Gene dosage effects of the imprinted delta-like homologue 1 (Dlk1/Pref1) in development: Implications for the evolution of imprinting

PLoS Genetics

Volumn 5, Issue 2, 2009, Pages

  Da Rocha, Simao Teixeira ^a   Charalambous, Marika ^a   Lin, Shau Ping ^b   Gutteridge, Isabel ^a   Ito, Yoko ^a   Gray, Dionne ^a   Dean, Wendy ^c   Ferguson Smith, Anne C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MATURATION; CONTROLLED STUDY; DELTA LIKE HOMOLOGUE 1 GENE; EMBRYO; EMBRYO GROWTH; FAILURE TO THRIVE; FEMALE; GENE; GENE DOSAGE; GENE LOCUS; GENE OVEREXPRESSION; GENOME IMPRINTING; MALE; MOUSE; NONHUMAN; ANIMAL; BONE; C57BL MOUSE; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR EVOLUTION; PRENATAL DEVELOPMENT; SKELETAL MUSCLE; TRANSGENIC MOUSE;

MUS MUSCULUS;

DLK1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMALS; BONE AND BONES; EMBRYONIC DEVELOPMENT; EVOLUTION, MOLECULAR; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOMIC IMPRINTING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SKELETAL;

EID: 61449215237     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000392     Document Type: Article

References (42)

1. da Rocha ST, Ferguson-Smith AC (2004) Genomic imprinting. Curr Biol 14: R646-649.
2. Schmidt JV, Matteson PG, Jones BK, Guan XJ, Tilghman SM (2000) The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev 14: 1997-2002.
3. Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, et al. (2000) Delta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr Biol 10: 1135-1138.
4. Smas CM, Sul HS (1993) Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73: 725-734.
5. Baladron V, Ruiz-Hidalgo MJ, Nueda ML, Diaz-Guerra MJ, Garcia-Ramirez JJ, et al. (2005) Dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. Exp Cell Res 303: 343-359.
6. Nueda ML, Baladron V, Sanchez-Solana B, Ballesteros MA, et al. (2007) The EGF-like protein Dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells. J Mol Biol 367: 1281-1293.
7. Bray SJ, Takada S, Harrison E, Shen SC, Ferguson-Smith AC (2008) The atypical mammalian ligand Delta-like1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol 8: 11.
8. Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, et al. (2004) Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1. J Bone Miner Res 19: 841-852.
9. Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A (2003) Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 116: 1775-1786.
10. da Rocha ST, Tevendale M, Knowles E, Takada S, Watkins M, et al. (2007) Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control. Dev Biol 306: 810-823.
11. Yevtodiyenko A, Schmidt JV (2006) Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta. Dev Dyn 235: 1115-1123.
12. Edwards C, Mungall A, Matthews L, Ryder E, Gray D, et al. (2008) The evolution of an imprinted domain in mammals. PLoS Biology 6: e135.
13. da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC (2008) Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends in Genetics 24: 306-316.
14. Lin SP, Youngson N, Takada S, Seitz H, Reik W, et al. (2003) Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet 35: 97-102.
15. Takada S, Paulsen M, Tevendale M, Tsai CE, Kelsey G, et al. (2002) Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19. Hum Mol Genet 11: 77-86.
16. Georgiades P, Watkins M, Surani MA, Ferguson-Smith AC (2000) Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12. Development 127: 4719-4728.
17. Georgiades P, Watkins M, Burton GJ, Ferguson-Smith AC (2001) Roles for genomic imprinting and the zygotic genome in placental development. Proc Natl Acad Sci U S A 98: 4522-4527.
18. Tevendale M, Watkins M, Rasberry C, Cattanach B, Ferguson-Smith AC (2006) Analysis of mouse conceptuses with uniparental duplication/deficiency for distal chromosome 12: comparison with chromosome 12 uniparental disomy and implications for genomic imprinting. Cytogenet Genome Res 113: 215-222.
19. Lin SP, Coan P, da Rocha ST, Seitz H, Cavaille J, et al. (2007) Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region. Development 134: 417-426.
20. Constancia M, Kelsey G, Reik W (2004) Resourceful imprinting. Nature 432: 53-57.
21. Moon YS, Smas CM, Lee K, Villena JA, Kim KH, et al. (2002) Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol 22: 5585-5592.
22. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, et al. (2005) Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol 7: 601-611.
23. Plagge A, Gordon E, Dean W, Boiani R, Cinti S, et al. (2004) The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet 36: 818-826.
24. Ainscough JF, Koide T, Tada M, Barton S, Surani MA (1997) Imprinting of Igf2 and H19 from a 130 kb YAC transgene. Development 124: 3621-3632.
25. John RM, Ainscough JF, Barton SC, Surani MA (2001) Distant cis-elements regulate imprinted expression of the mouse p57(Kip2) (Cdkn1c) gene: implications for the human disorder, Beckwith-Wiedemann syndrome. Hum Mol Genet 10: 1601-1609.
26. Yevtodiyenko A, Steshina EY, Farner SC, Levorse JM, Schmidt JV (2004) A 178-kb BAC transgene imprints the mouse Gtl2 gene and localizes tissue-specific regulatory elements. Genomics 84: 277-287.
27. Mei B, Zhao L, Chen L, Sul HS (2002) Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing. Biochem J 364: 137-144.
28. Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, et al. (2002) Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 417: 945-948.
29. Constancia M, Angiolini E, Sandovici I, Smith P, Smith R, et al. (2005) Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A 102: 19219-19124.
30. Charalambous M, da Rocha ST, Ferguson-Smith AC (2007) Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life. Curr Opin Endocrinol Diabetes Obes 14: 3-12.
31. Haig D, Westboy M (1989) Parent-specific gene expression and the triploid endosperm. Am Anat 134: 147-155.
32. Wilkins JF, Haig D (2003) What good is genomic imprinting: the function of parent-specific gene expression. Nat Rev Genet 4: 359-368.
33. Haig D (2004) Genomic imprinting and kinship: how good is the evidence? Annu Rev Genet 38: 553-585.
34. Haig D (2008) Huddling: brown fat, genomic imprinting and the warm inner glow. Curr Biol 18: R172-174.
35. Collins BJ, Kleeberger W, Ball DW (2004) Notch in lung development and lung cancer. Semin Cancer Biol 14: 357-364.
36. Ito T, Udaka N, Yazawa T, Okudela K, Hayashi H, et al. (2000) Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 127: 3913-3921.
37. Dang TP, Eichenberger S, Gonzalez A, Olson S, Carbone DP (2003) Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice. Oncogene 22: 1988-1997.
38. Sekita Y, Wagatsuma H, Nakamura K, Ono R, Kagami M, et al. (2008) Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet 40: 243-248.
39. Hurst LD (1997) Evolutionary theories of genomic imprinting. In: Genomic Imprinting. Wolf Reik, Azim Surani, eds. Oxford University Press. pp 211-237.
40. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4): 402-408.
41. Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, et al. (2005) The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes 54: 1706-1716.
42. Charalambous M, Smith FM, Bennett WR, Crew TE, Mackenzie F, et al. (2003) Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A 100: 8292-8297.