Motilin-induced gastric contractions signal hunger in man

Gut

Volumn 65, Issue 2, 2016, Pages 214-224

  Tack, J ^a   Deloose, E ^a   Ang, D ^a   Scarpellini, E ^a   Vanuytsel, T ^a   Van Oudenhove, L ^a   Depoortere, I ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; MOTILIN; CHOLINESTERASE INHIBITOR; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ERYTHROMYCIN; NEOSTIGMINE; OCTREOTIDE; PEPTIDE FRAGMENT; SOMATOSTATIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GASTROINTESTINAL MOTILITY; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HUNGER; LOSS OF APPETITE; MALE; MIGRATING MOTOR COMPLEX; MOTOR ACTIVITY; MOTOR CONTROL; MUSCLE TONE; NORMAL HUMAN; PARASYMPATHETIC FUNCTION; PRIORITY JOURNAL; STOMACH MUSCLE; AGONISTS; APPETITE; BLOOD; DRUG EFFECTS; DUODENUM; EATING; MANOMETRY; MIGRATING MYOELECTRIC COMPLEX; MUSCLE CONTRACTION; PHYSIOLOGY; STOMACH;

APPETITE; CHOLINESTERASE INHIBITORS; DUODENUM; EATING; ERYTHROMYCIN; GASTROINTESTINAL MOTILITY; GHRELIN; HUMANS; HUNGER; MANOMETRY; MOTILIN; MUSCLE CONTRACTION; MYOELECTRIC COMPLEX, MIGRATING; NEOSTIGMINE; OCTREOTIDE; PEPTIDE FRAGMENTS; SOMATOSTATIN; STOMACH;

EID: 84958538597     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-308472     Document Type: Article

References (44)

