-
1
-
-
78649361823
-
Beta-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and beta-amyloid accumulation
-
Cai Y., Xiong K., Zhang X.M., Cai H., Luo X.G., Feng J.C., Clough R.W., Struble R.G., Patrylo P.R., Chu Y., Kordower J.H., Yan X.X. beta-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and beta-amyloid accumulation. Eur. J. Neurosci. 2010, 32:1223-1238.
-
(2010)
Eur. J. Neurosci.
, vol.32
, pp. 1223-1238
-
-
Cai, Y.1
Xiong, K.2
Zhang, X.M.3
Cai, H.4
Luo, X.G.5
Feng, J.C.6
Clough, R.W.7
Struble, R.G.8
Patrylo, P.R.9
Chu, Y.10
Kordower, J.H.11
Yan, X.X.12
-
2
-
-
84875975993
-
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss
-
Cohen R.M., Rezai-Zadeh K., Weitz T.M., Rentsendorj A., Gate D., Spivak I., Bholat Y., Vasilevko V., Glabe C.G., Breunig J.J., Rakic P., Davtyan H., Agadjanyan M.G., Kepe V., Barrio J.R., Bannykh S., Szekely C.A., Pechnick R.N., Town T. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss. J. Neurosci. 2013, 33:6245-6256.
-
(2013)
J. Neurosci.
, vol.33
, pp. 6245-6256
-
-
Cohen, R.M.1
Rezai-Zadeh, K.2
Weitz, T.M.3
Rentsendorj, A.4
Gate, D.5
Spivak, I.6
Bholat, Y.7
Vasilevko, V.8
Glabe, C.G.9
Breunig, J.J.10
Rakic, P.11
Davtyan, H.12
Agadjanyan, M.G.13
Kepe, V.14
Barrio, J.R.15
Bannykh, S.16
Szekely, C.A.17
Pechnick, R.N.18
Town, T.19
-
3
-
-
84903947419
-
Alzheimer's disease drug-development pipeline: few candidates, frequent failures
-
Cummings J.L., Morstorf T., Zhong K. Alzheimer's disease drug-development pipeline: few candidates, frequent failures. Alzheimer's Res. Ther. 2014, 6:37.
-
(2014)
Alzheimer's Res. Ther.
, vol.6
, pp. 37
-
-
Cummings, J.L.1
Morstorf, T.2
Zhong, K.3
-
4
-
-
82355192272
-
The Abeta oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease
-
Ferreira S.T., Klein W.L. The Abeta oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiol. Learn. Mem. 2011, 96:529-543.
-
(2011)
Neurobiol. Learn. Mem.
, vol.96
, pp. 529-543
-
-
Ferreira, S.T.1
Klein, W.L.2
-
5
-
-
84922036803
-
Alzheimer's disease-like pathology induced by amyloid-beta oligomers in nonhuman primates
-
Forny-Germano L., Lyra e Silva N.M., Batista A.F., Brito-Moreira J., Gralle M., Boehnke S.E., Coe B.C., Lablans A., Marques S.A., Martinez A.M., Klein W.L., Houzel J.C., Ferreira S.T., Munoz D.P., De Felice F.G. Alzheimer's disease-like pathology induced by amyloid-beta oligomers in nonhuman primates. J. Neurosci. 2014, 34:13629-13643.
-
(2014)
J. Neurosci.
, vol.34
, pp. 13629-13643
-
-
Forny-Germano, L.1
Lyra e Silva, N.M.2
Batista, A.F.3
Brito-Moreira, J.4
Gralle, M.5
Boehnke, S.E.6
Coe, B.C.7
Lablans, A.8
Marques, S.A.9
Martinez, A.M.10
Klein, W.L.11
Houzel, J.C.12
Ferreira, S.T.13
Munoz, D.P.14
De Felice, F.G.15
-
6
-
-
0031824782
-
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
-
Geula C., Wu C.K., Saroff D., Lorenzo A., Yuan M., Yankner B.A. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat. Med. 1998, 4:827-831.
-
(1998)
Nat. Med.
, vol.4
, pp. 827-831
-
-
Geula, C.1
Wu, C.K.2
Saroff, D.3
Lorenzo, A.4
Yuan, M.5
Yankner, B.A.6
-
7
-
-
33750705653
-
A century of Alzheimer's disease
-
Goedert M., Spillantini M.G. A century of Alzheimer's disease. Science 2006, 314:777-781.
