메뉴 건너뛰기




Volumn 97, Issue 1, 2016, Pages 134-143

Hepatitis B virus X protein induces epithelial–mesenchymal transition by repressing E-cadherin expression via upregulation of E12/E47

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; HEPATITIS B VIRUS X PROTEIN; NERVE CELL ADHESION MOLECULE; PLAKOGLOBIN; PROTEASOME; SMALL INTERFERING RNA; UVOMORULIN; VIMENTIN; CADHERIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR 3;

EID: 84957543163     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/jgv.0.000324     Document Type: Article
Times cited : (18)

References (43)
  • 1
    • 84856528807 scopus 로고    scopus 로고
    • Epigenetic repression of E-cadherin expression by hepatitis B virus X antigen in liver cancer
    • Arzumanyan, A., Friedman, T., Kotei, E., Ng, I. O., Lian, Z. & Feitelson, M. A. (2012). Epigenetic repression of E-cadherin expression by hepatitis B virus X antigen in liver cancer. Oncogene 31, 563–572.
    • (2012) Oncogene , vol.31 , pp. 563-572
    • Arzumanyan, A.1    Friedman, T.2    Kotei, E.3    Ng, I.O.4    Lian, Z.5    Feitelson, M.A.6
  • 3
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
    • Birchmeier, W. & Behrens, J. (1994). Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198, 11–26.
    • (1994) Biochim Biophys Acta , vol.1198 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 4
    • 84888994574 scopus 로고    scopus 로고
    • Cross-talk between site-specific transcription factors and DNA methylation states
    • Blattler, A. & Farnham, P. J. (2013). Cross-talk between site-specific transcription factors and DNA methylation states. J Biol Chem 288, 34287–34294.
    • (2013) J Biol Chem , vol.288 , pp. 34287-34294
    • Blattler, A.1    Farnham, P.J.2
  • 5
    • 65549130040 scopus 로고    scopus 로고
    • Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression
    • Cha, M. Y., Ryu, D. K., Jung, H. S., Chang, H. E. & Ryu, W. S. (2009). Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression. J Gen Virol 90, 978–986.
    • (2009) J Gen Virol , vol.90 , pp. 978-986
    • Cha, M.Y.1    Ryu, D.K.2    Jung, H.S.3    Chang, H.E.4    Ryu, W.S.5
  • 6
    • 3042579870 scopus 로고    scopus 로고
    • Evaluation of nuclear factor kB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma
    • Chan, C. F., Yau, T. O., Jin, D. Y., Wong, C. M., Fan, S. T. & Ng, I. O. (2004). Evaluation of nuclear factor kB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma. Clin Cancer Res 10, 4140–4149.
    • (2004) Clin Cancer Res , vol.10 , pp. 4140-4149
    • Chan, C.F.1    Yau, T.O.2    Jin, D.Y.3    Wong, C.M.4    Fan, S.T.5    Ng, I.O.6
  • 7
    • 0025034673 scopus 로고
    • Two distinct transcription factors that bind the immunoglobulin enhancer mE5/ k2 motif
    • Henthorn, P., Kiledjian, M. & Kadesch, T. (1990). Two distinct transcription factors that bind the immunoglobulin enhancer mE5/ k2 motif. Science 247, 467–470.
    • (1990) Science , vol.247 , pp. 467-470
    • Henthorn, P.1    Kiledjian, M.2    Kadesch, T.3
  • 9
    • 0041561057 scopus 로고    scopus 로고
    • Cell adhesion system and human cancer morphogenesis
    • Hirohashi, S. & Kanai, Y. (2003). Cell adhesion system and human cancer morphogenesis. Cancer Sci 94, 575–581.
    • (2003) Cancer Sci , vol.94 , pp. 575-581
    • Hirohashi, S.1    Kanai, Y.2
  • 10
    • 34250854122 scopus 로고    scopus 로고
    • Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6- pRb-E2F1 pathway
    • Jung, J. K., Arora, P., Pagano, J. S. & Jang, K. L. (2007). Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6- pRb-E2F1 pathway. Cancer Res 67, 5771–5778.
