-
1
-
-
80052245888
-
Health and economic burden of the projected obesity trends in the USA and the UK
-
Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011; 378: 815-825.
-
(2011)
Lancet
, vol.378
, pp. 815-825
-
-
Wang, Y.C.1
McPherson, K.2
Marsh, T.3
Gortmaker, S.L.4
Brown, M.5
-
2
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137: 216-233.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
4
-
-
84896082963
-
From fly wings to targeted cancer therapies: A centennial for notch signaling
-
Ntziachristos P, Lim JS, Sage J, Aifantis I. From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell 2014; 25: 318-334.
-
(2014)
Cancer Cell
, vol.25
, pp. 318-334
-
-
Ntziachristos, P.1
Lim, J.S.2
Sage, J.3
Aifantis, I.4
-
5
-
-
79961173038
-
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
-
Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J et al. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med 2011; 17: 961-967.
-
(2011)
Nat Med
, vol.17
, pp. 961-967
-
-
Pajvani, U.B.1
Shawber, C.J.2
Samuel, V.T.3
Birkenfeld, A.L.4
Shulman, G.I.5
Kitajewski, J.6
-
6
-
-
84882245596
-
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
-
Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med 2013; 19: 1054-1060.
-
(2013)
Nat Med
, vol.19
, pp. 1054-1060
-
-
Pajvani, U.B.1
Qiang, L.2
Kangsamaksin, T.3
Kitajewski, J.4
Ginsberg, H.N.5
Accili, D.6
-
7
-
-
84891762279
-
Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease
-
Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ et al. Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease. Diabetes 2013; 62: 4052-4062.
-
(2013)
Diabetes
, vol.62
, pp. 4052-4062
-
-
Valenti, L.1
Mendoza, R.M.2
Rametta, R.3
Maggioni, M.4
Kitajewski, C.5
Shawber, C.J.6
-
8
-
-
50849103301
-
Notch signaling regulates tumor angiogenesis by diverse mechanisms
-
Dufraine J, Funahashi Y, Kitajewski J. Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene 2008; 27: 5132-5137.
-
(2008)
Oncogene
, vol.27
, pp. 5132-5137
-
-
Dufraine, J.1
Funahashi, Y.2
Kitajewski, J.3
-
9
-
-
1642382833
-
Notch signaling: Control of cell communication and cell fate
-
Lai EC. Notch signaling: control of cell communication and cell fate. Development 2004; 131: 965-973.
-
(2004)
Development
, vol.131
, pp. 965-973
-
-
Lai, E.C.1
-
10
-
-
12344297828
-
Dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats
-
Baladron V, Ruiz-Hidalgo MJ, Nueda ML, Diaz-Guerra MJ, Garcia-Ramirez JJ, Bonvini E et al. dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. Exp Cell Res 2005; 303: 343-359.
-
(2005)
Exp Cell Res
, vol.303
, pp. 343-359
-
-
Baladron, V.1
Ruiz-Hidalgo, M.J.2
Nueda, M.L.3
Diaz-Guerra, M.J.4
Garcia-Ramirez, J.J.5
Bonvini, E.6
-
11
-
-
33947164677
-
The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells
-
Nueda ML, Baladron V, Sanchez-Solana B, Ballesteros MA, Laborda J. The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells. J Mol Biol 2007; 367: 1281-1293.
-
(2007)
J Mol Biol
, vol.367
, pp. 1281-1293
-
-
Nueda, M.L.1
Baladron, V.2
Sanchez-Solana, B.3
Ballesteros, M.A.4
Laborda, J.5
-
12
-
-
40949124822
-
The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
-
Bray SJ, Takada S, Harrison E, Shen SC, Ferguson-Smith AC. The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol 2008; 8: 11.
-
(2008)
BMC Dev Biol
, vol.8
, pp. 11
-
-
Bray, S.J.1
Takada, S.2
Harrison, E.3
Shen, S.C.4
Ferguson-Smith, A.C.5
-
13
-
-
33745866965
-
Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation
-
Wang Y, Sul HS. Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation. Mol Cell Biol 2006; 26: 5421-5435.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5421-5435
-
-
Wang, Y.1
Sul, H.S.2
-
14
-
-
50849109798
-
Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
-
Backliwal G, Hildinger M, Chenuet S, Wulhfard S, De Jesus M, Wurm FM. Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions. Nucleic Acids Res 2008; 36: e96.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. e96
-
-
Backliwal, G.1
Hildinger, M.2
Chenuet, S.3
Wulhfard, S.4
De Jesus, M.5
Wurm, F.M.6
-
15
-
-
0018746734
-
Hepatocyte suspensions and cultures as tools in experimental carcinogenesis
-
Seglen PO. Hepatocyte suspensions and cultures as tools in experimental carcinogenesis. J Toxicol Environ Health 1979; 5: 551-560.
