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Volumn 126, Issue 2, 2016, Pages 415-423

Towards HIV-1 remission: Potential roles for broadly neutralizing antibodies

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FC RECEPTOR; NEUTRALIZING ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 84956871237     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI80561     Document Type: Review
Times cited : (53)

References (96)
  • 1
    • 0033592967 scopus 로고    scopus 로고
    • HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    • Davey RT Jr, et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci U S A. 1999;96(26):15109-15114.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.26 , pp. 15109-15114
    • Davey, R.T.1
  • 2
    • 84924365877 scopus 로고    scopus 로고
    • Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
    • Rothenberger MK, et al. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci U S A. 2015;112(10):E1126-E1134.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.10 , pp. E1126-E1134
    • Rothenberger, M.K.1
  • 3
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker LM, et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science. 2009;326(5950):285-289.
    • (2009) Science , vol.326 , Issue.5950 , pp. 285-289
    • Walker, L.M.1
  • 4
    • 77954920017 scopus 로고    scopus 로고
    • Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    • Wu X, et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science. 2010;329(5993):856-861.
    • (2010) Science , vol.329 , Issue.5993 , pp. 856-861
    • Wu, X.1
  • 5
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • Scheid JF, et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science. 2011;333(6049):1633-1637.
    • (2011) Science , vol.333 , Issue.6049 , pp. 1633-1637
    • Scheid, J.F.1
  • 6
    • 80053132436 scopus 로고    scopus 로고
    • Broad neutralization coverage of HIV by multiple highly potent antibodies
    • Walker LM, et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 2011;477(7365):466-470.
    • (2011) Nature , vol.477 , Issue.7365 , pp. 466-470
    • Walker, L.M.1
  • 7
    • 84869831194 scopus 로고    scopus 로고
    • Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
    • Mouquet H, et al. Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2012;109(47):E3268-E3277.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.47 , pp. E3268-E3277
    • Mouquet, H.1
  • 8
    • 84866493348 scopus 로고    scopus 로고
    • Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
    • Huang J, et al. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature. 2012;491(7424):406-412.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 406-412
    • Huang, J.1
  • 9
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao HX, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496(7446):469-476.
    • (2013) Nature , vol.496 , Issue.7446 , pp. 469-476
    • Liao, H.X.1
  • 10
    • 84921607768 scopus 로고    scopus 로고
    • Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface
    • Huang J, et al. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. Nature. 2014;515(7525):138-142.
    • (2014) Nature , vol.515 , Issue.7525 , pp. 138-142
    • Huang, J.1
  • 11
    • 0032947286 scopus 로고    scopus 로고
    • Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    • Mascola JR, et al. Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol. 1999;73(5):4009-4018.
    • (1999) J Virol , vol.73 , Issue.5 , pp. 4009-4018
    • Mascola, J.R.1
  • 12
    • 68349160853 scopus 로고    scopus 로고
    • Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
    • Hessell AJ, et al. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat Med. 2009;15(8):951-954.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 951-954
    • Hessell, A.J.1
  • 13
    • 84869232528 scopus 로고    scopus 로고
    • Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
    • Moldt B, et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci U S A. 2012;109(46):18921-18925.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.46 , pp. 18921-18925
    • Moldt, B.1
  • 14
    • 84907212727 scopus 로고    scopus 로고
    • Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
    • Shingai M, et al. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med. 2014;211(10):2061-2074.
    • (2014) J Exp Med , vol.211 , Issue.10 , pp. 2061-2074
    • Shingai, M.1
  • 15
    • 79551518897 scopus 로고    scopus 로고
    • Characteristics of the earliest cross-neutralizing antibody response to HIV-1
    • Mikell I, et al. Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog. 2011;7(1):e1001251.
    • (2011) PLoS Pathog , vol.7 , Issue.1 , pp. e1001251
    • Mikell, I.1
  • 16
    • 79955389756 scopus 로고    scopus 로고
    • The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection
    • Gray ES, et al. The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection. J Virol. 2011;85(10):4828-4840.
