Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise

Journal of Applied Physiology

Volumn 107, Issue 5, 2009, Pages 1600-1611

  Mikkelsen, U R ^a   Langberg, H ^a   Helmark, I C ^a   Skovgaard, D ^a   Andersen, L L ^b   Kjaer M ^a   Mackey, A L ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

Author keywords

Cyclooxygenase inhibitor; Indomethacin; Muscle damage; Myogenic precursor cells; Neural cell adhesion molecule; Pax7

Indexed keywords

CREATINE KINASE; DESMIN; INDOMETACIN; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR PAX7;

ADULT; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL DAMAGE; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; EXERCISE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATORY CELL; LEG MUSCLE; MALE; MUSCLE BIOPSY; MUSCLE CONTRACTION; MUSCLE STRENGTH; NORMAL HUMAN; PRIORITY JOURNAL; SATELLITE CELL; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL PROLIFERATION; CYTOKINES; HUMANS; INDOMETHACIN; INFUSIONS, PARENTERAL; INJECTIONS, INTRAMUSCULAR; MALE; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; PHYSICAL EXERTION; SATELLITE CELLS, SKELETAL MUSCLE; YOUNG ADULT;

EID: 72749119014     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00707.2009     Document Type: Article

References (45)

1. Alaranta A, Alaranta H, Helenius I. Use of prescription drugs in athletes. Sports Med 38: 449-463, 2008.
2. Andersen LL, Andersen JL, Magnusson SP, Suetta C, Madsen JL, Christensen LR, Aagaard P. Changes in the human muscle force-velocity relationship in response to resistance training and subsequent detraining. J Appl Physiol 99: 87-94, 2005. (Pubitemid 40934468)
3. Anderson J, Pilipowicz O. Activation of muscle satellite cells in single- fiber cultures. Nitric Oxide 7: 36-41, 2002. (Pubitemid 35007258)
4. Baldwin LA. Use of nonsteroidal anti-inflammatory drugs following exercise-induced muscle injury. Sports Med 33: 177-185, 2003. (Pubitemid 36433826)
5. Beaton LJ, Tarnopolsky MA, Phillips SM. Contraction-induced muscle damage in humans following calcium channel blocker administration. J Physiol 544: 849-859, 2002.
6. Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35: 609-616, 1975.
7. Bondesen BA, Mills ST, Kegley KM, Pavlath GK. The COX-2 pathway is essential during early stages of skeletal muscle regeneration. Am J Physiol Cell Physiol 287: C475-C483, 2004. (Pubitemid 38955239)
8. Bondesen BA, Mills ST, Pavlath GK. The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms. Am J Physiol Cell Physiol 290: C1651-C1659, 2006.
9. Boushel R, Langberg H, Gemmer C, Olesen J, Crameri R, Scheede C, Sander M, Kjaer M. Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise. J Physiol 543: 691-698, 2002. (Pubitemid 35012220)
10. Carlson BM, Faulkner JA. The regeneration of skeletal muscle fibers following injury: a review. Med Sci Sports Exerc 15: 187-198, 1983.
11. Child R, Brown S, Day S, Donnelly A, Roper H, Saxton J. Changes in indices of antioxidant status, lipid peroxidation and inflammation in human skeletal muscle after eccentric muscle actions. Clin Sci (Lond) 96: 105-115, 1999. (Pubitemid 29045871)
12. Crameri RM, Aagaard P, Qvortrup K, Langberg H, Olesen J, Kjaer M. Myofibre damage in human skeletal muscle: effects of electrical stimulation versus voluntary contraction. J Physiol 583: 365-380, 2007. (Pubitemid 47244265)
13. Crameri RM, Langberg H, Magnusson P, Jensen CH, Daa SH, Olesen JL, Suetta C, Teisner B, Kjaer M. Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise. J Physiol 558: 333-340, 2004. (Pubitemid 39077412)
14. Danish Rheumatism Association. Gigtforeningen (online). http://www.gigtforeningen.dk/ [3 September 2009].
15. Dreyer HC, Blanco CE, Sattler FR, Schroeder ET, Wiswell RA. Satellite cell numbers in young and older men 24 hours after eccentric exercise. Muscle Nerve 33: 242-253, 2006.
16. Hill M, Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol 549: 409-418, 2003. (Pubitemid 36701754)
17. Hill M, Wernig A, Goldspink G. Muscle satellite (stem) cell activation during local tissue injury and repair. J Anat 203: 89-99, 2003. (Pubitemid 36889245)
18. Horsley V, Pavlath GK. Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway. J Cell Biol 161: 111-118, 2003.
19. Hubal MJ, Chen TC, Thompson PD, Clarkson PM. Inflammatory gene changes associated with the repeated-bout effect. Am J Physiol Regul Integr Comp Physiol 294: R1628-R1637, 2008.
20. Krentz JR, Quest B, Farthing JP, Quest DW, Chilibeck PD. The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training. Appl Physiol Nutr Metab 33: 470-475, 2008.
