Endovascular Treatment Versus Intravenous Thrombolysis for Acute Ischemic Stroke: a Quantitative Review and Meta-Analysis of 21 Randomized Trials

Molecular Neurobiology

Volumn 54, Issue 2, 2017, Pages 1369-1378

  Tan, Chen Chen ^a   Wang, Hui Fu ^b   Ji, Jin Long ^a   Tan, Meng Shan ^a   Tan, Lan ^a   Yu, Jin Tai ^c  

^a QINGDAO UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute ischemic stroke; Endovascular treatment; Intravenous thrombolysis; Meta analysis; Systematic review

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; RETEPLASE;

ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CLINICAL EFFECTIVENESS; EMBOLECTOMY SYSTEM; ENDOVASCULAR SURGERY; FUNCTIONAL ASSESSMENT; HUMAN; INTERMETHOD COMPARISON; MECHANICAL THROMBECTOMY; META ANALYSIS; MORTALITY; PATIENT SAFETY; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; THROMBECTOMY DEVICE; TREATMENT OUTCOME; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; FIBRINOLYTIC THERAPY; INTRAVENOUS DRUG ADMINISTRATION; PROCEDURES; STANDARDS;

ADMINISTRATION, INTRAVENOUS; BRAIN ISCHEMIA; ENDOVASCULAR PROCEDURES; FIBRINOLYTIC AGENTS; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STROKE; THROMBOLYTIC THERAPY;

EID: 84957550946     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-9738-0     Document Type: Article

References (34)