    • (2011) J Virol , vol.85 , Issue.10 , pp. 4828-4840
    • Gray, E.S.1
  • 17
    • 84870562234 scopus 로고    scopus 로고
    • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
    • Klein F, et al. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature. 2012;492(7427):118-122.
    • (2012) Nature , vol.492 , Issue.7427 , pp. 118-122
    • Klein, F.1
  • 18
    • 84885338257 scopus 로고    scopus 로고
    • HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
    • Horwitz JA, et al. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci U S A. 2013;110(41):16538-16543.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.41 , pp. 16538-16543
    • Horwitz, J.A.1
  • 19
    • 84887626950 scopus 로고    scopus 로고
    • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    • Barouch DH, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature. 2013;503(7475):224-228.
    • (2013) Nature , vol.503 , Issue.7475 , pp. 224-228
    • Barouch, D.H.1
  • 20
    • 84887627657 scopus 로고    scopus 로고
    • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
    • Shingai M, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature. 2013;503(7475):277-280.
    • (2013) Nature , vol.503 , Issue.7475 , pp. 277-280
    • Shingai, M.1
  • 21
    • 84928405730 scopus 로고    scopus 로고
    • Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
    • Caskey M, et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 2015;522(7557):487-491.
    • (2015) Nature , vol.522 , Issue.7557 , pp. 487-491
    • Caskey, M.1
  • 22
    • 0033119374 scopus 로고    scopus 로고
    • Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo
    • Poignard P, et al. Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo. Immunity. 1999;10(4):431-438.
    • (1999) Immunity , vol.10 , Issue.4 , pp. 431-438
    • Poignard, P.1
  • 23
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • Trkola A, et al. Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat Med. 2005;11(6):615-622.
    • (2005) Nat Med , vol.11 , Issue.6 , pp. 615-622
    • Trkola, A.1
  • 24
    • 35148864699 scopus 로고    scopus 로고
    • Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection
    • Mehandru S, et al. Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection. J Virol. 2007;81(20):11016-11031.
    • (2007) J Virol , vol.81 , Issue.20 , pp. 11016-11031
    • Mehandru, S.1
  • 25
    • 84872069231 scopus 로고    scopus 로고
    • Anti-CD4 monoclonal antibody ibalizumab exhibits breadth and potency against HIV-1, with natural resistance mediated by the loss of a V5 glycan in envelope
    • Pace CS, Fordyce MW, Franco D, Kao CY, Seaman MS, Ho DD. Anti-CD4 monoclonal antibody ibalizumab exhibits breadth and potency against HIV-1, with natural resistance mediated by the loss of a V5 glycan in envelope. J Acquir Immune Defic Syndr. 2013;62(1):1-9.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , Issue.1 , pp. 1-9
    • Pace, C.S.1    Fordyce, M.W.2    Franco, D.3    Kao, C.Y.4    Seaman, M.S.5    Ho, D.D.6
  • 26
    • 0035173073 scopus 로고    scopus 로고
    • Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140
    • Trkola A, et al. Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140. J Virol. 2001;75(2):579-588.
    • (2001) J Virol , vol.75 , Issue.2 , pp. 579-588
    • Trkola, A.1
  • 27
    • 85034963123 scopus 로고    scopus 로고
    • Phase 2 efficacy and safety of the novel entry inhibitor, TNX-355, in combination with optimized background regimen (OBR)
    • - XVI International AIDS Conference; Abstract no. TUPE0058
    • Norris D, et al. Phase 2 efficacy and safety of the novel entry inhibitor, TNX-355, in combination with optimized background regimen (OBR). AIDS 2006 - XVI International AIDS Conference; Abstract no. TUPE0058.
