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Volumn 164, Issue , 2016, Pages 509-513

Do low-calorie sweeteners promote weight gain in rodents?

Author keywords

Caloric intake; Gut microbiota; Low calorie sweeteners; Rat; Weight gain; Yogurt

Indexed keywords

SWEETENING AGENT; YOGHURT; NONNUTRITIVE SWEETENER;

EID: 84957055940     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2016.01.043     Document Type: Review
Times cited : (11)

References (49)
  • 2
    • 0019459685 scopus 로고
    • Cephalic phase, reflex insulin secretion: neuroanatomical and physiological characterization
    • [2] Berthoud, H.-R., Bereiter, D.A., Trimble, E.R., Siegel, E.G., Jeanrenaud, B., Cephalic phase, reflex insulin secretion: neuroanatomical and physiological characterization. Diabetologia 20 (1981), 393–401.
    • (1981) Diabetologia , vol.20 , pp. 393-401
    • Berthoud, H.-R.1    Bereiter, D.A.2    Trimble, E.R.3    Siegel, E.G.4    Jeanrenaud, B.5
  • 3
    • 0019003702 scopus 로고
    • Cephalic-phase insulin secretion in normal and pancreatic islet-transplanted rats
    • [3] Berthoud, H.-R., Trimble, E.R., Siegel, E.G., Bereiter, D.A., Jeanrenaud, B., Cephalic-phase insulin secretion in normal and pancreatic islet-transplanted rats. Am. J. Physiol. 238 (1980), E336–E340.
    • (1980) Am. J. Physiol. , vol.238 , pp. E336-E340
    • Berthoud, H.-R.1    Trimble, E.R.2    Siegel, E.G.3    Bereiter, D.A.4    Jeanrenaud, B.5
  • 5
    • 79960943304 scopus 로고    scopus 로고
    • Intake of high-intensity sweeteners alters the ability of sweet taste to signal caloric consequences: implications for the learned control of energy and body weight regulation
    • [5] Davidson, T.L., Martin, A.A., Clark, K., Swithers, S.E., Intake of high-intensity sweeteners alters the ability of sweet taste to signal caloric consequences: implications for the learned control of energy and body weight regulation. Quart. J. Exp. Psychol. 64 (2011), 1430–1441.
    • (2011) Quart. J. Exp. Psychol. , vol.64 , pp. 1430-1441
    • Davidson, T.L.1    Martin, A.A.2    Clark, K.3    Swithers, S.E.4
  • 6
    • 0031736848 scopus 로고    scopus 로고
    • Aspartame consumption in rats selectively bred for high versus low saccharin intake
    • [6] De Francisco, J.C., Dess, N.K., Aspartame consumption in rats selectively bred for high versus low saccharin intake. Physiol. Behav. 65 (1998), 393–396.
    • (1998) Physiol. Behav. , vol.65 , pp. 393-396
    • De Francisco, J.C.1    Dess, N.K.2
  • 7
    • 0016325972 scopus 로고
    • Conditioned hypoglycemia: a mechanism for saccharin-induced sensitivity to insulin in the rat
    • [7] Deutch, R., Conditioned hypoglycemia: a mechanism for saccharin-induced sensitivity to insulin in the rat. J. Comp. Physiol. Psychol. 86 (1974), 350–358.
    • (1974) J. Comp. Physiol. Psychol. , vol.86 , pp. 350-358
    • Deutch, R.1
  • 8
    • 84862704637 scopus 로고    scopus 로고
    • Non-caloric sweeteners, sweetness modulators, and sweetener enhancers
    • [8] DuBois, G.E., Prakash, I., Non-caloric sweeteners, sweetness modulators, and sweetener enhancers. Annu. Rev. Food Sci. Technol. 3 (2012), 353–380.
    • (2012) Annu. Rev. Food Sci. Technol. , vol.3 , pp. 353-380
    • DuBois, G.E.1    Prakash, I.2
  • 9
    • 84899090680 scopus 로고    scopus 로고
    • Replication of obesity and associated signaling pathways through transfer of microbiota from obese-prone rats
    • [9] Duca, F.A., Sakar, Y., Lepage, P., Devime, F., Langelier, B., Doré, J., Covasa, M., Replication of obesity and associated signaling pathways through transfer of microbiota from obese-prone rats. Diabetes 63 (2014), 1624–1636.
