Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones

American Journal of Clinical Nutrition

Volumn 103, Issue 2, 2016, Pages 305-313

  Van Avesaat, Mark ^a,b   Troost, Freddy J ^a,b   Westerterp Plantenga, Margriet S ^c   Helyes, Zsuzsanna ^d   Le Roux, Carel W ^e   Dekker, Jan ^a   Masclee, Adrian A M ^a,b   Keszthelyi, Daniel ^a,b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF PÉCS   (Hungary)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Capsaicin; CCK; Gallbladder; Gastrointestinal distress; Gastrointestinal peptides; GLP 1; Satiety

Indexed keywords

CAPSAICIN; GLUCAGON LIKE PEPTIDE 1; ORAL CONTRACEPTIVE AGENT; PEPTIDE YY; PLACEBO; ANOREXIGENIC AGENT; BIOLOGICAL MARKER;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLOATING; BODY MASS; BURNING SENSATION; COMPARATIVE STUDY; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; GALLBLADDER; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HUNGER; MALE; NAUSEA; NORMAL HUMAN; OBESITY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REAL TIME ECHOGRAPHY; SATIETY; VISUAL ANALOG SCALE; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; DIETARY SUPPLEMENT; DIGESTIVE TRACT INTUBATION; ECHOGRAPHY; ENTERITIS; METABOLISM; ORGAN SIZE; PAIN MEASUREMENT; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOPHYSIOLOGY; SECRETION (PROCESS); SINGLE BLIND PROCEDURE; YOUNG ADULT;

ABDOMINAL PAIN; ADULT; APPETITE DEPRESSANTS; BIOMARKERS; CAPSAICIN; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; ENTERITIS; FEMALE; GALLBLADDER; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INTUBATION, GASTROINTESTINAL; NAUSEA; ORGAN SIZE; PAIN MEASUREMENT; PEPTIDE YY; SATIETY RESPONSE; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84956935061     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.123414     Document Type: Article

References (41)