    • (2006) AIDS
    • Norris, D.1
  • 28
    • 77957349209 scopus 로고    scopus 로고
    • Phase 2a study of the CCR5 monoclonal antibody PRO 140 administered intravenously to HIV-infected adults
    • Jacobson JM, et al. Phase 2a study of the CCR5 monoclonal antibody PRO 140 administered intravenously to HIV-infected adults. Antimicrob Agents Chemother. 2010;54(10):4137-4142.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.10 , pp. 4137-4142
    • Jacobson, J.M.1
  • 29
    • 79952832247 scopus 로고    scopus 로고
    • Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab
    • Toma J, et al. Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab. J Virol. 2011;85(8):3872-3880.
    • (2011) J Virol , vol.85 , Issue.8 , pp. 3872-3880
    • Toma, J.1
  • 30
    • 54249125999 scopus 로고    scopus 로고
    • Antiviral activity of single-dose PRO 140, a CCR5 monoclonal antibody, in HIV-infected adults
    • Jacobson JM, et al. Antiviral activity of single-dose PRO 140, a CCR5 monoclonal antibody, in HIV-infected adults. J Infect Dis. 2008;198(9):1345-1352.
    • (2008) J Infect Dis , vol.198 , Issue.9 , pp. 1345-1352
    • Jacobson, J.M.1
  • 31
    • 59749089619 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults
    • Jacobson JM, et al. Safety, pharmacokinetics, antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults. Antimicrob Agents Chemother. 2009;53(2):450-457.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.2 , pp. 450-457
    • Jacobson, J.M.1
  • 32
    • 84906968862 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
    • Chun TW, et al. Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir. Proc Natl Acad Sci U S A. 2014;111(36):13151-13156.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.36 , pp. 13151-13156
    • Chun, T.W.1
  • 33
    • 0032905728 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma
    • Igarashi T, et al. Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma. Nat Med. 1999;5(2):211-216.
    • (1999) Nat Med , vol.5 , Issue.2 , pp. 211-216
    • Igarashi, T.1
  • 34
    • 0032889275 scopus 로고    scopus 로고
    • Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques
    • Zhang L, et al. Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques. J Virol. 1999;73(1):855-860.
    • (1999) J Virol , vol.73 , Issue.1 , pp. 855-860
    • Zhang, L.1
  • 36
    • 14544308857 scopus 로고    scopus 로고
    • Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
    • Dhodapkar KM, et al. Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc Natl Acad Sci U S A. 2005;102(8):2910-2915.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.8 , pp. 2910-2915
    • Dhodapkar, K.M.1
  • 37
    • 84859393693 scopus 로고    scopus 로고
    • Immune-correlates analysis of an HIV-1 vaccine efficacy trial
    • Haynes BF, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med. 2012;366(14):1275-1286.
    • (2012) N Engl J Med , vol.366 , Issue.14 , pp. 1275-1286
    • Haynes, B.F.1
  • 38
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • Bonsignori M, et al. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol. 2012;86(21):11521-11532.
    • (2012) J Virol , vol.86 , Issue.21 , pp. 11521-11532
    • Bonsignori, M.1
  • 39
    • 84907379431 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
    • Halper-Stromberg A, et al. Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell. 2014;158(5):989-999.
    • (2014) Cell , vol.158 , Issue.5 , pp. 989-999
    • Halper-Stromberg, A.1
  • 40
    • 84908077691 scopus 로고    scopus 로고
    • Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity
    • Bournazos S, Klein F, Pietzsch J, Seaman MS, Nussenzweig MC, Ravetch JV. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell. 2014;158(6):1243-1253.
    • (2014) Cell , vol.158 , Issue.6 , pp. 1243-1253
    • Bournazos, S.1    Klein, F.2    Pietzsch, J.3    Seaman, M.S.4    Nussenzweig, M.C.5    Ravetch, J.V.6
  • 41
    • 34548496893 scopus 로고    scopus 로고
    • Fc receptor but not complement binding is important in antibody protection against HIV
    • Hessell AJ, et al. Fc receptor but not complement binding is important in antibody protection against HIV. Nature. 2007;449(7158):101-104.
