Endovascular therapy yields significantly superior outcomes for large vessel occlusions compared with intravenous thrombolysis: Is it time to randomize?

Journal of NeuroInterventional Surgery

Volumn 5, Issue 5, 2013, Pages 430-434

  Rai, Ansaar T ^a   Carpenter, Jeffrey S ^a   Raghuram, Karthikram ^b   Roberts, Thomas D ^a   Rodgers, Daniel ^a   Hobbs, Gerald R ^c  

^a WEST VIRGINIA UNIVERSITY HOSPITALS   (United States)

^b ST LUKE S MEDICAL CENTER   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE;

AGED; ARTICLE; BIFURCATION BRANCH OCCLUSION; BLOOD VESSEL OCCLUSION; CEREBROVASCULAR ACCIDENT; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; ENDOVASCULAR SURGERY; FEMALE; FIBRINOLYTIC THERAPY; GREAT BLOOD VESSEL; HUMAN; INTERNAL CAROTID ARTERY OCCLUSION; MAJOR CLINICAL STUDY; MALE; MECHANICAL THROMBECTOMY; MIDDLE CEREBRAL ARTERY OCCLUSION; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OCCLUSIVE CEREBROVASCULAR DISEASE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANKIN SCALE; RETROSPECTIVE STUDY; SCORING SYSTEM; TREATMENT OUTCOME;

AGED; ARTERIAL OCCLUSIVE DISEASES; CEREBRAL ANGIOGRAPHY; CEREBRAL ARTERIAL DISEASES; ENDOVASCULAR PROCEDURES; ENDPOINT DETERMINATION; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; NEUROLOGIC EXAMINATION; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84882295382     PISSN: 17598478     EISSN: 17598486     Source Type: Journal    
DOI: 10.1136/neurintsurg-2012-010429     Document Type: Article

