Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis

Biochemical and Biophysical Research Communications

Volumn 323, Issue 4, 2004, Pages 1157-1162

  Chen, Xuequn ^a,c   Li, Chenwei ^a   Izumi, Tetsuro ^a   Ernst, Stephen A ^b   Andrews, Philip C ^c   Williams, John A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

Dominant negative; Exocytosis; Mass spectrometry; Pancreatic acini; Proteomics; Rab27b; Zymogen granule

Indexed keywords

AMYLASE; CHOLECYSTOKININ; ENZYME PRECURSOR; RAB PROTEIN;

ACINAR CELL; ADENOVIRUS; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; DOSE RESPONSE; EXOCYTOSIS; IMMUNOCYTOCHEMISTRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEOMICS; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS; WESTERN BLOTTING; WILD TYPE;

AMINO ACID SEQUENCE; AMYLASES; ANIMALS; CELLS, CULTURED; EXOCYTOSIS; MALE; MOLECULAR SEQUENCE DATA; PANCREAS; RAB GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SECRETORY VESICLES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE DISTRIBUTION;

EID: 4644223420     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.08.212     Document Type: Article

References (34)

1. J.D. Jamieson, and G.E. Palade Intracellular transport of secretory proteins in the pancreatic exocrine cell. II. Transport to condensing vacuoles and zymogen granules J. Cell Biol. 34 1967 597 615
2. G. Palade Intracellular aspects of the process of protein synthesis Science 189 1975 347 358
3. J.B. Pereira-Leal, and M.C. Seabra Evolution of the Rab family of small GTP-binding proteins J. Mol. Biol. 313 2001 889 901
4. H. Ohnishi, S.A. Ernst, N. Wys, M. McNiven, and J.A. Williams Rab3D localizes to zymogen granules in rat pancreatic acini and other exocrine glands Am. J. Physiol. 271 1996 G531 538
5. X. Chen, J.A. Edwards, C.D. Logsdon, S.A. Ernst, and J.A. Williams Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini J. Biol. Chem. 277 2002 18002 18009
6. H. Ohnishi, L.C. Samuelson, D.I. Yule, S.A. Ernst, and J.A. Williams Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice J. Clin. Invest. 100 1997 3044 3052
7. T. Izumi, H. Gomi, K. Kasai, S. Mizutani, and S. Torii The roles of Rab27 and its effectors in the regulated secretory pathways Cell Struct. Funct. 28 2003 465 474
8. M.C. Seabra, E.H. Mules, and A.N. Hume Rab GTPases, intracellular traffic and disease Trends Mol. Med. 8 2002 23 30
9. S. Zhao, S. Torii, H. Yokota-Hashimoto, T. Takeuchi, and T. Izumi Involvement of Rab27b in the regulated secretion of pituitary hormones Endocrinology 143 2002 1817 1824
10. B. Goke, J.A. Williams, M.J. Wishart, and R.C. De Lisle Low molecular mass GTP-binding proteins in subcellular fractions of the pancreas: regulated phosphoryl G proteins Am. J. Physiol. 262 1992 C493 500
11. W.V. Bienvenut, C. Deon, C. Pasquarello, J.M. Campbell, J.C. Sanchez, M.L. Vestal, and D.F. Hochstrasser Matrix-assisted laser desorption/ionization- tandem mass spectrometry with high resolution and sensitivity for identification and characterization of proteins Proteomics 2 2002 868 876
12. K.F. Medzihradszky, J.M. Campbell, M.A. Baldwin, A.M. Falick, P. Juhasz, M.L. Vestal, and A.L. Burlingame The characteristics of peptide collision-induced dissociation using a high-performance MALDI-TOF/TOF tandem mass spectrometer Anal. Chem. 72 2000 552 558
13. X. Chen, S.A. Ernst, and J.A. Williams Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini J. Biol. Chem. 278 2003 50053 50060
14. C. Li, X. Chen, J.A. Williams, Regulation of CCK-induced amylase release by protein kinase C delta in rat pancreatic acinar cells, Am. J. Physiol. Gastrointest. Liver Physiol. (2004), in press (doi:ajpgi.00111.2004)