-
(1979)
J Toxicol Environ Health
, vol.5
, pp. 551-560
-
-
Seglen, P.O.1
-
16
-
-
84884850444
-
Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator-activated receptor gamma
-
Lee YH, Kim SH, Lee YJ, Kang ES, Lee BW, Cha BS et al. Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator-activated receptor gamma. Cell Mol Life Sci 2013; 70: 3959-3971.
-
(2013)
Cell Mol Life Sci
, vol.70
, pp. 3959-3971
-
-
Lee, Y.H.1
Kim, S.H.2
Lee, Y.J.3
Kang, E.S.4
Lee, B.W.5
Cha, B.S.6
-
17
-
-
4344674434
-
Dissecting the role of glucocorticoids on pancreas development
-
Gesina E, Tronche F, Herrera P, Duchene B, Tales W, Czernichow P et al. Dissecting the role of glucocorticoids on pancreas development. Diabetes 2004; 53: 2322-2329.
-
(2004)
Diabetes
, vol.53
, pp. 2322-2329
-
-
Gesina, E.1
Tronche, F.2
Herrera, P.3
Duchene, B.4
Tales, W.5
Czernichow, P.6
-
18
-
-
84905757105
-
Metformin-mode of action and clinical implications for diabetes and cancer
-
Pernicova I, Korbonits M. Metformin-mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014; 10: 143-156.
-
(2014)
Nat Rev Endocrinol
, vol.10
, pp. 143-156
-
-
Pernicova, I.1
Korbonits, M.2
-
19
-
-
79956114434
-
Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMPactivated protein kinase
-
Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z et al. Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMPactivated protein kinase. J Hepatol 2011; 54: 1214-1223.
-
(2011)
J Hepatol
, vol.54
, pp. 1214-1223
-
-
Ben-Shlomo, S.1
Zvibel, I.2
Shnell, M.3
Shlomai, A.4
Chepurko, E.5
Halpern, Z.6
-
20
-
-
65349177200
-
AMPK: An emerging drug target for diabetes and the metabolic syndrome
-
Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 2009; 9: 407-416.
-
(2009)
Cell Metab
, vol.9
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
21
-
-
0038187621
-
Insulinregulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F et al. Insulinregulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003; 423: 550-555.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
Walkey, C.J.4
Yoon, J.C.5
Oriente, F.6
-
22
-
-
0027245963
-
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
-
Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993; 73: 725-734.
-
(1993)
Cell
, vol.73
, pp. 725-734
-
-
Smas, C.M.1
Sul, H.S.2
-
23
-
-
33845322632
-
Pref-1, a preadipocyte secreted factor that inhibits adipogenesis
-
Wang Y, Kim KA, Kim JH, Sul HS. Pref-1, a preadipocyte secreted factor that inhibits adipogenesis. J Nutr 2006; 136: 2953-2956.
-
(2006)
J Nutr
, vol.136
, pp. 2953-2956
-
-
Wang, Y.1
Kim, K.A.2
Kim, J.H.3
Sul, H.S.4
-
24
-
-
70350464323
-
Minireview: Pref-1: Role in adipogenesis and mesenchymal cell fate
-
Sul HS. Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate. Mol Endocrinol 2009; 23: 1717-1725.
-
(2009)
Mol Endocrinol
, vol.23
, pp. 1717-1725
-
-
Sul, H.S.1
-
25
-
-
0036318227
-
Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity
-
Moon YS, Smas CM, Lee K, Villena JA, Kim KH, Yun EJ et al. Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol 2002; 22: 5585-5592.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5585-5592
-
-
Moon, Y.S.1
Smas, C.M.2
Lee, K.3
Villena, J.A.4
Kim, K.H.5
Yun, E.J.6
-
26
-
-
58149330245
-
Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): A new model of partial lipodystrophy
-
Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB et al. Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy. Diabetes 2008; 57: 3258-3266.
-
(2008)
Diabetes
, vol.57
, pp. 3258-3266
-
-
Villena, J.A.1
Choi, C.S.2
Wang, Y.3
Kim, S.4
Hwang, Y.J.5
Kim, Y.B.6
-
27
-
-
0037327403
-
Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1)
-
Lee K, Villena JA, Moon YS, Kim KH, Lee S, Kang C et al. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest 2003; 111: 453-461.
-
(2003)
J Clin Invest
, vol.111
, pp. 453-461
-
-
Lee, K.1
Villena, J.A.2
Moon, Y.S.3
Kim, K.H.4
Lee, S.5
Kang, C.6
-
28
-
-
79960631454
-
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis
-
Ferron SR, Charalambous M, Radford E, McEwen K, Wildner H, Hind E et al. Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature 2011; 475: 381-385.