    • (2014) Diabetes , vol.63 , pp. 1624-1636
    • Duca, F.A.1    Sakar, Y.2    Lepage, P.3    Devime, F.4    Langelier, B.5    Doré, J.6    Covasa, M.7
  • 11
    • 84868696777 scopus 로고    scopus 로고
    • Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels
    • [11] Feijó, F.D., Ballard, C.R., Foletto, K.C., Batista, B.A.M., Neves, A.M., Ribeiro, M.F.M., Bertoluci, M.C., Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels. Appetite 60 (2013), 203–207.
    • (2013) Appetite , vol.60 , pp. 203-207
    • Feijó, F.D.1    Ballard, C.R.2    Foletto, K.C.3    Batista, B.A.M.4    Neves, A.M.5    Ribeiro, M.F.M.6    Bertoluci, M.C.7
  • 12
    • 84860238262 scopus 로고    scopus 로고
    • Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners
    • [12] Fitch, C., K.S., Keim, Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners. J. Acad. Nutr. Diet. 112 (2012), 739–758.
    • (2012) J. Acad. Nutr. Diet. , vol.112 , pp. 739-758
    • Fitch, C.1    K.S., K.2
  • 13
    • 84947723508 scopus 로고    scopus 로고
    • Sweet taste of saccharin induces weight gain without increasing caloric intake, not related to insulin-resistance in Wistar rats
    • [13] Foletto, K.C., Batista, B.A.M., Neves, A.M., Feijó, F.D., Ballard, C.R., Ribeiro, M.F.M., Bertoluci, M.C., Sweet taste of saccharin induces weight gain without increasing caloric intake, not related to insulin-resistance in Wistar rats. Appetite 96 (2016), 604–610.
    • (2016) Appetite , vol.96 , pp. 604-610
    • Foletto, K.C.1    Batista, B.A.M.2    Neves, A.M.3    Feijó, F.D.4    Ballard, C.R.5    Ribeiro, M.F.M.6    Bertoluci, M.C.7
  • 14
    • 79953773104 scopus 로고    scopus 로고
    • Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects
    • [15] Ford, H.E., Peters, V., Martin, N.M., Sleeth, M.L., Ghatei, M.A., Frost, G.S., Bloom, S.R., Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects. Eur. J. Clin. Nutr. 65 (2011), 508–513.
    • (2011) Eur. J. Clin. Nutr. , vol.65 , pp. 508-513
    • Ford, H.E.1    Peters, V.2    Martin, N.M.3    Sleeth, M.L.4    Ghatei, M.A.5    Frost, G.S.6    Bloom, S.R.7
  • 15
    • 48749113139 scopus 로고    scopus 로고
    • Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain
    • [16] Fowler, S.P., Williams, K., Resendez, R.G., Hunt, K.J., Hazuda, H.P., Stern, M.P., Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity 16 (2008), 1894–1900.
    • (2008) Obesity , vol.16 , pp. 1894-1900
    • Fowler, S.P.1    Williams, K.2    Resendez, R.G.3    Hunt, K.J.4    Hazuda, H.P.5    Stern, M.P.6
  • 17
  • 18
    • 25744445698 scopus 로고
    • The influence of sweetener solutions on the secretion of insulin and the blood glucose level
    • [19] Härtel, B., Graubaum, H.-J., Schneider, B., The influence of sweetener solutions on the secretion of insulin and the blood glucose level. Ernährungs-Umschau. 40 (1993), 152–155.
    • (1993) Ernährungs-Umschau. , vol.40 , pp. 152-155
    • Härtel, B.1    Graubaum, H.-J.2    Schneider, B.3
  • 19
    • 50349097303 scopus 로고    scopus 로고
    • Cephalic phase insulin release in healthy humans after taste stimulation?
