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Volumn 34, Issue 8, 2015, Pages 996-1005

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

Author keywords

[No Author keywords available]

Indexed keywords

CERS6 PROTEIN, HUMAN; MEMBRANE PROTEIN; SPHINGOSINE ACYLTRANSFERASE;

EID: 84895913588     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.55     Document Type: Article
Times cited : (74)

References (40)
  • 1
    • 60149085396 scopus 로고    scopus 로고
    • The many roles of FAS receptor signaling in the immune system
    • Strasser A, Jost PJ, Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity 2009; 30: 180-192.
    • (2009) Immunity , vol.30 , pp. 180-192
    • Strasser, A.1    Jost, P.J.2    Nagata, S.3
  • 2
    • 77952829835 scopus 로고    scopus 로고
    • Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells
    • Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF et al. Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells. Gastroenterology 2010; 138: 2357-2367.
    • (2010) Gastroenterology , vol.138 , pp. 2357-2367
    • Hoogwater, F.J.1    Nijkamp, M.W.2    Smakman, N.3    Steller, E.J.4    Emmink, B.L.5    Westendorp, B.F.6
  • 5
    • 70349694386 scopus 로고    scopus 로고
    • Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
    • O' Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 2009; 461: 659-663.
    • (2009) Nature , vol.461 , pp. 659-663
    • O'Reilly, L.A.1    Tai, L.2    Lee, L.3    Kruse, E.A.4    Grabow, S.5    Fairlie, W.D.6
  • 6
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a deathinducing signaling complex (DISC) with the receptor
    • Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a deathinducing signaling complex (DISC) with the receptor. EMBO J 1995; 14: 5579-5588.
    • (1995) EMBO J , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3    Germer, M.4    Pawlita, M.5    Krammer, P.H.6
  • 8
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008; 9: 139-150.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 9
    • 84855918312 scopus 로고    scopus 로고
    • Ceramide synthases at the centre of sphingolipid metabolism and biology
    • Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J 2012; 441: 789-802.
    • (2012) Biochem J , vol.441 , pp. 789-802
    • Mullen, T.D.1    Hannun, Y.A.2    Obeid, L.M.3
  • 10
    • 33644635713 scopus 로고    scopus 로고
    • LASS6, an additional member of the longevity assurance gene family
    • Weinmann A, Galle PR, Teufel A. LASS6, an additional member of the longevity assurance gene family. Int J Mol Med 2005; 16: 905-910.
    • (2005) Int J Mol Med , vol.16 , pp. 905-910
    • Weinmann, A.1    Galle, P.R.2    Teufel, A.3
  • 11
    • 33846411845 scopus 로고    scopus 로고
    • Ceramide-domain formation and collapse in lipid rafts: Membrane reorganization by an apoptotic lipid
    • Silva LC, de Almeida RF, Castro BM, Fedorov A, Prieto M. Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid. Biophys J 2007; 92: 502-516.
    • (2007) Biophys J , vol.92 , pp. 502-516
    • Silva, L.C.1    De Almeida, R.F.2    Castro, B.M.3    Fedorov, A.4    Prieto, M.5
  • 12
    • 58149188064 scopus 로고    scopus 로고
    • Effects of ceramide and other simple sphingolipids on membrane lateral structure
    • Goni FM, Alonso A. Effects of ceramide and other simple sphingolipids on membrane lateral structure. Biochim Biophys Acta 2009; 1788: 169-177.
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 169-177
    • Goni, F.M.1    Alonso, A.2
  • 15
    • 77951234061 scopus 로고    scopus 로고
    • A critical role for ceramide synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways
    • Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J et al. A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem 2010; 285: 10902-10910.
    • (2010) J Biol Chem , vol.285 , pp. 10902-10910
    • Pewzner-Jung, Y.1    Park, H.2    Laviad, E.L.3    Silva, L.C.4    Lahiri, S.5    Stiban, J.6
  • 16
    • 0024361106 scopus 로고
    • A role of the cancer cell membrane fluidity in the cancer metastases: An ESR study
    • Nakazawa I, Iwaizumi M. A role of the cancer cell membrane fluidity in the cancer metastases: an ESR study. Tohoku J Exp Med 1989; 157: 193-198.
    • (1989) Tohoku J Exp Med , vol.157 , pp. 193-198
    • Nakazawa, I.1    Iwaizumi, M.2
  • 19
    • 33847223836 scopus 로고    scopus 로고
    • Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice
    • Zeisig R, Koklic T, Wiesner B, Fichtner I, Sentjurc M. Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice. Arch Biochem Biophys 2007; 459: 98-106.
    • (2007) Arch Biochem Biophys , vol.459 , pp. 98-106
    • Zeisig, R.1    Koklic, T.2    Wiesner, B.3    Fichtner, I.4    Sentjurc, M.5
  • 20
    • 0029073932 scopus 로고
    • Effect of hydration upon the fluidity of intercellular membranes of stratum corneum: An EPR study
    • Alonso A, Meirelles NC, Tabak M. Effect of hydration upon the fluidity of intercellular membranes of stratum corneum: an EPR study. Biochim Biophys Acta 1995; 1237: 6-15.
    • (1995) Biochim Biophys Acta , vol.1237 , pp. 6-15
    • Alonso, A.1    Meirelles, N.C.2    Tabak, M.3
  • 21
    • 0024434263 scopus 로고
    • Localization of cholesterol in the colonic epithelium of the guinea pig: Regional differences and functional implications
    • Luciano L, Konitz H, Reale E. Localization of cholesterol in the colonic epithelium of the guinea pig: regional differences and functional implications. Cell Tissue Res 1989; 258: 339-347.