1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics C, Stroke Statistics S (2015) Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation 131(4):e29–e322. doi:10.1161/CIR.0000000000000152
2. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W, Ecass AN, Group Er-PS, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS, Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G (2010) Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 375(9727):1695–1703. doi:10.1016/S0140-6736(10)60491-6
3. Chimowitz MI (2013) Endovascular treatment for acute ischemic stroke--still unproven. N Engl J Med 368(10):952–955. doi:10.1056/NEJMe1215730
4. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282(21):2003–2011
5. del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Rowley HA, Gent M (1998) PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 29(1):4–11
6. Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD, Investigators ET (2015) Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 372(11):1019–1030. doi:10.1056/NEJMoa1414905
7. Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, San Roman L, Serena J, Abilleira S, Ribo M, Millan M, Urra X, Cardona P, Lopez-Cancio E, Tomasello A, Castano C, Blasco J, Aja L, Dorado L, Quesada H, Rubiera M, Hernandez-Perez M, Goyal M, Demchuk AM, von Kummer R, Gallofre M, Davalos A, Investigators RT (2015) Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med 372(24):2296–2306. doi:10.1056/NEJMoa1503780
8. Broderick JP, Palesch YY, Demchuk AM, Yeatts SD, Khatri P, Hill MD, Jauch EC, Jovin TG, Yan B, Silver FL, von Kummer R, Molina CA, Demaerschalk BM, Budzik R, Clark WM, Zaidat OO, Malisch TW, Goyal M, Schonewille WJ, Mazighi M, Engelter ST, Anderson C, Spilker J, Carrozzella J, Ryckborst KJ, Janis LS, Martin RH, Foster LD, Tomsick TA, Interventional Management of Stroke IIII (2013) Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med 368(10):893–903. doi:10.1056/NEJMoa1214300
9. Ciccone A, Valvassori L, Nichelatti M, Sgoifo A, Ponzio M, Sterzi R, Boccardi E (2013) Endovascular treatment for acute ischemic stroke. N Engl J Med 368(10):904–913. doi:10.1056/NEJMoa1213701
10. Zhang B, Sun X, Li M, Wang F, Xu D, Duan H, Fang C (2010) Intra-arterial vs intra-venous. Thrombolysis for anterior cerebral occlusion. Can J Neurol Sci 37(2):240–244
11. Sugiura S, Iwaisako K, Toyota S, Takimoto H (2008) Simultaneous treatment with intravenous recombinant tissue plasminogen activator and endovascular therapy for acute ischemic stroke within 3 hours of onset. AJNR Am J Neuroradiol 29(6):1061–1066. doi:10.3174/ajnr.A1012
12. Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, van Walderveen MA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama a Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SF, van Dijk LC, Kappelle LJ, Lo RH, van Dijk EJ, de Vries J, de Kort PL, van Rooij WJ, van den Berg JS, van Hasselt BA, Aerden LA, Dallinga RJ, Visser MC, Bot JC, Vroomen PC, Eshghi O, Schreuder TH, Heijboer RJ, Keizer K, Tielbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers ME, Jenniskens SF, Beenen LF, van den Berg R, Koudstaal PJ, van Zwam WH, Roos YB, van der Lugt A, van Oostenbrugge RJ, Majoie CB, Dippel DW, Investigators MC (2015) A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 372(1):11–20. doi:10.1056/NEJMoa1411587
13. Burns TC, Rodriguez GJ, Patel S, Hussein HM, Georgiadis AL, Lakshminarayan K, Qureshi AI (2008) Endovascular interventions following intravenous thrombolysis may improve survival and recovery in patients with acute ischemic stroke: a case–control study. AJNR Am J Neuroradiol 29(10):1918–1924. doi:10.3174/ajnr.A1236
14. Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Priglinger M, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Donnan GA, Davis SM, Investigators E-I (2015) Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 372(11):1009–1018. doi:10.1056/NEJMoa1414792
15. Ciccone A, Valvassori L, Ponzio M, Ballabio E, Gasparotti R, Sessa M, Scomazzoni F, Tiraboschi P, Sterzi R, Investigators S (2010) Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial. J Neurointer Surgery 2(1):74–79. doi:10.1136/jnis.2009.001388
16. Ducrocq X, Bracard S, Taillandier L, Anxionnat R, Lacour JC, Guillemin F, Debouverie M, Bollaert PE (2005) Comparison of intravenous and intra-arterial urokinase thrombolysis for acute ischaemic stroke. J Neuroradiol 32(1):26–32
17. Investigators IIT (2007) The Interventional Management of Stroke (IMS) II Study. Stroke 38(7):2127–2135. doi:10.1161/STROKEAHA.107.483131
18. Keris V, Rudnicka S, Vorona V, Enina G, Tilgale B, Fricbergs J (2001) Combined intraarterial/intravenous thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 22(2):352–358