1. Hill JO, Peters JC, Wyatt HR. Using the energy gap to address obesity: a commentary. J Am Diet Assoc 2009;109:1848-53.
2. Ludy MJ, Moore GE, Mattes RD. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012;37:103-21.
3. Kovacs EM, Mela DJ. Metabolically active functional food ingredients for weight control. Obes Rev 2006;7:59-78.
4. Westerterp-Plantenga M, Diepvens K, Joosen AM, Berube-Parent S, Tremblay A. Metabolic effects of spices, teas, and caffeine. Physiol Behav 2006;89:85-91.
5. Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki M. Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol (Tokyo) 1995;41:647-56.
6. Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 2013;24:71-7.
7. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012;95: 845-50.
8. Watanabe T, Kawada T, Kurosawa M, Sato A, Iwai K. Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats. Am J Physiol 1988;255:E23-7.
9. Watanabe T, Kawada T, Yamamoto M, Iwai K. Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem Biophys Res Commun 1987;142:259-64.
10. Yoshioka M, St-Pierre S, Drapeau V, Dionne I, Doucet E, Suzuki M, Tremblay A. Effects of red pepper on appetite and energy intake. Br J Nutr 1999;82:115-23.
11. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab (Lond) 2010;7: 65
12. Lejeune MP, Kovacs EM, Westerterp-Plantenga MS. Effect of capsaicin on substrate oxidation and weight maintenance after modest bodyweight loss in human subjects. Br J Nutr 2003;90:651-9.
13. Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am J Clin Nutr 2006;84:63-9.
14. Ludy MJ, Mattes RD. The effects of hedonically acceptable red pepper doses on thermogenesis and appetite. Physiol Behav 2011;102:251-8.
15. Whiting S, Derbyshire EJ, Tiwari B. Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data. Appetite 2014;73:183-8.
16. Szolcsányi J, Pinter E. Transient receptor potential vanilloid 1 as a therapeutic target in analgesia. Expert Opin Ther Targets 2013;17: 641-57.
17. Wang P, Yan Z, Zhong J, Chen J, Ni Y, Li L, Ma L, Zhao Z, Liu D, Zhu Z. Transient receptor potential vanilloid 1 activation enhances gut glucagon-like peptide-1 secretion and improves glucose homeostasis. Diabetes 2012;61:2155-65.
18. Smeets AJ, Westerterp-Plantenga MS. The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. Eur J Nutr 2009;48:229-34.
19. Westerterp-Plantenga MS, Smeets A, Lejeune MP. Sensory and gastrointestinal satiety effects of capsaicin on food intake. Int J Obes (Lond) 2005;29:682-8.
20. Yoshioka M, Imanaga M, Ueyama H, Yamane M, Kubo Y, Boivin A, St-Amand J, Tanaka H, Kiyonaga A. Maximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouth. Br J Nutr 2004;91:991-5.
21. European Commission. Opinion of the Scientific Committee on Food on Capsaicin [Internet]. Brussels, Belgium: European Commission; 2002 Feb 26 [cited 2015 Oct 9]. Available from: http://eceuropaeu/food/fs/sc/scf/out120-enpd.f.
22. Everson GT, Braverman DZ, Johnson ML, Kern F Jr. A critical evaluation of real-time ultrasonography for the study of gallbladder volume and contraction. Gastroenterology 1980;79:40-6.
23. Hopman WP, Brouwer WF, Rosenbusch G, Jansen JB, Lamers CB. A computerized method for rapid quantification of gallbladder volume from real-time sonograms. Radiology 1985;154:236-7.
24. Ledeboer M, Masclee AA, Biemond I, Lamers CB. Differences in cholecystokinin release and gallbladder contraction between emulsified and nonemulsified long-chain triglycerides. JPEN J Parenter Enteral Nutr 1999;23:203-6.
25. Masclee AA, Gielkens HA, Lieverse RJ, Penning C, Schipper J, Lamers CB. Gallbladder motility in response to sham feeDing and cholecystokinin in lean and obese subjects. Digestion 1997;58:43-9.
26. Shibata C, Jin XL, Naito H, Matsuno S, Sasaki I. Intraileal capsaicin inhibits gastrointestinal contractions via a neural reflex in conscious dogs. Gastroenterology 2002;123:1904-11.
27. Kadohisa M, Rolls ET, Verhagen JV. Orbitofrontal cortex: neuronal representation of oral temperature and capsaicin in addition to taste and texture. Neuroscience 2004;127:207-21.
28. Rolls ET. Taste, olfactory, and food reward value processing in the brain. Prog Neurobiol 2015;127-128:64-90.
29. Astrup A, Kristensen M, Gregersen NT, Belza A, Lorenzen JK, Due A, Larsen TM. Can bioactive foods affect obesity? Ann N Y Acad Sci 2010;1190:25-41.
30. Costa RM, Liu L, Nicolelis MA, Simon SA. Gustatory effects of capsaicin that are independent of TRPV1 receptors. Chem Senses 2005;30(Suppl 1):i198-200.
31. Arendt-Nielsen L, Schipper KP, Dimcevski G, Sumikura H, Krarup AL, Giamberardino MA, Drewes AM. Viscero-somatic reflexes in referred pain areas evoked by capsaicin stimulation of the human gut. Eur J Pain 2008;12:544-51.
32. Drewes AM, Schipper KP, Dimcevski G, Petersen P, Gregersen H, Funch-Jensen P, Arendt-Nielsen L. Gut pain and hyperalgesia induced by capsaicin: a human experimental model. Pain 2003;104:333-41.
33. Hammer J, Hammer HF, Eherer AJ, Petritsch W, Holzer P, Krejs GJ. Intraluminal capsaicin does not affect fluid and electrolyte absorption in the human jejunum but does cause pain. Gut 1998;43:252-5.
34. Schmidt B, Hammer J, Holzer P, Hammer HF. Chemical nociception in the jejunum induced by capsaicin. Gut 2004;53:1109-16.
35. Coen SJ. When pain and hunger collide; psychological influences on differences in brain activity during physiological and non-physiological gastric distension. Neurogastroenterol Motil 2011;23:485-9.
36. Geeraerts B, Van Oudenhove L, Dupont P, Vanderghinste D, Bormans G, Van Laere K, Tack J. Different regional brain activity during physiological gastric distension compared to balloon distension: a H2 15OPET study. Neurogastroenterol Motil 2011;23:503-533.
37. Camilleri M, Grudell AB. Appetite and obesity: a gastroenterologist's perspective. Neurogastroenterol Motil 2007;19:333-41.
38. Delgado-Aros S, Camilleri M, Castillo EJ, Cremonini F, Stephens D, Ferber I, Baxter K, Burton D, Zinsmeister AR. Effect of gastric volume or emptying on meal-related symptoms after liquid nutrients in obesity: a pharmacologic study. Clin Gastroenterol Hepatol 2005; 3:997-1006.
39. Shibata C, Naito H, Ueno T, Jin XL, Funayama Y, Fukushima K, Matsuno S, Sasaki I. Intraduodenal capsaicin inhibits gastric migrating motor complex via an extrinsic neural reflex in conscious dogs. Neurogastroenterol Motil 2002;14:543-51.
40. Tack J, Deloose E, Ang D, Scarpellini E, Vanuytsel T, Van Oudenhove L, Depoortere I. Motilin-induced gastric contractions signal hunger in man. Gut 2014 Dec 24 (Epub ahead of print; DOI: 10.1136/gutjnl-2014-308472).
41. Elamin E, Masclee A, Troost F, Pieters HJ, Keszthelyi D, Aleksa K, Dekker J, Jonkers D. Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One 2014;9:e107421.