Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator- activated receptor γ

Cellular and Molecular Life Sciences

Volumn 70, Issue 20, 2013, Pages 3959-3971

  Lee, Yong Ho ^a   Kim, Soo Hyun ^a   Lee, Yoo Jeong ^a   Kang, Eun Seok ^a   Lee, Byung Wan ^a   Cha, Bong Soo ^a   Kim, Jae Woo ^a   Song, Dae Hyun ^b   Lee, Hyun Chul ^a  

^a Yonsei University College of Medicine   (South Korea)

^b The Armed Forces Capital Hospital   (South Korea)

Author keywords

Adipogenesis; PPAR ; Snail; WNT signaling

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR SNAIL; WNT10B PROTEIN;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA GENE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BETA CATENIN; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; MALE; MICE; MICE, NUDE; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDE MOTIFS; PPAR GAMMA; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTORS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84884850444     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1363-8     Document Type: Article

References (28)

1. Nguyen DM, El-Serag HB (2010) The epidemiology of obesity. Gastroenterol Clin North Am 39:1-7
2. Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH, Rimm E, Colditz GA (2001) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 161:1581-1586
3. Farmer SR (2006) Transcriptional control of adipocyte formation. Cell Metab 4:263-273
4. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA (2000) Inhibition of adipogenesis by Wnt signaling. Science 289:950-953
5. Nieto MA (2002) The Snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3:155-166
6. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A (2000) The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2:84-89
7. de Frutos CA, Dacquin R, Vega S, Jurdic P, Machuca Gayet I, Nieto MA (2009) Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J 28:686-696
8. Perez-Mancera PA, Bermejo-Rodriguez C, Gonzalez-Herrero I, Herranz M, Flores T, Jimenez R, Sanchez-Garcia I (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet 16:2972-2986
9. Park YM, Lee YH, Kim SH, Lee EY, Kim KS, Williams DR, Lee HC (2012) Snail, a transcriptional regulator, represses adiponectin expression by directly binding to an E-box motif in the promoter. Metabolism 61:1622-1632
10. Yook JI, Li XY, Ota I, Fearon ER, Weiss SJ (2005) Wnt-dependent regulation of the E-cadherin repressor Snail. J Biol Chem 280:11740-11748
11. Lee Y, Kim JM, Lee EJ (2008) Functional expression of CXCR4 in somatotrophs: CXCL12 activates GH gene, GH production and secretion, and cellular proliferation. J Endocrinol 199:191-199
12. Lee H, Lee YJ, Choi H, Ko EH, Kim J (2009) Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem 284:10601-10609
13. Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Saladin R, Najib J, Laville M, Fruchart JC, Deeb S, Vidal-Puig A, Flier J, Briggs MR, Staels B, Vidal H, Auwerx J (1997) The organization, promoter analysis, and expression of the human PPARγ gene. J Biol Chem 272:18779-18789
14. Mandrup S, Loftus TM, MacDougald OA, Kuhajda FP, Lane MD (1997) Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes. Proc Natl Acad Sci USA 94:4300-4305
15. Lefterova MI, Lazar MA (2009) New developments in adipogenesis. Trends Endocrinol Metab 20:107-114
16. Lehrke M, Lazar MA (2005) The many faces of PPARγ. Cell 123:993-999
17. Franc C, Takkunen M, Dave N, Alameda F, Gmez S, Rodrguez R, Escriv M, Montserrat-Sents B, Bar T, Garrido M, Bonilla F, Virtanen I, García de Herreros A (2006) Expression of Snail protein in tumor-stroma interface. Oncogene 25:5134-5144
18. Park SJ, Jung SH, Jogeswar G, Ryoo HM, Yook JI, Choi HS, Rhee Y, Kim CH, Lim SK (2010) The transcription factor Snail regulates osteogenic differentiation by repressing Runx2 expression. Bone 46:1498-1507
19. Saladin R, Fajas L, Dana S, Halvorsen YD, Auwerx J, Briggs M (1999) Differential regulation of peroxisome proliferator activated receptor γ1 (PPARγ1) and PPARγ2 messenger RNA expression in the early stages of adipogenesis. Cell Growth Differ 10:43-48
20. Shi XM, Blair HC, Yang X, McDonald JM, Cao X (2000) Tandem repeat of C/EBP binding sites mediates PPARγ2 gene transcription in glucocorticoid-induced adipocyte differentiation. J Cell Biochem 76:518-527
21. Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS (2000) Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290:134-138
22. Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, Fruchart JC, Briggs M, Spiegelman BM, Auwerx J (1999) Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol 19:5495-5503
23. Muller YL, Bogardus C, Beamer BA, Shuldiner AR, Baier LJ (2003) A functional variant in the peroxisome proliferator-activated receptor γ2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. Diabetes 52:1864-1871
24. Peinado H, Ballestar E, Esteller M, Cano A (2004) Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol 24:306-319
25. Pérez-Mancera PA, Pérez-Caro M, González-Herrero I, Flores T, Orfao A, de Herreros AG, Gutiérrez-Adán A, Pintado B, Sagrera A, Sánchez-Martín M, Sánchez-García I (2005) Cancer development induced by graded expression of Snail in mice. Hum Mol Genet 14:3449-3461
26. Carver EA, Jiang R, Lan Y, Oram KF, Gridley T (2001) The mouse Snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol 21:8184-8188
27. Bourlier V, Sengenes C, Zakaroff-Girard A, Decaunes P, Wdziekonski B, Galitzky J, Villageois P, Esteve D, Chiotasso P, Dani C, Bouloumie A (2012) TGFβ family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages. PLoS One 7:e31274
28. Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE (2009) Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29:1575-1591