Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury

Acta Biomaterialia

Volumn 31, Issue , 2016, Pages 50-60

  Dearth, Christopher L ^a,b,c   Slivka, Peter F ^a   Stewart, Scott A ^a   Keane, Timothy J ^a,d   Tay, Justin K ^a   Londono, Ricardo ^a,e   Goh, Qingnian ^f   Pizza, Francis X ^f   Badylak, Stephen F ^a,b,d  

^a MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

^d University of Pittsburgh   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

^f UNIVERSITY OF TOLEDO   (United States)

Author keywords

Biologic scaffold; Extracellular matrix; Extremity Trauma; Host response; Macrophage polarization; Regenerative medicine; Skeletal muscle injury

Indexed keywords

DEFECTS; MACROPHAGES; MUSCLE; RATS; REPAIR; SCAFFOLDS; SCAFFOLDS (BIOLOGY); SURGERY; TISSUE REGENERATION;

BIOLOGIC SCAFFOLD; EXTRACELLULAR MATRICES; EXTREMITY TRAUMA; HOST RESPONSE; MACROPHAGE POLARIZATION; MUSCLE INJURIES; REGENERATIVE MEDICINE; SKELETAL MUSCLE; SKELETAL MUSCLE INJURY; TISSUE REMODELING;

REGENERATIVE MEDICINE;

ACETYLSALICYLIC ACID; CD206 ANTIGEN; CELL ANTIGEN; COLLAGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PROSTAGLANDIN; UNCLASSIFIED DRUG; CD86 ANTIGEN; CELL SURFACE RECEPTOR; LECTIN; MANNOSE BINDING LECTIN; MANNOSE RECEPTOR; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PEPSIN A; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS1 PROTEIN, RAT; PTGS2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MUSCLE DEVELOPMENT; MUSCLE INJURY; MUSCLE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; TISSUE REGENERATION; TISSUE SCAFFOLD; ANIMAL; ANTAGONISTS AND INHIBITORS; BLADDER; CELL LINE; CHEMISTRY; COCULTURE; INFLAMMATION; INJURIES; METABOLISM; PHENOTYPE; PROCEDURES; REGENERATIVE MEDICINE; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; TISSUE ENGINEERING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS, CD86; ASPIRIN; CELL LINE; COCULTURE TECHNIQUES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; EXTRACELLULAR MATRIX; FEMALE; HUMANS; INFLAMMATION; LECTINS, C-TYPE; MACROPHAGES; MANNOSE-BINDING LECTINS; MEMBRANE PROTEINS; MUSCLE, SKELETAL; PEPSIN A; PHENOTYPE; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; REGENERATIVE MEDICINE; TISSUE ENGINEERING; URINARY BLADDER;

EID: 84957428417     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.11.043     Document Type: Article

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