IV vs. IA TPA in acute ischemic stroke with CT angiographic evidence of major vessel occlusion: A feasibility study

Neurocritical Care

Volumn 11, Issue 1, 2009, Pages 76-81

  Sen, Souvik ^a   Huang, David Y ^a   Akhavan, Omid ^a   Wilson, Susan ^a   Verro, Piero ^b   Solander, Sten ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CT angiogram; Intra arterial; Stroke; Thrombolysis

Indexed keywords

ALTEPLASE; IOHEXOL; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BARTHEL INDEX; BLOOD CLOT LYSIS; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE INCREASE; EMERGENCY WARD; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANKIN SCALE; RECANALIZATION; SINGLE BLIND PROCEDURE; ACUTE DISEASE; BRAIN ANGIOGRAPHY; BRAIN ISCHEMIA; CAROTID ARTERY DISEASE; CEREBRAL ARTERY DISEASE; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; FEASIBILITY STUDY; INTENSIVE CARE; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; RADIOGRAPHY; STROKE; VERTEBROBASILAR INSUFFICIENCY;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CAROTID ARTERY DISEASES; CEREBRAL ANGIOGRAPHY; CRITICAL CARE; FEASIBILITY STUDIES; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; STROKE; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; VERTEBROBASILAR INSUFFICIENCY;

EID: 70349309347     PISSN: 15416933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12028-009-9204-1     Document Type: Article

References (27)