-
(2006)
Science
, vol.314
, pp. 777-781
-
-
Goedert, M.1
Spillantini, M.G.2
-
8
-
-
45749151056
-
Animal models of Alzheimer's disease and frontotemporal dementia
-
Gotz J., Ittner L.M. Animal models of Alzheimer's disease and frontotemporal dementia. Nat. Rev. Neurosci. 2008, 9:532-544.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 532-544
-
-
Gotz, J.1
Ittner, L.M.2
-
9
-
-
84891906038
-
Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment
-
Hara Y., Yuk F., Puri R., Janssen W.G., Rapp P.R., Morrison J.H. Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc. Nat. Acad. Sci. U. S. A. 2014, 111(1):486-491.
-
(2014)
Proc. Nat. Acad. Sci. U. S. A.
, vol.111
, Issue.1
, pp. 486-491
-
-
Hara, Y.1
Yuk, F.2
Puri, R.3
Janssen, W.G.4
Rapp, P.R.5
Morrison, J.H.6
-
10
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
11
-
-
84857126830
-
Nonhuman primate models of Alzheimer-like cerebral proteopathy
-
Heuer E., Rosen R.F., Cintron A., Walker L.C. Nonhuman primate models of Alzheimer-like cerebral proteopathy. Curr. Pharm. Des. 2012, 18:1159-1169.
-
(2012)
Curr. Pharm. Des.
, vol.18
, pp. 1159-1169
-
-
Heuer, E.1
Rosen, R.F.2
Cintron, A.3
Walker, L.C.4
-
12
-
-
21044453723
-
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
-
Klyubin I., Walsh D.M., Lemere C.A., Cullen W.K., Shankar G.M., Betts V., Spooner E.T., Jiang L., Anwyl R., Selkoe D.J., Rowan M.J. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat. Med. 2005, 11:556-561.
-
(2005)
Nat. Med.
, vol.11
, pp. 556-561
-
-
Klyubin, I.1
Walsh, D.M.2
Lemere, C.A.3
Cullen, W.K.4
Shankar, G.M.5
Betts, V.6
Spooner, E.T.7
Jiang, L.8
Anwyl, R.9
Selkoe, D.J.10
Rowan, M.J.11
-
14
-
-
17044439021
-
Alzheimer's disease: Abeta, tau and synaptic dysfunction
-
LaFerla F.M., Oddo S. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol. Med. 2005, 11:170-176.
-
(2005)
Trends Mol. Med.
, vol.11
, pp. 170-176
-
-
LaFerla, F.M.1
Oddo, S.2
-
15
-
-
79952897537
-
Microglia activation mediates fibrillar amyloid-beta toxicity in the aged primate cortex
-
Leung E., Guo L., Bu J., Maloof M., El Khoury J., Geula C. Microglia activation mediates fibrillar amyloid-beta toxicity in the aged primate cortex. Neurobiol. Aging 2011, 32:387-397.
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 387-397
-
-
Leung, E.1
Guo, L.2
Bu, J.3
Maloof, M.4
El Khoury, J.5
Geula, C.6
-
16
-
-
62049083420
-
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
-
Nagahara A.H., Merrill D.A., Coppola G., Tsukada S., Schroeder B.E., Shaked G.M., Wang L., Blesch A., Kim A., Conner J.M., Rockenstein E., Chao M.V., Koo E.H., Geschwind D., Masliah E., Chiba A.A., Tuszynski M.H. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat. Med. 2009, 15:331-337.
-
(2009)
Nat. Med.
, vol.15
, pp. 331-337
-
-
Nagahara, A.H.1
Merrill, D.A.2
Coppola, G.3
Tsukada, S.4
Schroeder, B.E.5
Shaked, G.M.6
Wang, L.7
Blesch, A.8
Kim, A.9
Conner, J.M.10
Rockenstein, E.11
Chao, M.V.12
Koo, E.H.13
Geschwind, D.14
Masliah, E.15
Chiba, A.A.16
Tuszynski, M.H.17
-
17
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
-
Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., Metherate R., Mattson M.P., Akbari Y., LaFerla F.M. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003, 39:409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
18
-
-
75349095224
-
Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition
-
Oikawa N., Kimura N., Yanagisawa K. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain Res. 2010, 1315:137-149.
-
(2010)
Brain Res.
, vol.1315
, pp. 137-149
-
-
Oikawa, N.1
Kimura, N.2
Yanagisawa, K.3
-
19
-
-
0026176190
-
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease
-
Podlisny M.B., Tolan D.R., Selkoe D.J. Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am. J. Pathol. 1991, 138:1423-1435.
-
(1991)
Am. J. Pathol.
