-
1
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004;4(8):604-616.
-
(2004)
Nat Rev Cancer.
, vol.4
, Issue.8
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
2
-
-
80051514415
-
Many ceramides
-
Hannun YA, Obeid LM. Many ceramides. J Biol Chem. 2011;286(32):27855-27862.
-
(2011)
J Biol Chem.
, vol.286
, Issue.32
, pp. 27855-27862
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
3
-
-
0027511687
-
Programmed cell death induced by ceramide
-
Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science. 1993;259(5102):1769-1771.
-
(1993)
Science.
, vol.259
, Issue.5102
, pp. 1769-1771
-
-
Obeid, L.M.1
Linardic, C.M.2
Karolak, L.A.3
Hannun, Y.A.4
-
4
-
-
0032696035
-
Mass spectrometric identification of increased C16 ceramide levels during apoptosis
-
Thomas RL Jr, Matsko CM, Lotze MT, Amoscato AA. Mass spectrometric identification of increased C16 ceramide levels during apoptosis. J Biol Chem. 1999;274(43):30580-30588.
-
(1999)
J Biol Chem.
, vol.274
, Issue.43
, pp. 30580-30588
-
-
Thomas, R.L.1
Matsko, C.M.2
Lotze, M.T.3
Amoscato, A.A.4
-
6
-
-
34548286300
-
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis
-
Karahatay S, et al. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 2007;256(1):101-111.
-
(2007)
Cancer Lett.
, vol.256
, Issue.1
, pp. 101-111
-
-
Karahatay, S.1
-
7
-
-
72949118520
-
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression
-
Erez-Roman R, Pienik R, Futerman AH. Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression. Biochem Biophys Res Commun. 2010;391(1):219-223.
-
(2010)
Biochem Biophys Res Commun.
, vol.391
, Issue.1
, pp. 219-223
-
-
Erez-Roman, R.1
Pienik, R.2
Futerman, A.H.3
-
8
-
-
75149176725
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
-
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 2010;24(1):296-308.
-
(2010)
FASEB J.
, vol.24
, Issue.1
, pp. 296-308
-
-
Senkal, C.E.1
Ponnusamy, S.2
Bielawski, J.3
Hannun, Y.A.4
Ogretmen, B.5
-
9
-
-
33645804773
-
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors
-
Takeuchi T, et al. Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol. 2006;24(11):1679-1688.
-
(2006)
J Clin Oncol.
, vol.24
, Issue.11
, pp. 1679-1688
-
-
Takeuchi, T.1
-
10
-
-
67649965344
-
Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis
-
Tomida S, et al. Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J Clin Oncol. 2009;27(17):2793-2799.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.17
, pp. 2793-2799
-
-
Tomida, S.1
-
11
-
-
72949101986
-
Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells
-
Huang QM, Akashi T, Masuda Y, Kamiya K, Takahashi T, Suzuki M. Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells. Biochem Biophys Res Commun. 2010;391(1):542-546.
-
(2010)
Biochem Biophys Res Commun.
, vol.391
, Issue.1
, pp. 542-546
-
-
Huang, Q.M.1
Akashi, T.2
Masuda, Y.3
Kamiya, K.4
Takahashi, T.5
Suzuki, M.6
-
12
-
-
78449307955
-
Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer
-
Huang QM, et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res. 2010;70(21):8407-8416.
-
(2010)
Cancer Res.
, vol.70
, Issue.21
, pp. 8407-8416
-
-
Huang, Q.M.1
-
13
-
-
23944483995
-
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
-
Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005;390(pt 1):263-271.
-
(2005)
Biochem J.
, vol.390
, pp. 263-271
-
-
Mizutani, Y.1
Kihara, A.2
Igarashi, Y.3
-
14
-
-
78650194092
-
Let-7 and miR-17-92: Small-sized major players in lung cancer development
-
Osada H, Takahashi T. let-7 and miR-17-92: small-sized major players in lung cancer development. Cancer Sci. 2011;102(1):9-17.
-
(2011)
Cancer Sci.
, vol.102
, Issue.1
, pp. 9-17
-
-
Osada, H.1
Takahashi, T.2
-
15
-
-
84882454959
-
Atypical protein kinase C in cell motility
-
Xiao H, Liu M. Atypical protein kinase C in cell motility. Cell Mol Life Sci. 2013;70(17):3057-3066.