    • (2007) Nature , vol.449 , Issue.7158 , pp. 101-104
    • Hessell, A.J.1
  • 42
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney JB, et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature. 2014;512(7512):74-77.
    • (2014) Nature , vol.512 , Issue.7512 , pp. 74-77
    • Whitney, J.B.1
  • 43
    • 84883206439 scopus 로고    scopus 로고
    • Three distinct phases of HIV-1 RNA decay in treatment-naive patients receiving raltegravir-based antiretroviral therapy: ACTG A5248
    • Andrade A, et al. Three distinct phases of HIV-1 RNA decay in treatment-naive patients receiving raltegravir-based antiretroviral therapy: ACTG A5248. J Infect Dis. 2013;208(6):884-891.
    • (2013) J Infect Dis , vol.208 , Issue.6 , pp. 884-891
    • Andrade, A.1
  • 44
    • 84863579036 scopus 로고    scopus 로고
    • A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques
    • Moldt B, et al. A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques. J Virol. 2012;86(11):6189-6196.
    • (2012) J Virol , vol.86 , Issue.11 , pp. 6189-6196
    • Moldt, B.1
  • 45
    • 84911947017 scopus 로고    scopus 로고
    • Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants
    • Klein F, et al. Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med. 2014;211(12):2361-2372.
    • (2014) J Exp Med , vol.211 , Issue.12 , pp. 2361-2372
    • Klein, F.1
  • 46
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    • Chun TW, et al. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc Natl Acad Sci U S A. 1998;95(15):8869-8873.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.15 , pp. 8869-8873
    • Chun, T.W.1
  • 47
    • 0028791836 scopus 로고
    • Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl) adenine
    • Tsai CC, et al. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl) adenine. Science. 1995;270(5239):1197-1199.
    • (1995) Science , vol.270 , Issue.5239 , pp. 1197-1199
    • Tsai, C.C.1
  • 48
    • 0031979775 scopus 로고    scopus 로고
    • Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment
    • Tsai CC, et al. Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol. 1998;72(5):4265-4273.
    • (1998) J Virol , vol.72 , Issue.5 , pp. 4265-4273
    • Tsai, C.C.1
  • 49
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med. 2003;9(6):727-728.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 727-728
    • Siliciano, J.D.1
  • 50
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun TW, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 1997;387(6629):183-188.
    • (1997) Nature , vol.387 , Issue.6629 , pp. 183-188
    • Chun, T.W.1
  • 51
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med. 1999;340(21):1605-1613.
    • (1999) N Engl J Med , vol.340 , Issue.21 , pp. 1605-1613
    • Zhang, L.1
  • 52
    • 0033984045 scopus 로고    scopus 로고
    • The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
    • Ramratnam B, et al. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med. 2000;6(1):82-85.
    • (2000) Nat Med , vol.6 , Issue.1 , pp. 82-85
    • Ramratnam, B.1
  • 53
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism of lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, et al. Latent infection of CD4+ T cells provides a mechanism of lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5(5):512-517.
    • (1999) Nat Med , vol.5 , Issue.5 , pp. 512-517
    • Finzi, D.1
  • 54
    • 84946096080 scopus 로고    scopus 로고
    • Precise quantitation of the latent HIV-1 reservoir: Implications for eradication strategies
    • Crooks AM, et al. Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies. J Infect Dis. 2015;212(9):1361-1365.
    • (2015) J Infect Dis , vol.212 , Issue.9 , pp. 1361-1365
    • Crooks, A.M.1
  • 55
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci U S A. 2009;106(23):9403-9408.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9403-9408
    • Dinoso, J.B.1
  • 56
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi RT, et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med. 2010;7(8):e1000321.
    • (2010) PLoS Med , vol.7 , Issue.8 , pp. e1000321
    • Gandhi, R.T.1
  • 57
    • 84864243685 scopus 로고    scopus 로고
    • HIV: Shock and kill
    • Deeks SG. HIV: Shock and kill. Nature. 2012;487(7408):439-440.