    • (2007) Cancer Res , vol.67 , pp. 5771-5778
    • Jung, J.K.1    Arora, P.2    Pagano, J.S.3    Jang, K.L.4
  • 11
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial– mesenchymal transition
    • Kalluri, R. & Weinberg, R. A. (2009). The basics of epithelial– mesenchymal transition. J Clin Invest 119, 1420–1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 12
    • 0030920634 scopus 로고    scopus 로고
    • The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas
    • Kanai, Y., Ushijima, S., Hui, A. M., Ochiai, A., Tsuda, H., Sakamoto, M. & Hirohashi, S. (1997). The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int J Cancer 71, 355–359.
    • (1997) Int J Cancer , vol.71 , pp. 355-359
    • Kanai, Y.1    Ushijima, S.2    Hui, A.M.3    Ochiai, A.4    Tsuda, H.5    Sakamoto, M.6    Hirohashi, S.7
  • 13
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transitions: Twist in development and metastasis
    • Kang, Y. & Massagué, J. (2004). Epithelial–mesenchymal transitions: twist in development and metastasis. Cell 118, 277–279.
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massagué, J.2
  • 14
    • 0028872721 scopus 로고
    • Loss of E-cadherin-dependent cell–cell adhesion due to mutation of the b-catenin gene in a human cancer cell line
    • Kawanishi, J., Kato, J., Sasaki, K., Fujii, S., Watanabe, N. & Niitsu, Y. (1995). Loss of E-cadherin-dependent cell–cell adhesion due to mutation of the b-catenin gene in a human cancer cell line, HSC- 39.Mol Cell Biol 15, 1175–1181.
    • (1995) HSC- 39.Mol Cell Biol , vol.15 , pp. 1175-1181
    • Kawanishi, J.1    Kato, J.2    Sasaki, K.3    Fujii, S.4    Watanabe, N.5    Niitsu, Y.6
  • 15
    • 2342484993 scopus 로고    scopus 로고
    • Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene
    • Kwun, H. J. & Jang, K. L. (2004). Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene. Nucleic Acids Res 32, 2202–2213.
    • (2004) Nucleic Acids Res , vol.32 , pp. 2202-2213
    • Kwun, H.J.1    Jang, K.L.2
  • 17
    • 0035821645 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
    • Lara-Pezzi, E., Roche, S., Andrisani, O. M., Sánchez-Madrid, F. & López-Cabrera, M. (2001b). The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 20, 3323–3331.
    • (2001) Oncogene , vol.20 , pp. 3323-3331
    • Lara-Pezzi, E.1    Roche, S.2    Risani, O.M.3    Sánchez-Madrid, F.4    López-Cabrera, M.5
  • 19
    • 84867251505 scopus 로고    scopus 로고
    • The regulation of cell–cell adhesion during epithelial–mesenchymal transition, motility and tumor progression
    • Le Bras, G. F., Taubenslag, K. J. & Andl, C. D. (2012). The regulation of cell–cell adhesion during epithelial–mesenchymal transition, motility and tumor progression. Cell Adhes Migr 6, 365–373.
    • (2012) Cell Adhes Migr , vol.6 , pp. 365-373
    • Le Bras, G.F.1    Taubenslag, K.J.2    Andl, C.D.3
  • 20
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • Lee, S., Lee, H. J., Kim, J. H., Lee, H. S., Jang, J. J. & Kang, G. H. (2003). Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 163, 1371–1378.
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3    Lee, H.S.4    Jang, J.J.5    Kang, G.H.6
  • 21
    • 27144448810 scopus 로고    scopus 로고
    • Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1
    • Lee, J. O., Kwun, H. J., Jung, J. K., Choi, K. H., Min, D. S. & Jang, K. L. (2005). Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.Oncogene 24, 6617–6625.
    • (2005) Oncogene , vol.24 , pp. 6617-6625
    • Lee, J.O.1    Kwun, H.J.2    Jung, J.K.3    Choi, K.H.4    Min, D.S.5    Jang, K.L.6
  • 22
    • 46049106122 scopus 로고    scopus 로고
    • Identification of a novel intermediate filament-linked N-cadherin/c-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells
    • Leonard, M., Chan, Y. & Menko, A. S. (2008). Identification of a novel intermediate filament-linked N-cadherin/c-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells. Dev Biol 319, 298–308.
