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Volumn 64, Issue 4, 2016, Pages 785-791

Betulinic Acid Increases eNOS Phosphorylation and NO Synthesis via the Calcium-Signaling Pathway

Author keywords

AMPK; betulinic acid; CaMKII; CaMKK; eNOS

Indexed keywords

BARIUM COMPOUNDS; ENDOTHELIAL CELLS; ENZYME ACTIVITY; ENZYMES; NITRIC OXIDE; PHOSPHORYLATION; PIGMENTS; PROTEINS;

EID: 84957077396     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b05416     Document Type: Article
Times cited : (26)

References (41)
  • 1
    • 0025993736 scopus 로고
    • Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis
    • Zeiher, A. M.; Drexler, H.; Wollschlager, H.; Just, H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis Circulation 1991, 84, 1984-1992 10.1161/01.CIR.84.5.1984
    • (1991) Circulation , vol.84 , pp. 1984-1992
    • Zeiher, A.M.1    Drexler, H.2    Wollschlager, H.3    Just, H.4
  • 2
    • 0028092958 scopus 로고
    • Nitric oxide synthases: Roles, tolls, and controls
    • Nathan, C.; Xie, Q. W. Nitric oxide synthases: roles, tolls, and controls Cell 1994, 78, 915-918 10.1016/0092-8674(94)90266-6
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 3
    • 0342723791 scopus 로고    scopus 로고
    • Nitric oxide in the pathogenesis of vascular disease
    • Li, H.; Forstermann, U. Nitric oxide in the pathogenesis of vascular disease J. Pathol. 2000, 190, 244-254 10.1002/(SICI)1096-9896(200002)190:3<244::AID-PATH575>3.0.CO;2-8
    • (2000) J. Pathol. , vol.190 , pp. 244-254
    • Li, H.1    Forstermann, U.2
  • 4
    • 84948172078 scopus 로고    scopus 로고
    • Vascular nitric oxide: Beyond eNOS
    • Zhao, Y.; Vanhoutte, P. M.; Leung, S. W. Vascular nitric oxide: beyond eNOS J. Pharmacol. Sci. 2015, 129, 83-94 10.1016/j.jphs.2015.09.002
    • (2015) J. Pharmacol. Sci. , vol.129 , pp. 83-94
    • Zhao, Y.1    Vanhoutte, P.M.2    Leung, S.W.3
  • 5
    • 0025296139 scopus 로고
    • Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin
    • Busse, R.; Mulsch, A. Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin FEBS Lett. 1990, 265, 133-136 10.1016/0014-5793(90)80902-U
    • (1990) FEBS Lett. , vol.265 , pp. 133-136
    • Busse, R.1    Mulsch, A.2
  • 6
    • 0028011459 scopus 로고
    • Thapsigargin, a Ca(2+)-ATPase inhibitor, relaxes rat aorta via nitric oxide formation
    • Moritoki, H.; Hisayama, T.; Kondoh, W.; Takeuchi, S. Thapsigargin, a Ca(2+)-ATPase inhibitor, relaxes rat aorta via nitric oxide formation Life Sci. 1994, 54, PL153-PL158 10.1016/0024-3205(94)00875-2
    • (1994) Life Sci. , vol.54 , pp. PL153-PL158
    • Moritoki, H.1    Hisayama, T.2    Kondoh, W.3    Takeuchi, S.4
  • 8
    • 0041355355 scopus 로고    scopus 로고
    • Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells
    • Morrow, V. A.; Foufelle, F.; Connell, J. M.; Petrie, J. R.; Gould, G. W.; Salt, I. P. Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells J. Biol. Chem. 2003, 278, 31629-31639 10.1074/jbc.M212831200
    • (2003) J. Biol. Chem. , vol.278 , pp. 31629-31639
    • Morrow, V.A.1    Foufelle, F.2    Connell, J.M.3    Petrie, J.R.4    Gould, G.W.5    Salt, I.P.6
  • 10
    • 84871455879 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Implications on ischemic diseases
    • Ahn, Y. J.; Kim, H.; Lim, H.; Lee, M.; Kang, Y.; Moon, S.; Kim, H. S.; Kim, H. H. AMP-activated protein kinase: implications on ischemic diseases BMB Rep. 2012, 45, 489-495 10.5483/BMBRep.2012.45.9.169
    • (2012) BMB Rep. , vol.45 , pp. 489-495
    • Ahn, Y.J.1    Kim, H.2    Lim, H.3    Lee, M.4    Kang, Y.5    Moon, S.6    Kim, H.S.7    Kim, H.H.8
  • 11
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    • Hawley, S. A.; Pan, D. A.; Mustard, K. J.; Ross, L.; Bain, J.; Edelman, A. M.; Frenguelli, B. G.; Hardie, D. G. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase Cell Metab. 2005, 2, 9-19 10.1016/j.cmet.2005.05.009
    • (2005) Cell Metab. , vol.2 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 12