-
(2013)
Cell Mol Life Sci.
, vol.70
, Issue.17
, pp. 3057-3066
-
-
Xiao, H.1
Liu, M.2
-
16
-
-
34047248886
-
Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis
-
Krishnamurthy K, Wang G, Silva J, Condie BG, Bieberich E. Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis. J Biol Chem. 2007;282(5):3379-3390.
-
(2007)
J Biol Chem.
, vol.282
, Issue.5
, pp. 3379-3390
-
-
Krishnamurthy, K.1
Wang, G.2
Silva, J.3
Condie, B.G.4
Bieberich, E.5
-
17
-
-
70350380859
-
Regulation of primary cilia formation by ceramide
-
Wang G, Krishnamurthy K, Bieberich E. Regulation of primary cilia formation by ceramide. J Lipid Res. 2009;50(10):2103-2110.
-
(2009)
J Lipid Res.
, vol.50
, Issue.10
, pp. 2103-2110
-
-
Wang, G.1
Krishnamurthy, K.2
Bieberich, E.3
-
18
-
-
67649827252
-
The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells
-
Wang G, Krishnamurthy K, Umapathy NS, Verin AD, Bieberich E. The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells. J Biol Chem. 2009;284(21):14469-14475.
-
(2009)
J Biol Chem.
, vol.284
, Issue.21
, pp. 14469-14475
-
-
Wang, G.1
Krishnamurthy, K.2
Umapathy, N.S.3
Verin, A.D.4
Bieberich, E.5
-
19
-
-
42449138318
-
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ ceramide pathway
-
Zeidan YH, Jenkins RW, Hannun YA. Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ ceramide pathway. J Cell Biol. 2008;181(2):335-350.
-
(2008)
J Cell Biol.
, vol.181
, Issue.2
, pp. 335-350
-
-
Zeidan, Y.H.1
Jenkins, R.W.2
Hannun, Y.A.3
-
20
-
-
2442693091
-
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells
-
Lacour S, et al. Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. Cancer Res. 2004;64(10):3593-3598.
-
(2004)
Cancer Res.
, vol.64
, Issue.10
, pp. 3593-3598
-
-
Lacour, S.1
-
21
-
-
84862788946
-
Hybrid liposomes affect cellular lipid constituents and caveolae structures
-
Cao K, et al. Hybrid liposomes affect cellular lipid constituents and caveolae structures. Bioorg Med Chem Lett. 2012;22(4):1731-1733.
-
(2012)
Bioorg Med Chem Lett.
, vol.22
, Issue.4
, pp. 1731-1733
-
-
Cao, K.1
-
22
-
-
18644376989
-
Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells
-
Matsumoto Y, Iwamoto Y, Matsushita T, Ueoka R. Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells. Int J Cancer. 2005;115(3):377-382.
-
(2005)
Int J Cancer.
, vol.115
, Issue.3
, pp. 377-382
-
-
Matsumoto, Y.1
Iwamoto, Y.2
Matsushita, T.3
Ueoka, R.4
-
23
-
-
16044364385
-
Acid sphingomyelinasedeficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
Santana P, et al. Acid sphingomyelinasedeficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 1996;86(2):189-199.
-
(1996)
Cell.
, vol.86
, Issue.2
, pp. 189-199
-
-
Santana, P.1
-
24
-
-
0034126244
-
Development of a new inhibitor of glucosylceramide synthase
-
Jimbo M, et al. Development of a new inhibitor of glucosylceramide synthase. J Biochem. 2000;127(3):485-491.
-
(2000)
J Biochem.
, vol.127
, Issue.3
, pp. 485-491
-
-
Jimbo, M.1
-
25
-
-
79955821500
-
TMSG-1 and its roles in tumor biology
-
Xu XY, Pei F, You JF. TMSG-1 and its roles in tumor biology. Chin J Cancer. 2010;29(7):697-702.
-
(2010)
Chin J Cancer.
, vol.29
, Issue.7
, pp. 697-702
-
-
Xu, X.Y.1
Pei, F.2
You, J.F.3
-
26
-
-
84872808956
-
Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
-
Wang H, et al. Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma. Med Oncol. 2012;29(3):1921-1927.
