Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats

Pharmaceutical Biology

Volumn 54, Issue 3, 2016, Pages 419-432

  Kandhare, Amit D ^a   Alam, Javed ^a   Patil, Mithun V K ^a   Sinha, Akanksha ^a   Bodhankar, Subhash L ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

Collagen 1; NF B; pol ; Smad 3; Smad 7; TGF ; VEGF

Indexed keywords

AURANTIIN; COLLAGEN TYPE 1; DNA DIRECTED DNA POLYMERASE GAMMA; GLUTATHIONE; HYDROXYPROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; NITRIC OXIDE; PROTEIN BAX; SMAD7 PROTEIN; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; VASCULOTROPIN; AUTACOID; FLAVANONE DERIVATIVE; LYMPHOTOXIN; OINTMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG FORMULATION; DRUG MECHANISM; DRUG SCREENING; EPITHELIZATION; EVALUATION STUDY; EXPERIMENTAL SURGICAL WOUND; GENE EXPRESSION REGULATION; GENE SEQUENCE; HISTOLOGY; LIPID PEROXIDATION; MALE; MEDIATOR RELEASE; NITROSATIVE STRESS; NONHUMAN; OINTMENT; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TENSILE STRENGTH; TREATMENT DURATION; TREATMENT RESPONSE; UPREGULATION; VISCOSITY; WOUND CONTRACTION; WOUND HEALING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; MEDICINAL CHEMISTRY; METABOLISM; PHYSIOLOGY; TOPICAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, TOPICAL; ANIMALS; APOPTOSIS; CHEMISTRY, PHARMACEUTICAL; FLAVANONES; INFLAMMATION MEDIATORS; LYMPHOTOXIN-ALPHA; MALE; OINTMENTS; RATS; RATS, WISTAR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84956599103     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2015.1038755     Document Type: Article

References (89)