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw, R. J.; Kosmatka, M.; Bardeesy, N.; Hurley, R. L.; Witters, L. A.; DePinho, R. A.; Cantley, L. C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 3329-3335 10.1073/pnas.0308061100
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 14
    • 0029582676 scopus 로고
    • Antibacterial triterpenoids from Dillenia papuana and their structure-activity relationships
    • Nick, A.; Wright, A. D.; Rali, T.; Sticher, O. Antibacterial triterpenoids from Dillenia papuana and their structure-activity relationships Phytochemistry 1995, 40, 1691-1695 10.1016/0031-9422(95)00491-O
    • (1995) Phytochemistry , vol.40 , pp. 1691-1695
    • Nick, A.1    Wright, A.D.2    Rali, T.3    Sticher, O.4
  • 15
    • 0343565453 scopus 로고    scopus 로고
    • New triterpenoids with antibacterial activity from Zizyphus joazeiro
    • Schuhly, W.; Heilmann, J.; Calis, I.; Sticher, O. New triterpenoids with antibacterial activity from Zizyphus joazeiro Planta Med. 1999, 65, 740-743 10.1055/s-1999-14054
    • (1999) Planta Med. , vol.65 , pp. 740-743
    • Schuhly, W.1    Heilmann, J.2    Calis, I.3    Sticher, O.4
  • 16
    • 84859210571 scopus 로고    scopus 로고
    • Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in rats
    • Nader, M. A.; Baraka, H. N. Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in rats Eur. J. Pharm. Sci. 2012, 46, 106-113 10.1016/j.ejps.2012.02.015
    • (2012) Eur. J. Pharm. Sci. , vol.46 , pp. 106-113
    • Nader, M.A.1    Baraka, H.N.2
  • 18
    • 84873738624 scopus 로고    scopus 로고
    • Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: Possible role for inhibition of deubiquitinase activity
    • Reiner, T.; Parrondo, R.; de Las Pozas, A.; Palenzuela, D.; Perez-Stable, C. Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity PLoS One 2013, 8, e56234 10.1371/journal.pone.0056234
    • (2013) PLoS One , vol.8 , pp. e56234
    • Reiner, T.1    Parrondo, R.2    De Las Pozas, A.3    Palenzuela, D.4    Perez-Stable, C.5
  • 21
    • 0025291446 scopus 로고
    • Ecological aspects of four species of ticks found on cattle in Salta, northwest Argentina
    • Guglielmone, A. A.; Mangold, A. J.; Aguirre, D. H.; Gaido, A. B. Ecological aspects of four species of ticks found on cattle in Salta, northwest Argentina Vet. Parasitol. 1990, 35, 93-101 10.1016/0304-4017(90)90119-V
    • (1990) Vet. Parasitol. , vol.35 , pp. 93-101
    • Guglielmone, A.A.1    Mangold, A.J.2    Aguirre, D.H.3    Gaido, A.B.4
  • 22
    • 84892736281 scopus 로고    scopus 로고
    • Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production
    • Kim, S. J.; Quan, H. Y.; Jeong, K. J.; Kim do, Y.; Kim, G.; Jo, H. K.; Chung, S. H. Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production J. Agric. Food Chem. 2014, 62, 434-442 10.1021/jf4030739
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 434-442
    • Kim, S.J.1    Quan, H.Y.2    Jeong, K.J.3    Kim Do, Y.4    Kim, G.5    Jo, H.K.6    Chung, S.H.7
  • 26
    • 80053900695 scopus 로고    scopus 로고
    • Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress
    • Fu, J. Y.; Qian, L. B.; Zhu, L. G.; Liang, H. T.; Tan, Y. N.; Lu, H. T.; Lu, J. F.; Wang, H. P.; Xia, Q. Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress Eur. J. Pharm. Sci. 2011, 44, 385-391 10.1016/j.ejps.2011.08.025
    • (2011) Eur. J. Pharm. Sci. , vol.44 , pp. 385-391
    • Fu, J.Y.1    Qian, L.B.2    Zhu, L.G.3    Liang, H.T.4    Tan, Y.N.5    Lu, H.T.6    Lu, J.F.7    Wang, H.P.8    Xia, Q.9
  • 28
    • 34547096987 scopus 로고    scopus 로고
    • Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells
    • Steinkamp-Fenske, K.; Bollinger, L.; Xu, H.; Yao, Y.; Horke, S.; Förstermann, U.; Li, H. Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells J. Pharmacol. Exp. Ther. 2007, 322, 836-842 10.1124/jpet.107.123356
    • (2007) J. Pharmacol. Exp. Ther. , vol.322 , pp. 836-842