19. Kidwell CS, Jahan R, Gornbein J, Alger JR, Nenov V, Ajani Z, Feng L, Meyer BC, Olson S, Schwamm LH, Yoo AJ, Marshall RS, Meyers PM, Yavagal DR, Wintermark M, Guzy J, Starkman S, Saver JL, Investigators MR (2013) A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 368(10):914–923. doi:10.1056/NEJMoa1212793
20. Macleod MR, Davis SM, Mitchell PJ, Gerraty RP, Fitt G, Hankey GJ, Stewart-Wynne EG, Rosen D, McNeil JJ, Bladin CF, Chambers BR, Herkes GK, Young D, Donnan GA (2005) Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke. Cerebrovasc Dis 20(1):12–17. doi:10.1159/000086121
21. Mazighi M, Serfaty JM, Labreuche J, Laissy JP, Meseguer E, Lavallee PC, Cabrejo L, Slaoui T, Guidoux C, Lapergue B, Klein IF, Olivot JM, Abboud H, Simon O, Niclot P, Nifle C, Touboul PJ, Raphaeli G, Gohin C, Claeys ES, Amarenco P, investigators R (2009) Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study. Lancet Neurol 8(9):802–809. doi:10.1016/S1474-4422(09)70182-6
22. Jang MU, Hong JH, Kang J, Kim BJ, Han MK, Lee BC, Yu KH, Oh MS, Hong KS, Cho YJ, Park JM, Kang K, Cha JK, Kim DH, Park TH, Lee KB, Lee SJ, Ko Y, Lee J, Cho KH, Kim JT, Lee J, Lee JS, Bae HJ (2014) Current status of recanalization therapy in acute ischemic stroke with symptomatic intracranial arterial occlusion in Korea. J Stroke Cerebrovasc Dis 23(5):e339–e346. doi:10.1016/j.jstrokecerebrovasdis.2013.12.027
23. Ogawa A, Mori E, Minematsu K, Taki W, Takahashi A, Nemoto S, Miyamoto S, Sasaki M, Inoue T, Group MJS (2007) Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke 38(10):2633–2639. doi:10.1161/STROKEAHA.107.488551
24. Paciaroni M, Inzitari D, Agnelli G, Caso V, Balucani C, Grotta JC, Sarraj A, Sung-Il S, Chamorro A, Urra X, Leys D, Henon H, Cordonnier C, Dequatre N, Aguettaz P, Alberti A, Venti M, Acciarresi M, D’Amore C, Zini A, Vallone S, Dell’Acqua ML, Menetti F, Nencini P, Mangiafico S, Barlinn K, Kepplinger J, Bodechtel U, Gerber J, Bovi P, Cappellari M, Linfante I, Dabus G, Marcheselli S, Pezzini A, Padovani A, Alexandrov AV, Shahripour RB, Sessa M, Giacalone G, Silvestrelli G, Lanari A, Ciccone A, De Vito A, Azzini C, Saletti A, Fainardi E, Orlandi G, Chiti A, Gialdini G, Silvestrini M, Ferrarese C, Beretta S, Tassi R, Martini G, Tsivgoulis G, Vasdekis SN, Consoli D, Baldi A, D’Anna S, Luda E, Varbella F, Galletti G, Invernizzi P, Donati E, De Lodovici ML, Bono G, Corea F, Sette MD, Monaco S, Riva M, Tassinari T, Scoditti U, Toni D (2015) Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study. J Neurol 262(2):459–468. doi:10.1007/s00415-014-7550-1
25. Rai AT, Carpenter JS, Raghuram K, Roberts TD, Rodgers D, Hobbs GR (2013) Endovascular therapy yields significantly superior outcomes for large vessel occlusions compared with intravenous thrombolysis: is it time to randomize? J Neurointervent Surg 5(5):430–434. doi:10.1136/neurintsurg-2012-010429
26. Sen S, Huang DY, Akhavan O, Wilson S, Verro P, Solander S (2009) IV vs. IA TPA in acute ischemic stroke with CT angiographic evidence of major vessel occlusion: a feasibility study. Neurocrit Care 11(1):76–81. doi:10.1007/s12028-009-9204-1
27. Strbian D, Mustanoja S, Pekkola J, Putaala J, Haapaniemi E, Paananen T, Kaste M, Lappalainen K, Tatlisumak T (2015) Intravenous alteplase versus rescue endovascular procedure in patients with proximal middle cerebral artery occlusion. Int J Stroke 10(2):188–193. doi:10.1111/j.1747-4949.2012.00918.x
28. Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahan R, Investigators SP (2015) Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 372(24):2285–2295. doi:10.1056/NEJMoa1415061
29. Larrue V, von Kummer RR, Muller A, Bluhmki E (2001) Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 32(2):438–441
30. Prabhakaran S, Ruff I, Bernstein RA (2015) Acute stroke intervention: a systematic review. Jama 313(14):1451–1462. doi:10.1001/jama.2015.3058
31. Lin C, Li N, Wang K, Zhao X, Li BQ, Sun L, Lin YX, Fan JM, Zhang M, Sun HC (2013) Efficacy and safety of endovascular treatment versus intravenous thrombolysis for acute ischemic stroke: a meta-analysis of randomized controlled trials. PLoS One 8(10), e77849. doi:10.1371/journal.pone.0077849
32. Singh B, Parsaik AK, Prokop LJ, Mittal MK (2013) Endovascular therapy for acute ischemic stroke: a systematic review and meta-analysis. Mayo Clin Proc 88(10):1056–1065. doi:10.1016/j.mayocp.2013.07.015
33. Nogueira RG, Lutsep HL, Gupta R, Jovin TG, Albers GW, Walker GA, Liebeskind DS, Smith WS (2012) Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet 380(9849):1231–1240. doi:10.1016/S0140-6736(12)61299-9
34. Saver JL, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO (2012) Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet 380(9849):1241–1249. doi:10.1016/S0140-6736(12)61384-1