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Volumn 60, Issue 28, 2012, Pages 6977-6983

Exploration of the antiplatelet activity profile of betulinic acid on human platelets

Author keywords

ADP; antithrombotics; betulinic acid; platelet aggregation

Indexed keywords

ACTIVATED PLATELETS; ADENOSINE DIPHOSPHATE; ANTI-INFLAMMATORY ACTIVITY; ANTI-PLATELET ACTIVITIES; ANTIRETROVIRALS; ANTITHROMBOTIC; ANTITHROMBOTICS; ARACHIDONIC ACIDS; BETULINIC ACID; BIOLOGICAL ACTIONS; CARBOXYLATE GROUPS; FLOW-CYTOMETRIC ANALYSIS; IN-VITRO; P-SELECTIN; PHARMACOPHORES; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGONISTS; THROMBIN RECEPTORS; TRITERPENES;

EID: 84863965376     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3006728     Document Type: Article
Times cited : (28)

References (43)
  • 2
    • 33645283921 scopus 로고    scopus 로고
    • Platelets in the onset of atherosclerosis
    • Gawaz, M. Platelets in the onset of atherosclerosis Blood Cells Mol. Dis. 2006, 36 (2) 206-210
    • (2006) Blood Cells Mol. Dis. , vol.36 , Issue.2 , pp. 206-210
    • Gawaz, M.1
  • 3
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman, D. J.; Cragg, G. M.; Snader, K. M. Natural products as sources of new drugs over the period 1981-2002 J. Nat. Prod. 2003, 66 (7) 1022-1037
    • (2003) J. Nat. Prod. , vol.66 , Issue.7 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 4
    • 44949134801 scopus 로고    scopus 로고
    • The impact of natural products upon modern drug discovery
    • Ganesan, A. The impact of natural products upon modern drug discovery Curr. Opin. Chem. Biol. 2008, 12 (3) 306-317
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , Issue.3 , pp. 306-317
    • Ganesan, A.1
  • 5
    • 72949101438 scopus 로고    scopus 로고
    • Structure and organization of drug-target networks: Insights from genomic approaches for drug discovery
    • Janga, S. C.; Tzakos, A. Structure and organization of drug-target networks: insights from genomic approaches for drug discovery Mol. Biosyst. 2009, 5 (12) 1536-1548
    • (2009) Mol. Biosyst. , vol.5 , Issue.12 , pp. 1536-1548
    • Janga, S.C.1    Tzakos, A.2
  • 7
    • 84872684431 scopus 로고    scopus 로고
    • Phytochemical composition of "mountain tea" from Sideritis clandestina subsp. clandestina and evaluation of its behavioral and oxidant/antioxidant effects on adult mice
    • DOI: 10.1007/s00394-011-0292-2.
    • Vasilopoulou, C. G.; Kontogianni, V. G.; Linardaki, Z. I.; Iatrou, G.; Lamari, F. N.; Nerantzaki, A. A.; Gerothanassis, I. P.; Tzakos, A. G.; Margarity, M. Phytochemical composition of "mountain tea" from Sideritis clandestina subsp. clandestina and evaluation of its behavioral and oxidant/antioxidant effects on adult mice. Eur. J. Nutr. 2011, DOI: 10.1007/s00394-011-0292-2.
    • (2011) Eur. J. Nutr.
    • Vasilopoulou, C.G.1    Kontogianni, V.G.2    Linardaki, Z.I.3    Iatrou, G.4    Lamari, F.N.5    Nerantzaki, A.A.6    Gerothanassis, I.P.7    Tzakos, A.G.8    Margarity, M.9
  • 8
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D. J.; Cragg, G. M. Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 2007, 70 (3) 461-477
    • (2007) J. Nat. Prod. , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 9
    • 70349504155 scopus 로고    scopus 로고
    • Comparison of quercetin and dihydroquercetin: Antioxidant-independent actions on erythrocyte and platelet membrane
    • Chen, Y.; Deuster, P. Comparison of quercetin and dihydroquercetin: antioxidant-independent actions on erythrocyte and platelet membrane Chem.-Biol. Interact. 2009, 182 (1) 7-12