-
(2011)
Nature
, vol.475
, pp. 381-385
-
-
Ferron, S.R.1
Charalambous, M.2
Radford, E.3
McEwen, K.4
Wildner, H.5
Hind, E.6
-
29
-
-
61449215237
-
Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: Implications for the evolution of imprinting
-
da Rocha ST, Charalambous M, Lin S, Gutteridge I, Ito Y, Gray D et al. Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting. PLOS Genet 2009; 5: e1000392.
-
(2009)
PLOS Genet
, vol.5
, pp. e1000392
-
-
Da Rocha, S.T.1
Charalambous, M.2
Lin, S.3
Gutteridge, I.4
Ito, Y.5
Gray, D.6
-
30
-
-
84868029397
-
Membrane-tethered delta-like 1 homolog (DLK1) restricts adipose tissue size by inhibiting preadipocyte proliferation
-
Mortensen SB, Jensen CH, Schneider M, Thomassen M, Kruse TA, Laborda J et al. Membrane-tethered delta-like 1 homolog (DLK1) restricts adipose tissue size by inhibiting preadipocyte proliferation. Diabetes 2012; 61: 2814-2822.
-
(2012)
Diabetes
, vol.61
, pp. 2814-2822
-
-
Mortensen, S.B.1
Jensen, C.H.2
Schneider, M.3
Thomassen, M.4
Kruse, T.A.5
Laborda, J.6
-
31
-
-
84909619346
-
DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
-
Charalambous M, Da Rocha ST, Radford EJ, Medina-Gomez G, Curran S, Pinnock SB et al. DLK1/PREF1 regulates nutrient metabolism and protects from steatosis. Proc Natl Acad Sci USA 2014; 111: 16088-16093.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 16088-16093
-
-
Charalambous, M.1
Da Rocha, S.T.2
Radford, E.J.3
Medina-Gomez, G.4
Curran, S.5
Pinnock, S.B.6
-
32
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13: 251-262.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
34
-
-
1142275114
-
The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia
-
Huang CC, Chuang JH, Huang LL, Chou MH, Wu CL, Chen CM et al. The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia. J Pathol 2004; 202: 172-179.
-
(2004)
J Pathol
, vol.202
, pp. 172-179
-
-
Huang, C.C.1
Chuang, J.H.2
Huang, L.L.3
Chou, M.H.4
Wu, C.L.5
Chen, C.M.6
-
35
-
-
84858988409
-
Hepatic stellate cellderived delta-like homolog 1 (DLK1) protein in liver regeneration
-
Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y et al. Hepatic stellate cellderived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem 2012; 287: 10355-10367.
-
(2012)
J Biol Chem
, vol.287
, pp. 10355-10367
-
-
Zhu, N.L.1
Asahina, K.2
Wang, J.3
Ueno, A.4
Lazaro, R.5
Miyaoka, Y.6
-
36
-
-
84908110335
-
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation
-
Labialle S, Marty V, Bortolin-Cavaille ML, Hoareau-Osman M, Pradere JP, Valet P et al. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J 2014; 33: 2216-2230.
-
(2014)
EMBO J
, vol.33
, pp. 2216-2230
-
-
Labialle, S.1
Marty, V.2
Bortolin-Cavaille, M.L.3
Hoareau-Osman, M.4
Pradere, J.P.5
Valet, P.6
-
37
-
-
84925485114
-
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
-
Li P, daY Oh, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O et al. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med 2015; 21: 239-247.
-
(2015)
Nat Med
, vol.21
, pp. 239-247
-
-
Li, P.1
Oh, D.Y.2
Bandyopadhyay, G.3
Lagakos, W.S.4
Talukdar, S.5
Osborn, O.6
-
38
-
-
84937555322
-
Tumor necrosis factoralpha as a predictor for the development of nonalcoholic fatty liver disease: A 4-year follow-up study
-
Seo YY, Cho YK, Bae JC, Seo MH, Park SE, Rhee EJ et al. Tumor necrosis factoralpha as a predictor for the development of nonalcoholic fatty liver disease: a 4-year follow-up study. Endocrinol Metab (Seoul) 2013; 28: 41-45.
-
(2013)
Endocrinol Metab (Seoul)
, vol.28
, pp. 41-45
-
-
Seo, Y.Y.1
Cho, Y.K.2
Bae, J.C.3
Seo, M.H.4
Park, S.E.5
Rhee, E.J.6
-
39
-
-
33845490856
-
Review: The role of insulin resistance in nonalcoholic fatty liver disease
-
Utzschneider KM, Kahn SE. Review: the role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2006; 91: 4753-4761.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 4753-4761
-
-
Utzschneider, K.M.1
Kahn, S.E.2
|