    • [20] Just, T., Pau, H.W., Engel, U., Hummel, T., Cephalic phase insulin release in healthy humans after taste stimulation?. Appetite 51 (2008), 622–627.
    • (2008) Appetite , vol.51 , pp. 622-627
    • Just, T.1    Pau, H.W.2    Engel, U.3    Hummel, T.4
  • 21
    • 71549129519 scopus 로고    scopus 로고
    • Artificially sweetened beverages: cause for concern
    • [22] Ludwig, D.S., Artificially sweetened beverages: cause for concern. JAMA 301 (2009), 2477–2478.
    • (2009) JAMA , vol.301 , pp. 2477-2478
    • Ludwig, D.S.1
  • 23
    • 1842407153 scopus 로고    scopus 로고
    • Physiological responses to sensory stimulation by food: nutritional implications
    • [24] Mattes, R.D., Physiological responses to sensory stimulation by food: nutritional implications. J. Am. Diet. Assoc. 97 (1997), 406–413.
    • (1997) J. Am. Diet. Assoc. , vol.97 , pp. 406-413
    • Mattes, R.D.1
  • 24
    • 84907358367 scopus 로고    scopus 로고
    • Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies
    • [25] Miller, P.E., Perez, V., Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am. J. Clin. Nutr. 100 (2014), 765–777.
    • (2014) Am. J. Clin. Nutr. , vol.100 , pp. 765-777
    • Miller, P.E.1    Perez, V.2
  • 25
    • 84962609703 scopus 로고    scopus 로고
    • Probiotics in digestive diseases: focus on Lactobacillus GG
    • [26] Pace, F., Pace, M., Quartarone, G., Probiotics in digestive diseases: focus on Lactobacillus GG. Minerva Gastroenterol. Dietol. 61 (2015), 273–292.
    • (2015) Minerva Gastroenterol. Dietol. , vol.61 , pp. 273-292
    • Pace, F.1    Pace, M.2    Quartarone, G.3
  • 26
    • 84946830070 scopus 로고    scopus 로고
    • Mireia Urpi-Sarda, Tinahones, F. J., Andres-Lacueva, C. Metabolomic insights into the intricate gut microbial–host interaction in the development of obesity and type-2 diabetes. Front. Microbiol., 6: article 1151.
    • [27] Palau-Rodriguez, M., Tulipani, S., Queipo-Ortuño, M. I., Mireia Urpi-Sarda, Tinahones, F. J., Andres-Lacueva, C. Metabolomic insights into the intricate gut microbial–host interaction in the development of obesity and type-2 diabetes. Front. Microbiol. 2015, 6: article 1151.
    • (2015)
    • Palau-Rodriguez, M.1    Tulipani, S.2    Queipo-Ortuño, M.I.3
  • 27
    • 84907999777 scopus 로고    scopus 로고
    • Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat
    • e109841
    • [28] Palmnäs, M.S.A., Cowan, T.E., Bomhof, M.R., Su, J., Reimer, R.A., Vogel, H.J., Hittel, D.S., Shearer, J., Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One, 9, 2014, e109841.
    • (2014) PLoS One , vol.9
    • Palmnäs, M.S.A.1    Cowan, T.E.2    Bomhof, M.R.3    Su, J.4    Reimer, R.A.5    Vogel, H.J.6    Hittel, D.S.7    Shearer, J.8
  • 28
    • 0022369517 scopus 로고
    • Diet and cephalic phase insulin responses
    • [29] Powley, T.L., Berthoud, H.-R., Diet and cephalic phase insulin responses. Am. J. Clin. Nutr. 42 (1985), 991–1002.
    • (1985) Am. J. Clin. Nutr. , vol.42 , pp. 991-1002
    • Powley, T.L.1    Berthoud, H.-R.2
  • 29
    • 0022968928 scopus 로고
    • The metabolism of intense sweeteners
    • [30] Renwick, A.G., The metabolism of intense sweeteners. Xenobiot. 16 (1986), 1057–1071.
