Tenuigenin Prevents IL-1β-induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing PI3K/AKT/NF-κB Signaling Pathway

Inflammation

Volumn 39, Issue 2, 2016, Pages 807-812

  Wang, Chunlei ^a   Zeng, Lihong ^b   Zhang, Tao ^a   Liu, Jiakun ^a   Wang, Wenbo ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b Department of Adolescent Medicine Harbin Children s Hospital   (China)

Author keywords

IL 1 ; NF B; osteoarthritis chondrocyte; PI3K; tenuigenin

Indexed keywords

ANTIINFLAMMATORY AGENT; COLLAGENASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROSTAGLANDIN E2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TENUIGENIN; UNCLASSIFIED DRUG; HERBACEOUS AGENT; IL1B PROTEIN, HUMAN; MMP1 PROTEIN, HUMAN; MMP13 PROTEIN, HUMAN; MMP3 PROTEIN, HUMAN; RELA PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KNEE OSTEOARTHRITIS; MIDDLE AGED; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TOTAL KNEE REPLACEMENT; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; CHONDROCYTE; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; KNEE REPLACEMENT; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; PHOSPHORYLATION;

ANTI-INFLAMMATORY AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; CELLS, CULTURED; CHONDROCYTES; DINOPROSTONE; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; NITRIC OXIDE; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTOR RELA;

EID: 84957539993     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-016-0309-3     Document Type: Article

References (27)

1. Benito, M.J., D.J. Veale, O. FitzGerald, W.B. van den Berg, and B. Bresnihan. 2005. Synovial tissue inflammation in early and late osteoarthritis. Annals of the Rheumatic Diseases 64: 1263–1267.
2. Pelletier, J.P., J. Martel‐Pelletier, and S.B. Abramson. 2001. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis & Rheumatism 44: 1237–1247.
3. Pelletier, J.-P., F. Mineau, P. Ranger, G. Tardif, and J. Martel-Pelletier. 1996. The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation. Osteoarthritis and Cartilage 4: 77–84.
4. Kobayashi, M., G.R. Squires, A. Mousa, M. Tanzer, D.J. Zukor, J. Antoniou, U. Feige, and A.R. Poole. 2005. Role of interleukin‐1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage. Arthritis & Rheumatism 52: 128–135.
5. Kapoor, M., J. Martel-Pelletier, D. Lajeunesse, J.-P. Pelletier, and H. Fahmi. 2011. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nature Reviews. Rheumatology 7: 33–42.
6. Amin, A.R., M. Dave, M. Attur, and S.B. Abramson. 2000. COX-2, NO, and cartilage damage and repair. Current Rheumatology Reports 2: 447–453.
7. Yang, G., H.-J. Im, and J.H.-C. Wang. 2005. Repetitive mechanical stretching modulates IL-1β induced COX-2, MMP-1 expression, and PGE 2 production in human patellar tendon fibroblasts. Gene 363: 166–172.
8. Burrage, P.S., K.S. Mix, and C.E. Brinckerhoff. 2006. Matrix metalloproteinases: role in arthritis. Frontiers in Bioscience 11: 529–543.
9. Silverstein, F.E., G. Faich, J.L. Goldstein, L.S. Simon, T. Pincus, A. Whelton, R. Makuch, G. Eisen, N.M. Agrawal, and W.F. Stenson. 2000. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. JAMA 284: 1247–1255.
10. Liang, Z., F. Shi, Y. Wang, L. Lu, Z. Zhang, X. Wang, and X. Wang. 2011. Neuroprotective effects of tenuigenin in a SH-SY5Y cell model with 6-OHDA-induced injury. Neuroscience Letters 497: 104–109.
11. Yuan, H.L., B. Li, J. Xu, Y. Wang, Y. He, Y. Zheng, and X.M. Wang. 2012. Tenuigenin protects dopaminergic neurons from inflammation‐mediated damage induced by the lipopolysaccharide. CNS Neuroscience & Therapeutics 18: 584–590.
12. Cai, Z.-L., C.-Y. Wang, X.-Y. Gu, N.-J. Wang, J.-J. Wang, W.-X. Liu, P. Xiao, and C.-H. Li. 2013. Tenuigenin ameliorates learning and memory impairments induced by ovariectomy. Physiology & Behavior 118: 112–117.
13. Chen, Y., X. Huang, W. Chen, N. Wang, and L. Li. 2012. Tenuigenin promotes proliferation and differentiation of hippocampal neural stem cells. Neurochemical Research 37: 771–777.
14. Lv H, Zhu C, Liao Y, Gao Y, Lu G, Zhong W, Zheng Y, Chen W, Ci X. 2015. Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways. Respiratory Physiology & Neurobiology 216: 43–51.
15. Cheng, A.W., T.V. Stabler, M. Bolognesi, and V.B. Kraus. 2011. Selenomethionine inhibits IL-1beta inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. Osteoarthritis and Cartilage 19: 118–125.
16. Fukui, N., Y. Zhu, W.J. Maloney, J. Clohisy, and L.J. Sandell. 2003. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-α in normal and osteoarthritic chondrocytes. The Journal of Bone & Joint Surgery 85: 59–66.
17. Daheshia, M., and J.Q. Yao. 2008. The interleukin 1β pathway in the pathogenesis of osteoarthritis. The Journal of Rheumatology 35: 2306–2312.
18. Jacques, C., M. Gosset, F. Berenbaum, and C. Gabay. 2006. The role of IL‐1 and IL‐1Ra in joint inflammation and cartilage degradation. Vitamins & Hormones 74: 371–403.
19. Goldring, M.B., and F. Berenbaum. 2004. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clinical Orthopaedics and Related Research 427: S37–S46.
20. Studer, R., D. Jaffurs, M. Stefanovic-Racic, P. Robbins, and C. Evans. 1999. Nitric oxide in osteoarthritis. Osteoarthritis and Cartilage 7: 377–379.
21. Futani, H., A. Okayama, K. Matsui, S. Kashiwamura, T. Sasaki, T. Hada, K. Nakanishi, H. Tateishi, S. Maruo, and H. Okamura. 2002. Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation. Journal of Immunotherapy 25: S61–S64.
22. Karan, A., M.A. Karan, P. Vural, N. Erten, C. Taşçıoğlu, C. Aksoy, M. Canbaz, and A. Öncel. 2003. Synovial fluid nitric oxide levels in patients with knee osteoarthritis. Clinical Rheumatology 22: 397–399.
23. Koskinen, A., K. Vuolteenaho, R. Nieminen, T. Moilanen, and E. Moilanen. 2010. Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients. Clinical and Experimental Rheumatology 29: 57–64.
24. Baker, R.G., M.S. Hayden, and S. Ghosh. 2011. NF-κB, inflammation, and metabolic disease. Cell Metabolism 13: 11–22.
25. Lawrence, T., and C. Fong. 2010. The resolution of inflammation: anti-inflammatory roles for NF-κB. The International Journal of Biochemistry & Cell Biology 42: 519–523.
26. Roman-Blas, J., and S. Jimenez. 2006. NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis and Cartilage 14: 839–848.
27. Jeong JW, Lee HH, Choi EO, Lee KW, Kim KY, Kim SG, Hong SH, Kim GY, Park C, Kim HK, et al. 2015. Schisandrae Fructus inhibits IL-1beta-induced matrix metalloproteinases and inflammatory mediators production in SW1353 human chondrocytes by suppressing NF-kappaB and MAPK activation. Drug Development Research 76: 474–483.