-
(2012)
Med Oncol.
, vol.29
, Issue.3
, pp. 1921-1927
-
-
Wang, H.1
-
27
-
-
80052239397
-
MiR-101 DNA copy loss is a prominent subtype specific event in lung cancer
-
Thu KL, Chari R, Lockwood WW, Lam S, Lam WL. miR-101 DNA copy loss is a prominent subtype specific event in lung cancer. J Thorac Oncol. 2011;6(9):1594-1598.
-
(2011)
J Thorac Oncol.
, vol.6
, Issue.9
, pp. 1594-1598
-
-
Thu, K.L.1
Chari, R.2
Lockwood, W.W.3
Lam, S.4
Lam, W.L.5
-
28
-
-
58149239686
-
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
-
Varambally S, et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 2008;322(5908):1695-1699.
-
(2008)
Science.
, vol.322
, Issue.5908
, pp. 1695-1699
-
-
Varambally, S.1
-
29
-
-
81855193960
-
Radiosensitizing effects of ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous miR-101 level
-
Chen S, Wang H, Ng WL, Curran WJ, Wang Y. Radiosensitizing effects of ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous miR-101 level. Int J Radiat Oncol Biol Phys. 2011;81(5):1524-1529.
-
(2011)
Int J Radiat Oncol Biol Phys.
, vol.81
, Issue.5
, pp. 1524-1529
-
-
Chen, S.1
Wang, H.2
Ng, W.L.3
Curran, W.J.4
Wang, Y.5
-
30
-
-
84895913588
-
Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility
-
Edmond V, et al. Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. Oncogene. 2015;34(8):996-1005.
-
(2015)
Oncogene.
, vol.34
, Issue.8
, pp. 996-1005
-
-
Edmond, V.1
-
31
-
-
0023258056
-
Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase
-
Inokuchi J, Radin NS. Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. J Lipid Res. 1987;28(5):565-571.
-
(1987)
J Lipid Res.
, vol.28
, Issue.5
, pp. 565-571
-
-
Inokuchi, J.1
Radin, N.S.2
-
32
-
-
10944228766
-
Oncogene addiction: Sometimes a temporary slavery
-
Jonkers J, Berns A. Oncogene addiction: sometimes a temporary slavery. Cancer Cell. 2004;6(6):535-538.
-
(2004)
Cancer Cell.
, vol.6
, Issue.6
, pp. 535-538
-
-
Jonkers, J.1
Berns, A.2
-
33
-
-
22044442973
-
Tyrosine kinases as targets for cancer therapy
-
Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med. 2005;353(2):172-187.
-
(2005)
N Engl J Med.
, vol.353
, Issue.2
, pp. 172-187
-
-
Krause, D.S.1
Van Etten, R.A.2
-
34
-
-
0034192370
-
Establishment and characterization of a human lung cancer cell line NCIH460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation
-
Kozaki K, Miyaishi O, Tsukamoto T, Tatematsu Y, Hida T, Takahashi T. Establishment and characterization of a human lung cancer cell line NCIH460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation. Cancer Res. 2000;60(9):2535-2540.
-
(2000)
Cancer Res.
, vol.60
, Issue.9
, pp. 2535-2540
-
-
Kozaki, K.1
Miyaishi, O.2
Tsukamoto, T.3
Tatematsu, Y.4
Hida, T.5
Takahashi, T.6
-
35
-
-
27544495514
-
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
-
Hayashita Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 2005;65(21):9628-9632.
-
(2005)
Cancer Res.
, vol.65
, Issue.21
, pp. 9628-9632
-
-
Hayashita, Y.1
-
36
-
-
84867062467
-
Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo
-
Ichihara H, Hino M, Umebayashi M, Matsumoto Y, Ueoka R. Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo. Eur J Med Chem. 2012;57:143-148.
-
(2012)
Eur J Med Chem.
, vol.57
, pp. 143-148
-
-
Ichihara, H.1
Hino, M.2
Umebayashi, M.3
Matsumoto, Y.4
Ueoka, R.5
-
37
-
-
0026528994
-
Improved inhibitors of glucosylceramide synthase
-
Abe A, et al. Improved inhibitors of glucosylceramide synthase. J Biochem. 1992;111(2):191-196.