21. Li YP. TNF-α is a mitogen in skeletal muscle. Am J Physiol Cell Physiol 285: C370-C376, 2003.
22. Lindstrom M, Thornell LE. New multiple labelling method for improved satellite cell identification in human muscle: application to a cohort of power-lifters and sedentary men. Histochem Cell Biol 132: 141-157, 2009.
23. Mackey AL, Donnelly AE, Turpeenniemi-Hujanen T, Roper HP. Skeletal muscle collagen content in humans after high-force eccentric contractions. J Appl Physiol 97: 197-203, 2004. (Pubitemid 38802520)
24. Mackey AL, Kjaer M, Charifi N, Henriksson J, Bojsen-Moller J, Holm L, Kadi F. Assessment of satellite cell number and activity status in human skeletal muscle biopsies. Muscle Nerve 40: 455-465, 2009.
25. Mackey AL, Kjaer M, Dandanell S, Mikkelsen KH, Holm L, Dossing S, Kadi F, Koskinen SO, Jensen CH, Schroder HD, Langberg H. The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans. J Appl Physiol 103: 425-431, 2007. (Pubitemid 47204959)
26. Mendias CL, Tatsumi R, Allen RE. Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. Muscle Nerve 30: 497-500, 2004. (Pubitemid 39288155)
27. Mikkelsen UR, Helmark IC, Kjaer M, Langberg H. Prostaglandin synthesis can be inhibited locally by infusion of NSAIDS through microdialysis catheters in human skeletal muscle. J Appl Physiol 104: 534-537, 2008. (Pubitemid 351231499)
28. Novak ML, Billich W, Smith SM, Sukhija KB, McLoughlin TJ, Hornberger TA, Koh TJ. COX-2 inhibitor reduces skeletal muscle hypertrophy in mice. Am J Physiol Regul Integr Comp Physiol 296: R1132-R1139, 2009.
29. O'Reilly C, McKay B, Phillips S, Tarnopolsky M, Parise G. Hepatocyte growth factor (HGF) and the satellite cell response following muscle lengthening contractions in humans. Muscle Nerve 38: 1434-1442, 2008.
30. Otis JS, Burkholder TJ, Pavlath GK. Stretch-induced myoblast proliferation is dependent on the COX2 pathway. Exp Cell Res 310: 417-425, 2005. (Pubitemid 41457344)
31. Paulsen G, Crameri R, Benestad HB, Fjeld JG, Mørkrid L, Hallén J, Raastad T. Time course of leukocyte accumulation in human muscle after eccentric exercise. Med Sci Sports Exerc. In press.
32. Paulsen G, Egner IM, Drange M, Langberg H, Benestad HB, Fjeld JG, Hallen J, Raastad T. A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. Scand J Med Sci Sports. In press.
33. Przybyla B, Gurley C, Harvey JF, Bearden E, Kortebein P, Evans WJ, Sullivan DH, Peterson CA, Dennis RA. Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. Exp Gerontol 41: 320-327, 2006.
34. Reimann J, Brimah K, Schroder R, Wernig A, Beauchamp JR, Partridge TA. Pax7 distribution in human skeletal muscle biopsies and myogenic tissue cultures. Cell Tissue Res 315: 233-242, 2004. (Pubitemid 38657430)
35. Serrano AL, Baeza-Raja B, Perdiguero E, Jardí M, Muñoz-Cánoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab 7: 33-44, 2008.
36. Shen W, Li Y, Tang Y, Cummins J, Huard J. NS-398, a cyclooxygenase- 2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am J Pathol 167: 1105-1117, 2005. (Pubitemid 41416261)
37. 2α. J Appl Physiol 101: 1215-1221, 2006.
38. Soltow QA, Betters JL, Sellman JE, Lira VA, Long JH, Criswell DS. Ibuprofen inhibits skeletal muscle hypertrophy in rats. Med Sci Sports Exerc 38: 840-846, 2006.
39. Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ. Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab 282: E551-E556, 2002. (Pubitemid 34654769)
40. Tscholl P, Feddermann N, Junge A, Dvorak J. The use and abuse of painkillers in international soccer: data from 6 FIFA tournaments for female and youth players. Am J Sports Med 37: 260-265, 2009.
41. Warner DC, Schnepf G, Barrett MS, Dian D, Swigonski NL. Prevalence, attitudes, and behaviors related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in student athletes. J Adolesc Health 30: 150-153, 2002. (Pubitemid 34175138)
42. Wozniak AC, Kong J, Bock E, Pilipowicz O, Anderson JE. Signaling satellite-cell activation in skeletal muscle: markers, models, stretch, and potential alternate pathways. Muscle Nerve 31: 283-300, 2005. (Pubitemid 40261402)
43. Yu JG, Furst DO, Thornell LE. The mode of myofibril remodelling in human skeletal muscle affected by DOMS induced by eccentric contractions. Histochem Cell Biol 119: 383-393, 2003.
44. Yu JG, Malm C, Thornell LE. Eccentric contractions leading to DOMS do not cause loss of desmin nor fibre necrosis in human muscle. Histochem Cell Biol 118: 29-34, 2002. (Pubitemid 34762316)
45. Yu JG, Thornell LE. Desmin and actin alterations in human muscles affected by delayed onset muscle soreness: a high resolution immunocytochemical study. Histochem Cell Biol 118: 171-179, 2002.