    • Steinkamp-Fenske, K.1    Bollinger, L.2    Xu, H.3    Yao, Y.4    Horke, S.5    Förstermann, U.6    Li, H.7
  • 29
    • 33746581658 scopus 로고    scopus 로고
    • Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium
    • Formoso, G.; Chen, H.; Kim, J. A.; Montagnani, M.; Consoli, A.; Quon, M. J. Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium Mol. Endocrinol. 2006, 20, 1153-1163 10.1210/me.2005-0266
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1153-1163
    • Formoso, G.1    Chen, H.2    Kim, J.A.3    Montagnani, M.4    Consoli, A.5    Quon, M.J.6
  • 30
    • 77951184302 scopus 로고    scopus 로고
    • Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis
    • Gavet, O.; Pines, J. Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis Dev. Cell 2010, 18, 533-543 10.1016/j.devcel.2010.02.013
    • (2010) Dev. Cell , vol.18 , pp. 533-543
    • Gavet, O.1    Pines, J.2
  • 31
    • 33846392950 scopus 로고    scopus 로고
    • Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    • Mount, P. F.; Kemp, B. E.; Power, D. A. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation J. Mol. Cell. Cardiol. 2007, 42, 271-279 10.1016/j.yjmcc.2006.05.023
    • (2007) J. Mol. Cell. Cardiol. , vol.42 , pp. 271-279
    • Mount, P.F.1    Kemp, B.E.2    Power, D.A.3
  • 34
    • 0034789020 scopus 로고    scopus 로고
    • Ion channels and their functional role in vascular endothelium
    • Nilius, B.; Droogmans, G. Ion channels and their functional role in vascular endothelium Physiol. Rev. 2001, 81, 1415-1459
    • (2001) Physiol. Rev. , vol.81 , pp. 1415-1459
    • Nilius, B.1    Droogmans, G.2
  • 35
    • 70549098238 scopus 로고    scopus 로고
    • Vascular and cellular calcium in normal and hypertensive pregnancy
    • Adamova, Z.; Ozkan, S.; Khalil, R. A. Vascular and cellular calcium in normal and hypertensive pregnancy Curr. Clin. Pharmacol. 2009, 4, 172-190 10.2174/157488409789375320
    • (2009) Curr. Clin. Pharmacol. , vol.4 , pp. 172-190
    • Adamova, Z.1    Ozkan, S.2    Khalil, R.A.3
  • 36
    • 79953254567 scopus 로고    scopus 로고
    • Calcium dynamics and signaling in vascular regulation: Computational models
    • Tsoukias, N. M. Calcium dynamics and signaling in vascular regulation: computational models Wiley Interdiscip. Rev.-Syst. Biol. 2011, 3, 93-106 10.1002/wsbm.97
    • (2011) Wiley Interdiscip. Rev.-Syst. Biol. , vol.3 , pp. 93-106
    • Tsoukias, N.M.1
  • 38
    • 84939970590 scopus 로고    scopus 로고
    • Cardioprotective effects of luteolin on ischemia/reperfusion injury in diabetic rats are modulated by eNOS and the mitochondrial permeability transition pathway
    • Yang, J. T.; Qian, L. B.; Zhang, F. J.; Wang, J.; Ai, H.; Tang, L. H.; Wang, H. P. Cardioprotective effects of luteolin on ischemia/reperfusion injury in diabetic rats are modulated by eNOS and the mitochondrial permeability transition pathway J. Cardiovasc. Pharmacol. 2015, 65, 349-356 10.1097/FJC.0000000000000202
    • (2015) J. Cardiovasc. Pharmacol. , vol.65 , pp. 349-356
    • Yang, J.T.1    Qian, L.B.2    Zhang, F.J.3    Wang, J.4    Ai, H.5    Tang, L.H.6    Wang, H.P.7
  • 39
    • 0036276672 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase activity and gene expression
    • Wu, K. K. Regulation of endothelial nitric oxide synthase activity and gene expression Ann. N. Y. Acad. Sci. 2002, 962, 122-130 10.1111/j.1749-6632.2002.tb04062.x
    • (2002) Ann. N. Y. Acad. Sci. , vol.962 , pp. 122-130
    • Wu, K.K.1
  • 41
    • 84875700893 scopus 로고    scopus 로고
    • Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway
    • Quan, H. Y.; Kim do, Y.; Kim, S. J.; Jo, H. K.; Kim, G. W.; Chung, S. H. Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway Biochem. Pharmacol. 2013, 85, 1330-1340 10.1016/j.bcp.2013.02.007
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1330-1340
    • Quan, H.Y.1    Kim Do, Y.2    Kim, S.J.3    Jo, H.K.4    Kim, G.W.5    Chung, S.H.6


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