    • (1986) Xenobiot. , vol.16 , pp. 1057-1071
    • Renwick, A.G.1
  • 30
    • 84960803338 scopus 로고    scopus 로고
    • Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies
    • [31] Rogers, P.J., Hogenkamp, P.S., de Graaf, K., Higgs, S., Lluch, A., Ness, A.R., Penfold, C., Perry, R., Putz, P., Yeomans, M.R., Mela, D.J., Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies. Int. J. Obes. (Lond), 2015, 10.1038/ijo.2015.177.
    • (2015) Int. J. Obes. (Lond)
    • Rogers, P.J.1    Hogenkamp, P.S.2    de Graaf, K.3    Higgs, S.4    Lluch, A.5    Ness, A.R.6    Penfold, C.7    Perry, R.8    Putz, P.9    Yeomans, M.R.10    Mela, D.J.11
  • 31
    • 84866369224 scopus 로고    scopus 로고
    • Rationale for further medical and health research on high-potency sweeteners
    • [32] Schiffman, S.S., Rationale for further medical and health research on high-potency sweeteners. Chem. Senses 37 (2012), 671–679.
    • (2012) Chem. Senses , vol.37 , pp. 671-679
    • Schiffman, S.S.1
  • 32
    • 0022552072 scopus 로고
    • Rats show only a weak preference for the artificial sweetener aspartame
    • [33] Sclafani, A., Abrams, M., Rats show only a weak preference for the artificial sweetener aspartame. Physiol. Behav. 37 (1986), 253–256.
    • (1986) Physiol. Behav. , vol.37 , pp. 253-256
    • Sclafani, A.1    Abrams, M.2
  • 33
    • 40749151808 scopus 로고    scopus 로고
    • Relationship between taste-induced physiological reflexes and temperature of sweet taste
    • [34] Shinozaki, K., Shimizu, Y., Shiina, T., Morita, H., Takewaki, T., Relationship between taste-induced physiological reflexes and temperature of sweet taste. Physiol. Behav. 93 (2008), 1000–1004.
    • (2008) Physiol. Behav. , vol.93 , pp. 1000-1004
    • Shinozaki, K.1    Shimizu, Y.2    Shiina, T.3    Morita, H.4    Takewaki, T.5
  • 34
    • 0036343228 scopus 로고    scopus 로고
    • Saccharin as a sugar surrogate revisted
    • [35] Smith, J.C., Sclafani, A., Saccharin as a sugar surrogate revisted. Appetite 38 (2002), 155–160.
    • (2002) Appetite , vol.38 , pp. 155-160
    • Smith, J.C.1    Sclafani, A.2
  • 36
    • 84856736806 scopus 로고    scopus 로고
    • Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota
    • [37] Swartz, T.D., Duca, F.A., de Wouters, T., Sakar, Y., Covasa, M., Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota. British J. Nutr. 107 (2012), 621–630.
    • (2012) British J. Nutr. , vol.107 , pp. 621-630
    • Swartz, T.D.1    Duca, F.A.2    de Wouters, T.3    Sakar, Y.4    Covasa, M.5
  • 37
    • 84883183253 scopus 로고    scopus 로고
    • Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements
    • [38] Swithers, S.E., Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol. Metab. 24 (2013), 431–441.
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 431-441
    • Swithers, S.E.1
  • 38
    • 67949100464 scopus 로고    scopus 로고
    • General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats
    • [39] Swithers, S.E., Baker, C.R., Davidson, T.L., General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. Behav. Neurosci. 123 (2009), 772–780.
    • (2009) Behav. Neurosci. , vol.123 , pp. 772-780
    • Swithers, S.E.1    Baker, C.R.2    Davidson, T.L.3
  • 40
    • 40749142726 scopus 로고    scopus 로고
    • A role for sweet taste: calorie predictive relations in energy regulation by rats
    • [41] Swithers, S.E., Davidson, T.L., A role for sweet taste: calorie predictive relations in energy regulation by rats. Behav. Neurosci. 122 (2008), 161–173.