References (50)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Eng J Med 1995;333:1581-7.
2. Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432-8.
3. Smith WS, Sung G, Saver J, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the multi MERCI trial. Stroke 2008;39:1205-12.
4. Wehrschuetz M, Wehrschuetz E, Augustin M, et al. Early single center experience with the solitaire thrombectomy device for the treatment of acute ischemic stroke. Intervent Neuroradiol: J Peritherapeutic Neuroradiol, Surg Proced Relat Neurosci 2011;17:235-40.
5. Machi P, Costalat V, Lobotesis K, et al. Solitaire FR thrombectomy system: immediate results in 56 consecutive acute ischemic stroke patients. J Neuro Intervent Surg 2011.
6. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003-11.
7. Abelson M, Roos J, Rymer M. Mechanical thrombo-embolectomy in acute ischaemic stroke: a local experience. Cardiovasc J Afr 2008;19:204-7.
8. Smith WS, Lev MH, English JD, et al. Significance of large vessel intracranial occlusion causing acute ischemic stroke and TIA. Stroke 2009;40: 3834-40.
9. Nogueira RG, Smith WS. Emergency treatment of acute ischemic stroke: expanding the time window. Curr Treat Options Neurol 2009;11:433-43.
10. Barreto AD, Albright KC, Hallevi H, et al. Thrombus burden is associated with clinical outcome after intra-arterial therapy for acute ischemic stroke. Stroke 2008;39:3231-5.
11. Flint AC, Duckwiler GR, Budzik RF, et al. Mechanical thrombectomy of intracranial internal carotid occlusion: pooled results of the MERCI and multi MERCI part I trials. Stroke 2007;38:1274-80.
12. Josephson SA, Saver JL, Smith WS. Comparison of mechanical embolectomy and intraarterial thrombolysis in acute ischemic stroke within the MCA: MERCI and multi MERCI compared to PROACT II. Neurocrit Care 2009;10:43-9.
13. Rai AT, Jhadhav Y, Domico J, et al. Procedural predictors of outcome in patients undergoing endovascular therapy for acute ischemic stroke. Cardiovasc Intervent Radiol. Published Online First: 14 December 2012. doi:10.1007/s00270- 011-0323-7
14. Nogueira RG, Liebeskind DS, Sung G, et al. Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and multi MERCI Trials. Stroke 2009;40:3777-83.
15. Mattle HP, Arnold M, Georgiadis D, et al. Comparison of intraarterial and intravenous thrombolysis for ischemic stroke with hyperdense middle cerebral artery sign. Stroke 2008;39:379-83.
16. Agarwal P, Kumar S, Hariharan S, et al. Hyperdense middle cerebral artery sign: can it be used to select intra-arterial versus intravenous thrombolysis in acute ischemic stroke? Cerebrovasc Dis 2004;17:182-90.
17. Sugiura S, Iwaisako K, Toyota S, et al. Simultaneous treatment with intravenous recombinant tissue plasminogen activator and endovascular therapy for acute ischemic stroke within 3 hours of onset. AJNR 2008;29:1061-6.
18. Demchuk AM, Christou I, Wein TH, et al. Specific transcranial Doppler flow findings related to the presence and site of arterial occlusion. Stroke 2000;31:140-6.
19. Lin R, Vora N, Zaidi S, et al. Mechanical approaches combined with intra-arterial pharmacological therapy are associated with higher recanalization rates than either intervention alone in revascularization of acute carotid terminus occlusion. Stroke 2009;40:2092-7.
20. The IMS Study Investigators. Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 2004;35:904-11.
21. The Interventional Management of Stroke (IMS) II Study. Stroke 2007;38:2127-35.
22. Gupta R, Tayal AH, Levy EI, et al. Intra-arterial thrombolysis or stent placement during endovascular treatment for acute ischemic stroke leads to the highest recanalization rate: results of a multicenter retrospective study. Neurosurgery 2011;68:1618-22.
23. Penumbra Pivotal Stroke Trial Investigators. The Penumbra Pivotal Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 2009;40:2761-8.
24. Rouchaud A, Mazighi M, Labreuche J, et al. Outcomes of mechanical endovascular therapy for acute ischemic stroke: a clinical registry study and systematic review. Stroke 2011;42:1289-94.
25. Saqqur M, Uchino K, Demchuk AM, et al. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007;38:948-54.
26. Zivin JA, Fisher M, DeGirolami U, et al. Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science 1985;230:1289-92.
27. Sen S, Huang DY, Akhavan O, et al. IV vs. IA TPA in acute ischemic stroke with CT angiographic evidence of major vessel occlusion: a feasibility study. Neurocrit Care 2009;11:76-81.
28. Ciccone A, Valvassori L, Ponzio M, et al. Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial. J Neuro Intervent Surg 2010;2:74-9.
29. Ciccone A, Valvassori L, Nichelatti M. SYNTHESIS expansion: design of a nonprofit, pragmatic, randomized, controlled trial on the best fast-track endovascular treatment vs. standard intravenous alteplase for acute ischemic stroke. Int J Stroke: Official J Int Stroke Soc 2011;6:259-65.
30. Bhatia R, Hill MD, Shobha N, et al. Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action. Stroke 2010;41:2254-8.
31. Lee KY, Han SW, Kim SH, et al. Early recanalization after intravenous administration of recombinant tissue plasminogen activator as assessed by pre- and post-thrombolytic angiography in acute ischemic stroke patients. Stroke 2007;38:192-3.
32. Rother J, Schellinger PD, Gass A, et al. Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hours. Stroke 2002;33:2438-45.
33. Macleod MR, Davis SM, Mitchell PJ, et al. Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke. Cerebrovasc Dis 2005;20:12-17.
34. Ogawa A, Mori E, Minematsu K, et al. Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke 2007;38:2633-9.
35. Lee M, Hong KS, Saver JL. Efficacy of intra-arterial fibrinolysis for acute ischemic stroke: meta-analysis of randomized controlled trials. Stroke 2010;41:932-7.
36. Smith WS. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke. Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. AJNR 2006;27:1177-82.
37. Acheampong P, Ford GA. Pharmacokinetics of alteplase in the treatment of ischaemic stroke. Expert Opin Drug Metab Toxicol 2012;8:271-81.
38. Vance DL. Treating acute ischemic stroke with intravenous alteplase. Crit Care Nurse 2001;21:25-7, 29-32.
39. Mendonca N, Rodriguez-Luna D, Rubiera M, et al. Predictors of tissue-type plasminogen activator nonresponders according to location of vessel occlusion. Stroke 2012;43:417-21.
40. Mathews MS, Sharma J, Snyder KV, et al. Safety, effectiveness, and practicality of endovascular therapy within the first 3 hours of acute ischemic stroke onset. Neurosurgery 2009;65:860-5.
41. Mori E, Minematsu K, Nakagawara J, et al. Effects of 0.6 mg/kg intravenous alteplase on vascular and clinical outcomes in middle cerebral artery occlusion: Japan Alteplase Clinical Trial II ( J-ACT II). Stroke 2010;41:461-5.
42. Zanette EM, Roberti C, Mancini G, et al. Spontaneous middle cerebral artery reperfusion in ischemic stroke. A follow-up study with transcranial Doppler. Stroke 1995;26:430-3.
43. Christou I, Alexandrov AV, Burgin WS, et al. Timing of recanalization after tissue plasminogen activator therapy determined by transcranial Doppler correlates with clinical recovery from ischemic stroke. Stroke 2000;31:1812-16.
44. Mazighi M, Serfaty JM, Labreuche J, et al. Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study. Lancet Neurol 2009;8:802-9.
45. Kidwell CS, Alger JR, Saver JL. Evolving paradigms in neuroimaging of the ischemic penumbra. Stroke 2004;35(Suppl 1):2662-5.
46. Khatri P, Abruzzo T, Yeatts SD, et al. Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology 2009;73:1066-72.
47. Alberts MJ, Hademenos G, Latchaw RE, et al. Recommendations for the establishment of primary stroke centers. Brain Attack Coalition. JAMA 2000;283:3102-9.
48. Adams HP Jr, Brott TG, Furlan AJ, et al. Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. Circulation 1996;94:1167-74.
49. Marler JR, Jones PW, Emr M, National Institute of Neurological Disorders and Stroke (US). Office of Scientific and Health Reports. Setting new directions for stroke care: Proceedings of a National Symposium on Rapid Identification and Treatment of Acute Stroke. Bethesda, MD: The Institute, 1997.
50. Eesa M, Menon BK, Hill MD, et al. Achieving faster recanalization times by IA thrombolysis in acute ischemic stroke: where should we direct our efforts? Intervent Neuroradiol: J Peritherapeutic Neuroradiol, Surg Proced Relat Neurosci 2011;17:228-34.