Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis

Circulation

Volumn 133, Issue 2, 2016, Pages 177-186

  Tran, Khiem A ^a,b   Zhang, Xianming ^a,b   Predescu, Dan ^d   Huang, Xiaojia ^a,b   MacHado, Roberto F ^c   Göthert, Joachim R ^e   Malik, Asrar B ^a,b   Valyi Nagy, Tibor ^a   Zhao, You Yang ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b Center for Lung and Vascular Biology   (United States)

^c Department of Medicine ^*  (United States)

^d RUSH UNIVERSITY   (United States)

^e UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

blood brain barrier; brain; cerebrovascular disorders; endothelium; intracranial hemorrhages

Indexed keywords

BETA CATENIN; CLAUDIN 1; CLAUDIN 3; CLDN1 PROTEIN, HUMAN; CLDN1 PROTEIN, MOUSE; CLDN3 PROTEIN, MOUSE; CTNNB1 PROTEIN, HUMAN; CTNNB1 PROTEIN, MOUSE; CYTOKINE;

ADULT; AGED; ANIMAL; ANTIBODY SPECIFICITY; ATAXIA; BASAL GANGLION; BIOSYNTHESIS; BLOOD BRAIN BARRIER; BRAIN; CEREBRAL HEMORRHAGE; CROSS BREEDING; DEFICIENCY; DOWN REGULATION; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HOMEOSTASIS; HUMAN; HYPERESTHESIA; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; MOUSE; PATHOLOGY; PHYSIOLOGY; REPORTER GENE; RNA INTERFERENCE; SEIZURES; TIGHT JUNCTION; TRANSGENE; TRANSGENIC MOUSE;

ADULT; AGED; ANIMALS; ATAXIA; BASAL GANGLIA; BETA CATENIN; BLOOD-BRAIN BARRIER; BRAIN; CEREBRAL HEMORRHAGE; CLAUDIN-1; CLAUDIN-3; CROSSES, GENETIC; CYTOKINES; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENES, REPORTER; HOMEOSTASIS; HUMANS; HYPERESTHESIA; INFLAMMATION; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; ORGAN SPECIFICITY; RNA INTERFERENCE; SEIZURES; TIGHT JUNCTIONS; TRANSGENES;

EID: 84956667507     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.015982     Document Type: Article

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