15. J.A. Valentijn, D. Sengupta, F.D. Gumkowski, L.H. Tang, E.M. Konieczko, and J.D. Jamieson Rab3D localizes to secretory granules in rat pancreatic acinar cells Eur. J. Cell Biol. 70 1996 33 41
16. H. Ohnishi, T. Mine, H. Shibata, N. Ueda, T. Tsuchida, and T. Fujita Involvement of Rab4 in regulated exocytosis of rat pancreatic acini Gastroenterology 116 1999 943 952
17. A.C. Wagner, M.Z. Strowski, and J.A. Williams Identification of Rab 5 but not Rab 3A in rat pancreatic zymogen granule membranes Biochem. Biophys. Res. Commun. 200 1994 542 548
18. J.A. Valentijn, F.D. Gumkowski, and J.D. Jamieson The expression pattern of rab3D in the developing rat exocrine pancreas coincides with the acquisition of regulated exocytosis Eur. J. Cell Biol. 71 1996 129 136
19. J.A. Valentijn, K. Valentijn, L.M. Pastore, and J.D. Jamieson Actin coating of secretory granules during regulated exocytosis correlates with the release of rab3D Proc. Natl. Acad. Sci. USA 97 2000 1091 1095
20. D. Riedel, W. Antonin, R. Fernandez-Chacon, G. Alvarezde Toledo, T. Jo, M. Geppert, J.A. Valentijn, K. Valentijn, J.D. Jamieson, T.C. Sudhof, and R. Jahn Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules Mol. Cell Biol. 22 2002 6487 6497
21. M. Fukuda, E. Kanno, and A. Yamamoto Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells J. Biol. Chem. 279 2004 13065 13075
22. S. Cheviet, T. Coppola, L.P. Haynes, R.D. Burgoyne, and R. Regazzi The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis Mol. Endocrinol. 18 2004 117 126
23. M. Fukuda Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A J. Biol. Chem. 277 2002 40118 40124
24. D. Chen, J. Guo, T. Miki, M. Tachibana, and W.A. Gahl Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets Biochem. Mol. Med. 60 1997 27 37
25. D.C. Barral, J.S. Ramalho, R. Anders, A.N. Hume, H.J. Knapton, T. Tolmachova, L.M. Collinson, D. Goulding, K.S. Authi, and M.C. Seabra Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome J. Clin. Invest. 110 2002 247 257
26. R.E. Boissy Melanosome transfer to and translocation in the keratinocyte Exp. Dermatol. 12 Suppl 2 2003 5 12
27. M. Strom, A.N. Hume, A.K. Tarafder, E. Barkagianni, and M.C. Seabra A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport J. Biol. Chem. 277 2002 25423 25430
28. E.K. Novak, R. Gautam, M. Reddington, L.M. Collinson, N.G. Copeland, N.A. Jenkins, M.P. McGarry, and R.T. Swank The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background Blood 100 2002 128 135
29. S. Tiwari, J.E. Italiano, Jr., D.C. Barral, E.H. Mules, E.K. Novak, R.T. Swank, M.C. Seabra, and R.A. Shivdasani A role for Rab27b in NF-E2-dependent pathways of platelet formation Blood 102 2003 3970 3979
30. R. Shirakawa, T. Higashi, A. Tabuchi, A. Yoshioka, H. Nishioka, M. Fukuda, T. Kita, and H. Horiuchi Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets J. Biol. Chem. 279 2004 10730 10737
31. A. Imai, S. Yoshie, T. Nashida, H. Shimomura, and M. Fukuda The small GTPase Rab27B regulates amylase release from rat parotid acinar cells J. Cell Sci. 117 2004 1945 1953
32. K. Nagashima, S. Torii, Z. Yi, M. Igarashi, K. Okamoto, T. Takeuchi, and T. Izumi Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions FEBS Lett. 517 2002 233 238
33. T.S. Kuroda, M. Fukuda, H. Ariga, and K. Mikoshiba The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain J. Biol. Chem. 277 2002 9212 9218
34. M. Fukuda, T.S. Kuroda, and K. Mikoshiba Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport J. Biol. Chem. 277 2002 12432 12436