    • (2012) Nature , vol.487 , Issue.7408 , pp. 439-440
    • Deeks, S.G.1
  • 58
    • 0033031218 scopus 로고    scopus 로고
    • Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
    • Chun TW, et al. Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat Med. 1999;5(6):651-655.
    • (1999) Nat Med , vol.5 , Issue.6 , pp. 651-655
    • Chun, T.W.1
  • 59
    • 0035144503 scopus 로고    scopus 로고
    • Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission
    • Lafeuillade A, et al. Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission. J Acquir Immune Defic Syndr. 2001;26(1):44-55.
    • (2001) J Acquir Immune Defic Syndr , vol.26 , Issue.1 , pp. 44-55
    • Lafeuillade, A.1
  • 60
    • 0037178320 scopus 로고    scopus 로고
    • Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial)
    • Stellbrink HJ, et al. Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial). AIDS. 2002;16(11):1479-1487.
    • (2002) AIDS , vol.16 , Issue.11 , pp. 1479-1487
    • Stellbrink, H.J.1
  • 61
    • 70249100307 scopus 로고    scopus 로고
    • Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors
    • Archin NM, et al. Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors. AIDS. 2009;23(14):1799-1806.
    • (2009) AIDS , vol.23 , Issue.14 , pp. 1799-1806
    • Archin, N.M.1
  • 62
    • 65449148344 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    • Contreras X, et al. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J Biol Chem. 2009;284(11):6782-6789.
    • (2009) J Biol Chem , vol.284 , Issue.11 , pp. 6782-6789
    • Contreras, X.1
  • 63
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature. 2012;487(7408):482-485.
    • (2012) Nature , vol.487 , Issue.7408 , pp. 482-485
    • Archin, N.M.1
  • 64
    • 84912122037 scopus 로고    scopus 로고
    • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
    • Elliott JH, et al. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLoS Pathog. 2014;10(11):e1004473.
    • (2014) PLoS Pathog , vol.10 , Issue.11 , pp. e1004473
    • Elliott, J.H.1
  • 65
    • 84911460971 scopus 로고    scopus 로고
    • Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: A phase 1/2, single group, clinical trial
    • Rasmussen TA, et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV. 2014;1(1):e13-e21.
    • (2014) Lancet HIV , vol.1 , Issue.1 , pp. e13-e21
    • Rasmussen, T.A.1
  • 66
    • 84906764768 scopus 로고    scopus 로고
    • HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat
    • Archin NM, et al. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat. J Infect Dis. 2014;210(5):728-735.
    • (2014) J Infect Dis , vol.210 , Issue.5 , pp. 728-735
    • Archin, N.M.1
  • 67
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L, et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity. 2012;36(3):491-501.
    • (2012) Immunity , vol.36 , Issue.3 , pp. 491-501
    • Shan, L.1
  • 68
    • 84900473405 scopus 로고    scopus 로고
    • Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy
    • Cillo AR, et al. Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy. Proc Natl Acad Sci U S A. 2014;111(19):7078-7083.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.19 , pp. 7078-7083
    • Cillo, A.R.1
  • 69
    • 84864934043 scopus 로고    scopus 로고
    • Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy
    • Blazkova J, et al. Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy. J Infect Dis. 2012;206(5):765-769.
    • (2012) J Infect Dis , vol.206 , Issue.5 , pp. 765-769
    • Blazkova, J.1
  • 70
    • 84922764937 scopus 로고    scopus 로고
    • Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
    • Deng K, et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 2015;517(7534):381-385.
    • (2015) Nature , vol.517 , Issue.7534 , pp. 381-385
    • Deng, K.1
  • 71
    • 84912530131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes
    • Jones RB, et al. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLoS Pathog. 2014;10(8):e1004287.
    • (2014) PLoS Pathog , vol.10 , Issue.8 , pp. e1004287
    • Jones, R.B.1
  • 73
    • 84901309171 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing
    • Wei DG, et al. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog. 2014;10(4):e1004071.