1. Adil M, Visnagri A, Kumar VS, et al. (2014). Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats. Pharmacologia 5: 222-34
2. Akkol EK, Koca U, Peşin I, et al. (2009). Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. J Ethnopharmacol 124: 137-41
3. Albina JE. (1994). Nutrition and wound healing. J Parenter Enteral Nutr 18: 367-76
4. Atiyeh BS, Ioannovich J, Al-Amm CA, El-Musa KA. (2002). Management of acute and chronic open wounds: The importance of moist environment in optimal wound healing. Curr Pharm Biotechnol 3: 179-95
5. Attisano L, Wrana JL. (2000). Smads as transcriptional co-modulators. Curr Opin Cell Biol 12: 235-43
6. Bairy K, Rao C. (2001). Wound healing profiles of Ginkgo biloba. J Nat Remedies 1: 25-7
7. Bashir M, Sharma M, Werth V. (2009). TNF-αr; production in the skin. Arch Dermatol Res 301: 87-91
8. Bhat RS, Shankrappa J, Shivakumar H. (2007). Formulation and evaluation of polyherbal wound treatments. Asian J Pharm Sci 2: 11-17
9. Bowler PG. (2002). Wound pathophysiology, infection and therapeutic options. Ann Med 34: 419-27
10. Brunner G, Blakytny R. (2004). Extracellular regulation of TGF-beta activity in wound repair: Growth factor latency as a sensor mechanism for injury. Thromb Haemost Stuttgart 92: 253-61
11. Buck M, Houglum K, Chojkier M. (1996). Tumor necrosis factor-alpha inhibits collagen alpha-1 (I) gene expression and wound healing in a murine model of cachexia. Am J Pathol 149: 195-204
12. Chen Y, Nie YC, Luo YL, et al. (2013). Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol 58: 133-40
13. Childress BB, Stechmiller JK. (2002). Role of nitric oxide in wound healing. Biol Res Nurs 4: 5-15
14. Diegelmann RF, Evans MC. (2004). Wound healing: An overview of acute, fibrotic and delayed healing. Front Biosci 9: 283-9
15. Engelmayer J, Blezinger P, Varadhachary A. (2008). Talactoferrin stimulates wound healing with modulation of inflammation. J Surg Res 149: 278-86
16. Ganeshkumar M, Ponrasu T, Krithika R, et al. (2012). Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of Type I and III collagen. J Ethnopharmacol 142: 14-22
17. Ghosh P, Kandhare AD, Gauba D, et al. (2012a). Determination of efficacy, adverse drug reactions and cost effectiveness of three triple drug regimens for the treatment of H. Pylori infected acid peptic disease patients. Asian Pac J Trop Dis 2: S783-9
18. Ghosh P, Kandhare AD, Kumar VS, et al. (2012b). Determination of clinical outcome and pharmacoeconomics of anti-rheumatoid arthritis therapy using CDAI, EQ-5D-3L and EQ-VAS as indices of disease amelioration. Asian Pac J Trop Dis 2: S671-8
19. Ghosh P, Kandhare AD, Raygude KS, et al. (2012c). Cigarette smoking and H. Pylori infection: A meta-analysis of literature. Der Pharm Lett 4: 128-34
20. Ghosh P, Kandhare AD, Raygude KS, et al. (2012d). Determination of the long term diabetes related complications and cardiovascular events using UKPDS risk engine and UKPDS outcomes model in a representative western Indian population. Asian Pac J Trop Dis 2: S642-50
21. Golinko MS, Clark S, Rennert R, et al. (2009). Wound emergencies: The importance of assessment, documentation, and early treatment using a wound electronic medical record. Ostomy Wound Manage 55: 54-61
22. Gopinath K, Prakash D, Sudhandiran G. (2011). Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. Neurochem Intern 59: 1066-73
23. Gosain A, Dipietro LA. (2004). Aging and wound healing. World J Surg 28: 321-6
24. Gosavi T, Ghosh P, Kandhare A, Bodhankar S. (2011a). Unwrapping homeopathic principles in the wake of research: Serendipity, placebo or true therapeutic milestones. Pharmacologyonline 1: 894-906
25. Gosavi T, Kandhare A, Raygude K, et al. (2011b). A comparative study on the efficacy, safety and cost effectiveness of Viscum album and Rauwolfia serpentina mother tincture in hypertensive patients. Deccan J Nat Prod 2: 29-35
26. Gosavi TP, Ghosh P, Kandhare AD, et al. (2012a). Therapeutic effect of H. Pylori nosode, a homeopathic preparation in healing of chronic H. Pylori infected ulcers in laboratory animals. Asian Pac J Trop Dis 2: S603-11
27. Gosavi TP, Kandhare AD, Ghosh P, Bodhankar SL. (2012b). Anticonvulsant activity of Argentum metallicum, a homeopathic preparation. Der Pharm Lett 4: 626-37
28. Goswami S, Kandhare A, Zanwar AA, et al. (2014). Oral l-glutamine administration attenuated cutaneous wound healing in Wistar rats. Int Wound J. [Epub ahead of print]. doi: 10.1111/iwj.12246