1. http://www.iaso.org/iotf/obesity/obesitytheglobalepidemic (accessed 1 Apr 2014).
2. Miras AD, le Roux CW. Mechanisms underlying weight loss after bariatric surgery. Nat Rev Gastroenterol Hepatol 2013;10:575-84.
3. Farré R, Tack J. Food and symptom generation in functional gastrointestinal disorders: physiological aspects. Am J Gastroenterol 2013;108:698-706.
4. Janssen P, Vanden Berghe P, Verschueren S, et al. Review article: the role of gastric motility in the control of food intake. Aliment Pharmacol Ther 2011;33:880-94.
5. Janssen P, Verschueren S, Ly HG, et al. Intragastric pressure during food intake: a physiological and minimally invasive method to assess gastric accommodation. Neurogastroenterol Motil 2011;23:316-22, e153-4.
6. Deloose E, Janssen P, Depoortere I, et al. The migrating motor complex: control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol 2012;9:271-85.
7. Cannon W, Washburn A. An explanation of hunger. Am J Physiol 1912; 29:441-54.
8. Itoh Z, Aizawa R, Takeuchi S, et al. Hunger contractions and motilin. Proc Int Symp Gastrointest Motil 1975;5:48-5.
9. Tack J, Depoortere I, Bisschops R, et al. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006;55:327-33.
10. Deloose E, Vos R, Corsetti M, et al. Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man. Neurogastroenterol Motil Published Online First: 13 Nov 2014.
11. Janssen P, Vos R, Tack J. The influence of citalopram on interdigestive gastrointestinal motility in man. Aliment Pharmacol Ther 2010;32:289-5.
12. Janssen S, Laermans J, Verhulst PJ, et al. Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci 2011;108:2094-9.
13. Andrioli A, Wilmer A, Coremans G, et al. Computer-supported analysis of continuous ambulatory manometric recordings in the human small bowel. Med Biol Eng Comput 1996;34:336-43.
14. Cuomo R, Vandaele P, Coulie B, et al. Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways. Am J Gastroenterol 2006;101:804-11.
15. Ghoos YF, Maes BD, Geypens BJ, et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993;104:1640-7.
16. Szurszewski JH. A migrating electric complex of canine small intestine. Am J Physiol 1969;217:1757-63.
17. Vantrappen G, Janssens J, Hellemans J, et al. The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 1977;59:1158-66.
18. Vantrappen G, Janssens J, Peeters TL, et al. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci 1979;24:497-500.
19. Avau B, Carbone F, Tack J, et al. Ghrelin signaling in the gut, its physiological properties, and therapeutic potential. Neurogastroenterol Motil 2013; 25:720-32.
20. Romański KW. Migrating motor complex in biological sciences: characterization, animal models and disturbances. Indian J Exp Biol 2009;47:229-44.
21. Vincent RP, Ashrafian H, le Roux CW. Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity. Nat Clin Pract Gastroenterol Hepatol 2008;5:268-77.
22. De Silva A, Bloom SR. Gut hormones and appetite control: a focus on PYY and GLP-1 as therapeutic targets in obesity. Gut Liver 2012;6:10-20.
23. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-8.
24. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-4.
25. Dakin CL, Small CJ, Batterham RL, et al. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 2004;145:2687-95.
26. Aerssens J, Depoortere I, Thielemans L, et al. The rat lacks functional genes for motilin and for the motilin receptor. Neurogastroenterol Motil 2004; 16:841.
27. He J, Irwin DM, Chen R, et al. Stepwise loss of motilin and its specific receptor genes in rodents. J Mol Endocrinol 2010;44:37-44.
28. Fujino K, Inui A, Asakawa A, et al. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 2003;550:227-40.
29. Ariga H, Tsukamoto K, Chen C, et al. Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach. Neurogastroenterol Motil 2007;19:675-80.
30. Zheng J, Ariga H, Taniguchi H, et al. Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice. Neurogastroenterol Motil 2009;21:78-84.
31. Depoortere I, De Winter B, Thijs T, et al. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur J Pharmacol 2005;515:160-8.
32. Malik S, McGlone F, Bedrossian D, et al. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 2008;7:400-9.
33. Goldstone AP, Prechtl CG, Scholtz S, et al. Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food. Am J Clin Nutr 2014;99:1319-30.
34. Sárvári M, Kocsis P, Deli L, et al. Ghrelin modulates the fMRI BOLD response of homeostatic and hedonic brain centers regulating energy balance in the rat. PLoS ONE 2014;9:e97651.
35. Depoortere I. Targeting the ghrelin receptor to regulate food intake. Regul Pept 2009;156:13-23.
36. Depoortere I, Van Assche G, Peeters TL. Distribution and subcellular localization of motilin binding sites in the rabbit brain. Brain Res 1997;777:103-9.
37. Thielemans L, Depoortere I, Van Assche G, et al. Demonstration of a functional motilin receptor in TE671 cells from human cerebellum. Brain Res 2001;895:119-28.
38. Pieramico O, Malfertheiner P, Nelson DK, et al. Interdigestive gastroduodenal motility and cycling of putative regulatory hormones in severe obesity. Scand J Gastroenterol 1992;27:538-44.
39. Civalleri D, Bloom SR, Sarson DL, et al. Behavior of plasma pancreatic polypeptides and motilin in obese patients subjected to biliopancreatic bypass. Boll Soc Ital Biol Sper 1980;56:1929-35.
40. Weiss H, Labeck B, Klocker J, et al. Effects of adjustable gastric banding on altered gut neuropeptide levels in morbidly obese patients. Obes Surg 2001;11:735-9.
41. Poitras P, Peeters TL. Motilin. Curr Opin Endocrinol Diabetes Obes 2008; 15:54-7.
42. Deloose E, Janssen P, Lannoo M, et al. Origin of phase 3 of the migrating motor complex differs between lean and obese subjects. Gastroenterology 2012;142:S294.
43. Masheb RM, Grilo CM. Eating patterns and breakfast consumption in obese patients with binge eating disorder. Behav Res Ther 2006;44:1545-53.
44. Masheb RM, Grilo CM, White MA. An examination of eating patterns in community women with bulimia nervosa and binge eating disorder. Int J Eat Disord 2011;44:618-24.