Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

Biochemistry

Volumn 55, Issue 5, 2016, Pages 809-819

  Masaoka, Takashi ^a   Zhao, Haiyan ^b   Hirsch, Danielle R ^c,d   D'Erasmo, Michael P ^c,d   Meck, Christine ^c,d   Varnado, Brittany ^b   Gupta, Ankit ^e   Meyers, Marvin J ^f   Baines, Joel ^g   Beutler, John A ^a   Murelli, Ryan P ^c,d   Tang, Liang ^b   Le Grice, Stuart F J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Saint Louis University   (United States)

^g LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; DISEASES; DNA; ENZYMES; FLUORESCENCE; HYDROLYSIS; MOLECULES; NUCLEIC ACIDS; PROBES; PROTEINS;

CRYSTALLOGRAPHIC ANALYSIS; DIFFERENTIAL SCANNING FLUORIMETRY; ENZYME-SUBSTRATE COMPLEXES; HERPES SIMPLEX VIRUS; HIV-1 REVERSE TRANSCRIPTASE; HYDROLYSIS PRODUCTS; NONTOXIC CONCENTRATIONS; PHOSPHATE BACKBONE;

VIRUSES;

ANTIVIRUS AGENT; DOUBLE STRANDED DNA; NUCLEASE; NUCLEOTIDYLTRANSFERASE INHIBITOR; PHOSPHATE; PUL15 PROTEIN; UNCLASSIFIED DRUG; DNA CLEAVAGE AND PACKAGING PROTEINS, HERPESVIRUS; ENZYME INHIBITOR; NUCLEOTIDYLTRANSFERASE; VIRAL PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTALLOGRAPHY; DISSOCIATION; DRUG DNA BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; FLUOROMETRY; HERPES SIMPLEX VIRUS; HYDROLYSIS; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TURNOVER TIME; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HERPES SIMPLEX VIRUS 1;

ENZYME INHIBITORS; FLUORESCENCE; HERPESVIRUS 1, HUMAN; NUCLEOTIDYLTRANSFERASES; VIRAL PROTEINS;

EID: 84957879752     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b01254     Document Type: Article

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