29. Grose R, Werner S. (2004). Wound-healing studies in transgenic and knockout mice. Mol Biotechnol 28: 147-66
30. Gutteridge JM, Halliwell B. (1993). Invited review free radicals in disease processes: A compilation of cause and consequence. Free Radic Res 19: 141-58
31. Hart J. (2002). Inflammation. 2: Its role in the healing of chronic wounds. J Wound Care 11: 245-9
32. Jeon SM, Bok SH, Jang MK, et al. (2001). Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci 69: 2855-66
33. Kamble H, Kandhare AD, Bodhankar S, et al. (2013). Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol 3: 145-51
34. Kandhare AD, Bodhankar SL, Singh V, et al. (2013a). Anti-asthmatic effects of type-A procyanidine polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals. Biomed Aging Pathol 3: 23-30
35. Kandhare AD, Ghosh P, Bodhankar SL. (2014a). Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chem-Biol Inter 219C: 101-12
36. Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. (2013b). Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol induced neuropathic pain. Fund Clin Pharmacol 27: 603-22
37. Kandhare AD, Ghosh P, Ghule AE, et al. (2013c). Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: Role of phyllanthin and hypophyllanthin. Apollo Med 10: 87-97
38. Kandhare AD, Kumar VS, Adil M, et al. (2012a). Investigation of gastro protective activity of Xanthium strumarium L. by modulation of cellular and biochemical marker. Orient Pharm Exp Med 12: 287-99
39. Kandhare AD, Raygude KS, Ghosh P, et al. (2011b). Patentability of animal models: India and the globe. Int J Pharm Biol Arch 2: 1024-32
40. Kandhare AD, Raygude KS, Ghosh P, et al. (2012b). Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia 83: 650-9
41. Kandhare AD, Raygude KS, Ghosh P, et al. (2012c). Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett 511: 18-22
42. Kandhare AD, Raygude KS, Ghosh P, et al. (2012d). Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats. Asian Pac J Trop Biomed 5: 337-44
43. Kandhare A, Raygude K, Ghosh P, Bodhankar S. (2011a). The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats. Int J Green Pharm 5: 236-43
44. Kandhare AD, Raygude KS, Shiva Kumar V, et al. (2012e). Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomed Aging Pathol 2: 173-86
45. Kandhare AD, Shivakumar V, Rajmane A, et al. (2014b). Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury. J Nat Med 68: 1-18
46. Kanno S-I, Shouji A, Asou K, Ishikawa M. (2003). Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. J Pharmacol Sci 92: 166-70
47. Kumar VS, Rajmane AR, Adil M, et al. (2014). Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res 28: 132-45
48. Lawrence WT, Norton J, Sporn M, et al. (1986). The reversal of an adriamycin induced healing impairment with chemoattractants and growth factors. Ann Surg 203: 142-7
49. Lin Y, Xu J, Cao L, et al. (2010). Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine. Neurosci Lett 474: 22-5
50. Lovvorn HN, Nance ML, Ferry RJ, et al. (1999). Congenital hyperinsulinism and the surgeon: Lessons learned over 35 years. J Pediatr Surg 34: 786-92
51. Lowry O, Rosebrough N, Farr A, Randall R. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-75
52. Margaret I, Srinivasa RP, Kaiser J. (1998). Antiinflammatory profile of Tridax procumbens in animal and fibroblast cell models. Phytother Res 12: 285-7
53. Meyer NL, Hosier KV, Scott K, Lipscomb GH. (2003). Cefazolin versus cefazolin plus metronidazole for antibiotic prophylaxis at cesarean section. South Med J 96: 992-5
54. Monaco JL, Lawrence WT. (2003). Acute wound healing: An overview. Clin Plast Surg 30: 1-12
55. Moulin V, Auger FA, Garrel D, Germain L. (2000). Role of wound healing myofibroblasts on re-epithelialization of human skin. Burns 26: 3-12
56. Natarajan S, Williamson D, Stiltz AJ, Harding K. (2000). Advances in wound care and healing technology. Am J Clin Dermatol 1: 269-75
57. Nguyen D, Orgill D, Murphy G. (2009). The pathophysiologic basis for wound healing and cutaneous regeneration. In: Orgill DP, Blanco C, eds. Biomaterials for Treating Skin Loss. Boca Raton (FL): CRC Press, 25-57
58. Nirmala S, Karthiyayini T. (2011). Wound healing activity on the leaves of Achillea millefolium L. by excision, incision, and dead space model on adult Wistar albino rats. Int Res J Pharm 2: 240-5
59. Opalenik SR, Davidson JM. (2005). Fibroblast differentiation of bone marrow-derived cells during wound repair. FASEB J 19: 1561-3
60. Panda P, Nayak S, Mohanty A, et al. (2009). Formulation and evaluation of topical dosage form of Pandanus fascicularis Lamk. And their wound healing activity. J Pharm Res 2: 630-5