-
(1992)
J Biochem.
, vol.111
, Issue.2
, pp. 191-196
-
-
Abe, A.1
-
38
-
-
0037131721
-
Specific accumulation and growth inhibitory effects of hybrid liposomes to hepatoma cells in vitro
-
Nakano K, Iwamoto Y, Takata W, Matsumoto Y, Ueoka R. Specific accumulation and growth inhibitory effects of hybrid liposomes to hepatoma cells in vitro. Bioorg Med Chem Lett. 2002;12(22):3251-3254.
-
(2002)
Bioorg Med Chem Lett.
, vol.12
, Issue.22
, pp. 3251-3254
-
-
Nakano, K.1
Iwamoto, Y.2
Takata, W.3
Matsumoto, Y.4
Ueoka, R.5
-
39
-
-
42549137252
-
Chemotherapy using hybrid liposomes along with induction of apoptosis
-
Ichihara H, Nagami H, Kiyokawa T, Matsumoto Y, Ueoka R. Chemotherapy using hybrid liposomes along with induction of apoptosis. Anticancer Res. 2008;28(2B):1187-1195.
-
(2008)
Anticancer Res.
, vol.28
, Issue.2 B
, pp. 1187-1195
-
-
Ichihara, H.1
Nagami, H.2
Kiyokawa, T.3
Matsumoto, Y.4
Ueoka, R.5
-
40
-
-
0023501151
-
Antitumor activity via inhibition of glycosphingolipid biosynthesis
-
Inokuchi J, Mason I, Radin NS. Antitumor activity via inhibition of glycosphingolipid biosynthesis. Cancer Lett. 1987;38(1-2):23-30.
-
(1987)
Cancer Lett.
, vol.38
, Issue.1-2
, pp. 23-30
-
-
Inokuchi, J.1
Mason, I.2
Radin, N.S.3
-
41
-
-
34447101200
-
Apoptosis induction by antisense oligonucleotides against miR-17-5p miR-20a in lung cancers overexpressing miR-17-92
-
Matsubara H, et al. Apoptosis induction by antisense oligonucleotides against miR-17-5p miR-20a in lung cancers overexpressing miR-17-92. Oncogene. 2007;26(41):6099-6105.
-
(2007)
Oncogene.
, vol.26
, Issue.41
, pp. 6099-6105
-
-
Matsubara, H.1
-
42
-
-
37049016679
-
Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer
-
Ebi H, et al. Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer. Cancer Res. 2007;67(23):11158-11165.
-
(2007)
Cancer Res.
, vol.67
, Issue.23
, pp. 11158-11165
-
-
Ebi, H.1
-
43
-
-
84857189404
-
MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis
-
Hosono Y, et al. MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. EMBO J. 2012;31(2):481-493.
-
(2012)
EMBO J.
, vol.31
, Issue.2
, pp. 481-493
-
-
Hosono, Y.1
-
44
-
-
55549127406
-
Let-7 regulates Dicer expression and constitutes a negative feedback loop
-
Tokumaru S, Suzuki M, Yamada H, Nagino M, Takahashi T. let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis. 2008;29(11):2073-2077.
-
(2008)
Carcinogenesis.
, vol.29
, Issue.11
, pp. 2073-2077
-
-
Tokumaru, S.1
Suzuki, M.2
Yamada, H.3
Nagino, M.4
Takahashi, T.5
-
45
-
-
77951091722
-
Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
-
Kasumov T, Huang H, Chung YM, Zhang R, McCullough AJ, Kirwan JP. Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Biochem. 2010;401(1):154-161.
-
(2010)
Anal Biochem.
, vol.401
, Issue.1
, pp. 154-161
-
-
Kasumov, T.1
Huang, H.2
Chung, Y.M.3
Zhang, R.4
McCullough, A.J.5
Kirwan, J.P.6
-
46
-
-
84926452140
-
Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features
-
Arima C, et al. Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features. Carcinogenesis. 2014;35(10):2224-2231.
-
(2014)
Carcinogenesis.
, vol.35
, Issue.10
, pp. 2224-2231
-
-
Arima, C.1
|