Stimulation of Cell Migration by Flagellin Through the p38 MAP Kinase Pathway in Cultured Intestinal Epithelial Cells

Journal of Cellular Biochemistry

Volumn 117, Issue 1, 2016, Pages 247-258

  Kondo, Yutaka ^a   Higa Nakamine, Sayomi ^a   Maeda, Noriko ^a   Toku, Seikichi ^a   Kakinohana, Manabu ^a   Sugahara, Kazuhiro ^a   Kukita, Ichiro ^a   Yamamoto, Hideyuki ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

FLAGELLIN; IEC 6 CELLS; INTESTINAL EPITHELIAL CELLS; MIGRATION; p38 MAPK; TLR5

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FLAGELLIN; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; CELL LINE; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; HUMAN; INTESTINE; METABOLISM; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; SIGNAL TRANSDUCTION; WOUND HEALING;

CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITHELIAL CELLS; FLAGELLIN; HUMANS; INTESTINES; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; PHOSPHORYLATION; WOUND HEALING;

EID: 84957310650     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.25272     Document Type: Article

References (31)

1. Akira S., 2003. Toll-like receptor signaling. J Biol Chem 278: 38105-38108.
2. Ahmed Haji Omar A, Korvala J, Haglund C, Virolainen S, Hayry V, Atula T, Kontio R, Rihtniemi J, Pihakari A, Sorsa T, Hagstrom J, Salo T,. 2015. Toll-like receptors -4 and -5 in oral and cutaneous squamous cell carcinomas. J Oral Pathol Med 44: 258-265.
3. Alam R, Schultz CR, Golembieski WA, Poisson LM, Rempel SA,. 2013. PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma. Neuro Oncol 15: 451-461.
4. Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL,. 2002. P38 mitogen-activated protein kinase is required for TGFb-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115: 3193-3206.
5. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P,. 1995. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J 14: 5920-5930.
6. Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R,. 2010. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 285: 20202-20212.
7. Friedl P, Wolf K, Zegers MM,. 2014. Rho-directed forces in collective migration. Nat Cell Biol 16: 208-210.
8. Harrison LM, Rallabhandi P, Michalski J, Zhou X, Steyert SR, Vogel SN, Kaper JB,. 2008. Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kB activation. Infect Immun 76: 5524-5534.
9. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A,. 2001. The innate immune response to bacteria flagellin is mediated by Toll-like receptor 5. Nature 410: 1099-1103.
10. Higa-Nakamine S, Maeda N, Toku S, Yamamoto T, Yingyuenyong M, Kawahara M, Yamamoto H,. 2012. Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons. J Cell Physiol 227: 2492-2501.
11. Huebener P, Schwabe RF,. 2013. Regulation of wound healing and organ fibrosis by toll-like receptors. Biochim Biophys Acta 1832: 1005-1017.
12. Kolosova I, Nethery D, Kern JA,. 2011. Role of Smad2/3 and p38 MAP kinase in TGF-b1-induced epithelial-mesenchymal transition of pulmonary epithelial cells. J Cell Physiol 226: 1248-1254.
13. Kondo Y, Higa-Nakamine S, Noguchi N, Maeda N, Toku S, Isohama Y, Sugahara K, Kukita I, Yamamoto H,. 2012. Induction of epithelial-mesenchymal transition by flagellin in cultured lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 303: L1057-L1069.
14. Laemmli UK., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
15. Lavoie JN, Hickey E, Weber LA, Landry J,. 1993. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J Biol Chem 268: 24210-24214.
16. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, Fort M, Hershberg RM,. 2004. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 113: 1296-1306.
17. Miron T, Vancompernolle K, Vandekerckhove J, Wilchek M, Geiger B,. 1991. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol 114: 255-261.
18. Mizutani A, Maeda N, Toku S, Isohama Y, Sugahara K, Yamamoto H,. 2010. Inhibition by ethyl pyruvate of the nuclear translocation of nuclear factor-kB in cultured lung epithelial cells. Pulm Pharmacol Ther 23: 308-315.
19. Newton HJ, Ang DK, van Driel IR, Hartland EL,. 2010. Molecular pathogenesis of infections caused by Legionella pneumophila. Clin Microbiol Rev 23: 274-298.
20. Nishi H, Maeda N, Izumi S, Higa-Nakamine S, Toku S, Kakinohana M, Sugahara K, Yamamoto H,. 2015. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. Eur J Pharmacol 748: 133-142.
21. Noguchi N, Kondo Y, Maeda N, Higa-Nakamine S, Toku S, Maruyama J, Isohama Y, Kukita I, Sugahara K, Yamamoto H,. 2013. Phosphorylation of epidermal growth factor receptor at serine 1047 by MAP kinase-activated protein kinase-2 in cultured lung epithelial cells treated with flagellin. Arch Biochem Biophys 529: 75-85.
22. Park J-H, Yoon H-F, Kim D-J, Kim S-A, Ahn S-G, Yoon J-H,. 2011. Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma. J Oral Pathol Med 40: 187-193.
23. Rolli J, Loukili N, Levrand S, Rosenblatt-Velin N, Rignault-Clerc S, Waeber B, Feihl F, Pacher P, Liaudet L,. 2010. Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice. Crit Care 14: R160.
24. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR,. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78: 1027-1037.
25. Rousseau S, Dolado I, Beardmore V, Shpiro N, Marqez R, Nebreda AR, Arthur JSC, Case LM, Tessier-Lavigne M, Gaestel M, Cuenda A, Cohen P,. 2006. CXCL12 and C5a trigger cell migration via a PAK1/2-p38a MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal 18: 1897-1905.
26. Sierro F, Dubois B, Coste A, Kaiserlian D, Kraehenbuhl JP, Sirard JC,. 2001. Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci USA 98: 21-30.
27. Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A,. 2003. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nature Immun 4: 1247-1253.
28. Sun J, Fegan PE, Desai AS, Madara JL, Hobert ME,. 2007. Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 292: G767-G778.
29. Towbin H, Staehelin T, Gordon J,. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.
30. Yamanaka A, Hiragami Y, Maeda N, Toku S, Kawahara M, Naito Y, Yamamoto H,. 2007. Involvement of CaM kinase II in gonadotropin-releasing hormone-induced activation of MAP kinase in cultured hypothalamic neurons. Arch Biochem Biophys 466: 234-241.
31. Zeng H, Wu H, Sloane V, Jones R, Yu Y, Lin P, Gewirtz AT, Neish AS,. 2006. Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol 290: G96-G108.