    • (2009) Chem.-Biol. Interact. , vol.182 , Issue.1 , pp. 7-12
    • Chen, Y.1    Deuster, P.2
  • 10
    • 34648837869 scopus 로고    scopus 로고
    • Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-γ2 phosphorylation and cyclooxygenase-1 activity
    • Jin, Y. R.; Han, X. H.; Zhang, Y. H.; Lee, J. J.; Lim, Y.; Chung, J. H.; Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-γ2 phosphorylation and cyclooxygenase-1 activity Atherosclerosis 2007, 194 (1) 144-152
    • (2007) Atherosclerosis , vol.194 , Issue.1 , pp. 144-152
    • Jin, Y.R.1    Han, X.H.2    Zhang, Y.H.3    Lee, J.J.4    Lim, Y.5    Chung, J.H.6    Yun, Y.P.7
  • 11
    • 27144452018 scopus 로고    scopus 로고
    • Induction of central signalling pathways and select functional effects in human platelets by β-boswellic acid
    • Poeckel, D.; Tausch, L.; Altmann, A.; Feisst, C.; Klinkhardt, U.; Graff, J.; Harder, S.; Werz, O. Induction of central signalling pathways and select functional effects in human platelets by β-boswellic acid Br. J. Pharmacol. 2005, 146 (4) 514-524
    • (2005) Br. J. Pharmacol. , vol.146 , Issue.4 , pp. 514-524
    • Poeckel, D.1    Tausch, L.2    Altmann, A.3    Feisst, C.4    Klinkhardt, U.5    Graff, J.6    Harder, S.7    Werz, O.8
  • 12
    • 67649836518 scopus 로고    scopus 로고
    • Pentacyclic triterpene distribution in various plants - Rich sources for a new group of multi-potent plant extracts
    • Jager, S.; Trojan, H.; Kopp, T.; Laszczyk, M. N.; Scheffler, A. Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts Molecules 2009, 14 (6) 2016-2031
    • (2009) Molecules , vol.14 , Issue.6 , pp. 2016-2031
    • Jager, S.1    Trojan, H.2    Kopp, T.3    Laszczyk, M.N.4    Scheffler, A.5
  • 14
    • 77954176611 scopus 로고    scopus 로고
    • Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma
    • Eichenmuller, M.; Hemmerlein, B.; von Schweinitz, D.; Kappler, R. Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma Br. J. Cancer 2010, 103 (1) 43-51
    • (2010) Br. J. Cancer , vol.103 , Issue.1 , pp. 43-51
    • Eichenmuller, M.1    Hemmerlein, B.2    Von Schweinitz, D.3    Kappler, R.4
  • 15
    • 34247526984 scopus 로고    scopus 로고
    • Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
    • Liby, K. T.; Yore, M. M.; Sporn, M. B. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer Nat. Rev. Cancer 2007, 7 (5) 357-369
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.5 , pp. 357-369
    • Liby, K.T.1    Yore, M.M.2    Sporn, M.B.3
  • 17
    • 0036327903 scopus 로고    scopus 로고
    • Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: Identification of the inhibitory step, the major functional group responsible and development of more potent derivatives
    • Chowdhury, A. R.; Mandal, S.; Mittra, B.; Sharma, S.; Mukhopadhyay, S.; Majumder, H. K. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives Med. Sci. Monit. 2002, 8 (7) BR254-BR265
    • (2002) Med. Sci. Monit. , vol.8 , Issue.7
    • Chowdhury, A.R.1    Mandal, S.2    Mittra, B.3    Sharma, S.4    Mukhopadhyay, S.5    Majumder, H.K.6
  • 18
    • 34047261665 scopus 로고    scopus 로고
    • Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    • Chintharlapalli, S.; Papineni, S.; Ramaiah, S. K.; Safe, S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors Cancer Res. 2007, 67 (6) 2816-2823
    • (2007) Cancer Res. , vol.67 , Issue.6 , pp. 2816-2823
    • Chintharlapalli, S.1    Papineni, S.2    Ramaiah, S.K.3    Safe, S.4
  • 19
    • 58149357667 scopus 로고    scopus 로고