    • (2008) Dev Biol , vol.319 , pp. 298-308
    • Leonard, M.1    Chan, Y.2    Menko, A.S.3
  • 23
    • 77953107054 scopus 로고    scopus 로고
    • The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    • Lin, Y., Wu, Y., Li, J., Dong, C., Ye, X., Chi, Y. I., Evers, B. M. & Zhou, B. P. (2010). The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1.EMBO J 29, 1803–1816.
    • (2010) EMBO J , vol.29 , pp. 1803-1816
    • Lin, Y.1    Wu, Y.2    Li, J.3    Dong, C.4    Ye, X.5    Chi, Y.I.6    Evers, B.M.7    Zhou, B.P.8
  • 24
    • 33244455402 scopus 로고    scopus 로고
    • Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma
    • Liu, J., Lian, Z., Han, S., Waye, M. M., Wang, H., Wu, M. C., Wu, K., Ding, J., Arbuthnot, P. & other authors (2006). Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene 25, 1008–1017.
    • (2006) Oncogene , vol.25 , pp. 1008-1017
    • Liu, J.1    Lian, Z.2    Han, S.3    Waye, M.M.4    Wang, H.5    Wu, M.C.6    Wu, K.7    Ding, J.8    Arbuthnot, P.9    Authors, O.10
  • 25
    • 84870712078 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein
    • Liu, H., Xu, L., He, H., Zhu, Y., Liu, J., Wang, S., Chen, L., Wu, Q., Xu, J. & Gu, J. (2012). Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein. Cancer Sci 103, 2072–2081.
    • (2012) Cancer Sci , vol.103 , pp. 2072-2081
    • Liu, H.1    Xu, L.2    He, H.3    Zhu, Y.4    Liu, J.5    Wang, S.6    Chen, L.7    Wu, Q.8    Xu, J.9    Gu, J.10
  • 26
    • 77949654113 scopus 로고    scopus 로고
    • Mechanisms of HBVrelated hepatocarcinogenesis
    • Neuveut, C., Wei, Y. & Buendia, M. A. (2010). Mechanisms of HBVrelated hepatocarcinogenesis. J Hepatol 52, 594–604.
    • (2010) J Hepatol , vol.52 , pp. 594-604
    • Neuveut, C.1    Wei, Y.2    Buendia, M.A.3
  • 27
  • 28
    • 0028960362 scopus 로고
    • Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma
    • Paterlini, P., Poussin, K., Kew, M., Franco, D. & Brechot, C. (1995). Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 21, 313–321.
    • (1995) Hepatology , vol.21 , pp. 313-321
    • Paterlini, P.1    Poussin, K.2    Kew, M.3    Franco, D.4    Brechot, C.5
  • 29
    • 0035920152 scopus 로고    scopus 로고
    • A new role for E12/E47 in the repression of E-cadherin expression and epithelial–mesenchymal transitions
    • Perez-Moreno, M. A., Locascio, A., Rodrigo, I., Dhondt, G., Portillo, F., Nieto, M. A. & Cano, A. (2001). A new role for E12/E47 in the repression of E-cadherin expression and epithelial–mesenchymal transitions. J Biol Chem 276, 27424–27431.
    • (2001) J Biol Chem , vol.276 , pp. 27424-27431
    • Perez-Moreno, M.A.1    Locascio, A.2    Rodrigo, I.3    Dhondt, G.4    Portillo, F.5    Nieto, M.A.6    Cano, A.7
  • 30
    • 0036217915 scopus 로고    scopus 로고
    • E protein function in lymphocyte development
    • Quong, M. W., Romanow, W. J. & Murre, C. (2002). E protein function in lymphocyte development. Annu Rev Immunol 20, 301–322.
    • (2002) Annu Rev Immunol , vol.20 , pp. 301-322
    • Quong, M.W.1    Romanow, W.J.2    Murre, C.3
  • 32
    • 0000934401 scopus 로고
    • Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA
    • Sells, M. A., Chen, M. L. & Acs, G. (1987). Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci U S A 84, 1005–1009.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 1005-1009
    • Sells, M.A.1    Chen, M.L.2    Acs, G.3
  • 33
    • 84922395039 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer
    • Tania, M., Khan, M. A. & Fu, J. (2014). Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer. Tumour Biol 35, 7335–7342.