1. NINDS Stroke Study Group 1995 Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group N Engl J Med 333 24 1581 1587 10.1056/ NEJM199512143332401 10.1056/NEJM199512143332401
2. W Hacke M Kaste E Bluhmki M Brozman A Dávalos D Guidetti V Larrue KR Lees Z Medeghri T Machnig D Schneider R von Kummer N Wahlgren D Toni ECASS Investigators 2008 Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N Engl J Med 359 13 1317 1329 10.1056/NEJMoa0804656 18815396 10.1056/NEJMoa0804656 1:CAS:528:DC%2BD1cXhtFGqu77E
3. A Furlan R Higashida L Wechsler M Gent H Rowley C Kase M Pessin A Ahuja F Callahan WM Clark F Silver F Rivera 1999 Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism JAMA 282 21 2003 2011 10.1001/jama.282.21.2003 10591382 10.1001/jama.282.21.2003 1:CAS:528:DC%2BD3cXhtFek
4. HP Adams Jr G del Zoppo MJ Alberts DL Bhatt L Brass A Furlan RL Grubb RT Higashida EC Jauch C Kidwell PD Lyden LB Morgenstern AI Qureshi RH Rosenwasser PA Scott EF Wijdicks 2007 Guidelines for the early management of adults with ischemic stroke Stroke 38 5 1655 1711 10.1161/STROKEAHA.107.181486 17431204 10.1161/STROKEAHA.107.181486 (Pubitemid 46691097)
5. RC Lisboa BD Jovanovic MJ Alberts 2002 Analysis of the safety and efficacy of intra-arterial thrombolytic therapy in ischemic stroke Stroke 33 12 2866 2871 10.1161/01.STR.0000038987.62325.14 12468783 10.1161/01.STR.0000038987. 62325.14 1:CAS:528:DC%2BD38XptVSht70%3D (Pubitemid 35462858)
6. MH Lev J Farkas VR Rodriguez LH Schwamm GJ Hunter CM Putman GA Rordorf FS Buonanno R Budzik WJ Koroshetz RG Gonzalez 2001 CT angiography in the rapid triage of patients with hyperacute stroke to intraarterial thrombolysis: accuracy in the detection of large vessel thrombus J Comput Assist Tomogr 25 4 520 528 10.1097/00004728-200107000-00003 11473180 10.1097/00004728-200107000- 00003 1:STN:280:DC%2BD3Mvis1altQ%3D%3D (Pubitemid 33041507)
7. IMS Study Investigators 2004 Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study Stroke 35 4 904 911 10.1161/01.STR.0000121641.77121.98 10.1161/01.STR.0000121641.77121.98 (Pubitemid 38419800)
8. A Ciccone L Valvassori R Gasparotti F Scomazzoni E Ballabio R Sterzi 2007 Debunking 7 myths that hamper the realization of randomized controlled trials on intra-arterial thrombolysis for acute ischemic stroke Stroke 38 7 2191 2195 10.1161/STROKEAHA.106.465567 17540973 10.1161/STROKEAHA.106.465567 (Pubitemid 47012289)
9. JJ Bookstein FL Bookstein 2000 Augmented experimental pulse-spray thrombolysis with tissue plasminogen activator, enabling dose reduction by one or more orders of magnitude J Vasc Interv Radiol 11 299 303 10.1016/S1051- 0443(07)61421-3 10735423 10.1016/S1051-0443(07)61421-3 1:STN:280: DC%2BD3c7pslCksg%3D%3D
10. TIMI Study Group The Thrombolysis in Myocardial Infarction (TIMI) Trial 1985 Phase I findings N Engl J Med 312 932 936
11. T Neumann-Haefelin R de Rochemont JB Fiebach A Gass C Nolte T Kucinski J Rother M Siebler OC Singer K Szabo A Villringer PD Schellinger Kompetenznetz Schlaganfall Study Group 2004 Effect of incomplete (spontaneous and postthrombolytic) recanalization after middle cerebral artery occlusion: a magnetic resonance imaging study Stroke 35 109 114 10.1161/01.STR.0000106482. 31425.D1 14671246 10.1161/01.STR.0000106482.31425.D1 1:STN:280: DC%2BD2c%2FgtVCitQ%3D%3D (Pubitemid 38057601)
12. S Bastianello A Pierallini C Colonnese G Brughitta U Angeloni M Antonelli LM Fantozzi 1991 Fieschi, Bozzao L. Hyperdense middle cerebral artery CT sign Neuroradiology 33 207 211 10.1007/BF00588219 1881536 10.1007/BF00588219 1:STN:280:DyaK3MzltFCntQ%3D%3D
13. T Moulin F Cattin T Crépin-Leblond L Tatu D Chavot M Piotin JF Viel L Rumbach JF Bonneville 1996 Early CT signs in acute middle cerebral artery infarction: Predictive value for subsequent infarct locations and outcome Neurology 47 366 375 8757006 1:STN:280:DyaK28zjsF2qsg%3D%3D
14. M Zorzon G Mase F Pozzi-Mucelli E Biasutti L Antonutti L Iona G Cazzato 1993 Increased density in the middle cerebral artery by nonenhanced computed tomography: Prognostic value in acute cerebral infarction Eur Neurol 33 256 259 10.1159/000116949 8467850 10.1159/000116949 1:STN:280:DyaK3s3itlOmsA%3D%3D
15. J Launes L Ketonen 1987 Dense middle cerebral artery sign: an indicator of poor outcome in middle cerebral artery area infarction J Neurol Neurosurg Psychiatry 50 1550 1552 10.1136/jnnp.50.11.1550 3694213 10.1136/jnnp.50.11.1550 1:STN:280:DyaL1c%2FovFOjtA%3D%3D
16. C Manelfe V Larrue R von Kummer L Bozzao P Ringleb S Bastianello F Iweins E Lasaffre 1999 Association of hyperdense middle cerebral artery sign with clinical outcome in patients with tissue plasminogen activator Stroke 30 769 772 10187877 1:STN:280:DyaK1M3gsFegsg%3D%3D
17. T Tomsick T Brott W Barsan J Broderick E Clarke Haley J Spilker J Khoury 1996 Prognostic value of the hyperdense middle cerebral artery sign and stroke scale score before ultraearly thrombolytic therapy AJNR Am J Neuroradiol 17 79 85 8770253 1:STN:280:DyaK28zms1SktA%3D%3D
18. The NINDS rtPA Stroke Study Group 1997 Generalized efficacy of rtPA for acute stroke: subgroup analysis of the NINDS rtPA stroke trial Stroke 28 2119 2125
19. AI Qureshi 2004 Endovascular treatment of cerebrovascular diseases and intracranial neoplasms Lancet 363 804 813 10.1016/S0140-6736(04)15697-3 15016492 10.1016/S0140-6736(04)15697-3 (Pubitemid 38315172)
20. P Agarwal S Kumar S Hariharan N Eshkar P Verro B Cohen S Sen 2004 Hyperdense middle cerebral artery sign: can it be used to select intraarterial versus intravenous thrombolysis in acute ischemic stroke? Cerebrovasc Dis 17 182 190 10.1159/000075789 14707420 10.1159/000075789 (Pubitemid 38529196)
21. N Garg N Eshkar L Tanenbaum B Cohen S Sen 2004 Computed tomography angiographic correlates of early computed tomography signs in acute ischemic stroke J Neuroimaging 14 3 242 245 10.1177/1051228404264938 15228765 10.1177/1051228404264938 (Pubitemid 38781395)
22. http://clinicaltrials.gov/ct2/show/NCT00640367?term=synthesis&rank= 10. Accessed December 27, 2008.
23. http://www.neurorad-bern.ch/combatstroke/. Accessed December 27, 2008.
24. MR Macleod SM Davis PJ Mitchell RP Gerraty G Fitt GJ Hankey EG Stewart-Wynne D Rosen JJ McNeil CF Bladin BR Chambers GK Herkes D Young GA Donnan 2005 Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke Cerebrovasc Dis 20 1 12 17 10.1159/000086121 15925877 10.1159/000086121 1:CAS:528:DC%2BD2MXmt1Gntbc%3D (Pubitemid 41003629)
25. JP Broderick 1998 Practical considerations in the early treatment of ischemic stroke Am Fam Physician 57 73 79 9447215 1:STN:280:DyaK1c7gvVCksA%3D%3D
26. HP Mattle M Arnold D Georgiadis C Baumann K Nedeltchev D Benninger L Remonda C von Büdingen A Diana A Pangalu G Schroth RW Baumgartner 2008 Comparison of intraarterial and intravenous thrombolysis for ischemic stroke with hyperdense middle cerebral artery sign Stroke 39 2 379 383 10.1161/STROKEAHA.107.492348 18096842 10.1161/STROKEAHA.107.492348 (Pubitemid 351619459)
27. JH Rha JL Saver 2007 The impact of recanalization on ischemic stroke ourcome, a meta-analysis Stroke 38 967 973 10.1161/01.STR.0000258112.14918.24 17272772 10.1161/01.STR.0000258112.14918.24 (Pubitemid 46568460)