    • (2008) Behav. Neurosci. , vol.122 , pp. 161-173
    • Swithers, S.E.1    Davidson, T.L.2
  • 41
    • 84861619861 scopus 로고    scopus 로고
    • Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats
    • [42] Swithers, S.E., Laboy, A.F., Clark, K., Cooper, S., Davidson, T.L., Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats. Behav. Brain Res. 233 (2012), 1–14.
    • (2012) Behav. Brain Res. , vol.233 , pp. 1-14
    • Swithers, S.E.1    Laboy, A.F.2    Clark, K.3    Cooper, S.4    Davidson, T.L.5
  • 42
    • 78649450332 scopus 로고    scopus 로고
    • Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition
    • [43] Swithers, S.E., Martin, A.A., Clark, K.M., Laboy, A.F., Davidson, T.L., Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition. Appetite 55 (2010), 528–533.
    • (2010) Appetite , vol.55 , pp. 528-533
    • Swithers, S.E.1    Martin, A.A.2    Clark, K.M.3    Laboy, A.F.4    Davidson, T.L.5
  • 43
    • 84876015230 scopus 로고    scopus 로고
    • Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats
    • [44] Swithers, S.E., Sample, C.H., Davidson, T.L., Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats. Behav. Neurosci. 127 (2013), 262–274.
    • (2013) Behav. Neurosci. , vol.127 , pp. 262-274
    • Swithers, S.E.1    Sample, C.H.2    Davidson, T.L.3
  • 44
    • 84871931694 scopus 로고    scopus 로고
    • Influence of ovarian and non-ovarian estrogens on weight gain in response to disruption of sweet taste-calorie relations in female rats
    • [45] Swithers, S.E., Sample, C.H., Katz, D.P., Influence of ovarian and non-ovarian estrogens on weight gain in response to disruption of sweet taste-calorie relations in female rats. Horm. Behav. 63 (2013), 40–48.
    • (2013) Horm. Behav. , vol.63 , pp. 40-48
    • Swithers, S.E.1    Sample, C.H.2    Katz, D.P.3
  • 45
    • 84865504323 scopus 로고    scopus 로고
    • Sugar substitutes: health controversy over perceived benefits
    • [46] Tandel, K.R., Sugar substitutes: health controversy over perceived benefits. J. Pharmacol. Pharmacother. 2 (2011), 236–243.
    • (2011) J. Pharmacol. Pharmacother. , vol.2 , pp. 236-243
    • Tandel, K.R.1
  • 46
    • 0029049938 scopus 로고
    • Sweet taste: effect on cephalic phase insulin release in men
    • [47] Teff, K.L., Devine, J., Engelman, K., Sweet taste: effect on cephalic phase insulin release in men. Physiol. Behav. 57 (1995), 1089–1095.
    • (1995) Physiol. Behav. , vol.57 , pp. 1089-1095
    • Teff, K.L.1    Devine, J.2    Engelman, K.3
  • 47
    • 34249796653 scopus 로고    scopus 로고
    • Relationship between insulin release and taste
    • [48] Tonosaki, K., Hori, Y., Shimizu, Y., Tonosaki, K., Relationship between insulin release and taste. Biomed. Res. 28 (2007), 79–83.
    • (2007) Biomed. Res. , vol.28 , pp. 79-83
    • Tonosaki, K.1    Hori, Y.2    Shimizu, Y.3    Tonosaki, K.4
  • 48
    • 0024556315 scopus 로고
    • Drinking saccharin increases food intake and preference-IV. Cephalic phase and metabolic factors
    • [49] Tordoff, M.G., Friedman, M.I., Drinking saccharin increases food intake and preference-IV. Cephalic phase and metabolic factors. Appetite 12 (1989), 37–56.
    • (1989) Appetite , vol.12 , pp. 37-56
    • Tordoff, M.G.1    Friedman, M.I.2
  • 49
    • 0026231847 scopus 로고
    • The eating paradox: how we tolerate food
    • [50] Woods, S.C., The eating paradox: how we tolerate food. Psychol. Rev. 98 (1991), 488–505.
    • (1991) Psychol. Rev. , vol.98 , pp. 488-505
    • Woods, S.C.1


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