61. Patil M, Kandhare A, Bhise S. (2011). Pharmacological evaluation of ameliorative effect of aqueous extract of Cucumis sativus L. fruit formulation on wound healing in Wistar rats. Chron Young Sci 2: 207-13
62. Patil M, Kandhare A, Bhise S. (2012a). Anti-inflammatory effect of Daucus carota root on experimental colitis in rats. Int J Pharm Pharm Sci 4: 337-43
63. Patil MVK, Kandhare AD, Bhise SD. (2012b). Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. Ethanolic extract in Freund's complete adjuvant induced arthritis. Biomed Aging Pathol 2: 6-15
64. Patil MVK, Kandhare AD, Bhise SD. (2012c). Effect of aqueous extract of Cucumis sativus Linn. fruit in ulcerative colitis in laboratory animals. Asian Pac J Trop Biomed 2: S962-9
65. Patil MVK, Kandhare AD, Bhise SD. (2012d). Pharmacological evaluation of ethanolic extract of Daucus carota Linn root formulated cream on wound healing using excision and incision wound model. Asian Pac J Trop Biomed 2: S646-55
66. Patil MVK, Kandhare AD, Ghosh P, Bhise SD. (2012e). Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. Ethanolic extract in chemically induced epilepsy in laboratory animals. Orient Pharm Exp Med 12: 255-64
67. Pierce PD, Md, Glenn F, Mustoe M, Thomas A. (1995). Pharmacologic enhancement of wound healing. Ann Rev Med 46: 467-81
68. Prasad SK, Kumar R, Patel DK, Hemalatha S. (2010). Wound healing activity of Withania coagulans in streptozotocin-induced diabetic rats. Pharm Biol 48: 1397-404
69. Rashed A, Afifi F, Disi A. (2003). Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. J Ethnopharmacol 88: 131-6
70. Raygude KS, Kandhare AD, Ghosh P, Bodhankar SL. (2012a). Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prev Nutr 2: 215-22
71. Raygude KS, Kandhare AD, Ghosh P, et al. (2012b). Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology 20: 331-41
72. Robson MC, Steed DL, Franz MG. (2001). Wound healing: Biologic features and approaches to maximize healing trajectories. Curr Probl Surg 38: 72-140
73. Ross R, Everett NB, Tyler R. (1970). Wound healing and collagen formation VI. The origin of the wound fibroblast studied in parabiosis. J Cell Biol 44: 645-54
74. Sarma SP, Aithal KS, Srinivasan K, et al. (1990). Anti-inflammatory and wound healing activities of the crude alcoholic extract and flavonoids of Vitex leucoxylon. Fitoterapia 61: 263-5
75. Sekelsky JJ, Newfeld SJ, Raftery LA, et al. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-58
76. Shetty S, Udupa S, Udupa L. (2008). Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats. Evid Based Complement Alternat Med 5: 95-101
77. Shirwaikar A, Shenoy R, Udupa A, et al. (2003). Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes. Ind J Exp Biol 41: 238-41
78. Shivakumar V, Kandhare A, Rajmane A, et al. (2014). Estimation of the long-term cardiovascular events using ukpds risk engine in metabolic syndrome patients. Ind J Pharm Sci 76: 174-8
79. Singer AJ, Clark R. (1999). Cutaneous wound healing. N Engl J Med 341: 738-46
80. Suguna L, Singh S, Sivakumar P, et al. (2002). Influence of Terminalia chebula on dermal wound healing in rats. Phytother Res 16: 227-31
81. Szabowski A, Maas-Szabowski N, Andrecht S, et al. (2000). c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103: 745-55
82. Tonnesen MG, Feng X, Clark RA. (2000). Angiogenesis in wound healing. J Investig Dermatol Symp Proc 5: 40-6
83. Tsuchiya T, Suzuki O, Igarashi K. (1996). Protective effects of chlorogenic acid on paraquat-induced oxidative stress in rats. Biosci Biotechnol Biochem 60: 765-8
84. Visnagri A, Kandhare AD, Chakravarty S, et al. (2014). Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm Biol 52: 814-28
85. Visnagri A, Kandhare AD, Ghosh P, Bodhankar SL. (2013). Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats. Cardiovasc Endocrinol 2: 85-97
86. Visnagri A, Kandhare AD, Shiva Kumar V, et al. (2012). Elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomed Aging Pathol 2: 157-72
87. Werner S, Grose R. (2003). Regulation of wound healing by growth factors and cytokines. Physiol Rev 83: 835-70
88. Werner S, Krieg T, Smola H. (2007). Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 127: 998-1008
89. Zhang GY, Li X, Yi CG, et al. (2009). Angiotensin II activates connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen-activated protein kinase signalling pathways in human dermal fibroblasts. Exp Dermatol 18: 947-53