    • Betulinic acid: A natural product with anticancer activity
    • Fulda, S. Betulinic acid: a natural product with anticancer activity Mol. Nutr. Food Res. 2009, 53 (1) 140-146
    • (2009) Mol. Nutr. Food Res. , vol.53 , Issue.1 , pp. 140-146
    • Fulda, S.1
  • 20
    • 0042834196 scopus 로고    scopus 로고
    • Betulinic acid suppresses carcinogen-induced NF-κB activation through inhibition of i κb α kinase and p65 phosphorylation: Abrogation of cyclooxygenase-2 and matrix metalloprotease-9
    • Takada, Y.; Aggarwal, B. B. Betulinic acid suppresses carcinogen-induced NF-κB activation through inhibition of I κB α kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9 J. Immunol. 2003, 171 (6) 3278-3286
    • (2003) J. Immunol. , vol.171 , Issue.6 , pp. 3278-3286
    • Takada, Y.1    Aggarwal, B.B.2
  • 21
    • 79951984775 scopus 로고    scopus 로고
    • Betulinic acid inhibits endotoxin stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells
    • Vijayan, V.; Antony, H.; Varma, R. L. Betulinic acid inhibits endotoxin stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells Br. J. Pharmacol. 2011, 162, 1291-1303
    • (2011) Br. J. Pharmacol. , vol.162 , pp. 1291-1303
    • Vijayan, V.1    Antony, H.2    Varma, R.L.3
  • 24
    • 84874933500 scopus 로고    scopus 로고
    • http://www.chemaxon.com/.
  • 28
    • 33747808268 scopus 로고    scopus 로고
    • Investigation of the role of adjacent amino acids to the 313-320 sequence of the αiIb subunit on platelet activation and fibrinogen binding to αiIbβ3
    • Mitsios, J. V.; Stamos, G.; Rodis, F. I.; Tsironis, L. D.; Stanica, M. R.; Sakarellos, C.; Tsoukatos, D.; Tsikaris, V.; Tselepis, A. D. Investigation of the role of adjacent amino acids to the 313-320 sequence of the αIIb subunit on platelet activation and fibrinogen binding to αIIbβ3 Platelets 2006, 17 (5) 277-282
    • (2006) Platelets , vol.17 , Issue.5 , pp. 277-282
    • Mitsios, J.V.1    Stamos, G.2    Rodis, F.I.3    Tsironis, L.D.4    Stanica, M.R.5    Sakarellos, C.6    Tsoukatos, D.7    Tsikaris, V.8    Tselepis, A.D.9
  • 29
    • 73649148682 scopus 로고    scopus 로고
    • Inhibition of platelet activation by peptide analogs of the β(3)-intracellular domain of platelet integrin α(IIb)β(3) conjugated to the cell-penetrating peptide Tat(48-60)
    • Dimitriou, A. A.; Stathopoulos, P.; Mitsios, J. V.; Sakarellos- Daitsiotis, M.; Goudevenos, J.; Tsikaris, V.; Tselepis, A. D. Inhibition of platelet activation by peptide analogs of the β(3)-intracellular domain of platelet integrin α(IIb)β(3) conjugated to the cell-penetrating peptide Tat(48-60) Platelets 2009, 20 (8) 539-547
    • (2009) Platelets , vol.20 , Issue.8 , pp. 539-547
    • Dimitriou, A.A.1    Stathopoulos, P.2    Mitsios, J.V.3    Sakarellos-Daitsiotis, M.4    Goudevenos, J.5    Tsikaris, V.6    Tselepis, A.D.7
  • 31
    • 33846118743 scopus 로고    scopus 로고
    • Platelets as immune cells: Bridging inflammation and cardiovascular disease
    • von Hundelshausen, P.; Weber, C. Platelets as immune cells: bridging inflammation and cardiovascular disease Circ. Res. 2007, 100 (1) 27-40
    • (2007) Circ. Res. , vol.100 , Issue.1 , pp. 27-40
    • Von Hundelshausen, P.1    Weber, C.2
  • 32
    • 0028228508 scopus 로고
    • CDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla
    • Namba, T.; Oida, H.; Sugimoto, Y.; Kakizuka, A.; Negishi, M.; Ichikawa, A.; Narumiya, S. cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla J. Biol. Chem. 1994, 269 (13) 9986-9992