    • (2014) PLoS Pathog , vol.10 , Issue.4 , pp. e1004071
    • Wei, D.G.1
  • 74
    • 84928986546 scopus 로고    scopus 로고
    • Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations
    • Laird GM, et al. Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. J Clin Invest. 2015;125(5):1901-1912.
    • (2015) J Clin Invest , vol.125 , Issue.5 , pp. 1901-1912
    • Laird, G.M.1
  • 75
    • 84934311252 scopus 로고    scopus 로고
    • Treatment with a TLR7 agonist induces transient viremia in SIV-infected ARTsuppressed monkeys
    • February 23-26; Seattle, Washington, USA. Abstract 108
    • Whitney JB, et al. Treatment with a TLR7 agonist induces transient viremia in SIV-infected ARTsuppressed monkeys. Presented at: Conference on Retroviruses and Opportunistic Infections (CROI 2015); February 23-26, 2015; Seattle, Washington, USA. Abstract 108.
    • (2015) Conference on Retroviruses and Opportunistic Infections (CROI 2015)
    • Whitney, J.B.1
  • 76
    • 84920890693 scopus 로고    scopus 로고
    • The HDAC inhibitor romidepsin is safe and effectively reverses HIV-1 latency in vivo as measured by standard clinical assays
    • July 20-25, Melbourne, Australia. Abstract OA2-4 LB
    • Sogaard, OS, et al. The HDAC inhibitor romidepsin is safe and effectively reverses HIV-1 latency in vivo as measured by standard clinical assays. Presented at: 20th International AIDS Conference; July 20-25, 2014; Melbourne, Australia. Abstract OA2-4 LB.
    • (2014) 20th International AIDS Conference
    • Sogaard, O.S.1
  • 77
    • 84907359983 scopus 로고    scopus 로고
    • Neutralizing the HIV reservoir
    • Marsden MD, Zack JA. Neutralizing the HIV reservoir. Cell. 2014;158(5):971-972.
    • (2014) Cell , vol.158 , Issue.5 , pp. 971-972
    • Marsden, M.D.1    Zack, J.A.2
  • 78
    • 84902665600 scopus 로고    scopus 로고
    • Screening for noise in gene expression identifies drug synergies
    • Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Screening for noise in gene expression identifies drug synergies. Science. 2014;344(6190):1392-1396.
    • (2014) Science , vol.344 , Issue.6190 , pp. 1392-1396
    • Dar, R.D.1    Hosmane, N.N.2    Arkin, M.R.3    Siliciano, R.F.4    Weinberger, L.S.5
  • 79
    • 79953689313 scopus 로고    scopus 로고
    • Activation of latent HIV using drug-loaded nanoparticles
    • Kovochich M, Marsden MD, Zack JA. Activation of latent HIV using drug-loaded nanoparticles. PLoS One. 2011;6(4):e18270.
    • (2011) PLoS One , vol.6 , Issue.4 , pp. e18270
    • Kovochich, M.1    Marsden, M.D.2    Zack, J.A.3
  • 80
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
    • Veazey RS, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science. 1998;280(5362):427-431.
    • (1998) Science , vol.280 , Issue.5362 , pp. 427-431
    • Veazey, R.S.1
  • 81
    • 17844376742 scopus 로고    scopus 로고
    • Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    • Li Q, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature. 2005;434(7037):1148-1152.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1148-1152
    • Li, Q.1
  • 82
    • 80052395837 scopus 로고    scopus 로고
    • Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
    • Sigal A, et al. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature. 2011;477(7362):95-98.
    • (2011) Nature , vol.477 , Issue.7362 , pp. 95-98
    • Sigal, A.1
  • 83
    • 84861205063 scopus 로고    scopus 로고
    • Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies
    • Abela IA, et al. Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. PLoS Pathog. 2012;8(4):e1002634.
    • (2012) PLoS Pathog , vol.8 , Issue.4 , pp. e1002634
    • Abela, I.A.1
  • 84
    • 84890824652 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission
    • Malbec M, et al. Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission. J Exp Med. 2013;210(13):2813-2821.