    • (1989) Cell Tissue Res , vol.258 , pp. 339-347
    • Luciano, L.1    Konitz, H.2    Reale, E.3
  • 22
  • 23
    • 0034050902 scopus 로고    scopus 로고
    • Systematic variation in gene expression patterns in human cancer cell lines
    • Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P et al. Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 2000; 24: 227-235.
    • (2000) Nat Genet , vol.24 , pp. 227-235
    • Ross, D.T.1    Scherf, U.2    Eisen, M.B.3    Perou, C.M.4    Rees, C.5    Spellman, P.6
  • 24
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22: 894-907.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 25
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Donaher JL et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 2001; 15: 50-65.
    • (2001) Genes Dev , vol.15 , pp. 50-65
    • Elenbaas, B.1    Spirio, L.2    Koerner, F.3    Fleming, M.D.4    Zimonjic, D.B.5    Donaher, J.L.6
  • 26
    • 0036118368 scopus 로고    scopus 로고
    • Enumeration of the simian virus 40 early region elements necessary for human cell transformation
    • Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 2002; 22: 2111-2123.
    • (2002) Mol Cell Biol , vol.22 , pp. 2111-2123
    • Hahn, W.C.1    Dessain, S.K.2    Brooks, M.W.3    King, J.E.4    Elenbaas, B.5    Sabatini, D.M.6
  • 27
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008; 3: e2888.
    • (2008) PLoS One , vol.3 , pp. e2888
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 28
    • 79959969184 scopus 로고    scopus 로고
    • Antagonistic regulation of EMT by TIF1gamma and Smad4 in mammary epithelial cells
    • Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J et al. Antagonistic regulation of EMT by TIF1gamma and Smad4 in mammary epithelial cells. EMBO Rep 2011; 12: 665-672.
    • (2011) EMBO Rep , vol.12 , pp. 665-672
    • Hesling, C.1    Fattet, L.2    Teyre, G.3    Jury, D.4    Gonzalo, P.5    Lopez, J.6
  • 29
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98: 10869-10874.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3    Aas, T.4    Geisler, S.5    Johnsen, H.6
  • 32
    • 0026317132 scopus 로고
    • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
    • Wang E, Norred WP, Bacon CW, Riley RT, Merrill Jr. AH. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 1991; 266: 14486-14490.
    • (1991) J Biol Chem , vol.266 , pp. 14486-14490
    • Wang, E.1    Norred, W.P.2    Bacon, C.W.3    Riley, R.T.4    Merrill, A.H.5
  • 33
    • 66149101390 scopus 로고    scopus 로고
    • Specific glycosphingolipids mediate epithelial-tomesenchymal transition of human and mouse epithelial cell lines
    • Guan F, Handa K, Hakomori SI. Specific glycosphingolipids mediate epithelial-tomesenchymal transition of human and mouse epithelial cell lines. Proc Natl Acad Sci USA 2009; 106: 7461-7466.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7461-7466
    • Guan, F.1    Handa, K.2    Hakomori, S.I.3
  • 34
    • 84865140619 scopus 로고    scopus 로고
    • Regulation of cell migration by sphingomyelin synthases: Sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway
    • Asano S, Kitatani K, Taniguchi M, Hashimoto M, Zama K, Mitsutake S et al. Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway. Mol Cell Biol 2012; 32: 3242-3252.
    • (2012) Mol Cell Biol , vol.32 , pp. 3242-3252
    • Asano, S.1    Kitatani, K.2    Taniguchi, M.3    Hashimoto, M.4    Zama, K.5    Mitsutake, S.6
  • 35
    • 0023893097 scopus 로고
    • A novel ganglioside de-N-acetyl-GM3 (II3NeuNH2LacCer) acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth
    • Hanai N, Dohi T, Nores GA, Hakomori S. A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth. J Biol Chem 1988; 263: 6296-6301.
    • (1988) J Biol Chem , vol.263 , pp. 6296-6301
    • Hanai, N.1    Dohi, T.2    Nores, G.A.3    Hakomori, S.4
  • 37
    • 84888376754 scopus 로고    scopus 로고
    • CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer
    • Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F et al. CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer. Cancer Res 2013; 73: 6711-6721.
    • (2013) Cancer Res , vol.73 , pp. 6711-6721
    • Malleter, M.1    Tauzin, S.2    Bessede, A.3    Castellano, R.4    Goubard, A.5    Godey, F.6
  • 38
    • 33845947971 scopus 로고    scopus 로고
    • Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu-and m-calpains
    • Xu L, Deng X. Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu-and m-calpains. J Biol Chem 2006; 281: 35567-35575.
    • (2006) J Biol Chem , vol.281 , pp. 35567-35575
    • Xu, L.1    Deng, X.2
  • 39
    • 34548710863 scopus 로고    scopus 로고
    • Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation
    • Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP et al. Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation. Cancer Res 2007; 67: 8460-8467.
    • (2007) Cancer Res , vol.67 , pp. 8460-8467
    • Konishi, H.1    Karakas, B.2    Abukhdeir, A.M.3    Lauring, J.4    Gustin, J.P.5    Garay, J.P.6
  • 40
    • 29744466690 scopus 로고    scopus 로고
    • Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool
    • Sergent O, Tomasi A, Ceccarelli D, Masini A, Nohl H, Cillard P et al. Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool. Biometals 2005; 18: 567-575.
    • (2005) Biometals , vol.18 , pp. 567-575
    • Sergent, O.1    Tomasi, A.2    Ceccarelli, D.3    Masini, A.4    Nohl, H.5    Cillard, P.6


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