    • (1994) J. Biol. Chem. , vol.269 , Issue.13 , pp. 9986-9992
    • Namba, T.1    Oida, H.2    Sugimoto, Y.3    Kakizuka, A.4    Negishi, M.5    Ichikawa, A.6    Narumiya, S.7
  • 33
    • 0036840566 scopus 로고    scopus 로고
    • Pharmacophore definition and three-dimensional quantitative structure-activity relationship study on structurally diverse prostacyclin receptor agonists
    • Stoll, F.; Liesener, S.; Hohlfeld, T.; Schror, K.; Fuchs, P. L.; Holtje, H. D. Pharmacophore definition and three-dimensional quantitative structure-activity relationship study on structurally diverse prostacyclin receptor agonists Mol. Pharmacol. 2002, 62 (5) 1103-1111
    • (2002) Mol. Pharmacol. , vol.62 , Issue.5 , pp. 1103-1111
    • Stoll, F.1    Liesener, S.2    Hohlfeld, T.3    Schror, K.4    Fuchs, P.L.5    Holtje, H.D.6
  • 34
    • 0037423211 scopus 로고    scopus 로고
    • The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling
    • Stitham, J.; Stojanovic, A.; Merenick, B. L.; O'Hara, K. A.; Hwa, J. The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling J. Biol. Chem. 2003, 278 (6) 4250-4257
    • (2003) J. Biol. Chem. , vol.278 , Issue.6 , pp. 4250-4257
    • Stitham, J.1    Stojanovic, A.2    Merenick, B.L.3    O'Hara, K.A.4    Hwa, J.5
  • 35
    • 0024166556 scopus 로고
    • The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation
    • Sturzebecher, S.; Witt, W. The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation Prostaglandins 1988, 36 (6) 751-760
    • (1988) Prostaglandins , vol.36 , Issue.6 , pp. 751-760
    • Sturzebecher, S.1    Witt, W.2
  • 36
    • 77954791521 scopus 로고    scopus 로고
    • The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function
    • Iyu, D.; Glenn, J. R.; White, A. E.; Johnson, A. J.; Fox, S. C.; Heptinstall, S. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function Platelets 2010, 21 (5) 329-342
    • (2010) Platelets , vol.21 , Issue.5 , pp. 329-342
    • Iyu, D.1    Glenn, J.R.2    White, A.E.3    Johnson, A.J.4    Fox, S.C.5    Heptinstall, S.6
  • 37
    • 80052214031 scopus 로고    scopus 로고
    • P2Y(1)(2) and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP
    • Iyu, D.; Glenn, J. R.; White, A. E.; Fox, S. C.; Dovlatova, N.; Heptinstall, S. P2Y(1)(2) and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP Platelets 2011, 22 (7) 504-515
    • (2011) Platelets , vol.22 , Issue.7 , pp. 504-515
    • Iyu, D.1    Glenn, J.R.2    White, A.E.3    Fox, S.C.4    Dovlatova, N.5    Heptinstall, S.6
  • 39
    • 0033556625 scopus 로고    scopus 로고
    • Increased platelet sensitivity toward platelet inhibitors during physical exercise in patients with coronary artery disease
    • Lindemann, S.; Klingel, B.; Fisch, A.; Meyer, J.; Darius, H. Increased platelet sensitivity toward platelet inhibitors during physical exercise in patients with coronary artery disease Thromb. Res. 1999, 93 (2) 51-59
    • (1999) Thromb. Res. , vol.93 , Issue.2 , pp. 51-59
    • Lindemann, S.1    Klingel, B.2    Fisch, A.3    Meyer, J.4    Darius, H.5
  • 40
    • 0034727708 scopus 로고    scopus 로고
    • Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy
    • Sakamaki, F.; Kyotani, S.; Nagaya, N.; Sato, N.; Oya, H.; Satoh, T.; Nakanishi, N. Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy Circulation 2000, 102 (22) 2720-2725
    • (2000) Circulation , vol.102 , Issue.22 , pp. 2720-2725
    • Sakamaki, F.1    Kyotani, S.2    Nagaya, N.3    Sato, N.4    Oya, H.5    Satoh, T.6    Nakanishi, N.7


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