    • (2014) Tumour Biol , vol.35 , pp. 7335-7342
    • Tania, M.1    Khan, M.A.2    Fu, J.3
  • 34
    • 84897572927 scopus 로고    scopus 로고
    • The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms
    • Teng, Y. & Li, X. (2014). The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms. Clin Exp Metastasis 31, 367–377.
    • (2014) Clin Exp Metastasis , vol.31 , pp. 367-377
    • Teng, Y.1    Li, X.2
  • 35
    • 84880674407 scopus 로고    scopus 로고
    • Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis
    • Tian, Y., Yang, W., Song, J., Wu, Y. & Ni, B. (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. Mol Cell Biol 33, 2810–2816.
    • (2013) Mol Cell Biol , vol.33 , pp. 2810-2816
    • Tian, Y.1    Yang, W.2    Song, J.3    Wu, Y.4    Ni, B.5
  • 36
    • 57349114162 scopus 로고    scopus 로고
    • The cell–cell adhesion molecule E-cadherin
    • van Roy, F. & Berx, G. (2008). The cell–cell adhesion molecule E-cadherin. Cell Mol Life Sci 65, 3756–3788.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3756-3788
    • van Roy, F.1    Berx, G.2
  • 37
    • 0028129695 scopus 로고
    • Induction of polarized cell–cell association and retardation of growth by activation of the E-cadherin–catenin adhesion system in a dispersed carcinoma line
    • Watabe, M., Nagafuchi, A., Tsukita, S. & Takeichi, M. (1994). Induction of polarized cell–cell association and retardation of growth by activation of the E-cadherin–catenin adhesion system in a dispersed carcinoma line. J Cell Biol 127, 247–256.
    • (1994) J Cell Biol , vol.127 , pp. 247-256
    • Watabe, M.1    Nagafuchi, A.2    Tsukita, S.3    Takeichi, M.4
  • 38
    • 0036725378 scopus 로고    scopus 로고
    • Altered expression of E-cadherin in hepatocellular carcinoma: Correlations with genetic alterations, bcatenin expression, and clinical features
    • Wei, Y., Van Nhieu, J. T., Prigent, S., Srivatanakul, P., Tiollais, P. & Buendia, M. A. (2002). Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, bcatenin expression, and clinical features. Hepatology 36, 692–701.
    • (2002) Hepatology , vol.36 , pp. 692-701
    • Wei, Y.1    van Nhieu, J.T.2    Prigent, S.3    Srivatanakul, P.4    Tiollais, P.5    Buendia, M.A.6
  • 39
    • 47549098263 scopus 로고    scopus 로고
    • E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas
    • Wells, A., Yates, C. & Shepard, C. R. (2008). E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin Exp Metastasis 25, 621–628.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 621-628
    • Wells, A.1    Yates, C.2    Shepard, C.R.3
  • 40
    • 84865974635 scopus 로고    scopus 로고
    • All-trans retinoic acid activates E-cadherin expression via promoter hypomethylation in the human colon carcinoma HCT116 cells
    • Woo, Y. J. & Jang, K. L. (2012). All-trans retinoic acid activates E-cadherin expression via promoter hypomethylation in the human colon carcinoma HCT116 cells. Biochem Biophys Res Commun 425, 944–949.
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 944-949
    • Woo, Y.J.1    Jang, K.L.2
  • 41
    • 84896740011 scopus 로고    scopus 로고
    • Hepatitis B virusinduced hepatocellular carcinoma
    • Xu, C., Zhou, W., Wang, Y. & Qiao, L. (2014). Hepatitis B virusinduced hepatocellular carcinoma. Cancer Lett 345, 216–222.
    • (2014) Cancer Lett , vol.345 , pp. 216-222
    • Xu, C.1    Zhou, W.2    Wang, Y.3    Qiao, L.4
  • 42
    • 0041924707 scopus 로고    scopus 로고
    • Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
    • Yang, B., Guo, M., Herman, J. G. & Clark, D. P. (2003). Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163, 1101–1107.
    • (2003) Am J Pathol , vol.163 , pp. 1101-1107
    • Yang, B.1    Guo, M.2    Herman, J.G.3    Clark, D.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.