    • (2013) J Exp Med , vol.210 , Issue.13 , pp. 2813-2821
    • Malbec, M.1
  • 85
    • 84922611542 scopus 로고    scopus 로고
    • B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
    • Fukazawa Y, et al. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat Med. 2015;21(2):132-139.
    • (2015) Nat Med , vol.21 , Issue.2 , pp. 132-139
    • Fukazawa, Y.1
  • 86
    • 0018720010 scopus 로고
    • Disproportionate elevation of the immunoglobulin G1 concentration in cerebrospinal fluids of patients with multiple sclerosis
    • Kaschka WP, Theilkaes L, Eickhoff K, Skvaril F. Disproportionate elevation of the immunoglobulin G1 concentration in cerebrospinal fluids of patients with multiple sclerosis. Infect Immun. 1979;26(3):933-941.
    • (1979) Infect Immun , vol.26 , Issue.3 , pp. 933-941
    • Kaschka, W.P.1    Theilkaes, L.2    Eickhoff, K.3    Skvaril, F.4
  • 87
    • 0037438494 scopus 로고    scopus 로고
    • Rituximab therapy for CNS lymphomas: Targeting the leptomeningeal compart ment
    • Rubenstein JL. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compart ment. Blood. 2002;101(2):466-468.
    • (2002) Blood , vol.101 , Issue.2 , pp. 466-468
    • Rubenstein, J.L.1
  • 88
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    • Balazs AB, et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med. 2014;20(3):296-300.
    • (2014) Nat Med , vol.20 , Issue.3 , pp. 296-300
    • Balazs, A.B.1
  • 89
    • 68349150945 scopus 로고    scopus 로고
    • Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    • Johnson PR, et al. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med. 2009;15(8):901-906.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 901-906
    • Johnson, P.R.1
  • 90
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2011;481(7379):81-84.
    • (2011) Nature , vol.481 , Issue.7379 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3    Rao, D.S.4    Yang, L.5    Baltimore, D.6
  • 91
    • 84907983318 scopus 로고    scopus 로고
    • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
    • Ko SY, et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature. 2014;514(7524):642-645.
    • (2014) Nature , vol.514 , Issue.7524 , pp. 642-645
    • Ko, S.Y.1
  • 92
    • 82755184131 scopus 로고    scopus 로고
    • Increasing the potency and breadth of an HIV antibody by using structure-based rational design
    • Diskin R, et al. Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science. 2011;334(6060):1289-1293.
    • (2011) Science , vol.334 , Issue.6060 , pp. 1289-1293
    • Diskin, R.1
  • 93
    • 84879523938 scopus 로고    scopus 로고
    • Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies
    • Diskin R, et al. Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies. J Exp Med. 2013;210(6):1235-1249.
    • (2013) J Exp Med , vol.210 , Issue.6 , pp. 1235-1249
    • Diskin, R.1
  • 94
    • 84922224963 scopus 로고    scopus 로고
    • Intra-spike crosslinking overcomes antibody evasion by HIV-1
    • Galimidi RP, et al. Intra-spike crosslinking overcomes antibody evasion by HIV-1. Cell. 2015;160(3):433-446.
    • (2015) Cell , vol.160 , Issue.3 , pp. 433-446
    • Galimidi, R.P.1
  • 95
    • 84882404868 scopus 로고    scopus 로고
    • Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1
    • Pace CS, et al. Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1. Proc Natl Acad Sci U S A. 2013;110(33):13540-13545.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.33 , pp. 13540-13545
    • Pace, C.S.1
  • 96
    • 84893815335 scopus 로고    scopus 로고
    • Targeted cytotoxic therapy kills persisting HIV infected cells during ART
    • Denton PW, et al. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Pathog. 2014;10(1):e1003872.
    • (2014) PLoS Pathog , vol.10 , Issue.1 , pp. e1003872
    • Denton, P.W.1


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