Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase

Journal of Biological Chemistry

Volumn 278, Issue 29, 2003, Pages 26526-26532

  Lener, Daniela ^a   Kvaratskhelia, Mamuka ^a   Le Grice, Stuart F J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; HYDROGEN BONDS; POLYMERS; RNA; SYNTHESIS (CHEMICAL);

MUTAGENESIS;

DNA;

2,4 DIFLUORO 5 METHYLBENZENE; DNA HYBRID; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; THYMINE DERIVATIVE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHEMICAL BOND; CORRELATION ANALYSIS; DNA TEMPLATE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; RETROPOSON; RETROVIRUS; RNA HYBRIDIZATION; SEQUENCE ANALYSIS;

CATALYTIC DOMAIN; DNA, FUNGAL; DNA, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; RETROELEMENTS; RIBONUCLEASE H, CALF THYMUS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, FUNGAL; RNA, VIRAL; RNA-DIRECTED DNA POLYMERASE; SACCHAROMYCES CEREVISIAE; THYMINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INSERTION SEQUENCES; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0037698250     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302374200     Document Type: Article

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