJ, Prior IA. Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain. J Cell Sci 2008;121:421-7.
    • (2008) J Cell Sci , vol.121 , pp. 421-427
    • Laude, A.J.1    Prior, I.A.2
  • 9
    • 75749150934 scopus 로고    scopus 로고
    • Ras membrane orientation and nanodomain localization generate isoformdiversity
    • Abankwa D, Gorfe AA, Inder K, Hancock JF. Ras membrane orientation and nanodomain localization generate isoformdiversity. Proc Natl Acad SciUS A 2010;107:1130-5.
    • (2010) Proc Natl Acad SciUS A , vol.107 , pp. 1130-1135
    • Abankwa, D.1    Gorfe, A.A.2    Inder, K.3    Hancock, J.F.4
  • 10
    • 0036787584 scopus 로고    scopus 로고
    • Intramembrane electrostatic interactions destabilize lipid vesicles
    • Shoemaker SD, Vanderlick TK. Intramembrane electrostatic interactions destabilize lipid vesicles. Biophys J 2002;83:2007-14.
    • (2002) Biophys J , vol.83 , pp. 2007-2014
    • Shoemaker, S.D.1    Vanderlick, T.K.2
  • 12
    • 33750266831 scopus 로고    scopus 로고
    • Trafficking and signaling by fatty-acylated and prenylated proteins
    • Resh MD. Trafficking and signaling by fatty-acylated and prenylated proteins. Nat Chem Biol 2006;2:584-90.
    • (2006) Nat Chem Biol , vol.2 , pp. 584-590
    • Resh, M.D.1
  • 13
    • 24744449132 scopus 로고    scopus 로고
    • RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
    • Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ, et al. RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years. Blood 2005;106:2113-9.
    • (2005) Blood , vol.106 , pp. 2113-2119
    • Bowen, D.T.1    Frew, M.E.2    Hills, R.3    Gale, R.E.4    Wheatley, K.5    Groves, M.J.6
  • 14
    • 34547621066 scopus 로고    scopus 로고
    • Oncogenic NRAS KRAS, and HRAS exhibit different leukemogenic potentials in mice
    • Parikh C, Subrahmanyam R, Ren R. Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res 2007;67: 7139-46.
    • (2007) Cancer Res , vol.67 , pp. 7139-7146
    • Parikh, C.1    Subrahmanyam, R.2    Ren, R.3
  • 16
  • 17
    • 44849117286 scopus 로고    scopus 로고
    • Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization
    • Lopez-Alcala C, Alvarez-Moya B, Villalonga P, Calvo M, Bachs O, Agell N. Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization. J Biol Chem 2008;283:10621-31.
    • (2008) J Biol Chem , vol.283 , pp. 10621-10631
    • Lopez-Alcala, C.1    Alvarez-Moya, B.2    Villalonga, P.3    Calvo, M.4    Bachs, O.5    Agell, N.6
  • 18
    • 0032555491 scopus 로고    scopus 로고
    • Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1)
    • Bosch M, Gil J, Bachs O, Agell N. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1). J Biol Chem 1998;273:22145-50.
    • (1998) J Biol Chem , vol.273 , pp. 22145-22150
    • Bosch, M.1    Gil, J.2    Bachs, O.3    Agell, N.4
  • 21
    • 33749570066 scopus 로고    scopus 로고
    • Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms
    • Liao J, Planchon SM, Wolfman JC, Wolfman A. Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms. J Biol Chem 2006;281:29730-8.
    • (2006) J Biol Chem , vol.281 , pp. 29730-29738
    • Liao, J.1    Planchon, S.M.2    Wolfman, J.C.3    Wolfman, A.4
  • 22
    • 68849095670 scopus 로고    scopus 로고
    • The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin
    • Abraham SJ, Nolet RP, Calvert RJ, Anderson LM, Gaponenko V. The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin. Biochemistry 2009;48:7575-83.
    • (2009) Biochemistry , vol.48 , pp. 7575-7583
    • Abraham, S.J.1    Nolet, R.P.2    Calvert, R.J.3    Anderson, L.M.4    Gaponenko, V.5
  • 23
    • 84899422030 scopus 로고    scopus 로고
    • Genetic analysis of Ras genes in epidermal development and tumorigenesis
    • Drosten M, Lechuga CG, Barbacid M. Genetic analysis of Ras genes in epidermal development and tumorigenesis. Small GTPases 2013;4: 236-41.
    • (2013) Small GTPases , vol.4 , pp. 236-241
    • Drosten, M.1    Lechuga, C.G.2    Barbacid, M.3
  • 24
    • 84886948259 scopus 로고    scopus 로고
    • 'Pathway drug cocktail': Targeting Ras signaling based on structural pathways
    • Nussinov R, Tsai CJ, Mattos C. 'Pathway drug cocktail': targeting Ras signaling based on structural pathways. Trends Mol Med 2013;19: 695-704.
    • (2013) Trends Mol Med , vol.19 , pp. 695-704
    • Nussinov, R.1    Tsai, C.J.2    Mattos, C.3
  • 25
    • 0038143229 scopus 로고    scopus 로고
    • Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras
    • Baker TL, Zheng H, Walker J, Coloff JL, Buss JE. Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras. J Biol Chem 2003;278:19292-300.
    • (2003) J Biol Chem , vol.278 , pp. 19292-19300
    • Baker, T.L.1    Zheng, H.2    Walker, J.3    Coloff, J.L.4    Buss, J.E.5
  • 28
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
    • Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 2008;40:600-8.
    • (2008) Nat Genet , vol.40 , pp. 600-608
    • Haigis, K.M.1    Kendall, K.R.2    Wang, Y.3    Cheung, A.4    Haigis, M.C.5    Glickman, J.N.6
  • 29
    • 79960038169 scopus 로고    scopus 로고
    • Functional specificity of ras isoforms: So similar but so different
    • Castellano E, Santos E. Functional specificity of ras isoforms: so similar but so different. Genes Cancer 2011;2:216-31.
    • (2011) Genes Cancer , vol.2 , pp. 216-231
    • Castellano, E.1    Santos, E.2
  • 31
    • 84875246715 scopus 로고    scopus 로고
    • Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding
    • Nishimura A, Linder ME. Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding. Mol Cell Biol 2013;33:1417-29.
    • (2013) Mol Cell Biol , vol.33 , pp. 1417-1429
    • Nishimura, A.1    Linder, M.E.2
  • 32
    • 84941578528 scopus 로고    scopus 로고
    • Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases
    • Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, et al. Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases. J Biol Chem 2015;290:22851-61.
    • (2015) J Biol Chem , vol.290 , pp. 22851-22861
    • Gentry, L.R.1    Nishimura, A.2    Cox, A.D.3    Martin, T.D.4    Tsygankov, D.5    Nishida, M.6
  • 33
    • 84907546523 scopus 로고    scopus 로고
    • The structural basis for cancer treatment decisions
    • Nussinov R, Jang H, Tsai CJ. The structural basis for cancer treatment decisions. Oncotarget 2014;5:7285-302.
    • (2014) Oncotarget , vol.5 , pp. 7285-7302
    • Nussinov, R.1    Jang, H.2    Tsai, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.