, vol.138
, pp. 1423-1435
-
-
Podlisny, M.B.1
Tolan, D.R.2
Selkoe, D.J.3
-
20
-
-
78049407029
-
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial
-
Quinn J.F., Raman R., Thomas R.G., Yurko-Mauro K., Nelson E.B., Van Dyck C., Galvin J.E., Emond J., Jack C.R., Weiner M., Shinto L., Aisen P.S. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 2010, 304:1903-1911.
-
(2010)
JAMA
, vol.304
, pp. 1903-1911
-
-
Quinn, J.F.1
Raman, R.2
Thomas, R.G.3
Yurko-Mauro, K.4
Nelson, E.B.5
Van Dyck, C.6
Galvin, J.E.7
Emond, J.8
Jack, C.R.9
Weiner, M.10
Shinto, L.11
Aisen, P.S.12
-
21
-
-
70049083865
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Relkin N.R., Szabo P., Adamiak B., Burgut T., Monthe C., Lent R.W., Younkin S., Younkin L., Schiff R., Weksler M.E. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol. Aging 2009, 30:1728-1736.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1728-1736
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
Burgut, T.4
Monthe, C.5
Lent, R.W.6
Younkin, S.7
Younkin, L.8
Schiff, R.9
Weksler, M.E.10
-
22
-
-
0034101474
-
Cortical cholinergic denervation elicits vascular Abeta deposition
-
Roher A.E., Kuo Y.M., Potter P.E., Emmerling M.R., Durham R.A., Walker D.G., Sue L.I., Honer W.G., Beach T.G. Cortical cholinergic denervation elicits vascular Abeta deposition. Ann. N. Y. Acad. Sci. 2000, 903:366-373.
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.903
, pp. 366-373
-
-
Roher, A.E.1
Kuo, Y.M.2
Potter, P.E.3
Emmerling, M.R.4
Durham, R.A.5
Walker, D.G.6
Sue, L.I.7
Honer, W.G.8
Beach, T.G.9
-
23
-
-
64549150594
-
Natural non-trasgenic animal models for research in Alzheimer's disease
-
Sarasa M., Pesini P. Natural non-trasgenic animal models for research in Alzheimer's disease. Curr. Alzheimer Res. 2009, 6(2):171-178.
-
(2009)
Curr. Alzheimer Res.
, vol.6
, Issue.2
, pp. 171-178
-
-
Sarasa, M.1
Pesini, P.2
-
24
-
-
80052501210
-
Resolving controversies on the path to Alzheimer's therapeutics
-
Selkoe D.J. Resolving controversies on the path to Alzheimer's therapeutics. Nat. Med. 2011, 17:1060-1065.
-
(2011)
Nat. Med.
, vol.17
, pp. 1060-1065
-
-
Selkoe, D.J.1
-
25
-
-
15744400473
-
The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs
-
Studzinski C.M., Araujo J.A., Milgram N.W. The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29:489-498.
-
(2005)
Prog. Neuropsychopharmacol. Biol. Psychiatry
, vol.29
, pp. 489-498
-
-
Studzinski, C.M.1
Araujo, J.A.2
Milgram, N.W.3
-
26
-
-
84926312823
-
Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
-
Viola K.L., Klein W.L. Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol. 2015, 129:183-206.
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 183-206
-
-
Viola, K.L.1
Klein, W.L.2
-
27
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama Y., Higuchi M., Zhang B., Huang S.M., Iwata N., Saido T.C., Maeda J., Suhara T., Trojanowski J.Q., Lee V.M. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007, 53:337-351.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
Saido, T.C.6
Maeda, J.7
Suhara, T.8
Trojanowski, J.Q.9
Lee, V.M.10
-
28
-
-
84908884134
-
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
-
261ra154
-
Yu Y.J., Atwal J.K., Zhang Y., Tong R.K., Wildsmith K.R., Tan C., Bien-Ly N., Hersom M., Maloney J.A., Meilandt W.J., Bumbaca D., Gadkar K., Hoyte K., Luk W., Lu Y., Ernst J.A., Scearce-Levie K., Couch J.A., Dennis M.S., Watts R.J. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Sci. Transl. Med. 2014, 6. 261ra154.
-
(2014)
Sci. Transl. Med.
, vol.6
-
-
Yu, Y.J.1
Atwal, J.K.2
Zhang, Y.3
Tong, R.K.4
Wildsmith, K.R.5
Tan, C.6
Bien-Ly, N.7
Hersom, M.8
Maloney, J.A.9
Meilandt, W.J.10
Bumbaca, D.11
Gadkar, K.12
Hoyte, K.13
Luk, W.14
Lu, Y.15
Ernst, J.A.16
Scearce-Levie, K.17
Couch, J.A.18
Dennis, M.S.19
Watts, R.J.20
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